{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:51:00Z","timestamp":1790661060399,"version":"4.1.0"},"reference-count":35,"publisher":"Pharmaceutical Society of Japan","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2019,7,1]]},"DOI":"10.1248\/bpb.b19-00105","type":"journal-article","created":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T18:03:21Z","timestamp":1561917801000},"page":"1185-1191","source":"Crossref","is-referenced-by-count":32,"title":["Analyses of Respiratory Depression Associated with Opioids in Cancer Patients Based on the Japanese Adverse Drug Event Report Database"],"prefix":"10.1248","volume":"42","author":[{"given":"Hideki","family":"Sugawara","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Kagoshima University Hospital"},{"name":"Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayako","family":"Uchida","sequence":"additional","affiliation":[{"name":"Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences"},{"name":"Education and Research Center for Clinical Pharmacy, Osaka University of Pharmaceutical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences"},{"name":"Department of Pharmacy, National Cancer Center Hospital East"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Suga","sequence":"additional","affiliation":[{"name":"Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences"},{"name":"Department of Clinical Drug Informatics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical & Health Science, Kanazawa University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Uesawa","sequence":"additional","affiliation":[{"name":"Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences"},{"name":"Department of Medical Molecular Informatics, Meiji Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences"},{"name":"Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisamitsu","family":"Takase","sequence":"additional","affiliation":[{"name":"Research Promotion Committee, Japanese Society for Pharmaceutical Palliative Care and Sciences"},{"name":"Nippon Medical School Tama-Nagayama Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Duthey B, Scholten W. Adequacy of opioid analgesic consumption at country, global, and regional levels in 2010, its relationship with development level, and changes compared with 2006. <i>J. Pain Symptom Manage.<\/i>, <b>47<\/b>, 283\u2013297 (2014).","DOI":"10.1016\/j.jpainsymman.2013.03.015"},{"key":"2","unstructured":"2) Practice guidelines for the prevention, detection, and management of respiratory depression associated with neuraxial opioid administration: an updated report by the American Society of Anesthesiologists Task Force on Neuraxial Opioids and the American Society of Regional Anesthesia and Pain Medicine. <i>Anesthesiology<\/i>, <b>124<\/b>, 535\u2013552 (2016)."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Southern DA, Read MS. Overdosage of opiate from patient controlled analgesia devices. <i>BMJ<\/i>, <b>309<\/b>, 1002 (1994).","DOI":"10.1136\/bmj.309.6960.1002"},{"key":"4","unstructured":"4) Cepeda MS, Farrar JT, Baumgarten M, Boston R, Carr DB, Strom BL. Side effects of opioids during short-term administration: effect of age, gender, and race. <i>Clin. Pharmacol. Ther.<\/i>, <b>74<\/b>, 102\u2013112 (2003)."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Ostermeier AM, Roizen MF, Hautkappe M, Klock PA, Klafta JM. Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea. <i>Anesth. Analg.<\/i>, <b>85<\/b>, 452\u2013460 (1997).","DOI":"10.1097\/00000539-199708000-00037"},{"key":"6","unstructured":"6) Taylor S, Kirton OC, Staff I, Kozol RA. Postoperative day one: a high risk period for respiratory events. <i>Am. J. Surg.<\/i>, <b>190<\/b>, 752\u2013756 (2005)."},{"key":"7","unstructured":"7) Ravenscroft P, Schneider J. Bedside prespectives on the use of opioids: transferring results of clinical research into practice. <i>Clin. Exp. Pharmacol. Physiol.<\/i>, <b>27<\/b>, 529\u2013532 (2000)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Baxter AD. Respiratory depression with patient-controlled analgesia. <i>Can. J. Anaesth.