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International union of pharmacology. XLVIII. Nomenclature and structure\u2013function relationships of voltage-gated calcium channels. <i>Pharmacol. Rev.<\/i>, <b>57<\/b>, 411\u2013425 (2005).","DOI":"10.1124\/pr.57.4.5"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Zamponi GW, Striessnig J, Koschak A, Dolphin AC. The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential. <i>Pharmacol. Rev.<\/i>, <b>67<\/b>, 821\u2013870 (2015).","DOI":"10.1124\/pr.114.009654"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Todorovic SM, Jevtovic-Todorovic V. T-type voltage-gated calcium channels as targets for the development of novel pain therapies. <i>Br. J. Pharmacol.<\/i>, <b>163<\/b>, 484\u2013495 (2011).","DOI":"10.1111\/j.1476-5381.2011.01256.x"},{"key":"4","unstructured":"4) Sekiguchi F, Kawabata A. T-type calcium channels: functional regulation and implication in pain signaling. <i>J. Pharmacol. Sci.<\/i>, <b>122<\/b>, 244\u2013250 (2013)."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Huang J, Zamponi GW. Regulation of voltage gated calcium channels by GPCRs and post-translational modification. <i>Curr. Opin. Pharmacol.<\/i>, <b>32<\/b>, 1\u20138 (2017).","DOI":"10.1016\/j.coph.2016.10.001"},{"key":"6","unstructured":"6) Roca-Lapirot O, Radwani H, Aby F, Nagy F, Landry M, Fossat P. Calcium signalling through L-type calcium channels: role in pathophysiology of spinal nociceptive transmission. <i>Br. J. Pharmacol.<\/i>, <b>175<\/b>, 2362\u20132374 (2018)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Ji RR, Xu ZZ, Gao YJ. Emerging targets in neuroinflammation-driven chronic pain. <i>Nat. Rev. Drug Discov.<\/i>, <b>13<\/b>, 533\u2013548 (2014).","DOI":"10.1038\/nrd4334"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Iyengar S, Ossipov MH, Johnson KW. The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine. <i>Pain<\/i>, <b>158<\/b>, 543\u2013559 (2017).","DOI":"10.1097\/j.pain.0000000000000831"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Corrigan F, Mander KA, Leonard AV, Vink R. Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation. <i>J. Neuroinflammation<\/i>, <b>13<\/b>, 264 (2016).","DOI":"10.1186\/s12974-016-0738-9"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Matsunami M, Miki T, Nishiura K, Hayashi Y, Okawa Y, Nishikawa H, Sekiguchi F, Kubo L, Ozaki T, Tsujiuchi T, Kawabata A. Involvement of the endogenous hydrogen sulfide\/Ca<sub>v<\/sub>3.2\u2009T-type Ca<sup>2+<\/sup> channel pathway in cystitis-related bladder pain in mice. <i>Br. J. Pharmacol.<\/i>, <b>167<\/b>, 917\u2013928 (2012).","DOI":"10.1111\/j.1476-5381.2012.02060.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Pietrobon D. Calcium channels and migraine. <i>Biochim. Biophys. Acta<\/i>, <b>1828<\/b>, 1655\u20131665 (2013).","DOI":"10.1016\/j.bbamem.2012.11.012"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Ophoff RA, Terwindt GM, Vergouwe MN, van Eijk R, Oefner PJ, Hoffman SM, Lamerdin JE, Mohrenweiser HW, Bulman DE, Ferrari M, Haan J, Lindhout D, van Ommen GJ, Hofker MH, Ferrari MD, Frants RR. Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca<sup>2+<\/sup> channel gene CACNL1A4. <i>Cell<\/i>, <b>87<\/b>, 543\u2013552 (1996).","DOI":"10.1016\/S0092-8674(00)81373-2"},{"key":"13","unstructured":"13) Ceruti S, Villa G, Fumagalli M, Colombo L, Magni G, Zanardelli M, Fabbretti E, Verderio C, van den Maagdenberg AM, Nistri A, Abbracchio MP. Calcitonin gene-related peptide-mediated enhancement of purinergic neuron\/glia communication by the algogenic factor bradykinin in mouse trigeminal ganglia from wild-type and R192Q Ca<sub>v<\/sub>2.1 Knock-in mice: implications for basic mechanisms of migraine pain. <i>J. Neurosci.