{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:42:08Z","timestamp":1792226528185,"version":"4.4.0"},"reference-count":42,"publisher":"Pharmaceutical Society of Japan","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2019,4,1]]},"DOI":"10.1248\/bpb.b18-00442","type":"journal-article","created":{"date-parts":[[2019,3,31]],"date-time":"2019-03-31T18:03:14Z","timestamp":1554055394000},"page":"538-542","source":"Crossref","is-referenced-by-count":95,"title":["Inflammation and Temporomandibular Joint Derangement"],"prefix":"10.1248","volume":"42","author":[{"given":"Miho","family":"Ibi","sequence":"first","affiliation":[{"name":"Division of Molecular and Cellular Pharmacology, Department of Pathophysiology and Pharmacology, School of Pharmaceutical Sciences, Iwate Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","unstructured":"1) \u201cTMJ (Temporomandibular joint and Muscle Disorders).\u201d: \u2039https:\/\/www.nidcr.nih.gov\/health-info\/tmj\/more-info#overview\u203a."},{"key":"2","unstructured":"2) Schiffman E, Ohrbach R, Truelove E, Look J, Anderson G, Goulet J-P, List T, Svensson P, Gonzalez Y, Lobbezoo F, Michelotti A, Brooks SL, Ceusters W, Drangsholt M, Ettlin D, Gaul C, Goldberg LJ, Haythornthwaite JA, Hollender L, Jensen R, John MT, De Laat A, de Leeuw R, Maixner W, van der Meulen M, Murray GM, Nixdorf DR, Palla S, Petersson A, Pionchon P, Smith B, Visscher CM, Zakrzewska J, Dworkin SF, International RDC\/TMD Consortium Network, International Association for Dental ResearchOrofacial Pain Special Interest Group, International Association for the Study of Pain. Diagnostic criteria for temporomandibular disorders (DC\/TMD) for clinical and research applications: recommendations of the international RDC\/TMD consortium network* and orofacial pain special interest groupdagger. <i>Journal of Oral &amp; Facial Pain and Headache<\/i>, <b>28<\/b>, 6\u201327 (2014)."},{"key":"3","unstructured":"3) Yatani H. \u2039Global trends and future perspectives of TMD management: Impact of the innovation of classificaition and diagnostic criteria\u203a New classification (2013) and its dianostic criteria of temporomandibular disorders revised by the Japanese Society for Temporomandibular Joint. <i>J. Jpn. Soc. TMJ<\/i>, <b>27<\/b>, 76\u201386 (2015)."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Nozawa-Inoue K, Amizuka N, Ikeda N, Suzuki A, Kawano Y, Maeda T. Synovial membrane in the temporomandibular joint\u2013its morphology, function and development. <i>Arch. Histol. Cytol.<\/i>, <b>66<\/b>, 289\u2013306 (2003).","DOI":"10.1679\/aohc.66.289"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Iwanaga T, Shikichi M, Kitamura H, Yanase H, Nozawa-Inoue K. Morphology and functional roles of synoviocytes in the joint. <i>Arch. Histol. Cytol.<\/i>, <b>63<\/b>, 17\u201331 (2000).","DOI":"10.1679\/aohc.63.17"},{"key":"6","unstructured":"6) Kellesarian SV, Al-Kheraif AA, Vohra F, Ghanem A, Malmstrom H, Romanos GE, Javed F. Cytokine profile in the synovial fluid of patients with temporomandibular joint disorders: A systematic review. <i>Cytokine<\/i>, <b>77<\/b>, 98\u2013106 (2016)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Ernberg M. The role of molecular pain biomarkers in temporomandibular joint internal derangement. <i>J. Oral Rehabil.<\/i>, <b>44<\/b>, 481\u2013491 (2017).","DOI":"10.1111\/joor.12480"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Ogura N, Tobe M, Sakamaki H, Kujiraoka H, Akiba M, Abiko Y, Nagura H. Interleukin-1 beta induces interleukin-6 mRNA expression and protein production in synovial cells from human temporomandibular joint. <i>J. Oral Pathol. Med.<\/i>, <b>31<\/b>, 353\u2013360 (2002).","DOI":"10.1034\/j.1600-0714.2002.310606.