{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:55:48Z","timestamp":1723060548546},"reference-count":40,"publisher":"Pharmaceutical Society of Japan","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2019,7,1]]},"DOI":"10.1248\/bpb.b18-00691","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T18:29:22Z","timestamp":1552501762000},"page":"1102-1111","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Tetrahydrobiopterin Combined with Nebivolol on Cardiac Diastolic Function in SHRs"],"prefix":"10.1248","volume":"42","author":[{"given":"Zhengyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Cardiac Hospital, Lanzhou University Second Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhong","family":"Lu","sequence":"additional","affiliation":[{"name":"Cardiac Hospital, Lanzhou University Second Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Meng","sequence":"additional","affiliation":[{"name":"Cardiac Hospital, Lanzhou University Second Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiongying","family":"Wang","sequence":"additional","affiliation":[{"name":"Cardiac Hospital, Lanzhou University Second Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Guan","sequence":"additional","affiliation":[{"name":"Cardiac Hospital, Lanzhou University Second Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[{"name":"Cardiac Hospital, Lanzhou University Second Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Nadruz W, Shah AM, Solomon SD. Diastolic dysfunction and hypertension. <i>Med. Clin. North Am.<\/i>, <b>101<\/b>, 7\u201317 (2017).","DOI":"10.1016\/j.mcna.2016.08.013"},{"key":"2","unstructured":"2) Borlaug BA, Paulus WJ. Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment. <i>Eur. Heart J.<\/i>, <b>32<\/b>, 670\u2013679 (2011)."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Schulz E, Jansen T, Wenzel P, Daiber A, M\u00fcnzel T. Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension. <i>Antioxid. Redox Signal.<\/i>, <b>10<\/b>, 1115\u20131126 (2008).","DOI":"10.1089\/ars.2007.1989"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) M\u00fcnzel T, Gori T, Keaney JF Jr, Maack C, Daiber A. Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications. <i>Eur. Heart J.<\/i>, <b>36<\/b>, 2555\u20132564 (2015).","DOI":"10.1093\/eurheartj\/ehv305"},{"key":"5","unstructured":"5) Nediani C, Raimondi L, Borchi E, Cerbai E. Nitric oxide\/reactive oxygen species generation and nitroso\/redox imbalance in heart failure: from molecular mechanisms to therapeutic implications. <i>Antioxid. Redox Signal.<\/i>, <b>14<\/b>, 289\u2013331 (2011)."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Ramachandran J, Peluffo RD. Threshold levels of extracellular l-arginine that trigger NOS-mediated ROS\/RNS production in cardiac ventricular myocytes. <i>Am. J. Physiol. Cell Physiol.<\/i>, <b>312<\/b>, C144\u2013C154 (2017).","DOI":"10.1152\/ajpcell.00150.2016"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Jeong EM, Monasky MM, Gu L, Taglieri DM, Patel BG, Liu H, Wang Q, Greener I, Dudley SC Jr, Solaro RJ. Tetrahydrobiopterin improves diastolic dysfunction by reversing changes in myofilament properties. <i>J. Mol. Cell. Cardiol.<\/i>, <b>56<\/b>, 44\u201354 (2013).","DOI":"10.1016\/j.yjmcc.2012.12.003"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Ali ZA, Rinze R, Douglas G, Hu Y, Xiao Q, Qi W, McNeill E, Bursill C, George I, Greaves DR, Xu Q, Channon KM. Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration. <i>Circulation<\/i>, <b>128<\/b> (Suppl. 1), S50\u2013S58 (2013).","DOI":"10.1161\/CIRCULATIONAHA.112.000249"},{"key":"9","unstructured":"9) V\u00e1squez-Vivar J, Kalyanaraman B, Martasek P, Hogg N, Masters BS, Karoui H, Tordo P, Pritchard KA Jr. Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>95<\/b>, 9220\u20139225 (1998)."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) M\u00e4ki-Pet\u00e4j\u00e4 KM, Day L, Cheriyan J, Hall FC, \u00d6st\u00f6r AJ, Shenker N, Wilkinson IB. Tetrahydrobiopterin supplementation improves endothelial function but does not alter aortic stiffness in patients with rheumatoid arthritis. <i>Journal of the American Heart Association<\/i>, <b>5<\/b>, e002762 (2016).","DOI":"10.1161\/JAHA.115.002762"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Silberman GA, Fan THM, Liu H, Jiao Z, Xiao HD, Lovelock JD, Boulden BM, Widder J, Fredd S, Bernstein KE, Wolska BM, Dikalov S, Harrison DG, Dudley SC Jr. Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction. <i>Circulation<\/i>, <b>121<\/b>, 519\u2013528 (2010).","DOI":"10.1161\/CIRCULATIONAHA.109.883777"},{"key":"12","unstructured":"12) Moens AL, Takimoto E, Tocchetti CG, Chakir K, Bedja D, Cormaci G, Ketner EA, Majmudar M, Gabrielson K, Halushka MK, Mitchell JB, Biswal S, Channon KM, Wolin MS, Alp NJ, Paolocci N, Champion HC, Kass DA. Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy. <i>Circulation<\/i>, <b>117<\/b>, 2626\u20132636 (2008)."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Cunnington C, Van Assche T, Shirodaria C, Kylintireas I, Lindsay AC, Lee JM, Antoniades C, Margaritis M, Lee R, Cerrato R, Crabtree MJ, Francis JM, Sayeed R, Ratnatunga C, Pillai R, Choudhury RP, Neubauer S, Channon KM. Systemic and vascular oxidation limits efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease. <i>Circulation<\/i>, <b>125<\/b>, 1356\u20131366 (2012).","DOI":"10.1161\/CIRCULATIONAHA.111.038919"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Perera RK, Sprenger JU, Steinbrecher JH, Hubscher D, Lehnart SE, Abesser M, Schuh K, El-Armouche A, Nikolaev VO. Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of beta-adrenoceptor-stimulated contractility in early cardiac hypertrophy. <i>Circ. Res.<\/i>, <b>116<\/b>, 1304\u20131311 (2015).","DOI":"10.1161\/CIRCRESAHA.116.306082"},{"key":"15","unstructured":"15) Niu X, Watts VL, Cingolani OH, Sivakumaran V, Leyton-Mange JS, Ellis CL, Miller KL, Vandegaer K, Bedja D, Gabrielson KL, Paolocci N, Kass DA, Barouch LA. Cardioprotective effect of beta-3 adrenergic receptor agonism: role of neuronal nitric oxide synthase. <i>J. Am. Coll. Cardiol.<\/i>, <b>59<\/b>, 1979\u20131987 (2012)."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Mollnau H, Schulz E, Daiber A, Baldus S, Oelze M, August M, Wendt M, Walter U, Geiger C, Agrawal R, Kleschyov AL, Meinertz T, Munzel T. Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells. <i>Arterioscler. Thromb. Vasc. Biol.<\/i>, <b>23<\/b>, 615\u2013621 (2003).","DOI":"10.1161\/01.ATV.0000065234.70518.26"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Balligand JL. beta(3)-Adrenoceptor stimulation on top of beta(1)-adrenoceptor blockade \u201cStop or Encore?.\u201d <i>J. Am. Coll. Cardiol.<\/i>, <b>53<\/b>, 1539\u20131542 (2009).","DOI":"10.1016\/j.jacc.2009.01.048"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Varagic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW Jr, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CM. Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. <i>J. Hypertens.<\/i>, <b>30<\/b>, 1766\u20131774 (2012).","DOI":"10.1097\/HJH.0b013e328356766f"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Zhou X, Ma L, Habibi J, Whaley-Connell A, Hayden MR, Tilmon RD, Brown AN, Kim JA, Demarco VG, Sowers JR. Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the Zucker obese rat. <i>Hypertension<\/i>, <b>55<\/b>, 880\u2013888 (2010).","DOI":"10.1161\/HYPERTENSIONAHA.109.145136"},{"key":"20","unstructured":"20) Fang Y, Nicol L, Harouki N, Monteil C, Wecker D, Debunne M, Bauer F, Lallemand F, Richard V, Thuillez C, Mulder P. Improvement of left ventricular diastolic function induced by \u03b2-blockade: a comparison between nebivolol and metoprolol. <i>J. Mol. Cell. Cardiol.<\/i>, <b>51<\/b>, 168\u2013176 (2011)."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Moens AL, Ketner EA, Takimoto E, Schmidt TS, O\u2019Neill CA, Wolin MS, Alp NJ, Channon KM, Kass DA. Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure. <i>J. Mol. Cell. Cardiol.<\/i>, <b>51<\/b>, 564\u2013569 (2011).","DOI":"10.1016\/j.yjmcc.2011.05.017"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Ma L, Gul R, Habibi J, Yang M, Pulakat L, Whaley-Connell A, Ferrario CM, Sowers JR. Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the transgenic (mRen2) rat. <i>Am. J. Physiol. Heart Circ. Physiol.<\/i>, <b>302<\/b>, H2341\u2013H2351 (2012).","DOI":"10.1152\/ajpheart.01126.2011"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Kokubo M, Uemura A, Matsubara T, Murohara T. Noninvasive evaluation of the time course of change in cardiac function in spontaneously hypertensive rats by echocardiography. <i>Hypertens. Res.<\/i>, <b>28<\/b>, 601\u2013609 (2005).","DOI":"10.1291\/hypres.28.601"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Slama M, Ahn J, Peltier M, Maizel J, Chemla D, Varagic J, Susic D, Tribouilloy C, Frohlich ED. Validation of echocardiographic and Doppler indexes of left ventricular relaxation in adult hypertensive and normotensive rats. <i>Am. J. Physiol. Heart Circ. Physiol.<\/i>, <b>289<\/b>, H1131\u2013H1136 (2005).","DOI":"10.1152\/ajpheart.00345.2004"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Wang Y, Zhang M, Liu Y, Liu Y, Chen M. The effect of nebivolol on asymmetric dimethylarginine system in spontaneously hypertension rats. <i>Vascul. Pharmacol.<\/i>, <b>54<\/b>, 36\u201343 (2011).","DOI":"10.1016\/j.vph.2010.12.001"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Fukushima T, Nixon JC. Analysis of reduced forms of biopterin in biological tissues and fluids. <i>Anal. Biochem.<\/i>, <b>102<\/b>, 176\u2013188 (1980).","DOI":"10.1016\/0003-2697(80)90336-X"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Widder JD, Chen W, Li L, Dikalov S, Thony B, Hatakeyama K, Harrison DG. Regulation of tetrahydrobiopterin biosynthesis by shear stress. <i>Circ. Res.<\/i>, <b>101<\/b>, 830\u2013838 (2007).","DOI":"10.1161\/CIRCRESAHA.107.153809"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Li H, Forstermann U. Pharmacological prevention of eNOS uncoupling. <i>Curr. Pharm. Des.<\/i>, <b>20<\/b>, 3595\u20133606 (2014).","DOI":"10.2174\/13816128113196660749"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Mitchell BM, Cook LG, Danchuk S, Puschett JB. Uncoupled endothelial nitric oxide synthase and oxidative stress in a rat model of pregnancy-induced hypertension. <i>Am. J. Hypertens.<\/i>, <b>20<\/b>, 1297\u20131304 (2007).","DOI":"10.1016\/j.amjhyper.2007.08.007"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Viappiani S, Schulz R. Detection of specific nitrotyrosine-modified proteins as a marker of oxidative stress in cardiovascular disease. <i>Am. J. Physiol. Heart Circ. Physiol.<\/i>, <b>290<\/b>, H2167\u2013H2168 (2006).","DOI":"10.1152\/ajpheart.00128.2006"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Chang P, Wang Q, Xu H, Yang M, Lin X, Li X, Zhang Z, Zhang X, Zhao F, Zhao X, Bai F, Yu J. Tetrahydrobiopterin reverse left ventricular hypertrophy and diastolic dysfunction through the PI3K\/p-Akt pathway in spontaneously hypertensive rats. <i>Biochem. Biophys. Res. Commun.