<\/i>, <b>31<\/b>, 3638\u20133649 (2011)."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Franceschini A, Vilotti S, Ferrari MD, van den Maagdenberg AM, Nistri A, Fabbretti E. TNF\u03b1 levels and macrophages expression reflect an inflammatory potential of trigeminal ganglia in a mouse model of familial hemiplegic migraine. <i>PLOS ONE<\/i>, <b>8<\/b>, e52394 (2013).","DOI":"10.1371\/journal.pone.0052394"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Pellacani S, Sicca F, Di Lorenzo C, Grieco GS, Valvo G, Cereda C, Rubegni A, Santorelli FM. The revolution in migraine genetics: from aching channels disorders to a next-generation medicine. <i>Front. Cell. Neurosci.<\/i>, <b>10<\/b>, 156 (2016).","DOI":"10.3389\/fncel.2016.00156"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Robert V, Triffaux E, Paulet PE, Guery JC, Pelletier L, Savignac M. Protein kinase C-dependent activation of Ca<sub>v<\/sub>1.2 channels selectively controls human T<sub>H<\/sub>2-lymphocyte functions. <i>J. Allergy Clin. Immunol.<\/i>, <b>133<\/b>, 1175\u20131183.e12 (2014).","DOI":"10.1016\/j.jaci.2013.10.038"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Rosa N, Triffaux E, Robert V, Mars M, Klein M, Bouchaud G, Canivet A, Magnan A, Guery JC, Pelletier L, Savignac M. The \u03b2 and \u03b1<sub>2<\/sub>\u03b4 auxiliary subunits of voltage-gated calcium channel 1 (Ca<sub>v<\/sub>1) are required for TH2 lymphocyte function and acute allergic airway inflammation. <i>J. Allergy Clin. Immunol.<\/i>, (2017), in press.","DOI":"10.1016\/j.jaci.2017.09.045"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Espinosa-Parrilla JF, Martinez-Moreno M, Gasull X, Mahy N, Rodriguez MJ. The L-type voltage-gated calcium channel modulates microglial pro-inflammatory activity. <i>Mol. Cell. Neurosci.<\/i>, <b>64<\/b>, 104\u2013115 (2015).","DOI":"10.1016\/j.mcn.2014.12.004"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Saegusa H, Tanabe T. N-type voltage-dependent Ca<sup>2+<\/sup> channel in non-excitable microglial cells in mice is involved in the pathophysiology of neuropathic pain. <i>Biochem. Biophys. Res. Commun.<\/i>, <b>450<\/b>, 142\u2013147 (2014).","DOI":"10.1016\/j.bbrc.2014.05.103"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Yang JL, Xu B, Li SS, Zhang WS, Xu H, Deng XM, Zhang YQ. Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats. <i>Mol. Brain<\/i>, <b>5<\/b>, 18 (2012).","DOI":"10.1186\/1756-6606-5-18"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Weiss N, Zamponi GW. Control of low-threshold exocytosis by T-type calcium channels. <i>Biochim. Biophys. Acta<\/i>, <b>1828<\/b>, 1579\u20131586 (2013).","DOI":"10.1016\/j.bbamem.2012.07.031"},{"key":"22","unstructured":"22) Todorovic SM, Jevtovic-Todorovic V. Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling. <i>Pflugers Arch.<\/i>, <b>465<\/b>, 921\u2013927 (2013)."},{"key":"23","unstructured":"23) Terada Y, Kawabata A. H<sub>2<\/sub>S and pain: a novel aspect for processing of somatic, visceral and neuropathic pain signals. <i>Handbook Exp. Pharmacol.<\/i>, <b>230<\/b>, 217\u2013230 (2015)."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Fukami K, Sekiguchi F, Kawabata A. Hydrogen sulfide and T-type Ca<sup>2+<\/sup> channels in pain processing, neuronal differentiation and neuroendocrine secretion. <i>Pharmacology<\/i>, <b>99<\/b>, 196\u2013203 (2017).","DOI":"10.1159\/000449449"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Iftinca MC, Zamponi GW. Regulation of neuronal T-type calcium channels. <i>Trends Pharmacol. Sci.