{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:50:30Z","timestamp":1793469030042,"version":"4.5.0"},"reference-count":29,"publisher":"Pharmaceutical Society of Japan","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological & Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2019,6,1]]},"DOI":"10.1248\/bpb.b18-00985","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T18:02:44Z","timestamp":1554400964000},"page":"960-967","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Prolonged Infusion of Alamandine on Cardiovascular Parameters and Cardiac ACE2 Expression in a Rat Model of Renovascular Hypertension"],"prefix":"10.1248","volume":"42","author":[{"given":"Ava Soltani","family":"Hekmat","sequence":"first","affiliation":[{"name":"Department of Physiology, Fasa University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Zare","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Fasa University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Moravej","sequence":"additional","affiliation":[{"name":"Department of Immunology, Fasa University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hassan","family":"Meshkibaf","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Fasa University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazem","family":"Javanmardi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Fasa University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Sparks MA, Crowley SD, Gurley SB, Mirotsou M, Coffman TM. Classical renin\u2013angiotensin system in kidney physiology. Comprehensive Physiology<\/i>. Vol. 4, John Wiley & Sons, Inc., Hoboken, NJ, U.S.A., pp. 1201\u20131228 (2014).","DOI":"10.1002\/cphy.c130040"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Hackenthal E, Paul M, Ganten D, Taugner R. Morphology, physiology, and molecular biology of renin secretion. Physiol. Rev.<\/i>, 70<\/b>, 1067\u20131116 (1990).","DOI":"10.1152\/physrev.1990.70.4.1067"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Bernstein KE, Berk BC. The biology of angiotensin II receptors. Am. J. Kidney Dis.<\/i>, 22<\/b>, 745\u2013754 (1993).","DOI":"10.1016\/S0272-6386(12)80441-0"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Herlitz H, Palmgren E, Widgren B, Aurell M. Failure of angiotensin II to suppress plasma renin activity in normotensive subjects with a positive family history of hypertension. Clin. Sci.<\/i> (Lond.), 109<\/b>, 311\u2013317 (2005).","DOI":"10.1042\/CS20050055"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Haddy FJ, Molnar JI, Borden CW, Texter EC Jr. Comparison of direct effects of angiotensin and other vasoactive agents on small and large blood vessels in several vascular beds. Circulation<\/i>, 25<\/b>, 239\u2013246 (1962).","DOI":"10.1161\/01.CIR.25.1.239"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Merrill AJ, Morrison JL, Branno ES. Concentration of renin in renal venous blood in patients with chronic heart failure. Am. J. Med.<\/i>, 1<\/b>, 468\u2013472 (1946).","DOI":"10.1016\/0002-9343(46)90067-8"},{"key":"7","unstructured":"7) Turner AJ. Exploring the structure and function of zinc metallopeptidases: old enzymes and new discoveries. Biochem. Soc. Trans.<\/i>, 31<\/b>, 723\u2013727 (2003)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1\u20139. Circ. Res.<\/i>, 87<\/b>, E1\u2013E9 (2000).","DOI":"10.1161\/01.RES.87.5.e1"},{"key":"9","unstructured":"9) Lautner RQ, Villela DC, Fraga-Silva RA, Silva N, Verano-Braga T, Costa-Fraga F, Jankowski J, Jankowski V, Sousa F, Alzamora A, Soares E, Barbosa C, Kjeldsen F, Oliveira A, Braga J, Savergnini S, Maia G, Peluso AB, Passos-Silva D, Ferreira A, Alves F, Martins A, Raizada M, Paula R, Motta-Santos D, Kemplin F, Pimenta A, Alenina N, Sinisterra R, Bader M, Campagnole-Santos MJ, Santos RAS. Discovery and characterization of alamandine: a novel component of the renin\u2013angiotensin system. Circ. Res.<\/i>, 112<\/b>, 1104\u20131111 (2013)."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Jankowski V, Vanholder R, van der Giet M, Tolle M, Karadogan S, Gobom J, Furkert J, Oksche A, Krause E, Anh Tran TN, Tepel M, Schuchardt M, Schluter H, Wiedon A, Beyermann M, Bader M, Todiras M, Zidek W, Jankowski J. Mass-spectrometric identification of a novel angiotensin peptide in human plasma. Arterioscler. Thromb. Vasc. Biol.<\/i>, 27<\/b>, 297\u2013302 (2006).","DOI":"10.1161\/01.ATV.0000253889.09765.5f"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Soltani Hekmat A, Javanmardi K, Kouhpayeh A, Baharamali E, Farjam M. Differences in cardiovascular responses to alamandine in two-kidney, one clip hypertensive and normotensive rats. Circ. J.<\/i>, 81<\/b>, 405\u2013412 (2017).","DOI":"10.1253\/circj.CJ-16-0958"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Choi KC, Woo YJ, Park JW, Lee JE, Kim WJ, Yoo KJ, Yoo KS, Kang YJ. Impairment of Endothelium-dependent relaxation in chronic two-kidney, one clip hypertensive rats. Korean J. Intern. Med.<\/i>, 9<\/b>, 99\u2013105 (1994).","DOI":"10.3904\/kjim.1994.9.2.99"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Liu C, Yang C-X, Chen X-R, Liu B-X, Li Y, Wang X-Z, Sun W, Li P, Kong X-Q. Alamandine attenuates hypertension and cardiac hypertrophy in hypertensive rats. Amino Acids<\/i>, 50<\/b>, 1071\u20131081 (2018).","DOI":"10.1007\/s00726-018-2583-x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Lin HY, Lee YT, Chan YW, Tse G. Animal models for the study of primary and secondary hypertension in humans. Biomed. Rep.