{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T08:32:19Z","timestamp":1770453139182,"version":"3.49.0"},"reference-count":32,"publisher":"Pharmaceutical Society of Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological & Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2018]]},"DOI":"10.1248\/bpb.b17-00769","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:10:37Z","timestamp":1511975437000},"page":"229-238","source":"Crossref","is-referenced-by-count":29,"title":["MicroRNA-21-Regulated Activation of the Akt Pathway Participates in the Protective Effects of H<sub>2<\/sub>S against Liver Ischemia\u2013Reperfusion Injury"],"prefix":"10.1248","volume":"41","author":[{"given":"Meng","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Surgery, Chinese Academy of Medical Sciences & Peking Union Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Hepatosplenic Surgery Center, Department of General Surgery, the First Affiliated Hospital of Harbin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liquan","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of General Surgery, the Fifth Affiliated Hospital of Harbin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, the Fifth Affiliated Hospital of Harbin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Surgery, Chinese Academy of Medical Sciences & Peking Union Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuesong","family":"Dong","sequence":"additional","affiliation":[{"name":"The Hepatosplenic Surgery Center, Department of General Surgery, the First Affiliated Hospital of Harbin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueying","family":"Sun","sequence":"additional","affiliation":[{"name":"The Hepatosplenic Surgery Center, Department of General Surgery, the First Affiliated Hospital of Harbin Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Zhai Y, Petrowsky H, Hong JC, Busuttil RW, Kupiec-Weglinski JW. Ischaemia\u2013reperfusion injury in liver transplantation\u2014from bench to bedside. Nat. Rev. Gastroenterol. Hepatol.<\/i>, 10<\/b>, 79\u201389 (2013).","DOI":"10.1038\/nrgastro.2012.225"},{"key":"2","unstructured":"2) Wallace JL, Wang R. Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter. Nat. Rev. Drug Discov.<\/i>, 14<\/b>, 329\u2013345 (2015)."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Wu D, Wang J, Li H, Xue M, Ji A, Li Y. Role of hydrogen sulfide in ischemia\u2013reperfusion injury. Oxid. Med. Cell. Longev.<\/i>, 2015<\/b>, 186908 (2015).","DOI":"10.1155\/2015\/186908"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Jang H, Oh MY, Kim YJ, Choi IY, Yang HS, Ryu WS, Lee SH, Yoon BW. Hydrogen sulfide treatment induces angiogenesis after cerebral ischemia. J. Neurosci. Res.<\/i>, 92<\/b>, 1520\u20131528 (2014).","DOI":"10.1002\/jnr.23427"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Spassov SG, Donus R, Ihle PM, Engelstaedter H, Hoetzel A, Faller S. Hydrogen sulfide prevents formation of reactive oxygen species through PI3K\/Akt signaling and limits ventilator-induced lung injury. Oxid. Med. Cell. Longev.<\/i>, 2017<\/b>, 3715037 (2017).","DOI":"10.1155\/2017\/9230134"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Tang B, Ma L, Yao X, Tan G, Han P, Yu T, Liu B, Sun X. Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release. J. Vasc. Surg.<\/i>, 65<\/b>, 501\u2013508.e1 (2017).","DOI":"10.1016\/j.jvs.2015.10.010"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Whiteman M, Li L, Rose P, Tan CH, Parkinson DB, Moore PK. The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages. Antioxid. Redox Signal.