{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:57:12Z","timestamp":1780433832556,"version":"3.54.1"},"reference-count":29,"publisher":"Pharmaceutical Society of Japan","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2018,10,1]]},"DOI":"10.1248\/bpb.b18-00217","type":"journal-article","created":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T18:10:24Z","timestamp":1538331024000},"page":"1561-1566","source":"Crossref","is-referenced-by-count":16,"title":["Tissue Taurine Depletion Induces Profibrotic Pattern of Gene Expression and Causes Aging-Related Cardiac Fibrosis in Heart in Mice"],"prefix":"10.1248","volume":"41","author":[{"given":"Takashi","family":"Ito","sequence":"first","affiliation":[{"name":"Faculty of Biotechnology, Fukui Prefectural University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuuki","family":"Hanahata","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hyogo University of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Kine","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hyogo University of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Murakami","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology, Fukui Prefectural University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W.","family":"Schaffer","sequence":"additional","affiliation":[{"name":"College of Medicine, University of South Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","unstructured":"1) Ito T, Schaffer S, Azuma J. The effect of taurine on chronic heart failure: Actions of taurine against catecholamine and angiotensin II, 2014. <i>Amino Acids<\/i>, <b>46<\/b>, 111\u2013119 (2014)."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Schaffer S, Takahashi K, Azuma J. Role of osmoregulation in the actions of taurine. <i>Amino Acids<\/i>, <b>19<\/b>, 527\u2013546 (2000).","DOI":"10.1007\/s007260070004"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Schaffer SW, Jong CJ, Ito T, Azuma J. Effect of taurine on ischemia\u2013reperfusion injury. <i>Amino Acids<\/i>, <b>46<\/b>, 21\u201330 (2014).","DOI":"10.1007\/s00726-012-1378-8"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Tsuboyama-Kasaoka N, Shozawa C, Sano K, Kamei Y, Kasaoka S, Hosokawa Y, Ezaki O. Taurine (2-aminoethanesulfonic acid) deficiency creates a vicious circle promoting obesity. <i>Endocrinology<\/i>, <b>147<\/b>, 3276\u20133284 (2006).","DOI":"10.1210\/en.2005-1007"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) W\u00f3jcik OP, Koenig KL, Zeleniuch-Jacquotte A, Costa M, Chen Y. The potential protective effects of taurine on coronary heart disease. <i>Atherosclerosis<\/i>, <b>208<\/b>, 19\u201325 (2010).","DOI":"10.1016\/j.atherosclerosis.2009.06.002"},{"key":"6","unstructured":"6) Pion PD, Kittleson MD, Rogers QR, Morris JG. Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy. <i>Science<\/i>, <b>237<\/b>, 764\u2013768 (1987)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Moise NS, Pacioretty LM, Kallfelz FA, Stipanuk MH, King JM, Gilmour RF Jr. Dietary taurine deficiency and dilated cardiomyopathy in the fox. <i>Am. Heart J.<\/i>, <b>121<\/b>, 541\u2013547 (1991).","DOI":"10.1016\/0002-8703(91)90724-V"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Hayes KC. Taurine nutrition. <i>Res. Rev.<\/i>, <b>1<\/b>, 99\u2013113 (1988).","DOI":"10.1079\/NRR19880009"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Ito T, Azuma J. Taurine depletion related cardiomyopathy in animals. <i>Cardiomyopathies\u2014From Basic Res. to Clin. Manag.<\/i>, <b>2012<\/b>, 537\u2013552 (2012).","DOI":"10.5772\/30023"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Mozaffari MS, Tan BH, Lucia MA, Schaffer SW. Effect of drug-induced taurine depletion on cardiac contractility and metabolism. <i>Biochem. Pharmacol.<\/i>, <b>35<\/b>, 985\u2013989 (1986).","DOI":"10.1016\/0006-2952(86)90087-0"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Ramila KC, Jong CJ, Pastukh V, Ito T, Azuma J, Schaffer SW. Role of protein phosphorylation in excitation\u2013contraction coupling in taurine deficient hearts. <i>Am. J. Physiol. Heart Circ. Physiol.<\/i>, <b>308<\/b>, H232\u2013H239 (2015).","DOI":"10.1152\/ajpheart.00497.2014"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Eley DW, Lake N, Ter Keurs HEDJ. Taurine depletion and excitation\u2013contraction coupling in rat myocardium. <i>Circ. Res.<\/i>, <b>74<\/b>, 1210\u20131219 (1994).","DOI":"10.1161\/01.RES.74.6.1210"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Kong P, Christia P, Frangogiannis NG. The pathogenesis of cardiac fibrosis. <i>Cell. Mol. Life Sci.<\/i>, <b>71<\/b>, 549\u2013574 (2014).","DOI":"10.1007\/s00018-013-1349-6"},{"key":"14","unstructured":"14) Biernacka A, Frangogiannis NG. Aging and Cardiac Fibrosis. <i>Aging Dis.<\/i>, <b>2<\/b>, 158\u2013173 (2011)."