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Tobe M, Ogura N, Abiko Y, Nagura H. Interleukin-1\u03b2 stimulates interleukin-8 production and gene expression in synovial cells from human temporomandibular joint. <i>J. Oral Maxillofac. Surg.<\/i>, <b>60<\/b>, 741\u2013747 (2002).","DOI":"10.1053\/joms.2002.33239"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Ogura N, Tobe M, Sakamaki H, Nagura H, Hosaka H, Akiba M, Abiko Y, Kondoh T. Interleukin-1beta increases RANTES gene expression and production in synovial fibroblasts from human temporomandibular joint. <i>J. Oral Pathol. Med.<\/i>, <b>33<\/b>, 629\u2013633 (2004).","DOI":"10.1111\/j.1600-0714.2004.00260.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Ogura N, Tobe M, Sakamaki H, Nagura H, Abiko Y, Kondoh T. Tumor necrosis factor-alpha increases chemokine gene expression and production in synovial fibroblasts from human temporomandibular joint. <i>J. Oral Pathol. Med.<\/i>, <b>34<\/b>, 357\u2013363 (2005).","DOI":"10.1111\/j.1600-0714.2005.00302.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Ogura N, Akutsu M, Tobe M, Sakamaki H, Abiko Y, Kondoh T. Microarray analysis of IL-1beta-stimulated chemokine genes in synovial fibroblasts from human TMJ. <i>J. Oral Pathol. Med.<\/i>, <b>36<\/b>, 223\u2013228 (2007).","DOI":"10.1111\/j.1600-0714.2007.00515.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Ibi M, Horie S, Kyakumoto S, Chosa N, Yoshida M, Kamo M, Ohtsuka M, Ishisaki A. Cell-cell interactions between monocytes\/macrophages and synoviocyte-like cells promote inflammatory cell infiltration mediated by augmentation of MCP-1 production in temporomandibular joint. <i>Biosci. Rep.<\/i>, <b>38<\/b>, BSR20171217 (2018).","DOI":"10.1042\/BSR20171217"},{"key":"14","unstructured":"14) Dijkgraaf LC, de Boni LGM, Boering G, Liem RSB. Structure of the normal synovial membrane of the temporomandibular joint: a review of the literature. <i>J. Oral Maxillofac. Surg.<\/i>, <b>54<\/b>, 332\u2013338 (1996)."},{"key":"15","unstructured":"15) Dijkgraaf LC, De Bont LGM, Boering G, Liem RSB. Function, biochemistry, and metabolism of the normal synovial membrane of the temporomandibular joint: a review of the literature. <i>J. Oral Maxillofac. Surg.<\/i>, <b>54<\/b>, 95\u2013100 (1996)."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Yokota S, Chosa N, Kyakumoto S, Kimura H, Ibi M, Kamo M, Satoh K, Ishisaki A. ROCK\/actin\/MRTF signaling promotes the fibrogenic phenotype of fibroblast-like synoviocytes derived from the temporomandibular joint. <i>Int. J. Mol. Med.<\/i>, <b>39<\/b>, 799\u2013808 (2017).","DOI":"10.3892\/ijmm.2017.2896"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Ogura N, Satoh K, Akutsu M, Tobe M, Kuyama K, Kuboyama N, Sakamaki H, Kujiraoka H, Kondoh T. MCP-1 production in temporomandibular joint inflammation. <i>J. Dent. Res.<\/i>, <b>89<\/b>, 1117\u20131122 (2010).","DOI":"10.1177\/0022034510376041"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Nagai H, Miyamoto Y, Nakata A, Hatakeyama S, Iwanami Y, Fukuda M. Isolation and characterization of synovial cells from the human temporomandibular joint. <i>J. Oral Pathol. Med.<\/i>, <b>35<\/b>, 104\u2013110 (2006).","DOI":"10.1111\/j.1600-0714.2006.00369.x"},{"key":"19","unstructured":"19) Gynther GW, Dijkgraaf LC, Reinholt FP, Holmlund AB, Liem RS, de Bont LGB. Synovial inflammation in arthroscopically obtained biopsy specimens from the temporomandibular joint: a review of the literature and a proposed histologic grading system. <i>J. Oral Maxillofac. Surg.<\/i>, <b>56<\/b>, 1281\u20131286, discussion, 1287 (1998)."