{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T22:36:59Z","timestamp":1770417419390,"version":"3.49.0"},"reference-count":42,"publisher":"Pharmaceutical Society of Japan","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2019,7,1]]},"DOI":"10.1248\/bpb.b18-00805","type":"journal-article","created":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T22:03:16Z","timestamp":1561932196000},"page":"1112-1119","source":"Crossref","is-referenced-by-count":21,"title":["Agarwood Extract Mitigates Intestinal Injury in Fluorouracil-Induced Mice"],"prefix":"10.1248","volume":"42","author":[{"given":"Canhong","family":"Wang","sequence":"first","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deqian","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hainan Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangxin","family":"Yu","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Guo","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College"},{"name":"National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhe","family":"Wei","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College"},{"name":"National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","unstructured":"1) Liu Y, Chen H, Yang Y, Zhang Z, Wei J, Meng H, Chen W, Feng J, Gan B, Chen X, Gao Z, Huang J, Chen B, Chen H. Whole-tree agarwood-inducing technique: an efficient novel technique for producing high-quality agarwood in cultivated <i>Aquilaria sinensis<\/i> trees. <i>Molecules<\/i>, <b>18<\/b>, 3086\u20133106 (2013)."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Yagura T, Ito M, Kiuchi F, Honda G, Shimada Y. Four new 2-(2-phenylethyl)chromone derivatives from withered wood of <i>Aquilaria sinensis<\/i>. <i>Chem. Pharm. Bull.<\/i>, <b>51<\/b>, 560\u2013564 (2003).","DOI":"10.1248\/cpb.51.560"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Chen H, Wei J, Yang J, Zhang Z, Yang Y, Gao Z, Sui C, Gong B. Chemical constituents of agarwood originating from the endemic genus <i>Aquilaria<\/i> plants. <i>Chem. Biodivers.<\/i>, <b>9<\/b>, 236\u2013250 (2012).","DOI":"10.1002\/cbdv.201100077"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Li W, Cai C, Dong W, Guo Z, Wang H, Mei W, Dai H. 2-(2-Phenylethyl)chromone derivatives from Chinese agarwood induced by artificial holing. <i>Fitoterapia<\/i>, <b>98<\/b>, 117\u2013123 (2014).","DOI":"10.1016\/j.fitote.2014.07.011"},{"key":"5","unstructured":"5) Wang C, Wang S, Peng D, Yu Z, Guo P, Wei J. Protective effect of whole-tree agarwood-inducing technique-produced agarwood alcohol extracts on the fluorouracil-induced liver injury in mice. <i>J. Int. Pharm. Res.<\/i>, <b>45<\/b>, 187\u2013197 (2018)."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Kim YC, Lee EH, Lee YM, Kim HK, Song BK, Lee EJ, Kim HM. Effect of the aqueous extract of <i>Aquilaria agallocha<\/i>, stems on the immediate hypersensitivity reactions. <i>J. Ethnopharmacol.<\/i>, <b>58<\/b>, 31\u201338 (1997).","DOI":"10.1016\/S0378-8741(97)00075-5"},{"key":"7","unstructured":"7) Hashim YZHY, Kerr PG, Abbas P, Salleh HM. <i>Aquilaria<\/i>, spp. (agarwood) as source of health beneficial compounds: a review of traditional use, phytochemistry and pharmacology. <i>J. Ethnopharmacol.<\/i>, <b>189<\/b>, 331\u2013360 (2016)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Kakino M, Izuta H, Ito T, Tsuruma K, Araki Y, Shimazawa M, Oyama M, Iinuma M, Hara H. Agarwood induced laxative effects acetylcholine receptors on loperamide-induced constipation in mice. <i>Biosci. Biotechnol. Biochem.