},{"key":"15","unstructured":"15) Horn MA, Trafford AW. Aging and the cardiac collagen matrix: Novel mediators of fibrotic remodelling. <i>J. Mol. Cell. Cardiol.<\/i>, <b>93<\/b>, 175\u2013185 (2016)."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Ito T, Kimura Y, Uozumi Y, Takai M, Muraoka S, Matsuda T, Ueki K, Yoshiyama M, Ikawa M, Okabe M, Schaffer SW, Fujio Y, Azuma J. Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy. <i>J. Mol. Cell. Cardiol.<\/i>, <b>44<\/b>, 927\u2013937 (2008).","DOI":"10.1016\/j.yjmcc.2008.03.001"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Ito T, Yoshikawa N, Schaffer SW, Azuma J, Tissue taurine depletion alters metabolic response to exercise and reduces running capacity in mice. <i>J. Amino Acids<\/i>, <b>2014<\/b>, 964680 (2014).","DOI":"10.1155\/2014\/964680"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Liu J, Masurekar MR, Vatner DE, Jyothirmayi GN, Regan TJ, Vatner SF, Meggs LG, Malhotra A. Glycation end-product cross-link breaker reduces collagen and improves cardiac function in aging diabetic heart. <i>Am. J. Physiol. Heart Circ. Physiol.<\/i>, <b>285<\/b>, H2587\u2013H2591 (2003).","DOI":"10.1152\/ajpheart.00516.2003"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Ogasawara M, Nakamura T, Koyama I, Nemoto M, Yoshida T. Reactivity of taurine with aldehydes and its physiological role. <i>Chem. Pharm. Bull.<\/i>, <b>41<\/b>, 2172\u20132175 (1993).","DOI":"10.1248\/cpb.41.2172"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Nandhini ATA, Thirunavukkarasu V, Anuradha CV. Stimulation of glucose utilization and inhibition of protein glycation and AGE products by taurine. <i>Acta Physiol. Scand.<\/i>, <b>181<\/b>, 297\u2013303 (2004).","DOI":"10.1111\/j.1365-201X.2004.01287.x"},{"key":"21","unstructured":"21) Nandhini ATA, Thirunavukkarasu V, Ravichandran MK, Anuradha CV. Effect of taurine on biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats. <i>Singapore Med. J.<\/i>, <b>46<\/b>, 82\u201387 (2005)."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Normandin K, P\u00e9ant B, Le Page C, de Ladurantaye M, Ouellet V, Tonin PN, Provencher DM, Mes-Masson A-M. Protease inhibitor SERPINA1 expression in epithelial ovarian cancer. <i>Clin. Exp. Metastasis<\/i>, <b>27<\/b>, 55\u201369 (2010).","DOI":"10.1007\/s10585-009-9303-6"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Hauck EW, Hauptmann A, Haag SM, Bohnert A, Weidner W, Bein G, Hackstein H. Alpha-1-antitrypsin levels and genetic variation of the alpha-1-antitrypsin gene in Peyronie\u2019s disease. <i>Eur. Urol.<\/i>, <b>46<\/b>, 623\u2013628, discussion, 628 (2004).","DOI":"10.1016\/j.eururo.2004.04.028"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) MacKinnon AC, Gibbons MA, Farnworth SL, Leffler H, Nilsson UJ, Delaine T, Simpson AJ, Forbes SJ, Hirani N, Gauldie J, Sethi T. Regulation of transforming growth factor-beta1-driven lung fibrosis by galectin-3. <i>Am. J. Respir. Crit. Care Med.<\/i>, <b>185<\/b>, 537\u2013546 (2012).","DOI":"10.1164\/rccm.201106-0965OC"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Henderson NC, Mackinnon AC, Farnworth SL, Poirier F, Russo FP, Iredale JP, Haslett C, Simpson KJ, Sethi T. Galectin-3 regulates myofibroblast activation and hepatic fibrosis. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>103<\/b>, 5060\u20135065 (2006).","DOI":"10.1073\/pnas.0511167103"},{"key":"26","unstructured":"26) De Boer RA, Voors AA, Muntendam P, Van Gilst WH, Van Veldhuisen DJ. Galectin-3: A novel mediator of heart failure development and progression. <i>Eur. J. Heart Fail.<\/i>, <b>11<\/b>, 811\u2013817 (2009)."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Ho JE, Liu C, Lyass A, Courchesne P, Pencina MJ, Vasan RS, Larson MG, Levy D. Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community. <i>J. Am. Coll. Cardiol.<\/i>, <b>60<\/b>, 1249\u20131256 (2012).","DOI":"10.1016\/j.jacc.2012.04.053"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Ito T, Yoshikawa N, Inui T, Miyazaki N, Schaffer SW, Azuma J. Tissue depletion of taurine accelerates skeletal muscle senescence and leads to early death in mice. <i>PLOS ONE<\/i>, <b>9<\/b>, e107409 (2014).","DOI":"10.1371\/journal.pone.0107409"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Hal\u00e1sz K, Kassner A, M\u00f6rgelin M, Heineg\u00e5rd D. COMP acts as a catalyst in collagen fibrillogenesis. <i>J. Biol. Chem.<\/i>, <b>282<\/b>, 31166\u201331173 (2007).","DOI":"10.1074\/jbc.M705735200"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/41\/10\/41_b18-00217\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T23:55:02Z","timestamp":1571961302000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/41\/10\/41_b18-00217\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,1]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b18-00217","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,1]]}}}