<\/i>, <b>41<\/b>, 87\u201390 (1994).","DOI":"10.1007\/BF03009796"},{"key":"9","unstructured":"9) Izumi N, Okuyama S, Abe K, Ishikawa D, Suzuki S. Prolonged disturbance of consciousness and respiratory depression induced by controlled-release morphine, requiring long-term naloxone administration in a hemodialysis patient with cancer\u2014a case report. <i>Gan To Kagaku Ryoho<\/i>, <b>39<\/b>, 1295\u20131299 (2012)."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Pauli-Magnus C, Hofmann U, Mikus G, Kuhlmann U, Mettang T. Pharmacokinetics of morphine and its glucuronides following intravenous administration of morphine in patients undergoing continuous ambulatory peritoneal dialysis. <i>Nephrol. Dial. Transplant.<\/i>, <b>14<\/b>, 903\u2013909 (1999).","DOI":"10.1093\/ndt\/14.4.903"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Nakamura M, Umetsu R, Abe J, Matsui T, Ueda N, Kato Y, Sasaoka S, Tahara K, Takeuchi H, Kinosada Y. Analysis of the time to-onset of osteonecrosis of jaw with bisphosphonate treatment using the data from a spontaneous reporting system of adverse drug events. <i>J. Pharm. Health Care Sci.<\/i>, <b>1<\/b>, 34 (2015).","DOI":"10.1186\/s40780-015-0035-2"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Abe J, Umetsu R, Mataki K, Kato Y, Ueda N, Nakayama Y, Hane Y, Matsui T, Hatahira H, Sasaoka S, Motooka Y, Hara H, Kato Z, Kinosada Y, Inagaki N, Nakamura M. Analysis of Stevens\u2013Johnson syndrome and toxic epidermal necrolysis using the Japanese Adverse Drug Event Report database. <i>J. Pharm. Health Care Sci.<\/i>, <b>2<\/b>, 14 (2016).","DOI":"10.1186\/s40780-016-0048-5"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Hosoya R, Uesawa Y, Ishii-Nozawa R, Kagaya H. Analysis of factors associated with hiccups based on the Japanese Adverse Drug Event Report database. <i>PLOS ONE<\/i>, <b>12<\/b>, e0172057 (2017).","DOI":"10.1371\/journal.pone.0172057"},{"key":"14","unstructured":"14) Ohyama K, Sugiura M. Evaluation of the association between topical prostaglandin F2\u03b1 analogs and asthma using the JADER database: comparison with \u03b2-blockers. <i>Yakugaku Zasshi<\/i>, <b>138<\/b>, 559\u2013564 (2018)."},{"key":"15","unstructured":"15) Caraceni A, Hanks G, Kaasa S, Bennett MI, Brunelli C, Cherny N, Dale O, De Conno F, Fallon M, Hanna M, Haugen DF, Juhl G, King S, Klepstad P, Laugsand EA, Maltoni M, Mercadante S, Nabal M, Pigni A, Radbruch L, Reid C, Sjogren P, Stone PC, Tassinari D, Zeppetella G. Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC. <i>Lancet Oncol.<\/i>, <b>13<\/b>, e58\u2013e68 (2012)."},{"key":"16","unstructured":"16) Poluzzi E, Raschi E, Piccinni C, De F. Data mining techniques in pharmacovigilance: analysis of the publicly accessible FDA Adverse Event Reporting System (AERS). <i>Data Mining Applications in Engineering and Medicine.<\/i> InTechOpen, London, pp. 265\u2013302 (2012)."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) van Puijenbroek EP, Bate A, Leufkens HGM, Lindquist M, Orre R, Egberts ACG. A comparison of measures of disproportionality for signal detection in spontaneous reporting systems for adverse drug reactions. <i>Pharmacoepidemiol. Drug Saf.<\/i>, <b>11<\/b>, 3\u201310 (2002).","DOI":"10.1002\/pds.668"},{"key":"18","unstructured":"18) Foundation for promotion of cancer research. \u201cCancer Statistics in Japan 2017.\u201d: \u2039https:\/\/ganjoho.jp\/reg_stat\/statistics\/brochure\/backnumber\/2017_jp.html\u203a, cited March, 2018."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Greenblatt DJ, von Moltke LL. Gender has a small but statistically significant effect on clearance of CYP3A substrate drugs. <i>J. Clin. Pharmacol.<\/i>, <b>48<\/b>, 1350\u20131355 (2008).","DOI":"10.1177\/0091270008323754"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Meibohm B, Beierle I, Derendorf H. How important are gender differences in pharmacokinetics? <i>Clin. Pharmacokinet.<\/i>, <b>41<\/b>, 329\u2013342 (2002).","DOI":"10.2165\/00003088-200241050-00002"},{"key":"21","unstructured":"21) Gupta K, Nagappa M, Prasad A, Abrahamyan L, Wong J, Weingarten TN, Chung F. Risk factors for opioid-induced respiratiory depression in surgical patients: a systematic review and meta-analyses. <i>BMJ Open<\/i>, <b>8<\/b>, e024086 (2018)."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Ishida T, Naito T, Sato H, Kawakami J. Relationship between the plasma fentanyl and serum 4\u03b2-hydroxycholesterol based on CYP3A5 genotype and gender in patients with cancer pain. <i>Drug Metab. Pharmacokinet.