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Pain<\/i>, 32<\/b>, 77\u201388 (1988).","DOI":"10.1016\/0304-3959(88)90026-7"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J. Neurosci. Methods<\/i>, 53<\/b>, 55\u201363 (1994).","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Uchida H, Ma L, Ueda H. Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain. J. Neurosci.<\/i>, 30<\/b>, 4806\u20134814 (2010).","DOI":"10.1523\/JNEUROSCI.5541-09.2010"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Hunskaar S, Fasmer OB, Hole K. Formalin test in mice, a useful technique for evaluating mild analgesics. J. Neurosci. Methods<\/i>, 14<\/b>, 69\u201376 (1985).","DOI":"10.1016\/0165-0270(85)90116-5"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Inoue M, Kobayashi M, Kozaki S, Zimmer A, Ueda H. Nociceptin\/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice. Proc. Natl. Acad. Sci. U.S.A.<\/i>, 95<\/b>, 10949\u201310953 (1998).","DOI":"10.1073\/pnas.95.18.10949"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Ueda H. Lysophosphatidic acid signaling is the definitive mechanism underlying neuropathic pain. Pain<\/i>, 158<\/b> (Suppl. 1), S55\u2013S65 (2017).","DOI":"10.1097\/j.pain.0000000000000813"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Jancso G, Kiraly E, Jancs\u00f3-Gabor A. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature<\/i>, 270<\/b>, 741\u2013743 (1977).","DOI":"10.1038\/270741a0"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Hiura A, Ishizuka H. Changes in features of degenerating primary sensory neurons with time after capsaicin treatment. Acta Neuropathol.<\/i>, 78<\/b>, 35\u201346 (1989).","DOI":"10.1007\/BF00687400"},{"key":"9","unstructured":"9) Ueda H, Inoue M. In vivo<\/i> signal transduction of nociceptive response by kyotorphin (tyrosine-arginine) through Galpha(i)- and inositol trisphosphate-mediated Ca(2+) influx. Mol. Pharmacol.<\/i>, 57<\/b>, 108\u2013115 (2000)."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Inoue M, Kawashima T, Takeshima H, Calo G, Inoue A, Nakata Y, Ueda H. In vivo<\/i> pain-inhibitory role of nociceptin\/orphanin FQ in spinal cord. J. Pharmacol. Exp. Ther.<\/i>, 305<\/b>, 495\u2013501 (2003).","DOI":"10.1124\/jpet.102.046326"},{"key":"11","unstructured":"11) Inoue M, Rashid MH, Kawashima T, Matsumoto M, Maeda T, Kishioka S, Ueda H. The algogenic-induced nociceptive flexion test in mice: studies on sensitivity of the test and stress on animals. Brain Res. Bull.<\/i>, 60<\/b>, 275\u2013281 (2003)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Ueda H, Rashid MH. Molecular mechanism of neuropathic pain. Drug News Perspect.<\/i>, 16<\/b>, 605\u2013613 (2003).","DOI":"10.1358\/dnp.2003.16.9.829343"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Matsumoto M, Kondo S, Usdin TB, Ueda H. Parathyroid hormone 2 receptor is a functional marker of nociceptive myelinated fibers responsible for neuropathic pain. J. Neurochem.<\/i>, 112<\/b>, 521\u2013530 (2010).","DOI":"10.1111\/j.1471-4159.2009.06473.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Koga K, Furue H, Rashid MH, Takaki A, Katafuchi T, Yoshimura M. Selective activation of primary afferent fibers evaluated by sine-wave electrical stimulation. Mol. Pain<\/i>, 1<\/b>, 13 (2005).","DOI":"10.1186\/1744-8069-1-13"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Matsumoto M, Xie W, Ma L, Ueda H. Pharmacological switch in Abeta-fiber stimulation-induced spinal transmission in mice with partial sciatic nerve injury. Mol. Pain<\/i>, 4<\/b>, 25 (2008).","DOI":"10.1186\/1744-8069-4-25"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Ueda H. Peripheral mechanisms of neuropathic pain\u2014involvement of lysophosphatidic acid receptor-mediated demyelination. Mol. Pain<\/i>, 4<\/b>, 11 (2008).","DOI":"10.1186\/1744-8069-4-11"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Matsumoto M, Inoue M, Hald A, Yamaguchi A, Ueda H. Characterization of three different sensory fibers by use of neonatal capsaicin treatment, spinal antagonism and a novel electrical stimulation-induced paw flexion test. Mol. Pain<\/i>, 2<\/b>, 16 (2006).","DOI":"10.1186\/1744-8069-2-16"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Seltzer Z, Dubner R, Shir Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain<\/i> (Amsterdam), 43<\/b>, 205\u2013218 (1990).","DOI":"10.1016\/0304-3959(90)91074-S"},{"key":"19","unstructured":"19) Malmberg AB, Basbaum AI. Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates. Pain<\/i> (Amsterdam), 76<\/b>, 215\u2013222 (1998)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Ueda H. Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms. Pharmacology & Therapeutics <\/i>(Oxford), 109<\/b>, 57\u201377 (2006).","DOI":"10.1016\/j.pharmthera.2005.06.003"},{"key":"21","unstructured":"21) Waxman SG. Transcriptional channelopathies: an emerging class of disorders. Nat. Rev. Neurosci.<\/i>, 2<\/b>, 652\u2013659 (2001)."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Dib-Hajj SD, Black JA, Cummins TR, Kenney AM, Kocsis JD, Waxman SG. Rescue of alpha-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo.<\/i> J. Neurophysiol.<\/i>, 79<\/b>, 2668\u20132676 (1998).","DOI":"10.1152\/jn.1998.79.5.2668"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Uchida H, Ma L, Ueda H. Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain. J. Neurosci.<\/i>, 30<\/b>, 4806\u20134814 (2010).","DOI":"10.1523\/JNEUROSCI.5541-09.2010"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Campbell DS, Holt CE. Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation. Neuron <\/i>, 32<\/b>, 1013\u20131026 (2001).","DOI":"10.1016\/S0896-6273(01)00551-7"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Weiner JA, Fukushima N, Contos JJ, Scherer SS, Chun J. Regulation of Schwann cell morphology and adhesion by receptor-mediated lysophosphatidic acid signaling. J. Neurosci.<\/i>, 21<\/b>, 7069\u20137078 (2001).","DOI":"10.1523\/JNEUROSCI.21-18-07069.2001"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Inoue M, Yamaguchi A, Kawakami M, Chun J, Ueda H. Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain. Mol. Pain<\/i>, 2<\/b>, 1744-8069-2-25 (2006).","DOI":"10.1186\/1744-8069-2-25"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Ueda H. Lysophosphatidic acid as the initiator of neuropathic pain. Biol. Pharm. Bull.<\/i>, 34<\/b>, 1154\u20131158 (2011).","DOI":"10.1248\/bpb.34.1154"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Inoue M, Rashid MH, Fujita R, Contos JJ, Chun J, Ueda H. Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat. Med.<\/i>, 10<\/b>, 712\u2013718 (2004).","DOI":"10.1038\/nm1060"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Fujita R, Kiguchi N, Ueda H. LPA-mediated demyelination in ex vivo<\/i> culture of dorsal root. Neurochem. Int.<\/i>, 50<\/b>, 351\u2013355 (2007).","DOI":"10.1016\/j.neuint.2006.09.003"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Tsukahara R, Ueda H. Myelin-related gene silencing mediated by LPA1 - Rho\/ROCK signaling is correlated to acetylation of NF\u03baB in S16 Schwann cells. J. Pharmacol. Sci.<\/i>, 132<\/b>, 162\u2013165 (2016).","DOI":"10.1016\/j.jphs.2016.07.010"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Xie W, Matsumoto M, Chun J, Ueda H. Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury. Mol. Pain<\/i>, 4<\/b>, 1744-8069-4-46 (2008).","DOI":"10.1186\/1744-8069-4-46"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Pierscionek BK, Li Y, Yasseen AA, Colhoun LM, Schachar RA, Chen W. Nanoceria have no genotoxic effect on human lens epithelial cells. Nanotechnology<\/i>, 21<\/b>, 035102 (2010).","DOI":"10.1088\/0957-4484\/21\/3\/035102"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Tomsig JL, Snyder AH, Berdyshev EV, Skobeleva A, Mataya C, Natarajan V, Brindley DN, Lynch KR. Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo.<\/i> Biochem. J.<\/i>, 419<\/b>, 611\u2013618 (2009).","DOI":"10.1042\/BJ20081888"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Xie W, Uchida H, Nagai J, Ueda M, Chun J, Ueda H. Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain. J. Neurochem.<\/i>, 113<\/b>, 1002\u20131011 (2010).","DOI":"10.1111\/j.1471-4159.2010.06664.x"},{"key":"35","unstructured":"35) Ma L, Nagai J, Chun J, Ueda H. An LPA species (18\u2009:\u20091 LPA) plays key roles in the self-amplification of spinal LPA production in the peripheral neuropathic pain model. Mol. Pain<\/i>, 9<\/b>, 1744-8069-9-29 (2013)."