<\/i>, <b>30<\/b>, 32\u201340 (2009).","DOI":"10.1016\/j.tips.2008.10.004"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Stemkowski P, Garcia-Caballero A, Gadotti VM, M\u2019Dahoma S, Huang S, Black SAG, Chen L, Souza IA, Zhang Z, Zamponi GW. TRPV1 nociceptor activity initiates USP5\/T-type channel-mediated plasticity. <i>Cell Reports<\/i>, <b>17<\/b>, 2901\u20132912 (2016).","DOI":"10.1016\/j.celrep.2016.11.047"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Ozaki T, Matsuoka J, Tsubota M, Tomita S, Sekiguchi F, Minami T, Kawabata A. Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Ca<sub>v<\/sub>3.2 in mice. <i>Toxicology<\/i>, <b>393<\/b>, 102\u2013112 (2018).","DOI":"10.1016\/j.tox.2017.11.012"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Kim JA, Park JY, Kang HW, Huh SU, Jeong SW, Lee JH. Augmentation of Ca<sub>v<\/sub>3.2\u2009T-type calcium channel activity by cAMP-dependent protein kinase A. <i>J. Pharmacol. Exp. Ther.<\/i>, <b>318<\/b>, 230\u2013237 (2006).","DOI":"10.1124\/jpet.106.101402"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Chemin J, Mezghrani A, Bidaud I, Dupasquier S, Marger F, Barrere C, Nargeot J, Lory P. Temperature-dependent modulation of Ca<sub>v<\/sub>3\u2009T-type calcium channels by protein kinases C and A in mammalian cells. <i>J. Biol. Chem.<\/i>, <b>282<\/b>, 32710\u201332718 (2007).","DOI":"10.1074\/jbc.M702746200"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Sekiguchi F, Aoki Y, Nakagawa M, Kanaoka D, Nishimoto Y, Tsubota-Matsunami M, Yamanaka R, Yoshida S, Kawabata A. AKAP-dependent sensitization of Ca<sub>v<\/sub>3.2 channels <i>via<\/i> the EP<sub>4<\/sub> receptor\/cAMP pathway mediates PGE<sub>2<\/sub>-induced mechanical hyperalgesia. <i>Br. J. Pharmacol.<\/i>, <b>168<\/b>, 734\u2013745 (2013).","DOI":"10.1111\/j.1476-5381.2012.02174.x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Huang D, Liang C, Zhang F, Men H, Du X, Gamper N, Zhang H. Inflammatory mediator bradykinin increases population of sensory neurons expressing functional T-type Ca<sup>2+<\/sup> channels. <i>Biochem. Biophys. Res. Commun.<\/i>, <b>473<\/b>, 396\u2013402 (2016).","DOI":"10.1016\/j.bbrc.2016.02.118"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Li L, Hsu A, Moore PK. Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation\u2014a tale of three gases! <i>Pharmacol. Ther.<\/i>, <b>123<\/b>, 386\u2013400 (2009).","DOI":"10.1016\/j.pharmthera.2009.05.005"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Li L, Whiteman M, Moore PK. Dexamethasone inhibits lipopolysaccharide-induced hydrogen sulphide biosynthesis in intact cells and in an animal model of endotoxic shock. <i>J. Cell. Mol. Med.<\/i>, <b>13<\/b> (8B), 2684\u20132692 (2009).","DOI":"10.1111\/j.1582-4934.2008.00610.x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Zhang J, Sio SW, Moochhala S, Bhatia M. Role of hydrogen sulfide in severe burn injury-induced inflammation in mice. <i>Mol. Med.<\/i>, <b>16<\/b>, 417\u2013424 (2010).","DOI":"10.2119\/molmed.2010.00027"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Sekiguchi F, Miyamoto Y, Kanaoka D, Ide H, Yoshida S, Ohkubo T, Kawabata A. Endogenous and exogenous hydrogen sulfide facilitates T-type calcium channel currents in Ca<sub>v<\/sub>3.2-expressing HEK293 cells. <i>Biochem. Biophys. Res. Commun.