{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:49:26Z","timestamp":1787021366862,"version":"build-2736575974"},"reference-count":25,"publisher":"Pharmaceutical Society of Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2018]]},"DOI":"10.1248\/bpb.b17-00861","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T17:25:55Z","timestamp":1517419555000},"page":"272-276","source":"Crossref","is-referenced-by-count":7,"title":["Methylglyoxal Impairs \u03b2&lt;sub&gt;2&lt;\/sub&gt;-Adrenoceptor-Mediated Vasodilatory Mechanisms in Rat Retinal Arterioles"],"prefix":"10.1248","volume":"41","author":[{"given":"Mari","family":"Akagawa","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asami","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Bursell SE, Clermont AC, Shiba T, King GL, Uusitalo H. Evaluating retinal circulation using video fluorescein angiography in control and diabetic rats. <i>Curr. Eye Res.<\/i>, <b>11<\/b>, 287\u2013295 (1992).","DOI":"10.3109\/02713689209001782"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Clermont AC, Bursell SE. Retinal blood flow in diabetes. <i>Microcirculation<\/i>, <b>14<\/b>, 49\u201361 (2007).","DOI":"10.1080\/10739680601072164"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) De La Cruz JP, Gonzalez-Correa JA, Guerrero A, de la Cuesta FS. Pharmacological approach to diabetic retinopathy. <i>Diabetes Metab. Res. Rev.<\/i>, <b>20<\/b>, 91\u2013113 (2004).","DOI":"10.1002\/dmrr.432"},{"key":"4","unstructured":"4) Feke GT, Buzney SM, Ogasawara H, Fujio N, Goger DG, Spack NP, Gabbay KH. Retinal circulatory abnormalities in type 1 diabetes. <i>Invest. Ophthalmol. Vis. Sci.<\/i>, <b>35<\/b>, 2968\u20132975 (1994)."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Ghirlanda G, Di Leo MA, Caputo S, Cercone S, Greco AV. From functional to microvascular abnormalities in early diabetic retinopathy. <i>Diabetes Metab. Rev.<\/i>, <b>13<\/b>, 15\u201335 (1997).","DOI":"10.1002\/(SICI)1099-0895(199703)13:1<15::AID-DMR176>3.0.CO;2-M"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Yim HS, Kang SO, Hah YC, Chock PB, Yim MB. Free radicals generated during the glycation reaction of amino acids by methylglyoxal. A model study of protein-cross-linked free radicals. <i>J. Biol. Chem.<\/i>, <b>270<\/b>, 28228\u201328233 (1995).","DOI":"10.1074\/jbc.270.47.28228"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) McLellan AC, Thornalley PJ, Benn J, Sonksen PH. Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications. <i>Clin. Sci.<\/i>, <b>87<\/b>, 21\u201329 (1994).","DOI":"10.1042\/cs0870021"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Ono Y, Aoki S, Ohnishi K, Yasuda T, Kawano K, Tsukada Y. Increased serum levels of advanced glycation end products in NIDDM patients with diabetic complications. <i>Diabetes Care<\/i>, <b>21<\/b>, 1027 (1998).","DOI":"10.2337\/diacare.21.6.1027a"},{"key":"9","unstructured":"9) Odani H, Shinzato T, Matsumoto Y, Usami J, Maeda K. Increase in three alpha,beta-dicarbonyl compound levels in human uremic plasma: specific <i>in vivo<\/i> determination of intermediates in advanced Maillard reaction. <i>Biochem. Biophys. Res. Commun.<\/i>, <b>256<\/b>, 89\u201393 (1999)."},{"key":"10","unstructured":"10) Lapolla A, Flamini R, Dalla Vedova A, Senesi A, Reitano R, Fedele D, Basso E, Seraglia R, Traldi P. Glyoxal and methylglyoxal levels in diabetic patients: quantitative determination by a new GC\/MS method. <i>Clin. Chem. Lab. Med.<\/i>, <b>41<\/b>, 1166\u20131173 (2003)."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Kong X, Ma MZ, Huang K, Qin L, Zhang HM, Yang Z, Li XY, Su Q. Increased plasma levels of the methylglyoxal in patients with newly diagnosed type 2 diabetes. <i>J. Diabetes<\/i>, <b>6<\/b>, 535\u2013540 (2014).","DOI":"10.1111\/1753-0407.12160"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Mukohda M, Yamawaki H, Nomura H, Okada M, Hara Y. Methylglyoxal inhibits smooth muscle contraction in isolated blood vessels. <i>J. Pharmacol. Sci.<\/i>, <b>109<\/b>, 305\u2013310 (2009).","DOI":"10.1254\/jphs.08300FP"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Kim J, Son JW, Lee JA, Oh YS, Shinn SH. Methylglyoxal induces apoptosis mediated by reactive oxygen species in bovine retinal pericytes. <i>J. Korean Med. Sci.