},{"key":"20","unstructured":"20) Suzuki T, Segami N, Nishimura M, Nojima T. Co-expression of interleukin-1beta and tumor necrosis factor alpha in synovial tissues and synovial fluids of temporomandibular joint with internal derangement: comparison with histological grading of synovial inflammation. <i>J. Oral Pathol. Med.<\/i>, <b>31<\/b>, 549\u2013557 (2002)."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Kardel R, Ulfgren AK, Reinholt FP, Holmlund A. Inflammatory cell and cytokine patterns in patients with painful clicking and osteoarthritis in the temporomandibular joint. <i>Int. J. Oral Maxillofac. Surg.<\/i>, <b>32<\/b>, 390\u2013396 (2003).","DOI":"10.1054\/ijom.2002.0357"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Takahashi T, Kondoh T, Fukuda M, Yamazaki Y, Toyosaki T, Suzuki R. Proinflammatory cytokines detectable in synovial fluids from patients with temporomandibular disorders. <i>Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.<\/i>, <b>85<\/b>, 135\u2013141 (1998).","DOI":"10.1016\/S1079-2104(98)90415-2"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Fu K, Xuchen MA, Zhang Z, Chen W. Tumor necrosis factor in synovial fluid of patients with temporomandibular disorders. <i>J. Oral Maxillofac. Surg.<\/i>, <b>53<\/b>, 424\u2013426 (1995).","DOI":"10.1016\/0278-2391(95)90717-3"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Kubota E, Kubota T, Matsumoto J, Shibata T, Murakami KI. Synovial fluid cytokines and proteinases as markers of temporomandibular joint disease. <i>J. Oral Maxillofac. Surg.<\/i>, <b>56<\/b>, 192\u2013198 (1998).","DOI":"10.1016\/S0278-2391(98)90868-0"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Tanimoto K, Iwabuchi Y, Tanne Y, Kamiya T, Inubushi T, Kunimatsu R, Mitsuyoshi T, Tanne K. Interleukin-1 beta affects cyclooxygenase-2 expression and cartilage metabolism in mandibular condyle. <i>Arch. Oral Biol.<\/i>, <b>56<\/b>, 1412\u20131418 (2011).","DOI":"10.1016\/j.archoralbio.2011.05.005"},{"key":"26","unstructured":"26) Deshmane SL, Kremlev S, Amini S, Sawaya BE. Monocyte chemoattractant protein-1 (MCP-1): an overview. <i>Journal of Interferon &amp; Cytokine Research<\/i>, <b>29<\/b>, 313\u2013326 (2009)."},{"key":"27","unstructured":"27) Ouanounou A, Goldberg M, Haas DA. Pharmacotherapy in Temporomandibular Disorders: A Review. <i>J. Can. Dent. Assoc.<\/i>, <b>83<\/b>, h7 (2017)."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Seki H, Fukuda M, Iino M, Takahashi T, Yoshioka N. Immunohistochemical localization of cyclooxygenase-1 and \u22122 in synovial tissues from patients with internal derangement or osteoarthritis of the temporomandibular joint. <i>Int. J. Oral Maxillofac. Surg.<\/i>, <b>33<\/b>, 687\u2013692 (2004).","DOI":"10.1016\/j.ijom.2004.01.026"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Quinn JH, Kent JH, Moise A, Lukiw WJ. Cyclooxygenase-2 in synovial tissue and fluid of dysfunctional temporomandibular joints with internal derangement. <i>J. Oral Maxillofac. Surg.<\/i>, <b>58<\/b>, 1229\u20131232, discussion, 1232\u20131233 (2000).","DOI":"10.1053\/joms.2000.16619"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Arinci A, Ademoglu E, Aslan A, Mutlu-Turkoglu U, Karabulut AB, Karan A. Molecular correlates of temporomandibular joint disease. <i>Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.<\/i>, <b>99<\/b>, 666\u2013670 (2005).","DOI":"10.1016\/j.tripleo.2004.08.029"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Kawashima M, Ogura N, Akutsu M, Ito K, Kondoh T. The anti-inflammatory effect of cyclooxygenase inhibitors in fibroblast-like synoviocytes from the human temporomandibular joint results from the suppression of PGE2 production. <i>J. Oral Pathol. Med.