<\/i>, <b>445<\/b>, 225\u2013229 (2014).","DOI":"10.1016\/j.bbrc.2014.01.185"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Kawabata A, Ishiki T, Nagasawa K, Yoshida S, Maeda Y, Takahashi T, Sekiguchi F, Wada T, Ichida S, Nishikawa H. Hydrogen sulfide as a novel nociceptive messenger. <i>Pain<\/i>, <b>132<\/b>, 74\u201381 (2007).","DOI":"10.1016\/j.pain.2007.01.026"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Fukami K, Sekiguchi F, Yasukawa M, Asano E, Kasamatsu R, Ueda M, Yoshida S, Kawabata A. Functional upregulation of the H<sub>2<\/sub>S\/Ca<sub>v<\/sub>3.2 channel pathway accelerates secretory function in neuroendocrine-differentiated human prostate cancer cells. <i>Biochem. Pharmacol.<\/i>, <b>97<\/b>, 300\u2013309 (2015).","DOI":"10.1016\/j.bcp.2015.08.005"},{"key":"38","unstructured":"38) Maeda Y, Aoki Y, Sekiguchi F, Matsunami M, Takahashi T, Nishikawa H, Kawabata A. Hyperalgesia induced by spinal and peripheral hydrogen sulfide: Evidence for involvement of Ca<sub>v<\/sub>3.2\u2009T-type calcium channels. <i>Pain<\/i>, <b>142<\/b>, 127\u2013132 (2009)."},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Okubo K, Matsumura M, Kawaishi Y, Aoki Y, Matsunami M, Okawa Y, Sekiguchi F, Kawabata A. Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Ca<sub>v<\/sub>3.2 and TRPA1 channels in mice. <i>Br. J. Pharmacol.<\/i>, <b>166<\/b>, 1738\u20131743 (2012).","DOI":"10.1111\/j.1476-5381.2012.01886.x"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Nelson MT, Woo J, Kang HW, Vitko I, Barrett PQ, Perez-Reyes E, Lee JH, Shin HS, Todorovic SM. Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels. <i>J. Neurosci.<\/i>, <b>27<\/b>, 8250\u20138260 (2007).","DOI":"10.1523\/JNEUROSCI.1800-07.2007"},{"key":"41","unstructured":"41) Matsunami M, Kirishi S, Okui T, Kawabata A. Chelating luminal zinc mimics hydrogen sulfide-evoked colonic pain in mice: possible involvement of T-type calcium channels. <i>Neuroscience<\/i>, <b>181<\/b>, 257\u2013264 (2011)."},{"key":"42","unstructured":"42) van Loo KM, Schaub C, Pernhorst K, Yaari Y, Beck H, Schoch S, Becker AJ. Transcriptional regulation of T-type calcium channel Ca<sub>v<\/sub>3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST). <i>J. Biol. Chem.<\/i>, <b>287<\/b>, 15489\u201315501 (2012)."},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Khachigian LM. Early growth response-1 in the pathogenesis of cardiovascular disease. <i>J. Mol. Med.<\/i> (Berl.), <b>94<\/b>, 747\u2013753 (2016).","DOI":"10.1007\/s00109-016-1428-x"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Garcia-Caballero A, Gadotti VM, Stemkowski P, Weiss N, Souza IA, Hodgkinson V, Bladen C, Chen L, Hamid J, Pizzoccaro A, Deage M, Francois A, Bourinet E, Zamponi GW. The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Ca<sub>v<\/sub>3.2 channel activity. <i>Neuron<\/i>, <b>83<\/b>, 1144\u20131158 (2014).","DOI":"10.1016\/j.neuron.2014.07.036"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Stemkowski PL, Garcia-Caballero A, Gadotti VM, M\u2019Dahoma S, Chen L, Souza IA, Zamponi GW. Identification of interleukin-1 beta as a key mediator in the upregulation of Ca<sub>v<\/sub>3.2\u2013USP5 interactions in the pain pathway. <i>Mol. Pain<\/i>, <b>13<\/b>, 1744806917724698 (2017).","DOI":"10.1177\/1744806917724698"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Sanders KM, Koh SD, Ro S, Ward SM. Regulation of gastrointestinal motility\u2014insights from smooth muscle biology. <i>Nat. Rev. Gastroenterol. Hepatol.<\/i>, <b>9<\/b>, 633\u2013645 (2012).","DOI":"10.1038\/nrgastro.2012.168"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Kinoshita K, Sato K, Hori M, Ozaki H, Karaki H. Decrease in activity of smooth muscle L-type Ca<sup>2+<\/sup> channels and its reversal by NF-kB inhibitors in Crohn\u2019s colitis model. <i>Am. J. Physiol. Gastrointest. Liver Physiol.