},{"key":"36","unstructured":"36) Ma L, Uchida H, Nagai J, Inoue M, Chun J, Aoki J, Ueda H. Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain. Mol. Pain<\/i>, 5<\/b>, 64 (2009)."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Ma L, Nagai J, Ueda H. Microglial activation mediates de novo<\/i> lysophosphatidic acid production in a model of neuropathic pain. J. Neurochem.<\/i>, 115<\/b>, 643\u2013653 (2010).","DOI":"10.1111\/j.1471-4159.2010.06955.x"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Lee HW. Clinicopathological characteristics of TERT promoter mutation and telomere length in hepatocellular carcinoma. Medicine<\/i> (Baltimore), 96<\/b>, (2017).","DOI":"10.1097\/MD.0000000000005766"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Inoue M, Ma L, Aoki J, Ueda H. Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain. J. Neurochem.<\/i>, 107<\/b>, 1556\u20131565 (2008).","DOI":"10.1111\/j.1471-4159.2008.05725.x"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Srikanth M, Chew WS, Hind T, Lim SM, Hay NWJ, Lee JHM, Rivera R, Chun J, Ong WY, Herr DR. Lysophosphatidic acid and its receptor LPA1 mediate carrageenan induced inflammatory pain in mice. Eur. J. Pharmacol.<\/i>, 841<\/b>, 49\u201356 (2018).","DOI":"10.1016\/j.ejphar.2018.10.005"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Ying H, Da L, Luo J, Li-Xia L, Yu X, Li-Mei X, Wei-Dong R. Quantitative assessment of bladder neck compliance by using transvaginal real-time elastography of women. Ultrasound Med. Biol.<\/i>, 39<\/b>, 1727\u20131734 (2013).","DOI":"10.1016\/j.ultrasmedbio.2013.04.015"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Liu SJ, McHowat J. Stimulation of different phospholipase A2 isoforms by TNF-alpha and IL-1beta in adult rat ventricular myocytes. Am. J. Physiol.<\/i>, 275<\/b>, H1462\u2013H1472 (1998).","DOI":"10.1152\/ajpheart.1998.275.4.H1462"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Inoue M, Rashid MH, Fujita R, Contos JJ, Chun J, Ueda H. Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat. Med.<\/i>, 10<\/b>, 712\u2013718 (2004).","DOI":"10.1038\/nm1060"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Fujita R, Ma Y, Ueda H. Lysophosphatidic acid-induced membrane ruffling and brain-derived neurotrophic factor gene expression are mediated by ATP release in primary microglia. J. Neurochem.<\/i>, 107<\/b>, 152\u2013160 (2008).","DOI":"10.1111\/j.1471-4159.2008.05599.x"},{"key":"45","unstructured":"45) Rivera C, Voipio J, Kaila K. Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII. J. Physiol.<\/i>, 562<\/b>, 27\u201336 (2005)."},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature<\/i>, 438<\/b>, 1017\u20131021 (2005).","DOI":"10.1038\/nature04223"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Ma L, Nagai J, Ueda H. Microglial activation mediates de novo<\/i> lysophosphatidic acid production in a model of neuropathic pain. J. Neurochem.<\/i>, 115<\/b>, 643\u2013653 (2010).","DOI":"10.1111\/j.1471-4159.2010.06955.x"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Ueda H, Neyama H, Nagai J, Matsushita Y, Tsukahara T, Tsukahara R. Involvement of lysophosphatidic acid-induced astrocyte activation underlying the maintenance of partial sciatic nerve injury-induced neuropathic pain. Pain<\/i>, 159<\/b>, 2170\u20132178 (2018).","DOI":"10.1097\/j.pain.0000000000001316"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Gao YJ, Ji RR. Chemokines, neuronal\u2013glial interactions, and central processing of neuropathic pain. Pharmacol. Ther.<\/i>, 126<\/b>, 56\u201368 (2010).","DOI":"10.1016\/j.pharmthera.2010.01.002"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Polomano RC, Mannes AJ, Clark US, Bennett GJ. A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel. Pain<\/i>, 94<\/b>, 293\u2013304 (2001).","DOI":"10.1016\/S0304-3959(01)00363-3"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Uchida H, Nagai J, Ueda H. Lysophosphatidic acid and its receptors LPA1 and LPA3 mediate paclitaxel-induced neuropathic pain in mice. Mol. Pain<\/i>, 10<\/b>, 1744-8069-10-71 (2014).","DOI":"10.1186\/1744-8069-10-71"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Schubnell T, Meuer L, Bengtson R. Improving surgical services performance through changing work culture. AORN J.