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Two new alkaloids from the rhizome of <i>Polygonatum sibiricum.<\/i> <i>J. Asian Nat. Prod. Res.<\/i>, <b>7<\/b>, 127\u2013130 (2005).","DOI":"10.1080\/10286020310001625157"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Zeng GF, Zhang ZY, Lu L, Xiao DQ, Xiong CX, Zhao YX, Zong SH. Protective effects of <i>Polygonatum sibiricum<\/i> polysaccharide on ovariectomy-induced bone loss in rats. <i>J. Ethnopharmacol.<\/i>, <b>136<\/b>, 224\u2013229 (2011).","DOI":"10.1016\/j.jep.2011.04.049"},{"key":"3","unstructured":"3) China Pharmacopoeia Committee <i>Pharmacopoeia of the People\u2019s Republic of China<\/i>. Chemical Industry Press, Beijing (2010)."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Liu L, Dong Q, Dong XT, Fang JN, Ding K. Structural investigation of two neutral polysaccharides isolated from rhizome of <i>Polygonatum sibiricum.<\/i> <i>Carbohydr. Polym.<\/i>, <b>70<\/b>, 304\u2013309 (2007).","DOI":"10.1016\/j.carbpol.2007.04.012"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Wang J, Lu CS, Liu DY, Xu YT, Zhu Y, Wu HH. Constituents from <i>Polygonatum sibiricum<\/i> and their inhibitions on the formation of advanced glycosylation end products. <i>J. Asian Nat. Prod. Res.<\/i>, <b>18<\/b>, 697\u2013704 (2016).","DOI":"10.1080\/10286020.2015.1135905"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Ahn MJ, Kim CY, Yoon KD, Ryu MY, Cheong JH, Chin YW, Kim J. Steroidal. saponins from the rhizomes of <i>Polygonatum sibiricum.<\/i> <i>J. Nat. Prod.<\/i>, <b>69<\/b>, 360\u2013364 (2006).","DOI":"10.1021\/np050394d"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Hu CY, Xu DP, Wu YM, Ou SY. Triterpenoid saponins from the rhizome of <i>Polygonatum sibiricum<\/i>. <i>J. Asian Nat. Prod. Res.<\/i>, <b>12<\/b>, 801\u2013808 (2010).","DOI":"10.1080\/10286020.2010.505562"},{"key":"8","unstructured":"8) Sun LR, Li X. Studies on chemical constituents of <i>Polygonatum sibiricum<\/i> (II). <i>Zhongcaoyao<\/i>, <b>32<\/b>, 586\u2013588 (2001)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Liang M, Zhao Q, Liu G, Yang S, Zuo X, Cui G, Zhong S, Sun J, Liu J, Zhu R. Pathogenicity of <i>Bordetella avium<\/i> under immunosuppression induced by <i>Reticuloendotheliosis<\/i> virus in specific-pathogen-free chickens. <i>Microb. Pathog.<\/i>, <b>54<\/b>, 40\u201345 (2013).","DOI":"10.1016\/j.micpath.2012.09.003"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Fan Y, Lu Y, Wang D, Liu J, Song X, Zhang W, Zhao X, Nguyen TL, Hu Y. Effect of epimedium polysaccharide-propolis flavone immunopotentiator on immunosuppression induced by cyclophosphamide in chickens. <i>Cell. Immunol.<\/i>, <b>281<\/b>, 37\u201343 (2013).","DOI":"10.1016\/j.cellimm.2013.01.008"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Zhang Y, Yang S, Zhao X, Yang Y, Li B, Zhu F, Zhu R. Immune enhancement of Taishan <i>Robinia pseudoacacia<\/i> polysaccharide on recombinant <i>Proteus mirabilis<\/i> OmpA in chickens. <i>Int. Immunopharmacol.<\/i>, <b>22<\/b>, 236\u2013241 (2014).","DOI":"10.1016\/j.intimp.2014.06.036"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Feng H, Fan J, Song Z, Du X, Chen Y, Wang J, Song G. Characterization and immunoenhancement activities of <i>Eucommia ulmoides<\/i> polysaccharides. <i>Carbohydr. Polym.