<\/i>, <b>285<\/b>, G483\u2013G493 (2003).","DOI":"10.1152\/ajpgi.00038.2003"},{"key":"48","unstructured":"48) Kang M, Morsy N, Jin X, Lupu F, Akbarali HI. Protein and gene expression of Ca<sup>2+<\/sup> channel isoforms in murine colon: effect of inflammation. <i>Pflugers Arch.<\/i>, <b>449<\/b>, 288\u2013297 (2004)."},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Akbarali HI, Hawkins EG, Ross GR, Kang M. Ion channel remodeling in gastrointestinal inflammation. <i>Neurogastroenterol. Motil.<\/i>, <b>22<\/b>, 1045\u20131055 (2010).","DOI":"10.1111\/j.1365-2982.2010.01560.x"},{"key":"50","unstructured":"50) Matsunami M, Kirishi S, Okui T, Kawabata A. Hydrogen sulfide-induced colonic mucosal cytoprotection involves T-type calcium channel-dependent neuronal excitation in rats. <i>J. Physiol. Pharmacol.<\/i>, <b>63<\/b>, 61\u201368 (2012)."},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Wallace JL, Vong L, McKnight W, Dicay M, Martin GR. Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats. <i>Gastroenterology<\/i>, <b>137<\/b>, 569\u2013578.e1 (2009).","DOI":"10.1053\/j.gastro.2009.04.012"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Ichikawa T, Ishihara K, Kusakabe T, Hiruma H, Kawakami T, Hotta K. CGRP modulates mucin synthesis in surface mucus cells of rat gastric oxyntic mucosa. <i>Am. J. Physiol. Gastrointest. Liver Physiol.<\/i>, <b>279<\/b>, G82\u2013G89 (2000).","DOI":"10.1152\/ajpgi.2000.279.1.G82"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Kawabata A, Kinoshita M, Nishikawa H, Kuroda R, Nishida M, Araki H, Arizono N, Oda Y, Kakehi K. The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection. <i>J. Clin. Invest.<\/i>, <b>107<\/b>, 1443\u20131450 (2001).","DOI":"10.1172\/JCI10806"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Fiorucci S, Mencarelli A, Palazzetti B, Distrutti E, Vergnolle N, Hollenberg MD, Wallace JL, Morelli A, Cirino G. Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>98<\/b>, 13936\u201313941 (2001).","DOI":"10.1073\/pnas.241377298"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Akiba Y, Furukawa O, Guth PH, Engel E, Nastaskin I, Kaunitz JD. Sensory pathways and cyclooxygenase regulate mucus gel thickness in rat duodenum. <i>Am. J. Physiol. Gastrointest. Liver Physiol.<\/i>, <b>280<\/b>, G470\u2013G474 (2001).","DOI":"10.1152\/ajpgi.2001.280.3.G470"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Qian A, Song D, Li Y, Liu X, Tang D, Yao W, Yuan Y. Role of voltage gated Ca<sup>2+<\/sup> channels in rat visceral hypersensitivity change induced by 2,4,6-trinitrobenzene sulfonic acid. <i>Mol. Pain<\/i>, <b>9<\/b>, 15 (2013).","DOI":"10.1186\/1744-8069-9-15"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Diop L, Raymond F, Fargeau H, Petoux F, Chovet M, Doherty AM. Pregabalin (CI-1008) inhibits the trinitrobenzene sulfonic acid-induced chronic colonic allodynia in the rat. <i>J. Pharmacol. Exp. Ther.<\/i>, <b>302<\/b>, 1013\u20131022 (2002).","DOI":"10.1124\/jpet.302.3.1013"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Ohashi-Doi K, Gale JD, Kurebayashi Y. Pregabalin inhibits accelerated defecation and decreased colonic nociceptive threshold in sensitized rats. <i>Eur. J. Pharmacol.