<\/i>, 12<\/b>, 1147\u20131154 (2010).","DOI":"10.1089\/ars.2009.2899"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Zhao Y, Zhang WD, Liu XQ, Zhang PF, Hao YN, Li L, Chen L, Shen W, Tang XF, Min LJ, Meng QS, Wang SK, Yi B, Zhang HF. Hydrogen sulfide and\/or ammonia reduces spermatozoa motility through AMPK\/AKT related pathways. Sci. Rep.<\/i>, 6<\/b>, 37884 (2016).","DOI":"10.1038\/srep37884"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Kang K, Zhao M, Jiang H, Tan G, Pan S, Sun X. Role of hydrogen sulfide in hepatic ischemia\u2013reperfusion-induced injury in rats. Liver Transpl.<\/i>, 15<\/b>, 1306\u20131314 (2009).","DOI":"10.1002\/lt.21810"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Wang D, Ma Y, Li Z, Kang K, Sun X, Pan S, Wang J, Pan H, Liu L, Liang D, Jiang H. The role of AKT1 and autophagy in the protective effect of hydrogen sulphide against hepatic ischemia\/reperfusion injury in mice. Autophagy<\/i>, 8<\/b>, 954\u2013962 (2012).","DOI":"10.4161\/auto.19927"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Suo L, Kang K, Wang X, Cao Y, Zhao H, Sun X, Tong L, Zhang F. Carvacrol alleviates ischemia reperfusion injury by regulating the PI3K-Akt pathway in rats. PLOS ONE<\/i>, 9<\/b>, e104043 (2014).","DOI":"10.1371\/journal.pone.0104043"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Yan-nan B, Zhao-yan Y, Li-xi L, Jiang Y, Qing-jie X, Yong Z. MicroRNA-21 accelerates hepatocyte proliferation in vitro via<\/i> PI3K\/Akt signaling by targeting PTEN. Biochem. Biophys. Res. Commun.<\/i>, 443<\/b>, 802\u2013807 (2014).","DOI":"10.1016\/j.bbrc.2013.12.047"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Chen X, Song M, Chen W, Dimitrova-Shumkovska J, Zhao Y, Cao Y, Song Y, Yang W, Wang F, Xiang Y, Yang C. MicroRNA-21 contributes to liver regeneration by targeting PTEN. Med. Sci. Monit.<\/i>, 22<\/b>, 83\u201391 (2016).","DOI":"10.12659\/MSM.896157"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Juskeviciute E, Dippold RP, Antony AN, Swarup A, Vadigepalli R, Hoek JB. Inhibition of miR-21 rescues liver regeneration after partial hepatectomy in ethanol-fed rats. Am. J. Physiol. Gastrointest. Liver Physiol.<\/i>, 311<\/b>, G794\u2013G806 (2016).","DOI":"10.1152\/ajpgi.00292.2016"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Jia P, Wu X, Dai Y, Teng J, Fang Y, Hu J, Zou J, Liang M, Ding X. MicroRNA-21 Is Required for local and remote ischemic preconditioning in multiple organ protection against sepsis. Crit. Care Med.<\/i>, 45<\/b>, e703\u2013e710 (2017).","DOI":"10.1097\/CCM.0000000000002363"},{"key":"16","unstructured":"16) Li L, Whiteman M, Guan YY, Neo KL, Cheng Y, Lee SW, Zhao Y, Baskar R, Tan CH, Moore PK. Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide. Circulation<\/i>, 117<\/b>, 2351\u20132360 (2008)."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Gao Y, Yao X, Zhang Y, Li W, Kang K, Sun L, Sun X. The protective role of hydrogen sulfide in myocardial ischemia\u2013reperfusion-induced injury in diabetic rats. Int. J. Cardiol.<\/i>, 152<\/b>, 177\u2013183 (2011).","DOI":"10.1016\/j.ijcard.2010.07.012"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Zhang F, Mao Y, Qiao H, Jiang H, Zhao H, Chen X, Tong L, Sun X. Protective effects of taurine against endotoxin-induced acute liver injury after hepatic ischemia reperfusion. Amino Acids<\/i>, 38<\/b>, 237\u2013245 (2010).","DOI":"10.1007\/s00726-009-0233-z"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) He C, Dong X, Zhai B, Jiang X, Dong D, Li B, Jiang H, Xu S, Sun X. MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via<\/i> the PTEN\/Akt pathway. Oncotarget<\/i>, 6<\/b>, 28867\u201328881 (2015).","DOI":"10.18632\/oncotarget.4814"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Kabil O, Vitvitsky V, Xie P, Banerjee R. The quantitative significance of the transsulfuration enzymes for H2<\/sub>S production in murine tissues. Antioxid. Redox Signal.