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Chlorhexidine\u2013alcohol versus<\/i> povidone\u2013iodine for surgical-site antisepsis. N. Engl. J. Med.<\/i>, 362<\/b>, 18\u201326 (2010).","DOI":"10.1056\/NEJMoa0810988"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Berry AR, Watt B, Goldacre MJ, Thomson JW, McNair TJ. A comparison of the use of povidone\u2013iodine and chlorhexidine in the prophylaxis of postoperative wound infection. J. Hosp. Infect.<\/i>, 3<\/b>, 55\u201363 (1982).","DOI":"10.1016\/0195-6701(82)90031-7"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Noble WC. Skin carriage of the Micrococcaceae. J. Clin. Pathol.<\/i>, 22<\/b>, 249\u2013253 (1969).","DOI":"10.1136\/jcp.22.3.249"},{"key":"4","unstructured":"4) Roth RR, James WD. Microbiology of the skin: resident flora, ecology, infection. J. Am. Acad. Dermatol.<\/i>, 20<\/b>, 367\u2013390 (1989)."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Ohtoshi T, Yamauchi N, Tadokoro K, Miyachi S, Suzuki S, Miyamoto T, Muranaka M. IgE antibody-mediated shock reaction caused by topical application of chlorhexidine. Clin. Allergy<\/i>, 16<\/b>, 155\u2013161 (1986).","DOI":"10.1111\/j.1365-2222.1986.tb00759.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Okano M, Nomura M, Hata S, Okada N, Sato K, Kitano Y, Tashiro M, Yoshimoto Y, Hama R, Aoki T. Anaphylactic symptoms due to chlorhexidine gluconate. Arch. Dermatol.<\/i>, 125<\/b>, 50\u201352 (1989).","DOI":"10.1001\/archderm.125.1.50"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Kobayashi H, Tsuzuki M, Hosobuchi K. Bactericidal effects of antiseptics and disinfectants against methicillin-resistant Staphylococcus aureus<\/i>. Infect. Control Hosp. Epidemiol.<\/i>, 10<\/b>, 562\u2013564 (1989).","DOI":"10.1086\/645952"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Kampf G, Hofer M, Wendt C. Efficacy of hand disinfectants against vancomycin-resistant enterococci in vitro<\/i>. J. Hosp. 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Lett.<\/i>, 93<\/b>, 195\u2013198 (1992).","DOI":"10.1016\/0378-1097(92)90528-V"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Kuroda M, Ohta T, Uchiyama I, Baba T, Yuzawa H, Kobayashi I, Cui L, Oguchi A, Aoki K, Nagai Y, Lian J, Ito T, Kanamori M, Matsumaru H, Maruyama A, Murakami H, Hosoyama A, Mizutani-Ui Y, Takahashi NK, Sawano T, Inoue R, Kaito C, Sekimizu K, Hirakawa H, Kuhara S, Goto S, Yabuzaki J, Kanehisa M, Yamashita A, Oshima K, Furuya K, Yoshino C, Shiba T, Hattori M, Ogasawara N, Hayashi H, Hiramatsu K. Whole genome sequencing of meticillin-resistant Staphylococcus aureus<\/i>. Lancet<\/i>, 357<\/b>, 1225\u20131240 (2001).","DOI":"10.1016\/S0140-6736(00)04403-2"},{"key":"13","unstructured":"13) American Society for Testing and Materials (ASTM) Standard. Standard Guide for Assessment of Antimicrobial Activity Using a Time-Kill Procedure.<\/i> ASTM International, pp. 1\u20135 (2008)."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Rose H, Baldwin A, Dowson CG, Mahenthiralingam E. Biocide susceptibility of the Burkholderia cepacia<\/i> complex. J. Antimicrob. Chemother.<\/i>, 63<\/b>, 502\u2013510 (2009).","DOI":"10.1093\/jac\/dkn540"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Cheng A, Sun HY, Tsai YT, Wu UI, Chuang YC, Wang JT, Sheng WH, Hsueh PR, Chen YC, Chang SC. In vitro<\/i> evaluation of povidone-iodine and chlorhexidine against outbreak and nonoutbreak strains of Mycobacterium abscessus<\/i> using standard quantitative suspension and carrier testing. Antimicrob. Agents Chemother.<\/i>, 62<\/b>, e01364-17 (2018).","DOI":"10.1128\/AAC.01364-17"},{"key":"16","unstructured":"16) McDonnell G, Russell AD. Antiseptics and disinfectants: activity, action, and resistance. Clin. Microbiol. Rev.<\/i>, 12<\/b>, 147\u2013179 (1999)."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Theraud M, Bedouin Y, Guiguen C, Gangneux JP. Efficacy of antiseptics and disinfectants on clinical and environmental yeast isolates in planktonic and biofilm conditions. J. Med. Microbiol.<\/i>, 53<\/b>, 1013\u20131018 (2004).","DOI":"10.1099\/jmm.0.05474-0"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Tortorano AM, Viviani MA, Biraghi E, Rigoni AL, Prigitano A, Grillot R, Network E; EBGA Network. In vitro<\/i> testing of fungicidal activity of biocides against Aspergillus fumigatus<\/i>. J. Med. Microbiol.<\/i>, 54<\/b>, 955\u2013957 (2005).","DOI":"10.1099\/jmm.0.45997-0"},{"key":"19","unstructured":"19) Nakata H, Tsubotani Y, Nii T, Hagi A, Inoue Y, Imamura T. Effects of olanexidine gluconate on preoperative skin preparation: an experimental study in cynomolgus monkeys. J. Med. 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