<\/i>, <b>643<\/b>, 107\u2013112 (2010).","DOI":"10.1016\/j.ejphar.2010.06.014"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Houghton LA, Fell C, Whorwell PJ, Jones I, Sudworth DP, Gale JD. Effect of a second-generation \u03b12\u03b4 ligand (pregabalin) on visceral sensation in hypersensitive patients with irritable bowel syndrome. <i>Gut<\/i>, <b>56<\/b>, 1218\u20131225 (2007).","DOI":"10.1136\/gut.2006.110858"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Matsunami M, Tarui T, Mitani K, Nagasawa K, Fukushima O, Okubo K, Yoshida S, Takemura M, Kawabata A. Luminal hydrogen sulfide plays a pronociceptive role in mouse colon. <i>Gut<\/i>, <b>58<\/b>, 751\u2013761 (2009).","DOI":"10.1136\/gut.2007.144543"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61) Tsubota-Matsunami M, Noguchi Y, Okawa Y, Sekiguchi F, Kawabata A. Colonic hydrogen sulfide-induced visceral pain and referred hyperalgesia involve activation of both Ca<sub>v<\/sub>3.2 and TRPA1 channels in mice. <i>J. Pharmacol. Sci.<\/i>, <b>119<\/b>, 293\u2013296 (2012).","DOI":"10.1254\/jphs.12086SC"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62) Sekiguchi F, Kawara Y, Tsubota M, Kawakami E, Ozaki T, Kawaishi Y, Tomita S, Kanaoka D, Yoshida S, Ohkubo T, Kawabata A. Therapeutic potential of RQ-00311651, a novel T-type Ca<sup>2+<\/sup> channel blocker, in distinct rodent models for neuropathic and visceral pain. <i>Pain<\/i>, <b>157<\/b>, 1655\u20131665 (2016).","DOI":"10.1097\/j.pain.0000000000000565"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63) Marger F, Gelot A, Alloui A, Matricon J, Ferrer JF, Barrere C, Pizzoccaro A, Muller E, Nargeot J, Snutch TP, Eschalier A, Bourinet E, Ardid D. T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>108<\/b>, 11268\u201311273 (2011).","DOI":"10.1073\/pnas.1100869108"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64) Ogawa T, Ishizuka O, Ueda T, Tyagi P, Chancellor MB, Yoshimura N. Current and emerging drugs for interstitial cystitis\/bladder pain syndrome (IC\/BPS). <i>Expert Opin. Emerg. Drugs<\/i>, <b>20<\/b>, 555\u2013570 (2015).","DOI":"10.1517\/14728214.2015.1105216"},{"key":"65","unstructured":"65) Homma Y. Hypersensitive bladder: a solution to confused terminology and ignorance concerning interstitial cystitis. <i>Int. J. Urol.<\/i>, <b>21<\/b> (Suppl. 1), 43\u201347 (2014)."},{"key":"66","doi-asserted-by":"crossref","unstructured":"66) Rudick CN, Schaeffer AJ, Klumpp DJ. Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis. <i>BMC Urol.<\/i>, <b>9<\/b>, 16 (2009).","DOI":"10.1186\/1471-2490-9-16"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67) Kwon WA, Ahn SH, Oh TH, Lee JW, Han DY, Jeong HJ. Effect of low-dose triple therapy using gabapentin, amitriptyline, and a nonsteroidal anti-inflammatory drug for overactive bladder symptoms in patients with bladder pain syndrome. <i>Int. Neurourol. J.<\/i>, <b>17<\/b>, 78\u201382 (2013).","DOI":"10.5213\/inj.2013.17.2.78"},{"key":"68","unstructured":"68) Nickel JC, Crossland A, Davis E, Haab F, Mills IW, Rovner E, Scholfield D, Crook T. Investigation of a Ca<sup>2+<\/sup> channel alpha2delta ligand for the treatment of interstitial cystitis: results of a randomized, double-blind, placebo controlled phase II trial. <i>J. Urol.<\/i>, <b>188<\/b>, 817\u2013823 (2012)."},{"key":"69","doi-asserted-by":"crossref","unstructured":"69) Su X, Leon LA, Laping NJ. Role of spinal Ca<sub>v<\/sub>2.2 and Ca<sub>v<\/sub>2.1 ion channels in bladder nociception. <i>J. Urol.<\/i>, <b>179<\/b>, 2464\u20132469 (2008).","DOI":"10.1016\/j.juro.2008.01.088"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70) Igawa Y, Kumano S, Aizawa N, Saito Y, Ito H, Watanabe S, Takahashi N, Tajimi M, Nishimatsu H, Homma Y. Changes in the function and expression of T-type and N-type calcium channels in the rat bladder after bladder outlet obstruction. <i>J. Urol.<\/i>, <b>191<\/b>, 1159\u20131167 (2014).","DOI":"10.1016\/j.juro.2013.10.027"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71) Pang X, Marchand J, Sant GR, Kream RM, Theoharides TC, J. Increased number of substance P positive nerve fibres in interstitial cystitis. <i>Br. J. Urol.