<\/i>, 87<\/b>, 575\u2013583 (2008).","DOI":"10.1016\/j.aorn.2008.02.017"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Ueda H, Neyama H, Sasaki K, Miyama C, Iwamoto R. Lysophosphatidic acid LPA1 and LPA3 receptors play roles in the maintenance of late tissue plasminogen activator-induced central poststroke pain in mice. Neurobiol. Pain<\/i>, 5<\/b>, 100020 (2019).","DOI":"10.1016\/j.ynpai.2018.07.001"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Price DD. Psychological and neural mechanisms of the affective dimension of pain. Science<\/i>, 288<\/b>, 1769\u20131772 (2000).","DOI":"10.1126\/science.288.5472.1769"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Cort\u00e9s M, Malave L, Castello J, Flajolet M, Cenci MA, Friedman E, Rebholz H. CK2 oppositely modulates l-DOPA-induced dyskinesia via<\/i> striatal projection neurons expressing D1 or D2 receptors. J. Neurosci.<\/i>, 37<\/b>, 11930\u201311946 (2017).","DOI":"10.1523\/JNEUROSCI.0443-17.2017"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Russell IJ, Vaeroy H, Javors M, Nyberg F. Cerebrospinal fluid biogenic amine metabolites in fibromyalgia\/fibrositis syndrome and rheumatoid arthritis. Arthritis Rheum.<\/i>, 35<\/b>, 550\u2013556 (1992).","DOI":"10.1002\/art.1780350509"},{"key":"57","unstructured":"57) Clauw DJ. Fibromyalgia: a clinical review. JAMA<\/i>, 311<\/b>, 1547\u20131555 (2014)."},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Dickenson AH, Ghandehari J. Anti-convulsants and anti-depressants. Handbook Exp. Pharmacol.<\/i>, 177<\/b>, 145\u2013177 (2007).","DOI":"10.1007\/978-3-540-33823-9_6"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Welsch P, Uceyler N, Klose P, Walitt B, Hauser W. Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia. Cochrane Database Syst. Rev.<\/i>, 2<\/b>, CD010292 (2018).","DOI":"10.1002\/14651858.CD010292.pub2"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Khasar SG, Miao FJ, Janig W, Levine JD. Vagotomy-induced enhancement of mechanical hyperalgesia in the rat is sympathoadrenal-mediated. J. Neurosci.<\/i>, 18<\/b>, 3043\u20133049 (1998).","DOI":"10.1523\/JNEUROSCI.18-08-03043.1998"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61) Sluka KA, Kalra A, Moore SA. Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia. Muscle Nerve<\/i>, 24<\/b>, 37\u201346 (2001).","DOI":"10.1002\/1097-4598(200101)24:1<37::AID-MUS4>3.0.CO;2-8"},{"key":"62","unstructured":"62) Csan\u00e1dy L, Mindell JA. The twain shall meet: channels, transporters and things between. Meeting on Membrane Transport in Flux: the Ambiguous Interface between Channels and Pumps. EMBO Rep.<\/i>, 9<\/b>, 960\u2013965 (2008)."},{"key":"63","doi-asserted-by":"crossref","unstructured":"63) Sluka KA, Rohlwing JJ, Bussey RA, Eikenberry SA, Wilken JM. Chronic muscle pain induced by repeated acid Injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists. J. Pharmacol. Exp. Ther.<\/i>, 302<\/b>, 1146\u20131150 (2002).","DOI":"10.1124\/jpet.102.033167"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64) Yokoyama T, Maeda Y, Audette KM, Sluka KA. Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats. J. Pain<\/i>, 8<\/b>, 422\u2013429 (2007).","DOI":"10.1016\/j.jpain.2006.11.007"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65) Kim SH, Song J, Mun H, Park KU. Effect of the combined use of tramadol and milnacipran on pain threshold in an animal model of fibromyalgia. Korean J. Intern. Med.<\/i>, 24<\/b>, 139\u2013142 (2009).","DOI":"10.3904\/kjim.2009.24.2.139"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66) Nishiyori M, Ueda H. Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia. Mol. Pain<\/i>, 4<\/b>, 1744-8069-4-52 (2008).","DOI":"10.1186\/1744-8069-4-52"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67) Ueda H, Neyama H. LPA1 receptor involvement in fibromyalgia-like pain induced by intermittent psychological stress, empathy. Neurobiol. 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