<\/i>, <b>42<\/b>, 499\u2013506 (2013).","DOI":"10.1111\/jop.12045"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Kubota E, Imamura H, Kubota T, Shibata T, Murakami K. Interleukin 1 beta and stromelysin (MMP3) activity of synovial fluid as possible markers of osteoarthritis in the temporomandibular joint. <i>J. Oral Maxillofac. Surg.<\/i>, <b>55<\/b>, 20\u201327, discussion, 27\u201328 (1997).","DOI":"10.1016\/S0278-2391(97)90438-9"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Kaneyama K, Segami N, Nishimura M, Suzuki T, Sato J. Importance of proinflammatory cytokines in synovial fluid from 121 joints with temporomandibular disorders. <i>Br. J. Oral Maxillofac. Surg.<\/i>, <b>40<\/b>, 418\u2013423 (2002).","DOI":"10.1016\/S0266-4356(02)00215-2"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Shafer DM, Assael L, White LB, Rossomando EF. Tumor necrosis factor-alpha as a biochemical marker of pain and outcome in temporomandibular joints with internal derangements. <i>J. Oral Maxillofac. Surg.<\/i>, <b>52<\/b>, 786\u2013791, discussion, 791\u2013792 (1994).","DOI":"10.1016\/0278-2391(94)90217-8"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Sato J, Segami N, Kaneyama K, Mashiyama Y, Fujimura K, Yoshitake Y. Vascular endothelial growth factor concentrations in synovial fluids of patients with symptomatic internal derangement of the temporomandibular joint. <i>J. Oral Pathol. Med.<\/i>, <b>34<\/b>, 170\u2013177 (2005).","DOI":"10.1111\/j.1600-0714.2004.00286.x"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Ishimaru JI, Oguma Y, Goss AN. Matrix metalloproteinase and tissue inhibitor of metalloproteinase in serum and lavage synovial fluid of patients with temporomandibular joint disorders. <i>Br. J. Oral Maxillofac. Surg.<\/i>, <b>38<\/b>, 354\u2013359 (2000).","DOI":"10.1054\/bjom.2000.0306"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Wang GYF, Shi XQ, Wu W, Gueorguieva M, Yang M, Zhang J. Sustained and repeated mouth opening leads to development of painful temporomandibular disorders involving macrophage\/microglia activation in mice. <i>Pain<\/i>, <b>159<\/b>, 1277\u20131288 (2018).","DOI":"10.1097\/j.pain.0000000000001206"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Strowig T, Henao-Mejia J, Elinav E, Flavell R. Inflammasomes in health and disease. <i>Nature<\/i>, <b>481<\/b>, 278\u2013286 (2012).","DOI":"10.1038\/nature10759"},{"key":"39","unstructured":"39) Guo H, Callaway JB, Ting JP. Inflammasomes: mechanism of action, role in disease, and therapeutics. <i>Nat. Med.<\/i>, <b>21<\/b>, 677\u2013687 (2015)."},{"key":"40","unstructured":"40) Sharma D, Kanneganti TD. The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation. <i>J. Cell Biol.<\/i>, <b>213<\/b>, 617\u2013629 (2016)."},{"key":"41","unstructured":"41) Vanaja SK, Rathinam VA, Fitzgerald KA. Mechanisms of inflammasome activation: recent advances and novel insights. <i>Trends Cell Biol.<\/i>, <b>25<\/b>, 308\u2013315 (2015)."},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) McAllister MJ, Chemaly M, Eakin AJ, Gibson DS, McGilligan VE. NLRP3 as a potentially novel biomarker for the management of osteoarthritis. <i>Osteoarthritis Cartilage<\/i>, <b>26<\/b>, 612\u2013619 (2018).","DOI":"10.1016\/j.joca.2018.02.901"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/42\/4\/42_b18-00442\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T23:32:27Z","timestamp":1559345547000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/42\/4\/42_b18-00442\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,1]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b18-00442","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,1]]}}}