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The role of angiogenesis in damage and recovery from ischemic stroke. Curr. Treat. Options Cardiovasc. Med.<\/i>, 9<\/b>, 205\u2013212 (2007).","DOI":"10.1007\/s11936-007-0014-5"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Yang G, Fang Z, Liu Y, Zhang H, Shi X, Ji Q, Lin Q, Lin R. Protective effects of Chinese traditional medicine buyang huanwu decoction on myocardial injury. Evid. Based Complement. Alternat. Med.<\/i>, 2011<\/b>, 930324 (2011).","DOI":"10.1093\/ecam\/nep013"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Zhao LD, Wang JH, Jin GR, Zhao Y, Zhang HJ. Neuroprotective effect of Buyang Huanwu decoction against focal cerebral ischemia\/reperfusion injury in rats-time window and mechanism. J. Ethnopharmacol.<\/i>, 140<\/b>, 339\u2013344 (2012).","DOI":"10.1016\/j.jep.2012.01.026"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Feigin VL. Herbal medicine in stroke: does it have a future? Stroke<\/i>, 38<\/b>, 1734\u20131736 (2007).","DOI":"10.1161\/STROKEAHA.107.487132"},{"key":"6","unstructured":"6) Teng L, Shaw D, Barnes J. Traditional Chinese herbal medicine. Pharm. J.<\/i>, 276<\/b>, 361\u2013363 (2006)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Gong X, Sucher NJ. Stroke therapy in traditional Chinese medicine (TCM): prospects for drug discovery and development. Phytomedicine<\/i>, 9<\/b>, 478\u2013484 (2002).","DOI":"10.1078\/09447110260571760"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Wang NL, Liou YL, Lin MT, Lin CL, Chang CK. Chinese herbal medicine, Shengmai San, is effective for improving circulatory shock and oxidative damage in the brain during heatstroke. J. Pharmacol. Sci.<\/i>, 97<\/b>, 253\u2013265 (2005).","DOI":"10.1254\/jphs.FP0040793"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Hook IL. Danggui to Angelica sinensis<\/i> root: are potential benefits to European women lost in translation? A review. J. Ethnopharmacol.<\/i>, 152<\/b>, 1\u201313 (2014).","DOI":"10.1016\/j.jep.2013.12.018"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Hou YZ, Zhao GR, Yuan YJ, Zhu GG, Hiltunen R. Inhibition of rat vascular smooth muscle cell proliferation by extract of Ligusticum chuanxiong<\/i> and Angelica sinensis.<\/i> J. Ethnopharmacol.<\/i>, 100<\/b>, 140\u2013144 (2005).","DOI":"10.1016\/j.jep.2005.01.051"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Yang CL, Or TC, Ho MH, Lau AS. Scientific basis of botanical medicine as alternative remedies for rheumatoid arthritis. Clin. Rev. Allergy Immunol.<\/i>, 44<\/b>, 284\u2013300 (2013).","DOI":"10.1007\/s12016-012-8329-8"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Huang SH, Lin CM, Chiang BH. Protective effects of Angelica sinensis<\/i> extract on amyloid beta-peptide-induced neurotoxicity. Phytomedicine<\/i>, 15<\/b>, 710\u2013721 (2008).","DOI":"10.1016\/j.phymed.2008.02.022"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Yu Y, Du JR, Wang CY, Qian ZM. Protection against hydrogen peroxide-induced injury by Z<\/i>-ligustilide in PC12 cells. Exp. Brain Res.<\/i>, 184<\/b>, 307\u2013312 (2008).","DOI":"10.1007\/s00221-007-1100-3"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Oh TW, Park KH, Jung HW, Park YK. Neuroprotective effect of the hairy root extract of Angelica gigas<\/i> NAKAI on transient focal cerebral ischemia in rats through the regulation of angiogenesis. BMC Complement. Altern. Med.<\/i>, 15<\/b>, 101 (2015).","DOI":"10.1186\/s12906-015-0589-4"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Bang OY, Lee JS, Lee PH, Lee G. Autologous mesenchymal stem cell transplantation in stroke patients. Ann. Neurol.<\/i>, 57<\/b>, 874\u2013882 (2005).","DOI":"10.1002\/ana.20501"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Chen J, Sanberg PR, Li Y, Wang L, Lu M, Willing AE, Sanchez-Ramos J, Chopp M. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke<\/i>, 32<\/b>, 2682\u20132688 (2001).","DOI":"10.1161\/hs1101.098367"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Deng YB, Ye WB, Hu ZZ, Yan Y, Wang Y, Takon BF, Zhou GQ, Zhou YF. Intravenously administered BMSCs reduce neuronal apoptosis and promote neuronal proliferation through the release of VEGF after stroke in rats. Neurol. Res.<\/i>, 32<\/b>, 148\u2013156 (2010).","DOI":"10.1179\/174313209X414434"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Ikegame Y, Yamashita K, Hayashi S, Mizuno H, Tawada M, You F, Yamada K, Tanaka Y, Egashira Y, Nakashima S, Yoshimura S, Iwama T. Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy. Cytotherapy<\/i>, 13<\/b>, 675\u2013685 (2011).","DOI":"10.3109\/14653249.2010.549122"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Kim JM, Lee ST, Chu K, Jung KH, Song EC, Kim SJ, Sinn DI, Kim JH, Park DK, Kang KM, Hyung Hong N, Park HK, Won CH, Kim KH, Kim M, Kun Lee S, Roh JK. Systemic transplantation of human adipose stem cells attenuated cerebral inflammation and degeneration in a hemorrhagic stroke model. Brain Res.<\/i>, 1183<\/b>, 43\u201350 (2007).","DOI":"10.1016\/j.brainres.2007.09.005"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Zhang L, Li Y, Zhang C, Chopp M, Gosiewska A, Hong K. Delayed administration of human umbilical tissue-derived cells improved neurological functional recovery in a rodent model of focal ischemia. Stroke<\/i>, 42<\/b>, 1437\u20131444 (2011).","DOI":"10.1161\/STROKEAHA.110.593129"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Honmou O, Houkin K, Matsunaga T, Niitsu Y, Ishiai S, Onodera R, Waxman SG, Kocsis JD. Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke. Brain<\/i>, 134<\/b>, 1790\u20131807 (2011).","DOI":"10.1093\/brain\/awr063"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Lee JS, Hong JM, Moon GJ, Lee PH, Ahn YH, Bang OY, STARTING collaborators. A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. Stem Cells<\/i>, 28<\/b>, 1099\u20131106 (2010).","DOI":"10.1002\/stem.430"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Walczak P, Zhang J, Gilad AA, Kedziorek DA, Ruiz-Cabello J, Young RG, Pittenger MF, van Zijl PC, Huang J, Bulte JW. Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia. Stroke<\/i>, 39<\/b>, 1569\u20131574 (2008).","DOI":"10.1161\/STROKEAHA.107.502047"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Liu X, Ye R, Yan T, Yu SP, Wei L, Xu G, Fan X, Jiang Y, Stetler RA, Liu G, Chen J. Cell based therapies for ischemic stroke: from basic science to bedside. Prog. Neurobiol.<\/i>, 115<\/b>, 92\u2013115 (2014).","DOI":"10.1016\/j.pneurobio.2013.11.007"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Geng YJ. Molecular mechanisms for cardiovascular stem cell apoptosis and growth in the hearts with atherosclerotic coronary disease and ischemic heart failure. Ann. N. Y. Acad. Sci.<\/i>, 1010<\/b>, 687\u2013697 (2003).","DOI":"10.1196\/annals.1299.126"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation<\/i>, 105<\/b>, 93\u201398 (2002).","DOI":"10.1161\/hc0102.101442"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Nakagomi N, Nakagomi T, Kubo S, Nakano-Doi A, Saino O, Takata M, Yoshikawa H, Stern DM, Matsuyama T, Taguchi A. Endothelial cells support survival, proliferation, and neuronal differentiation of transplanted adult ischemia-induced neural stem\/progenitor cells after cerebral infarction. Stem Cells<\/i>, 27<\/b>, 2185\u20132195 (2009).","DOI":"10.1002\/stem.161"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Chang W, Song BW, Lim S, Song H, Shim CY, Cha MJ, Ahn DH, Jung YG, Lee DH, Chung JH, Choi KD, Lee SK, Chung N, Lee SK, Jang Y, Hwang KC. Mesenchymal stem cells pretreated with delivered Hph-1\u2013Hsp70 protein are protected from hypoxia-mediated cell death and rescue heart functions from myocardial injury. Stem Cells<\/i>, 27<\/b>, 2283\u20132292 (2009).","DOI":"10.1002\/stem.153"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke<\/i>, 20<\/b>, 84\u201391 (1989).","DOI":"10.1161\/01.STR.20.1.84"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Balkaya M, Endres M. Behavioral testing in mouse models of stroke. Rodent Models of Stroke<\/i>. (Dirnagl U ed) Vol. 47, Humana Press, New York, pp. 179\u2013197 (2010).","DOI":"10.1007\/978-1-60761-750-1_13"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Vakili A, Kataoka H, Plesnila N. Role of arginine vasopressin V1 and V2 receptors for brain damage after transient focal cerebral ischemia. J. Cereb. Blood Flow Metab.<\/i>, 25<\/b>, 1012\u20131019 (2005).","DOI":"10.1038\/sj.jcbfm.9600097"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Nam HS, Kwon I, Lee BH, Kim H, Kim J, An S, Lee OH, Lee PH, Kim HO, Namgoong H, Kim YD, Heo JH. Effects of mesenchymal stem cell treatment on the expression of matrix metalloproteinases and angiogenesis during ischemic stroke recovery. PLOS ONE<\/i>, 10<\/b>, e0144218 (2015).","DOI":"10.1371\/journal.pone.0144218"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Schallert T, Fleming SM, Leasure JL, Tillerson JL, Bland ST. CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology<\/i>, 39<\/b>, 777\u2013787 (2000).","DOI":"10.1016\/S0028-3908(00)00005-8"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Buga AM, Ciobanu O, B\u0103descu GM, Bogdan C, Weston R, Slevin M, Di Napoli M, Popa-Wagner A. Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients. Oncotarget<\/i>, 7<\/b>, 17415\u201317430 (2016).","DOI":"10.18632\/oncotarget.8277"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Gu Y, Chen J, Shen J. Herbal medicines for ischemic stroke: combating inflammation as therapeutic targets. J. Neuroimmune Pharmacol.<\/i>, 9<\/b>, 313\u2013339 (2014).","DOI":"10.1007\/s11481-014-9525-5"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Eltzschig HK, Eckle T. Ischemia and reperfusion-from mechanism to translation. Nat. Med.<\/i>, 17<\/b>, 1391\u20131401 (2011).","DOI":"10.1038\/nm.2507"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Chen YF. Traditional Chinese herbal medicine and cerebral ischemia. Front. Biosci.<\/i>, E4<\/b>, 809\u2013817 (2012).","DOI":"10.2741\/e420"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Hao L, Zou Z, Tian H, Zhang Y, Zhou H, Liu L. Stem cell-based therapies for ischemic stroke. Biomed. Res. Int.<\/i>, 2014<\/b>, 468748 (2014).","DOI":"10.1155\/2014\/468748"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Wang M, Crisostomo PR, Herring C, Meldrum KK, Meldrum DR. Human progenitor cells from bone marrow or adipose tissue produce VEGF, HGF, and IGF-I in response to TNF by a p38 MAPK-dependent mechanism. Am. J. Physiol. Regul. Integr. Comp. Physiol.<\/i>, 291<\/b>, R880\u2013R884 (2006).","DOI":"10.1152\/ajpregu.00280.2006"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Chen J, Zhang ZG, Li Y, Wang L, Xu YX, Gautam SC, Lu M, Zhu Z, Chopp M. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ. Res.<\/i>, 92<\/b>, 692\u2013699 (2003).","DOI":"10.1161\/01.RES.0000063425.51108.8D"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V, Ryan TE, Bruno J, Radziejewski C, Maisonpierre PC, Yancopoulos GD. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell<\/i>, 87<\/b>, 1161\u20131169 (1996).","DOI":"10.1016\/S0092-8674(00)81812-7"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Zhang ZG, Zhang L, Tsang W, Soltanian-Zadeh H, Morris D, Zhang R, Goussev A, Powers C, Yeich T, Chopp M. Correlation of VEGF and angiopoietin expression with disruption of blood\u2013brain barrier and angiogenesis after focal cerebral ischemia. J. Cereb. Blood Flow Metab.<\/i>, 22<\/b>, 379\u2013392 (2002).","DOI":"10.1097\/00004647-200204000-00002"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Zhu Y, Shwe Y, Du R, Chen Y, Shen FX, Young WL, Yang GY. Effects of angiopoietin-1 on vascular endothelial growth factor-induced angiogenesis in the mouse brain. Acta Neurochir. Suppl.<\/i>, 96<\/b>, 438\u2013443 (2006).","DOI":"10.1007\/3-211-30714-1_90"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Fresno Vara JA, Casado E, de Castro J, Cejas P, Belda-Iniesta C, Gonz\u00e1lez-Bar\u00f3n M. PI3K\/Akt signalling pathway and cancer. Cancer Treat. Rev.<\/i>, 30<\/b>, 193\u2013204 (2004).","DOI":"10.1016\/j.ctrv.2003.07.007"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Bederson JB, Pitts LH, Germano SM, Nishimura MC, Davis RL, Bartkowski HM. Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke<\/i>, 17<\/b>, 1304\u20131308 (1986).","DOI":"10.1161\/01.STR.17.6.1304"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Kurozumi K, Nakamura K, Tamiya T, Kawano Y, Kobune M, Hirai S, Uchida H, Sasaki K, Ito Y, Kato K, Honmou O, Houkin K, Date I, Hamada H. BDNF Gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model. Mol. Ther.<\/i>, 9<\/b>, 189\u2013197 (2004).","DOI":"10.1016\/j.ymthe.2003.10.012"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Nickoloff BJ. PECAM-1 (CD31) is expressed on proliferating endothelial cells, stromal spindle-shaped cells, and dermal dendrocytes in Kaposi\u2019s sarcoma. Arch. Dermatol.<\/i>, 129<\/b>, 250\u2013251 (1993).","DOI":"10.1001\/archderm.1993.01680230140028"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/41\/12\/41_b18-00193\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T04:11:16Z","timestamp":1543637476000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/41\/12\/41_b18-00193\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,1]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b18-00193","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,1]]}}}