<\/i>, <b>136<\/b>, 803\u2013811 (2016).","DOI":"10.1016\/j.carbpol.2015.09.079"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Xu Y, Cai F, Yu Z, Zhang L, Li X, Yang Y, Liu G. Optimisation of pressurised water extraction of polysaccharides from blackcurrant and its antioxidant activity. <i>Food Chem.<\/i>, <b>194<\/b>, 650\u2013658 (2016).","DOI":"10.1016\/j.foodchem.2015.08.061"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Chen JR, Yang ZQ, Hu TJ, Yan ZT, Niu TX, Wang L, Cui DA, Wang M. Immunomodulatory activity <i>in vitro<\/i> and <i>in vivo<\/i> of polysaccharide from <i>Potentilla anserina.<\/i> <i>Fitoterapia<\/i>, <b>81<\/b>, 1117\u20131124 (2010).","DOI":"10.1016\/j.fitote.2010.07.009"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Yu Q, Nie SP, Wang JQ, Liu XZ, Yin PF, Huang DF, Li WJ, Gong DM, Xie MY. Chemoprotective effects of Ganoderma atrum polysaccharide in cyclophosphamide-induced mice. <i>Int. J. Biol. Macromol.<\/i>, <b>64<\/b>, 395\u2013401 (2014).","DOI":"10.1016\/j.ijbiomac.2013.12.029"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Cui HX, Li T, Wang LP, Su Y, Xian CJ. Dioscorea bulbifera polysaccharide and cyclophosphamide combination enhances anti-cervical cancer effect and attenuates immunosuppression and oxidative stress in mice. <i>Sci. Rep.<\/i>, <b>6<\/b>, 19185 (2016).","DOI":"10.1038\/srep19185"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Han L, Suo Y, Yang Y, Meng J, Hu N. Optimization, characterization, and biological activity of polysaccharides from <i>Berberis dasystachya<\/i> Maxim. <i>Int. J. Biol. Macromol.<\/i>, <b>85<\/b>, 655\u2013666 (2016).","DOI":"10.1016\/j.ijbiomac.2015.10.038"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Wang Y, Liu X, Zhang J, Liu G, Liu Y, Wang K, Yang M, Cheng H, Zhao Z. Structural characterization and <i>in vitro<\/i> antitumor activity of polysaccharides from <i>Zizyphus jujuba<\/i> cv. <i>Muzao<\/i>. RSC<i> Adv.<\/i>, <b>5<\/b>, 7860\u20137867 (2015).","DOI":"10.1039\/C4RA13350A"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Zhang Z, Kong F, Ni H, Mo Z, Wan JB, Hua D, Yan C. Structural characterization, \u03b1-glucosidase inhibitory and DPPH scavenging activities of polysaccharides from guava. <i>Carbohydr. Polym.<\/i>, <b>144<\/b>, 106\u2013114 (2016).","DOI":"10.1016\/j.carbpol.2016.02.030"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) \u0160andula J, Kogan G, Ka\u010dur\u00e1kov\u00e1 M, Machov\u00e1 E. Microbial (1\u21923)-\u03b2-D-glucans, their preparation, physico-chemical characterization and immunomodulatory activity. <i>Carbohydr. Polym.<\/i>, <b>38<\/b>, 247\u2013253 (1999).","DOI":"10.1016\/S0144-8617(98)00099-X"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Chai Y, Zhao M. Purification, characterization and anti-proliferation activities of polysaccharides extracted from <i>Viscum coloratum<\/i> (Kom.). Nakai. <i>Carbohydr. Polym.<\/i>, <b>149<\/b>, 121\u2013130 (2016).","DOI":"10.1016\/j.carbpol.2016.04.090"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Wang H, Wang M, Chen J, Tang Y, Dou J, Yu J, Xi T, Zhou C. A polysaccharide from <i>Strongylocentrotus nudus<\/i> eggs protects against myelosuppression and immunosuppression in cyclophosphamide-treated mice. <i>Int. Immunopharmacol.