<\/i>, <b>75<\/b>, 744\u2013750 (1995).","DOI":"10.1111\/j.1464-410X.1995.tb07384.x"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72) Nazif O, Teichman JM, Gebhart GF. Neural upregulation in interstitial cystitis. <i>Urology<\/i>, <b>69<\/b> (Suppl.), s24\u2013s33 (2007).","DOI":"10.1016\/j.urology.2006.08.1108"},{"key":"73","unstructured":"73) Vesela R, Aronsson P, Andersson M, Wsol V, Tobin G. The potential of non-adrenergic, non-cholinergic targets in the treatment of interstitial cystitis\/painful bladder syndrome. <i>J. Physiol. Pharmacol.<\/i>, <b>63<\/b>, 209\u2013216 (2012)."},{"key":"74","doi-asserted-by":"crossref","unstructured":"74) Okinami T, Imamura M, Nishikawa N, Negoro H, Sugino Y, Yoshimura K, Kanematsu A, Hashitani H, Ogawa O. Altered detrusor gap junction communications induce storage symptoms in bladder inflammation: a mouse cyclophosphamide-induced model of cystitis. <i>PLOS ONE<\/i>, <b>9<\/b>, e104216 (2014).","DOI":"10.1371\/journal.pone.0104216"},{"key":"75","unstructured":"75) Olivar T, Laird JM. Cyclophosphamide cystitis in mice: behavioural characterisation and correlation with bladder inflammation. <i>Eur. J. Pain<\/i>, <b>3<\/b>, 141\u2013149 (1999)."},{"key":"76","doi-asserted-by":"crossref","unstructured":"76) Wang CC, Weng TI, Wu ET, Wu MH, Yang RS, Liu SH. Involvement of interleukin-6-regulated nitric oxide synthase in hemorrhagic cystitis and impaired bladder contractions in young rats induced by acrolein, a urinary metabolite of cyclophosphamide. <i>Toxicol. Sci.<\/i>, <b>131<\/b>, 302\u2013310 (2013).","DOI":"10.1093\/toxsci\/kfs270"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77) Ozaki T, Tsubota M, Sekiguchi F, Kawabata A. Involvement of NF-\u03baB in the upregulation of cystathionine-g-lyase, a hydrogen sulfide-forming enzyme, and bladder pain accompanying cystitis in mice. <i>Clin. Exp. Pharmacol. Physiol.<\/i>, <b>45<\/b>, 355\u2013361 (2018).","DOI":"10.1111\/1440-1681.12875"},{"key":"78","unstructured":"78) Matsunami M, Okawa Y, Okubo K, Sekiguchi F, Kawabata A. Study on molecular mechanisms for interstitial cystitis using a substance P-induced delayed bladder pain model in mice: roles of endogenous hydrogen sulfide and Ca<sub>v<\/sub>3.2\u2009T-type Ca<sup>2+<\/sup> channels. <i>J. Pharmacol. Sci.<\/i>, <b>118<\/b> (Suppl. 1), 193P (2012)."},{"key":"79","unstructured":"79) Theoharides TC, Pang X, Letourneau R, Sant GR. Interstitial cystitis: a neuroimmunoendocrine disorder. <i>Ann. N. Y. Acad. Sci.<\/i>, <b>840<\/b>, 619\u2013634 (1998)."},{"key":"80","doi-asserted-by":"crossref","unstructured":"80) Wang ZY, Wang P, Bjorling DE. Role of mast cells and protease-activated receptor-2 in cyclooxygenase-2 expression in urothelial cells. <i>Am. J. Physiol. Regul. Integr. Comp. Physiol.<\/i>, <b>297<\/b>, R1127\u2013R1135 (2009).","DOI":"10.1152\/ajpregu.00310.2009"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81) Miki T, Matsunami M, Nakamura S, Okada H, Matsuya H, Kawabata A. ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. <i>Pain<\/i>, <b>152<\/b>, 1373\u20131381 (2011).","DOI":"10.1016\/j.pain.2011.02.019"},{"key":"82","unstructured":"82) Tsubota M, Ozaki T, Hayashi Y, Okawa Y, Fujimura A, Sekiguchi F, Nishikawa H, Kawabata A. Prostanoid-dependent bladder pain caused by proteinase-activated receptor-2 activation in mice: Involvement of TRPV1 and T-type Ca<sup>2+<\/sup> channels. <i>J. Pharmacol. Sci.<\/i>, <b>136<\/b>, 46\u201349 (2018)."