<\/i>, 15<\/b>, 363\u2013372 (2011).","DOI":"10.1089\/ars.2010.3781"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Toldo S, Das A, Mezzaroma E, Chau VQ, Marchetti C, Durrant D, Samidurai A, Van Tassell BW, Yin C, Ockaili RA, Vigneshwar N, Mukhopadhyay ND, Kukreja RC, Abbate A, Salloum FN. Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice. Circ Cardiovasc Genet<\/i>, 7<\/b>, 311\u2013320 (2014).","DOI":"10.1161\/CIRCGENETICS.113.000381"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Ambros V. The functions of animal microRNAs. Nature<\/i>, 431<\/b>, 350\u2013355 (2004).","DOI":"10.1038\/nature02871"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Zhang P, Li F, Wiegman CH, Zhang M, Hong Y, Gong J, Chang Y, Zhang JJ, Adcock I, Chung KF, Zhou X. Inhibitory effect of hydrogen sulfide on ozone-induced airway inflammation, oxidative stress, and bronchial hyperresponsiveness. Am. J. Respir. Cell Mol. Biol.<\/i>, 52<\/b>, 129\u2013137 (2015).","DOI":"10.1165\/rcmb.2013-0415OC"},{"key":"24","unstructured":"24) Rose P, Moore PK, Zhu YZ. H2<\/sub>S biosynthesis and catabolism: new insights from molecular studies. Cell. Mol. Life Sci.<\/i>, 74<\/b>, 1391\u20131412 (2017)."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Mathai JC, Missner A, Kugler P, Saparov SM, Zeidel ML, Lee JK, Pohl P. No facilitator required for membrane transport of hydrogen sulfide. Proc. Natl. Acad. Sci. U.S.A.<\/i>, 106<\/b>, 16633\u201316638 (2009).","DOI":"10.1073\/pnas.0902952106"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O\u2019Leary JJ, Ruan Q, Johnson DS, Chen Y, O\u2019Neill LA. Negative regulation of TLR4 via<\/i> targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat. Immunol.<\/i>, 11<\/b>, 141\u2013147 (2010).","DOI":"10.1038\/ni.1828"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Rao J, Qian X, Li G, Pan X, Zhang C, Zhang F, Zhai Y, Wang X, Lu L. ATF3-mediated NRF2\/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia\/reperfusion injury. Am. J. Transplant.<\/i>, 15<\/b>, 76\u201387 (2015).","DOI":"10.1111\/ajt.12954"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Park SW, Chen SW, Kim M, Brown KM, D\u2019Agati VD, Lee HT. Protection against acute kidney injury via<\/i> A(1) adenosine receptor-mediated Akt activation reduces liver injury after liver ischemia and reperfusion in mice. J. Pharmacol. Exp. Ther.<\/i>, 333<\/b>, 736\u2013747 (2010).","DOI":"10.1124\/jpet.110.166884"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Mullonkal CJ, Toledo-Pereyra LH. Akt in ischemia and reperfusion. J. Invest. Surg.<\/i>, 20<\/b>, 195\u2013203 (2007).","DOI":"10.1080\/08941930701366471"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC. Regulation of cell death protease caspase-9 by phosphorylation. Science<\/i>, 282<\/b>, 1318\u20131321 (1998).","DOI":"10.1126\/science.282.5392.1318"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Wang H, Brown J, Gu Z, Garcia CA, Liang R, Alard P, Beurel E, Jope RS, Greenway T, Martin M. Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-beta-signaling pathways regulates the innate inflammatory response. J. Immunol.<\/i>, 186<\/b>, 5217\u20135226 (2011).","DOI":"10.4049\/jimmunol.1002513"},{"key":"32","unstructured":"32) Wang H, Brown J, Martin M. Glycogen synthase kinase 3: a point of convergence for the host inflammatory response. Cytokine<\/i>, 53<\/b>, 130\u2013140 (2011)."}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/41\/2\/41_b17-00769\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T23:35:04Z","timestamp":1570404904000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/41\/2\/41_b17-00769\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b17-00769","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}