<\/i>, <b>11<\/b>, 1946\u20131953 (2011).","DOI":"10.1016\/j.intimp.2011.06.006"},{"key":"23","unstructured":"23) Gong Y, Wu J, Li ST. Immuno-enhancement effects of <i>Lycium ruthenicum<\/i> Murr. polysaccharide on cyclophosphamide-induced immunosuppression in mice. <i>Int. J. Clin. Exp. Med.<\/i>, <b>8<\/b>, 20631\u201320637 (2015)."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Mei YX, Chen HX, Zhang J, Zhang XD, Liang YX. Protective effect of chitooligosaccharides against cyclophosphamide-induced immunosuppression in mice. <i>Int. J. Biol. Macromol.<\/i>, <b>62<\/b>, 330\u2013335 (2013).","DOI":"10.1016\/j.ijbiomac.2013.09.038"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Renoux G. The general immunopharmacology of levamisole. <i>Drugs<\/i>, <b>20<\/b>, 89\u201399 (1980).","DOI":"10.2165\/00003495-198020020-00001"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Chen LY, Lin YL, Chiang BL. Levamisole enhances immune response by affecting the activation and maturation of human monocyte-derived dendritic cells. <i>Clin. Exp. Immunol.<\/i>, <b>151<\/b>, 174\u2013181 (2008).","DOI":"10.1111\/j.1365-2249.2007.03541.x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Marits P, Wikstr\u00f6m AC, Popadic D, Winqvist O, Thunberg S. Evaluation of T and B lymphocyte function in clinical practice using a flow cytometry based proliferation assay. <i>Clin. Immunol.<\/i>, <b>153<\/b>, 332\u2013342 (2014).","DOI":"10.1016\/j.clim.2014.05.010"},{"key":"28","unstructured":"28) Dashputre NL, Naikwade NS. Immunomodulatory activity of Abutilon indicum linn on albino mice. <i>Int. J. Pharm. Sci. Res.<\/i>, <b>1<\/b>, 178\u2013184 (2010)."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Thakur M, Bhargava S, Dixit VK. Immunomodulatory activity of <i>Chlorophytum borivilianum<\/i> Sant. F. <i>Evid. Based Complement. Alternat. Med.<\/i>, <b>4<\/b>, 419\u2013423 (2007).","DOI":"10.1093\/ecam\/nel094"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Krug A, French AR, Barchet W, Fischer JA, Dzionek A, Pingel JT, Orihuela MM, Akira S, Yokoyama WM, Colonna M. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. <i>Immunity<\/i>, <b>21<\/b>, 107\u2013119 (2004).","DOI":"10.1016\/j.immuni.2004.06.007"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Huyan XH, Lin YP, Gao T, Chen RY, Fan YM. Immunosuppressive effect of cyclophosphamide on white blood cells and lymphocyte subpopulations from peripheral blood of Balb\/c mice. <i>Int. Immunopharmacol.<\/i>, <b>11<\/b>, 1293\u20131297 (2011).","DOI":"10.1016\/j.intimp.2011.04.011"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Liu XC, Zhu ZY, Tang YL, Wang MF, Wang Z, Liu AJ, Zhang YM. Structural properties of polysaccharides from cultivated fruit bodies and mycelium of <i>Cordyceps militaris.<\/i> <i>Carbohydr. Polym.<\/i>, <b>142<\/b>, 63\u201372 (2016).","DOI":"10.1016\/j.carbpol.2016.01.040"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Qiao D, He X, Wei C, Xia L, Bao L. 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Food Sci.<\/i>, <b>81<\/b>, H1288\u2013H1294 (2016).","DOI":"10.1111\/1750-3841.13288"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/43\/6\/43_b19-00978\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T03:20:15Z","timestamp":1591413615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/43\/6\/43_b19-00978\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b19-00978","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,1]]}}}