},{"key":"83","doi-asserted-by":"crossref","unstructured":"83) Vera-Portocarrero L, Westlund KN. Role of neurogenic inflammation in pancreatitis and pancreatic pain. <i>Neurosignals<\/i>, <b>14<\/b>, 158\u2013165 (2005).","DOI":"10.1159\/000087654"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84) Gurusamy KS, Lusuku C, Davidson BR. Pregabalin for decreasing pancreatic pain in chronic pancreatitis. <i>Cochrane Database Syst. Rev.<\/i>, <b>2<\/b>, CD011522 (2016).","DOI":"10.1002\/14651858.CD011522.pub2"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85) Liao XZ, Zhou MT, Mao YF, Xu H, Chen H, Sun JH, Xiong YC. Analgesic effects of gabapentin on mechanical hypersensitivity in a rat model of chronic pancreatitis. <i>Brain Res.<\/i>, <b>1337<\/b>, 104\u2013112 (2010).","DOI":"10.1016\/j.brainres.2010.04.035"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86) Nishimura S, Fukushima O, Ishikura H, Takahashi T, Matsunami M, Tsujiuchi T, Sekiguchi F, Naruse M, Kamanaka Y, Kawabata A. Hydrogen sulfide as a novel mediator for pancreatic pain in rodents. <i>Gut<\/i>, <b>58<\/b>, 762\u2013770 (2009).","DOI":"10.1136\/gut.2008.151910"},{"key":"87","doi-asserted-by":"crossref","unstructured":"87) Terada Y, Fujimura M, Nishimura S, Tsubota M, Sekiguchi F, Kawabata A. Roles of Ca<sub>v<\/sub>3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis. <i>J. Neurosci. Res.<\/i>, <b>93<\/b>, 361\u2013369 (2015).","DOI":"10.1002\/jnr.23490"},{"key":"88","unstructured":"88) Fukushima O, Nishimura S, Matsunami M, Aoki Y, Nishikawa H, Ishikura H, Kawabata A. Phosphorylation of ERK in the spinal dorsal horn following pancreatic pronociceptive stimuli with proteinase-activated receptor-2 agonists and hydrogen sulfide in rats: evidence for involvement of distinct mechanisms. <i>J. Neurosci. Res.<\/i>, <b>88<\/b>, 3198\u20133205 (2010)."},{"key":"89","doi-asserted-by":"crossref","unstructured":"89) Snutch TP, Zamponi GW. Recent advances in the development of T-type calcium channel blockers for pain intervention. <i>Br. J. Pharmacol.<\/i>, <b>175<\/b>, 2375\u20132383 (2018).","DOI":"10.1111\/bph.13906"},{"key":"90","unstructured":"90) Lee M. Z944: a first in class T-type calcium channel modulator for the treatment of pain. <i>J. Peripher. Nerv. Syst.<\/i>, <b>19<\/b> (Suppl. 2), S11\u2013S12 (2014)."},{"key":"91","doi-asserted-by":"crossref","unstructured":"91) Samour MS, Nagi SS, Mahns DA. Ca<sub>v<\/sub>3.2-expressing low-threshold C fibres in human hairy skin contribute to cold allodynia\u2014a non-TRPV1- and non-TRPM8-dependent phenomenon. <i>Pain<\/i>, <b>156<\/b>, 1566\u20131575 (2015).","DOI":"10.1097\/j.pain.0000000000000202"},{"key":"92","unstructured":"92) Serra J, Duan WR, Locke C, Sola R, Liu W, Nothaft W. Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial. <i>Pain<\/i>, <b>156<\/b>, 2175\u20132183 (2015)."},{"key":"93","doi-asserted-by":"crossref","unstructured":"93) Ziegler D, Duan WR, An G, Thomas JW, Nothaft W. A randomized double-blind, placebo-, and active-controlled study of T-type calcium channel blocker ABT-639 in patients with diabetic peripheral neuropathic pain. <i>Pain<\/i>, <b>156<\/b>, 2013\u20132020 (2015).","DOI":"10.1097\/j.pain.0000000000000263"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/41\/8\/41_b18-00054\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T16:18:40Z","timestamp":1571674720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/41\/8\/41_b18-00054\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,1]]},"references-count":93,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b18-00054","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,1]]}}}