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Brain extracellular space: the final frontier of neuroscience. <i>Biophys. J.<\/i>, <b>113<\/b>, 10 (2017)."},{"key":"7","unstructured":"7) Heiss WD. The ischemic penumbra: correlates in imaging and implications for treatment of ischemic stroke. The Johann Jacob Wepfer award 2011. <i>Cerebrovasc. Dis.<\/i>, <b>32<\/b>, 307\u2013320 (2011)."},{"key":"8","unstructured":"8) Lai TW, Zhang S, Wang YT. Excitotoxicity and stroke: identifying novel targets for neuroprotection. <i>Prog. Neurobiol.<\/i>, <b>115<\/b>, 157\u2013188 (2014)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Catanese L, Tarsia J, Fisher M. Acute ischemic stroke therapy overview. <i>Circ. Res.<\/i>, <b>120<\/b>, 541\u2013558 (2017).","DOI":"10.1161\/CIRCRESAHA.116.309278"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Petrovic-Djergovic D, Goonewardena SN, Pinsky DJ. Inflammatory disequilibrium in stroke. <i>Circ. 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Thymoquinone shows the diverse therapeutic actions by modulating multiple cell signaling pathways: single drug for multiple targets. <i>Curr. Pharm. Biotechnol.<\/i>, <b>19<\/b>, 934\u2013945 (2018)."},{"key":"15","unstructured":"15) Goyal SN, Prajapati CP, Gore PR, Patil CR, Mahajan UB, Sharma C, Talla SP, Ojha SK. Therapeutic potential and pharmaceutical development of thymoquinone: a multitargeted molecule of natural origin. <i>Front. Pharmacol.<\/i>, <b>8<\/b>, 656 (2017)."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Darakhshan S, Bidmeshki Pour A, Hosseinzadeh Colagar A, Sisakhtnezhad S. Thymoquinone and its therapeutic potentials. <i>Pharmacol. Res.<\/i>, <b>95\u201396<\/b>, 138\u2013158 (2015).","DOI":"10.1016\/j.phrs.2015.03.011"},{"key":"17","unstructured":"17) Miyaji Y, Yoshimura S, Sakai N, Yamagami H, Egashira Y, Shirakawa M, Uchida K, Kageyama H, Tomogane Y. Effect of edaravone on favorable outcome in patients with acute cerebral large vessel occlusion: subanalysis of RESCUE\u2014Japan Registry. <i>Neurol. Med. Chir.<\/i> (Tokyo), <b>55<\/b>, 241\u2013247 (2015)."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. <i>Stroke<\/i>, <b>20<\/b>, 84\u201391 (1989).","DOI":"10.1161\/01.STR.20.1.84"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Abdel-Fattah AM, Matsumoto K, Watanabe H. Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice. <i>Eur. J. Pharmacol.<\/i>, <b>400<\/b>, 89\u201397 (2000).","DOI":"10.1016\/S0014-2999(00)00340-X"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Simpkins JW, Rajakumar G, Zhang YQ, Simpkins CE, Greenwald D, Yu CJ, Bodor N, Day AL. 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