<\/i>, <b>74<\/b>, 1550\u20131555 (2010).","DOI":"10.1271\/bbb.100122"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Zhou M, Wang H, Suolangjiba, Kou J, Yu B. Antinociceptive and anti-inflammatory activities of <i>Aquilaria sinensis<\/i> (Lour.) Gilg. leaves extract. <i>J. Ethnopharmacol.<\/i>, <b>117<\/b>, 345\u2013350 (2008).","DOI":"10.1016\/j.jep.2008.02.005"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Huo H, Zhu Z, Pang D, Li Y, Huang Z, Shi S, Zheng J, Zhang Q, Zhao Y, Tu P, Li J. Anti-neuroinflammatory sesquiterpenes from Chinese eaglewood. <i>Fitoterapia<\/i>, <b>106<\/b>, 115\u2013121 (2015).","DOI":"10.1016\/j.fitote.2015.08.009"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Okugawa H, Ueda R, Matsumoto K, Kawanishi K, Kato A. Effects of agarwood extracts on the central nervous system in mice. <i>Planta Med.<\/i>, <b>59<\/b>, 32\u201336 (1993).","DOI":"10.1055\/s-2006-959599"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Zhu Z, Gu Y, Zhao Y, Song Y, Li J, Tu P. GYF-17, a chloride substituted 2-(2-phenethyl)-chromone, suppresses LPS-induced inflammatory mediator production in RAW264.7 cells by inhibiting STAT1\/3 and ERK1\/2 signaling pathways. <i>Int. Immunopharmacol.<\/i>, <b>35<\/b>, 185\u2013192 (2016).","DOI":"10.1016\/j.intimp.2016.03.044"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Huo H, Gu Y, Sun H, Zhang Y, Liu W, Zhu Z, Shi S, Song Y, Jin H, Zhao Y, Tu P, Li J. Anti-inflammatory 2-(2-phenylethyl)chromone derivatives from Chinese agarwood. <i>Fitoterapia<\/i>, <b>118<\/b>, 49\u201355 (2017).","DOI":"10.1016\/j.fitote.2017.02.009"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Kamonwannasit S, Nantapong N, Kumkrai P, Luecha P, Kupittayanant S, Chudapongse N. Antibacterial activity of <i>Aquilaria crassna<\/i> leaf extract against <i>Staphylococcus epidermidis<\/i> by disruption of cell wall. <i>Ann. Clin. Microbiol. Antimicrob.<\/i>, <b>12<\/b>, 20 (2013).","DOI":"10.1186\/1476-0711-12-20"},{"key":"15","unstructured":"15) Liu Y, Wang S, Zhou Y, Zhang Q, Ma F, Gong B, Guo P, Wei J. Effect of agarwood extracts produced by the whole-tree agarwood-inducing technique on gastrointestinal motility and gastric ulcer. <i>J. Int. Pharm. Res.<\/i>, <b>43<\/b>, 1076\u20131081 (2016)."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. International Multicentre Pooled Analysis of Colon Cancer Trials (IMPACT) investigators. <i>Lancet<\/i>, <b>345<\/b>, 939\u2013944 (1995).","DOI":"10.1016\/S0140-6736(95)90696-7"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Benson AB, Ajani JA, Catalano RB, Engelking C, Kornblau SM, Martenson JA, McCallum R, Mitchell EP, O\u2019Dorisio TM, Vokes EE, Wadler S. Recommended guidelines for the treatment of cancer treatment-induced diarrhea. <i>J. Clin. Oncol.<\/i>, <b>22<\/b>, 2918\u20132926 (2004).","DOI":"10.1200\/JCO.2004.04.132"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Wu Y, Deng Z, Wang H, Ma W, Zhou C, Zhang S. Repeated cycles of 5-fluorouracil chemotherapy impaired anti-tumor functions of cytotoxic T cells in a CT26 tumor-bearing mouse model. <i>BMC Immunol.<\/i>, <b>17<\/b>, 29 (2016).","DOI":"10.1186\/s12865-016-0167-7"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Zhao T, Mao G, Zhang M, Zou Y, Feng W, Gu X, Zhu Y, Mao R, Yang L, Wu X. Enhanced antitumor and reduced toxicity effect of <i>Schisanreae<\/i> polysaccharide in 5-FU treated Heps-bearing mice. <i>Inter. J. Biolog. Macromolecu.<\/i>, <b>63<\/b>, 114\u2013118 (2014).","DOI":"10.1016\/j.ijbiomac.2013.10.037"},{"key":"20","unstructured":"20) Bowen JM, Gibson RJ, Cummins AG, Keefe DMK. Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage. <i>Support. Care Cancer<\/i>, <b>14<\/b>, 713\u2013731 (2006)."},{"key":"21","unstructured":"21) Pritchard DM, Potten CS, Hickman JA. The relationships between p53-dependent apoptosis, inhibition of proliferation, and 5-fluorouracil-induced histopathology in murine intestinal epithelia. <i>Cancer Res.<\/i>, <b>58<\/b>, 5453\u20135465 (1998)."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Sonis ST. Regimen-related gastrointestinal toxicities in cancer patient. <i>Curr. Opin. Support. Palliat. Care<\/i>, <b>4<\/b>, 26\u201330 (2010).","DOI":"10.1097\/SPC.0b013e328335fb76"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Wright TH, Yazbeck R, Lymn KA, Whitford EJ, Cheah KY, Butler RN, Feinle-Bisset C, Pilichiewicz AN, Mashtoub S, Howarth GS. The herbal extract, Iberogast, improves jejunal integrity in rats with 5-fluorouracil (5-FU)-induced mucositis. <i>Cancer Biol. Ther.<\/i>, <b>8<\/b>, 923\u2013929 (2009).","DOI":"10.4161\/cbt.8.10.8146"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Wang S, Zhang X, Liu M, Luan H, Ji Y, Guo P, Wu C. Chrysin inhibits foam cell formation through promoting cholesterol efflux from RAW264.7 macrophages. <i>Pharm. Biol.<\/i>, <b>53<\/b>, 1481\u20131487 (2015).","DOI":"10.3109\/13880209.2014.986688"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) \u00c1vila PHMD, \u00c1vila RID, Filho EXDS, Bastos CCC, Batisa AC, Mendonca EF, Serpa RC, Marreto RN, Cruz AF, Lima EM, Valadares MC. Mucoadhesive formulation of <i>Bidens pilosa<\/i>, L. (Asteraceae) reduces intestinal injury from 5-fluorouracil-induced mucositis in mice. <i>Toxicol. Rep.<\/i>, <b>2<\/b>, 563\u2013573 (2015).","DOI":"10.1016\/j.toxrep.2015.03.003"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Jia N, Li Y, Wu Y, Xi M, Hur G, Zhang X, Cui J, Sun W, Wen A. Comparison of the anti-inflammatory and analgesic effects of <i>Gentiana macrophylla<\/i> Pall and <i>Gentiana straminea<\/i> Maxim and identification of their active constituents. <i>J. Ethnopharmacol.<\/i>, <b>144<\/b>, 638\u2013645 (2012).","DOI":"10.1016\/j.jep.2012.10.004"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Huo X, Zhang L, Gao L, Guo Y, Zhang L, Li L, Si J, Cao L. Antiinflammatory and analgesic activities of alcohol extract and isolated compounds from <i>Millettia pulchra<\/i>. <i>Biol. Pharm. Bull.<\/i>, <b>38<\/b>, 1328\u20131336 (2015).","DOI":"10.1248\/bpb.b15-00187"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Guo R, Zhao YF, Li J, Gu YF, Huo HX, Li SS, Song YL, Zhu ZX, Tu PF. GYF-21, an epoxide 2-(2-phenethyl)-chromone derivative, suppresses innate and adaptive immunity <i>via<\/i> inhibiting STAT1\/3 and NF-\u03baB signaling pathways. <i>Frontiers in Pharmacology<\/i>, 8 (2017).","DOI":"10.3389\/fphar.2017.00281"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Zheng H, Gao J, Man SL, Zhang JZ, Jin ZX, Gao WY. The protective effects of aquilariae lignum resinatum extract on 5-fuorouracil-induced intestinal mucositis in mice. <i>Phytomedicine<\/i>, <b>54<\/b>, 308\u2013317 (2019).","DOI":"10.1016\/j.phymed.2018.07.006"},{"key":"30","doi-asserted-by":"publisher","unstructured":"30) Sarawut KP, Eakapot P, Kanitha P, Piyanuch S, Rungnapa P, Panumart T. Anti-inflammatory effects of the ethyl acetate extract of <i>Aquilaria crassna<\/i> inhibits LPS-induced tumor necrosis factor-alpha production by attenuating P38 MAPK activation. <i>Inter. J. Green Pharm.