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Japanese guidelines for adult asthma 2017. <i>Allergol. Int.<\/i>, <b>66<\/b>, 163\u2013189 (2017).","DOI":"10.1016\/j.alit.2016.12.005"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Miravitlles M, Vogelmeier C, Roche N, Halpin D, Cardoso J, Chuchalin AG, Kankaanranta H, Sandstr\u00f6m T, \u015aliwi\u0144ski P, Zatloukal J, Blasi F. A review of national guidelines for management of COPD in Europe. <i>Eur. Respir. J.<\/i>, <b>47<\/b>, 625\u2013637 (2016).","DOI":"10.1183\/13993003.01170-2015"},{"key":"3","unstructured":"3) Ma YJ, Jiang DQ, Meng JX, Li MX, Zhao HH, Wang Y, Wang LQ. Theophylline: a review of population pharmacokinetic analyses. <i>J. Clin. Pharm. Ther.<\/i>, <b>41<\/b>, 594\u2013601 (2016)."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Sohn JA, Kim H-S, Oh J, Cho J-Y, Yu K-S, Lee J, Shin SH, Lee JA, Choi CW, Kim E-K, Kim B, Park EA. 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Theophylline pharmacokinetics: comparison of Cyp1a1(\u2212\/\u2212) and Cyp1a2(\u2212\/\u2212) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+\/+) wild-type mice. <i>Pharmacogenet. Genomics<\/i>, <b>15<\/b>, 503\u2013511 (2005)."},{"key":"13","unstructured":"13) Thompson RD, Nagasawa HT, Jenne JW. Determination of theophylline and its metabolites in human urine and serum by high-pressure liquid chromatography. <i>J. Lab. Clin. Med.<\/i>, <b>84<\/b>, 584\u2013593 (1974)."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Konishi H, Morita K, Yamaji A. Multiplicity of cytochrome P-450 species involved in theophylline metabolism in mouse hepatic microsomes. <i>Biol. Pharm. Bull.<\/i>, <b>18<\/b>, 576\u2013580 (1995).","DOI":"10.1248\/bpb.18.576"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Tr\u00f6ger U, Meyer FP. 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Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female nonsmokers. <i>J. Pharmacol. Exp. Ther.<\/i>, <b>280<\/b>, 627\u2013637 (1997)."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Kizu J, Arakawa M, Arakawa Y, Komoda F, Takamizawa M, Iwata T, Hayakawa T, Imai K. Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under. <i>Biomed. 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