<\/i>, <b>31<\/b>, 242\u2013248 (2016).","DOI":"10.1016\/j.dmpk.2016.04.001"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Lavan AH, Gallagher P. Predicting risk of adverse drug reactions in older adults. <i>Ther. Adv. Drug Saf.<\/i>, <b>7<\/b>, 11\u201322 (2016).","DOI":"10.1177\/2042098615615472"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Routledge PA, O\u2019Mahony MS, Woodhouse KW. Adverse drug reactions in elderly patients. <i>Br. J. Clin. Pharmacol.<\/i>, <b>57<\/b>, 121\u2013126 (2004).","DOI":"10.1046\/j.1365-2125.2003.01875.x"},{"key":"25","unstructured":"25) Morimoto T, Sakuma M, Matsui K, Kuramoto N, Toshiro J, Murakami J, Fukui T, Saito M, Hiraide A, Bates DW. Incidence of adverse drug events and medication errors in Japan: the JADE study. <i>J. Gen. Intern. Med.<\/i>, <b>26<\/b>, 148\u2013153 (2011)."},{"key":"26","unstructured":"26) Pedr\u00f3s C, Formiga F, Corbella X, Arnau JM. Adverse drug reactions leading to urgent hospital admission in an elderly population: prevalence and main features. <i>Eur. J. Clin. Pharmacol.<\/i>, <b>72<\/b>, 219\u2013226 (2016)."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Zedler B, Xie L, Wang L, Joyce A, Vick C, Kariburyo F, Rajan P, Baser O, Murrelle L. Risk factors for serious prescription opioid-related toxicity or overdose among Veterans Health Administration patients. <i>Pain Med.<\/i>, <b>15<\/b>, 1911\u20131929 (2014).","DOI":"10.1111\/pme.12480"},{"key":"28","unstructured":"28) Pergolizzi J, B\u00f6ger RH, Budd K, Dahan A, Erdine S, Hans G, Kress HG, Langford R, Likar R, Raffa RB, Sacerdote P. Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone). <i>Pain Pract.<\/i>, <b>8<\/b>, 287\u2013313 (2008)."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Bohnert AS, Valenstein M, Bair MJ, Ganoczy D, McCarthy JF, Ilgen MA, Blow FC. Association between opioid prescribing patterns and opioid overdose-related deaths. <i>JAMA<\/i>, <b>305<\/b>, 1315\u20131321 (2011).","DOI":"10.1001\/jama.2011.370"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Hara A, Matsumoto K, Yokoyama Y, Kizu J. Factorial analysis of hepatitis B virus reactivation-induced hepatitis B using JADER. <i>Biol. Pharm. Bull.<\/i>, <b>40<\/b>, 782\u2013788 (2017).","DOI":"10.1248\/bpb.b16-00765"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Hasegawa S, Matsui T, Hane Y, Abe J, Hatahira H, Motooka Y, Sasaoka S, Fukuda A, Naganuma M, Hirade K, Takahashi Y, Kinosada Y, Nakamura M. Thromboembolic adverse event study of combined estrogen-progestin preparations using Japanese Adverse Drug Event Report database. <i>PLOS ONE<\/i>, <b>12<\/b>, e0182045 (2017).","DOI":"10.1371\/journal.pone.0182045"},{"key":"32","unstructured":"32) Hatahira H, Abe J, Hane Y, Matsui T, Sasaoka S, Motooka Y, Hasegawa S, Fukuda A, Naganuma M, Ohmori T, Kinosada Y, Nakamura M. Drug-induced gingival hyperplasia: a retrospective study using spontaneous reporting system databases. <i>J. Pharm. Health.<\/i> <i>Care Sci.<\/i>, <b>3<\/b>, 19 (2017)."},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Pattinson KTS. Opioids and the control of respiration. <i>Br. J. Anaesth.<\/i>, <b>100<\/b>, 747\u2013758 (2008).","DOI":"10.1093\/bja\/aen094"},{"key":"34","unstructured":"34) van der Schier R, Roozekrans M, van Velzen M, Dahan A, Niesters M. Opioid-induced respiratory depression: reversal by non-opioid drugs. <i>F1000Prime Rep.<\/i>, <b>6<\/b>, 79 (2014)."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Young JC, Lund JL, Dasgupta N, Jonsson Funk M. Opioid tolerance and clinically recognized opioid poisoning among patients prescribed extended-release long-acting opioids. <i>Pharmacoepidemiol. Drug Saf.<\/i>, <b>28<\/b>, 39\u201347 (2019).","DOI":"10.1002\/pds.4572"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/42\/7\/42_b19-00105\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T23:21:27Z","timestamp":1562368887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/42\/7\/42_b19-00105\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,1]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b19-00105","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,1]]}}}