<\/i>, doi: 10.4103\/0973-8258.82099","DOI":"10.4103\/0973-8258.82099"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Wang S, Yu ZX, Wang CH, Wu CM, Guo P, Wei JH. Chemical constituents and pharmacological activity of agarwood and <i>Aquilaria<\/i> plants. <i>Molecules<\/i>, <b>23<\/b>, 342 (2018).","DOI":"10.3390\/molecules23020342"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Liu J, Wu KC, Lu Y, Ekuase E, Klaassen CD. Nrf2 protection against liver injury produced by various hepatotoxicants. <i>Oxid. Med. Cell. Longev.<\/i>, <b>2013<\/b>, 305861 (2013).","DOI":"10.1155\/2013\/305861"},{"key":"33","unstructured":"33) Van Sebille YZA, Stansborough R, Wardill HR, Bateman EB, Gibson RJ, Keefe DM. Management of mucositis during chemotherapy: from pathophysiology to pragmatic therapeutics. <i>Curr. Oncol. Rep.<\/i>, <b>17<\/b>, 50 (2015)."},{"key":"34","unstructured":"34) Gum SI, Cho MK. Recent updates on acetaminophen hepatotoxicity: the role of Nrf2 in hepatoprotection. <i>Toxicolog. Res.<\/i>, <b>29<\/b>, 165\u2013172 (2013)."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Saito Y, Tsuruma K, Ichihara K, Shimazawa M, Hara H. Brazilian green propolis water extract up-regulates the early expression level of HO-1 and accelerates Nrf2 after UVA irradiation. <i>BMC Complement. Alternat. Med.<\/i>, <b>15<\/b>, 421 (2015).","DOI":"10.1186\/s12906-015-0945-4"},{"key":"36","unstructured":"36) Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL. The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer. <i>Redox Biol.<\/i>, <b>1<\/b>, 45\u201349 (2013)."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Wardyn JD, Ponsford AH, Sanderson CM. Dissecting molecular cross-talk between Nrf2 and NF-\u03baB response pathways. <i>Biochem. Soc. Trans.<\/i>, <b>43<\/b>, 621\u2013626 (2015).","DOI":"10.1042\/BST20150014"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Kansanen E, Kivel\u00e4 AM, Levonen AL. Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta12,14-prostaglandin J2. <i>Free Radic. Biol. Med.<\/i>, <b>47<\/b>, 1310\u20131317 (2009).","DOI":"10.1016\/j.freeradbiomed.2009.06.030"},{"key":"39","unstructured":"39) Liu ZG, Hsu H, Goeddel DV, Karin M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-\u03baB activation prevents cell death. <i>Cell<\/i>, <b>87<\/b>, 565\u2013576 (1996)."},{"key":"40","unstructured":"40) Stordeur P, Goldman M. Interleukin-10 as a regulatory cytokine induced by cellular stress: molecular aspects. <i>Int. Rev. Immunol.<\/i>, <b>16<\/b>, 501\u2013522 (1998)."},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Saraiva M, O\u2019Garra A. The regulation of IL-10 production by immune cells. <i>Nat. Rev. Immunol.<\/i>, <b>10<\/b>, 170\u2013181 (2010).","DOI":"10.1038\/nri2711"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Herpers B, Wink S, Fredriksson L, Di Z, Hendriks G, Vrieling H, de Bont H, van de Water B. Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-\u03baB activation and sensitizes toward TNF\u03b1-induced cytotoxicity. <i>Arch. Toxicol.<\/i>, <b>90<\/b>, 1163\u20131179 (2016).","DOI":"10.1007\/s00204-015-1536-3"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/42\/7\/42_b18-00805\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T03:21:01Z","timestamp":1562383261000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/42\/7\/42_b18-00805\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,1]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b18-00805","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,1]]}}}