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LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance. <i>Diabetes<\/i>, <b>63<\/b>, 1649\u20131664 (2014).","DOI":"10.2337\/db13-0728"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Hill KE, Wu S, Motley AK, Stevenson TD, Winfrey VP, Capecchi MR, Atkins JF, Burk RF. Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. <i>J. Biol. Chem.<\/i>, <b>287<\/b>, 40414\u201340424 (2012).","DOI":"10.1074\/jbc.M112.421404"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Misu H, Takayama H, Saito Y, Mita Y, Kikuchi A, Ishii KA, Chikamoto K, Kanamori T, Tajima N, Lan F, Takeshita Y, Honda M, Tanaka M, Kato S, Matsuyama N, Yoshioka Y, Iwayama K, Tokuyama K, Akazawa N, Maeda S, Takekoshi K, Matsugo S, Noguchi N, Kaneko S, Takamura T. Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle. <i>Nat. Med.<\/i>, <b>23<\/b>, 508\u2013516 (2017).","DOI":"10.1038\/nm.4295"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T. Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells. <i>Diabetologia<\/i>, <b>57<\/b>, 1968\u20131976 (2014).","DOI":"10.1007\/s00125-014-3306-9"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Misu H, Ishikura K, Kurita S, Takeshita Y, Ota T, Saito Y, Takahashi K, Kaneko S, Takamura T. Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes. <i>PLOS ONE<\/i>, <b>7<\/b>, e34952 (2012).","DOI":"10.1371\/journal.pone.0034952"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Speckmann B, Walter PL, Alili L, Reinehr R, Sies H, Klotz LO, Steinbrenner H. Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4alpha transcription factors. <i>Hepatology<\/i>, <b>48<\/b>, 1998\u20132006 (2008).","DOI":"10.1002\/hep.22526"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Walter PL, Steinbrenner H, Barthel A, Klotz LO. Stimulation of selenoprotein P promoter activity in hepatoma cells by FoxO1a transcription factor. <i>Biochem. Biophys. Res. 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