<\/i>, <b>19<\/b>, 95\u2013100 (2004).","DOI":"10.3346\/jkms.2004.19.1.95"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Kim J, Kim CS, Lee YM, Jo K, Shin SD, Kim JS. Methylglyoxal induces hyperpermeability of the blood-retinal barrier <i>via<\/i> the loss of tight junction proteins and the activation of matrix metalloproteinases. <i>Graefes Arch. Clin. Exp. Ophthalmol.<\/i>, <b>250<\/b>, 691\u2013697 (2012).","DOI":"10.1007\/s00417-011-1912-5"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Nakazawa T, Sato A, Mori A, Saito M, Sakamoto K, Nakahara T, Ishii K. \u03b2-adrenoceptor-mediated vasodilation of retinal blood vessels is reduced in streptozotocin-induced diabetic rats. <i>Vascul. Pharmacol.<\/i>, <b>49<\/b>, 77\u201383 (2008).","DOI":"10.1016\/j.vph.2008.06.001"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Mori A, Nakahara T, Sakamoto K, Ishii K. Role of \u03b2<sub>3<\/sub>-adrenoceptors in regulation of retinal vascular tone in rats. <i>Naunyn Schmiedebergs Arch. Pharmacol.<\/i>, <b>384<\/b>, 603\u2013608 (2011).","DOI":"10.1007\/s00210-011-0682-2"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Mori A, Miwa T, Sakamoto K, Nakahara T, Ishii K. Pharmacological evidence for the presence of functional \u03b2<sub>3<\/sub>-adrenoceptors in rat retinal blood vessels. <i>Naunyn Schmiedebergs Arch. Pharmacol.<\/i>, <b>382<\/b>, 119\u2013126 (2010).","DOI":"10.1007\/s00210-010-0526-5"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Mori A, Takei T, Sakamoto K, Nakahara T, Ishii K. 4-Hydroxy-2-nonenal attenuates \u03b2<sub>2<\/sub>-adrenoceptor-mediated vasodilation of rat retinal arterioles. <i>Naunyn Schmiedebergs Arch. Pharmacol.<\/i>, <b>388<\/b>, 575\u2013582 (2015).","DOI":"10.1007\/s00210-015-1099-0"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K. Vasodilation of retinal arterioles induced by activation of BK<sub>Ca<\/sub> channels is attenuated in diabetic rats. <i>Eur. J. Pharmacol.<\/i>, <b>669<\/b>, 94\u201399 (2011b).","DOI":"10.1016\/j.ejphar.2011.07.042"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Mori A, Saigo O, Hanada M, Nakahara T, Ishii K. Hyperglycemia accelerates impairment of vasodilator responses to acetylcholine of retinal blood vessels in rats. <i>J. Pharmacol. Sci.<\/i>, <b>110<\/b>, 160\u2013168 (2009).","DOI":"10.1254\/jphs.08320FP"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Nakazawa T, Kaneko Y, Mori A, Saito M, Sakamoto K, Nakahara T, Ishii K. Attenuation of nitric oxide- and prostaglandin-independent vasodilation of retinal arterioles induced by acetylcholine in streptozotocin-treated rats. <i>Vascul. Pharmacol.<\/i>, <b>46<\/b>, 153\u2013159 (2007).","DOI":"10.1016\/j.vph.2006.09.002"},{"key":"22","unstructured":"22) Berkowitz BA, Lukaszew RA, Mullins CM, Penn JS. Impaired hyaloidal circulation function and uncoordinated ocular growth patterns in experimental retinopathy of prematurity. <i>Invest. Ophthalmol. Vis. Sci.<\/i>, <b>39<\/b>, 391\u2013396 (1998)."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR. Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gs\u03b1\u00b7GTP\u03b3S. <i>Science<\/i>, <b>278<\/b>, 1907\u20131916 (1997).","DOI":"10.1126\/science.278.5345.1907"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Zhang G, Liu Y, Ruoho AE, Hurley JH. Structure of the adenylyl cyclase catalytic core. <i>Nature<\/i>, <b>386<\/b>, 247\u2013253 (1997).","DOI":"10.1038\/386247a0"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Hiramatsu T, Kume H, Kotlikoff MI, Takagi K. Role of calcium-activated potassium channels in the relaxation of tracheal smooth muscles by forskolin. <i>Clin. Exp. Pharmacol. Physiol.<\/i>, <b>21<\/b>, 367\u2013375 (1994).","DOI":"10.1111\/j.1440-1681.1994.tb02529.x"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/41\/2\/41_b17-00861\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T23:07:11Z","timestamp":1570662431000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/41\/2\/41_b17-00861\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b17-00861","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}