{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:57:13Z","timestamp":1761238633425},"reference-count":17,"publisher":"Pharmaceutical Society of Japan","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2019,8,1]]},"DOI":"10.1248\/bpb.b18-00982","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T22:04:40Z","timestamp":1559599480000},"page":"1415-1418","source":"Crossref","is-referenced-by-count":10,"title":["G Protein-Coupled Receptor 39 Agonist Improves Concanavalin A-Induced Hepatitis in Mice"],"prefix":"10.1248","volume":"42","author":[{"given":"Satoshi","family":"Muneoka","sequence":"first","affiliation":[{"name":"Asubio Pharma Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Goto","sequence":"additional","affiliation":[{"name":"Asubio Pharma Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonari","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Asubio Pharma Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Asubio Pharma Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Kadoshima-Yamaoka","sequence":"additional","affiliation":[{"name":"Asubio Pharma Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Tomimori","sequence":"additional","affiliation":[{"name":"Asubio Pharma Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Krawitt EL. Autoimmune hepatitis. <i>N. Engl. J. Med.<\/i>, <b>354<\/b>, 54\u201366 (2006).","DOI":"10.1056\/NEJMra050408"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Cassim S, Bilodeau M, Vincent C, Lapierre P. Novel immunotherapies for autoimmune hepatitis. <i>Front. Pediatr.<\/i>, <b>5<\/b>, 8 (2017).","DOI":"10.3389\/fped.2017.00008"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Tiegs G, Hentschel J, Wendel AA. T cell-dependent experimental liver injury in mice inducible by concanavalin A. <i>J. Clin. Invest.<\/i>, <b>90<\/b>, 196\u2013203 (1992).","DOI":"10.1172\/JCI115836"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Wang H, Liu M, Weng S-Y, Li J-J, Xie C, He H-L, Guan W, Yuan Y-S, Gao J. Immune mechanisms of Concanavalin A model of autoimmune hepatitis. <i>World J. Gastroenterol.<\/i>, <b>18<\/b>, 119\u2013125 (2012).","DOI":"10.3748\/wjg.v18.i2.119"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Possamai LA, Antoniades CG, Anstee QM, Quaglia A, Vergani D, Thursz M, Wendon J. Role of monocytes and macrophages in experimental and human acute liver failure. <i>World J. Gastroenterol.<\/i>, <b>16<\/b>, 1811\u20131819 (2010).","DOI":"10.3748\/wjg.v16.i15.1811"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Louis H, Le Moine O, Peny MO, Quertinmont E, Fokan D, Goldman M, Devi\u00e8re J. Production and role of interleukin-10 in concanavalin A-induced hepatitis in mice. <i>Hepatology<\/i>, <b>25<\/b>, 1382\u20131389 (1997).","DOI":"10.1002\/hep.510250614"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Tagawa Y, Matthys P, Heremans H, Dillen C, Zaman Z, Iwakura Y, Billiau A. Bimodal role of endogenous interleukin-6 in concanavalin A-induced hepatitis in mice. <i>J. Leukoc. Biol.<\/i>, <b>67<\/b>, 90\u201396 (2000).","DOI":"10.1002\/jlb.67.1.90"},{"key":"8","unstructured":"8) Egerod KL, Holst B, Petersen PS, Hansen JB, Mulder J, H\u00f6kfelt T, Schwartz TW. GPR39 splice variants <i>versus<\/i> antisense Gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue. <i>Mol. Endocrinol.<\/i>, <b>21<\/b>, 1685\u20131698 (2007)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Holst B, Egerod KL, Schild E, Vickers SP, Cheetham S, Gerlach LO, Storjohann L, Stidsen CE, Jones R, Beck-Sickinger AG, Schwartz TW. GPR39 signaling is stimulated by zinc ions but not by obestatin. <i>Endocrinology<\/i>, <b>148<\/b>, 13\u201320 (2007).","DOI":"10.1210\/en.2006-0933"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Hershfinkel M. The zinc sensing receptor, ZnR\/GPR39, in health and disease. <i>Int. J. Mol. Sci.<\/i>, <b>19<\/b>, 439 (2018).","DOI":"10.3390\/ijms19020439"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Peukert S, Hughes R, Nunez J, He G, Yan Z, Jain R, Llamas L, Luchansky S, Carlson A, Liang G, Kunjathoor V, Pietropaolo M, Shapiro J, Castellana A, Wu X, Bose A. Discovery of 2-pyridylpyrimidines as the first orally bioavailable GPR39 agonists. <i>ACS Med. Chem. Lett.<\/i>, <b>5<\/b>, 1114\u20131118 (2014).","DOI":"10.1021\/ml500240d"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) M\u0142yniec K, Starowicz G, Gawel M, Frackiewicz E, Nowak G. Potential antidepressant-like properties of the TC G-1008, a GPR39 (zinc receptor) agonist. <i>J. Affect. Disord.<\/i>, <b>201<\/b>, 179\u2013184 (2016).","DOI":"10.1016\/j.jad.2016.05.007"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Pongkorpsakol P, Buasakdi C, Chantivas T, Chatsudthipong V, Muanprasat C. An agonist of a zinc-sensing receptor GPR39 enhances tight junction assembly in intestinal epithelial cells <i>via<\/i> an AMPK-dependent mechanism. <i>Eur. J. Pharmacol.<\/i>, <b>842<\/b>, 306\u2013313 (2019).","DOI":"10.1016\/j.ejphar.2018.10.038"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Muneoka S, Goto M, Kadoshima-Yamaoka K, Kamei R, Terakawa M, Tomimori Y. G protein-coupled receptor 39 plays an anti-inflammatory role by enhancing IL-10 production from macrophages under inflammatory conditions. <i>Eur. J. Pharmacol.<\/i>, <b>834<\/b>, 240\u2013245 (2018).","DOI":"10.1016\/j.ejphar.2018.07.045"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Sato S, Huang X-P, Kroeze WK, Roth BL. Discovery and characterization of novel GPR39 agonists allosterically modulated by zinc. <i>Mol. Pharmacol.<\/i>, <b>90<\/b>, 726\u2013737 (2016).","DOI":"10.1124\/mol.116.106112"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Amiya T, Nakamoto N, Chu PS, Teratani T, Nakajima H, Fukuchi Y, Taniki N, Yamaguchi A, Shiba S, Miyake R, Katayama T, Ebinuma H, Kanai T. Bone marrow-derived macrophages distinct from tissue-resident macrophages play a pivotal role in Concanavalin A-induced murine liver injury <i>via<\/i> CCR9 axis. <i>Sci. Rep.<\/i>, <b>6<\/b>, 35146 (2016).","DOI":"10.1038\/srep35146"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Matsuoka S, Matsumura H, Nakamura H, Oshiro S, Arakawa Y, Hayashi J, Sekine N, Nirei K, Yamagami H, Ogawa M, Nakajima N, Amaki S, Tanaka N, Moriyama M. Zinc supplementation improves the outcome of chronic hepatitis C and liver cirrhosis. <i>J. Clin. Biochem. Nutr.<\/i>, <b>45<\/b>, 292\u2013303 (2009).","DOI":"10.3164\/jcbn.jcbn08-246"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/42\/8\/42_b18-00982\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,3]],"date-time":"2019-08-03T03:21:48Z","timestamp":1564802508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/42\/8\/42_b18-00982\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,1]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b18-00982","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,1]]}}}