<\/i>, 5<\/b>, 653\u2013659 (2016).","DOI":"10.3892\/br.2016.784"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Chelko SP, Schmiedt CW, Lewis TH, Robertson TP, Lewis SJ. Occipital artery function during the development of 2-kidney, 1-clip hypertension in rats. Int. J. Vasc. Med.<\/i>, 2014<\/b>, 659617 (2014).","DOI":"10.1155\/2014\/659617"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Tikellis C, Thomas MC. Angiotensin-converting enzyme 2 (ACE2) is a key modulator of the renin angiotensin system in health and disease. Int. J. Pept.<\/i>, 2012<\/b>, 256294 (2012).","DOI":"10.1155\/2012\/256294"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Soltani Hekmat A, Najafipour H, Nekooian AA, Esmaeli-Mahani S, Javanmardi K. Cardiovascular responses to apelin in two-kidney\u2013one-clip hypertensive rats and its receptor expression in ischemic and non-ischemic kidneys. Regul. Pept.<\/i>, 172<\/b>, 62\u201368 (2011).","DOI":"10.1016\/j.regpep.2011.08.010"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Soares ER, Barbosa CM, Campagnole-Santos MJ, Santos RAS, Alzamora AC. Hypotensive effect induced by microinjection of Alamandine, a derivative of angiotensin(1\u20137), into caudal ventrolateral medulla of 2K1C hypertensive rats. Peptides<\/i>, 96<\/b>, 67\u201375 (2017).","DOI":"10.1016\/j.peptides.2017.09.005"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Shen Y-H, Chen X-R, Yang C-X, Liu B-X, Li P. Alamandine injected into the paraventricular nucleus increases blood pressure and sympathetic activation in spontaneously hypertensive rats. Peptides<\/i>, 103<\/b>, 98\u2013102 (2018).","DOI":"10.1016\/j.peptides.2018.03.014"},{"key":"20","unstructured":"20) Zile MR, Gaasch WH, Carroll JD, Feldman MD, Aurigemma GP, Schaer GL, Ghali JK, Liebson PR. Heart failure with a normal ejection fraction: is measurement of diastolic function necessary to make the diagnosis of diastolic heart failure? Circulation<\/i>, 104<\/b>, 779\u2013782 (2001)."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Soltani Hekmat A, Javanmardi K, Kouhpayeh A, Baharamali E, Farjam M. Differences in cardiovascular responses to alamandine in two-kidney, one clip hypertensive and normotensive rats. Circ. J.<\/i>, 81<\/b>, 405\u2013412 (2017).","DOI":"10.1253\/circj.CJ-16-0958"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) de Jesus ICG, Scalzo S, Alves F, Marques K, Rocha-Resende C, Bader M, Santos RAS, Guatimosim S. Alamandine acts via<\/i> MrgD to induce AMPK\/NO activation against Ang II hypertrophy in cardiomyocytes. Am. J. Physiol. Physiol.<\/i>, 314<\/b>, C702\u2013C711 (2018).","DOI":"10.1152\/ajpcell.00153.2017"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Li P, Chen X-R, Xu F, Liu C, Li C, Liu H, Wang H, Sun W, Sheng Y-H, Kong X-Q. Alamandine attenuates sepsis-associated cardiac dysfunction via<\/i> inhibiting MAPKs signaling pathways. Life Sci.<\/i>, 206<\/b>, 106\u2013116 (2018).","DOI":"10.1016\/j.lfs.2018.04.010"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Park BM, Phuong HTA, Yu L, Kim SH. Alamandine protects the heart against reperfusion injury via<\/i> the MrgD receptor. Circ. J.<\/i>, 82<\/b>, 2584\u20132593 (2018).","DOI":"10.1253\/circj.CJ-17-1381"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Gallagher PE, Ferrario CM, Tallant EA. Regulation of ACE2 in cardiac myocytes and fibroblasts. Am. J. Physiol. Heart Circ. Physiol.<\/i>, 295<\/b>, H2373\u2013H2379 (2008).","DOI":"10.1152\/ajpheart.00426.2008"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, Yagil Y, Penninger JM. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature<\/i>, 417<\/b>, 822\u2013828 (2002).","DOI":"10.1038\/nature00786"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Yang W, Huang W, Su S, Li B, Zhao W, Chen S, Gu D. Association study of ACE2<\/i> (angiotensin I-converting enzyme 2) gene polymorphisms with coronary heart disease and myocardial infarction in a Chinese Han population. Clin. Sci.<\/i>, 111<\/b>, 333\u2013340 (2006).","DOI":"10.1042\/CS20060020"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Vogel C, de Sousa Abreu R, Ko D, Le S-Y, Shapiro BA, Burns SC, Sandhu D, Boutz DR, Marcotte EM, Penalva LO. Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line. Mol. Syst. Biol.<\/i>, 6<\/b>, 400 (2010).","DOI":"10.1038\/msb.2010.59"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Deshotels MR, Xia H, Sriramula S, Lazartigues E, Filipeanu CM, Angiotensin II. Mediates angiotensin converting enzyme type 2 internalization and degradation through an angiotensin II type I receptor-dependent mechanism novelty and significance. Hypertension<\/i>, 64<\/b>, 1368\u20131375 (2014).","DOI":"10.1161\/HYPERTENSIONAHA.114.03743"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/42\/6\/42_b18-00985\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T23:30:37Z","timestamp":1559345437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/42\/6\/42_b18-00985\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,1]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b18-00985","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,1]]}}}