<\/i>, <b>463<\/b>, 1012\u20131020 (2015).","DOI":"10.1016\/j.bbrc.2015.06.051"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Van De Borne P, Fici F, Makel W, Fiasse A, Degaute J-P, Leeman M. The effect of nebivolol and atenolol on renal and systemic haemodynamics in hypertensive patients. <i>High Blood Press. Cardiovasc. Prev.<\/i>, <b>14<\/b>, 133\u2013137 (2007).","DOI":"10.2165\/00151642-200714030-00004"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Abdallah Y, Gkatzoflia A, Gligorievski D, Kasseckert S, Euler G, Schluter KD, Schafer M, Piper HM, Schafer C. Insulin protects cardiomyocytes against reoxygenation-induced hypercontracture by a survival pathway targeting SR Ca<sup>2+<\/sup> storage. <i>Cardiovasc. Res.<\/i>, <b>70<\/b>, 346\u2013353 (2006).","DOI":"10.1016\/j.cardiores.2006.02.020"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Kranias EG, Hajjar RJ. Modulation of cardiac contractility by the phospholamban\/SERCA2a regulatome. <i>Circ. Res.<\/i>, <b>110<\/b>, 1646\u20131660 (2012).","DOI":"10.1161\/CIRCRESAHA.111.259754"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) He H, Giordano FJ, Hilal-Dandan R, Choi DJ, Rockman HA, McDonough PM, Bluhm WF, Meyer M, Sayen MR, Swanson E, Dillmann WH. Overexpression of the rat sarcoplasmic reticulum Ca<sup>2+<\/sup> ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation. <i>J. Clin. Invest.<\/i>, <b>100<\/b>, 380\u2013389 (1997).","DOI":"10.1172\/JCI119544"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Kr\u00fcger M, Kotter S, Grutzner A, Lang P, Andresen C, Redfield MM, Butt E, dos Remedios CG, Linke WA. Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs. <i>Circ. Res.<\/i>, <b>104<\/b>, 87\u201394 (2009).","DOI":"10.1161\/CIRCRESAHA.108.184408"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Zhang Z, Ding L, Jin Z, Gao G, Li H, Zhang L, Zhang L, Lu X, Hu L, Lu B, Yu X, Hu T. Nebivolol protects against myocardial infarction injury <i>via<\/i> stimulation of beta3-adrenergic receptors and nitric oxide signaling. <i>PLOS ONE<\/i>, <b>9<\/b>, e98179 (2014).","DOI":"10.1371\/journal.pone.0098179"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Barr LA, Lambert JP, Shimizu Y, Barouch LA, Naqvi N, Calvert JW. Exercise training provides cardioprotection by activating and coupling endothelial nitric oxide synthase <i>via<\/i> a beta3-adrenergic receptor-AMP-activated protein kinase signaling pathway. <i>Medical Gas Research<\/i>, <b>7<\/b>, 1\u20138 (2017).","DOI":"10.4103\/2045-9912.202904"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Moens AL, Leyton-Mange JS, Niu X, Yang R, Cingolani O, Arkenbout EK, Champion HC, Bedja D, Gabrielson KL, Chen J, Xia Y, Hale AB, Channon KM, Halushka MK, Barker N, Wuyts FL, Kaminski PM, Wolin MS, Kass DA, Barouch LA. Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor. <i>J. Mol. Cell. Cardiol.<\/i>, <b>47<\/b>, 576\u2013585 (2009).","DOI":"10.1016\/j.yjmcc.2009.06.005"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Belge C, Hammond J, Dubois-Deruy E, Manoury B, Hamelet J, Beauloye C, Markl A, Pouleur AC, Bertrand L, Esfahani H, Jnaoui K, Gotz KR, Nikolaev VO, Vanderper A, Herijgers P, Lobysheva I, Iaccarino G, Hilfiker-Kleiner D, Tavernier G, Langin D, Dessy C, Balligand JL. Enhanced expression of beta3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase. <i>Circulation<\/i>, <b>129<\/b>, 451\u2013462 (2014).","DOI":"10.1161\/CIRCULATIONAHA.113.004940"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/42\/7\/42_b18-00691\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T23:20:41Z","timestamp":1562368841000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/42\/7\/42_b18-00691\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,1]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b18-00691","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,1]]}}}