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The efficacy and potential mechanisms of chinese herbal medicine on irritable bowel syndrome. <i>Curr. Pharm. Des.<\/i>, <b>23<\/b>, 5163\u20135172 (2017).","DOI":"10.2174\/1381612823666170822101606"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Li S, Fei G, Fang X, Yang X, Sun X, Qian J, Wood JD, Ke M. Changes in enteric neurons of small intestine in a rat model of irritable bowel syndrome with diarrhea. <i>J. Neurogastroenterol. Motil<\/i>, <b>22<\/b>, 310\u2013320 (2016).","DOI":"10.5056\/jnm15082"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Saito T, Mizutani F, Iwanaga Y, Morikawa K, Kato H. Laxative and anti-diarrheal activity of polycarbophil in mice and rats. <i>Jpn. J. Pharmacol.<\/i>, <b>89<\/b>, 133\u2013141 (2002).","DOI":"10.1254\/jjp.89.133"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Satoh K, Kase Y, Hayakawa T, Murata P, Ishige A, Sasaki H. Dai-kenchu-to enhances accelerated small intestinal movement. <i>Biol. Pharm. Bull.<\/i>, <b>24<\/b>, 1122\u20131126 (2001).","DOI":"10.1248\/bpb.24.1122"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Duangjai A, Goh BH, Lee LH, Saokaew S. Relaxant effects of <i>Azadirachta indica<\/i> A. Juss var. <i>siamensis<\/i> Valeton flower extract on isolated rat ileum contractions and the mechanisms of action. <i>J. Tradit. Complement. Med.<\/i>, <b>8<\/b>, 515\u2013520 (2018).","DOI":"10.1016\/j.jtcme.2018.01.003"},{"key":"6","unstructured":"6) Grundmann O, Yoon SL. Complementary and alternative medicines in irritable bowel syndrome: an integrative view. <i>World J. Gastroenterol.<\/i>, <b>20<\/b>, 346\u2013362 (2014)."},{"key":"7","unstructured":"7) Radulovic M, Anand P, Korsten MA, Gong B. Targeting ion channels: An important therapeutic implication in gastrointestinal dysmotility in patients with spinal cord injury. <i>J. Neurogastroenterol. Motil.<\/i>, <b>21<\/b>, 494\u2013502 (2015)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Lau KM, Yue GG, Chan YY, Kwok HF, Gao S, Wong CW, Lau CB. A review on the immunomodulatory activity of <i>Acanthopanax senticosus<\/i> and its active components. <i>Chin. Med.<\/i>, <b>14<\/b>, 25 (2019).","DOI":"10.1186\/s13020-019-0250-0"},{"key":"9","unstructured":"9) Li T, Ferns K, Yan ZQ, Yin SY, Kou JJ, Li D, Zeng Z, Yin L, Wang X, Bao HX, Zhou YJ, Li QH, Zhao YZ, Liu H, Liu SL. <i>Acanthopanax senticosus<\/i>: photochemistry and anticancer potential. <i>Am. J. Chin. Med.<\/i>, <b>44<\/b>, 1543\u20131558 (2016)."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Zhang XL, Ren F, Huang W, Ding RT, Zhou QS, Liu XW. Anti-fatigue activity of extracts of stem bark from <i>Acanthopanax senticosus.<\/i> <i>Molecules<\/i>, <b>16<\/b>, 28\u201337 (2010).","DOI":"10.3390\/molecules16010028"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Huang LZ, Huang BK, Ye Q, Qin LP. Bioactivity-guided fractionation for anti-fatigue property of <i>Acanthopanax senticosus.<\/i> <i>J. Ethnopharmacol.<\/i>, <b>133<\/b>, 213\u2013219 (2011).","DOI":"10.1016\/j.jep.2010.09.032"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Kuo J, Chen KW, Cheng IS, Tsai PH, Lu YJ, Lee NY. The effect of eight weeks of supplementation with <i>Eleutherococcus senticosus<\/i> on endurance capacity and metabolism in human. <i>Chin. J. Physiol.<\/i>, <b>53<\/b>, 105\u2013111 (2010).","DOI":"10.4077\/CJP.2010.AMK018"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Lee D, Park J, Yoon J, Kim MY, Choi HY, Kim H. Neuroprotective effects of <i>Eleutherococcus senticosus<\/i> bark on transient global cerebral ischemia in rats. <i>J. Ethnopharmacol.<\/i>, <b>139<\/b>, 6\u201311 (2012).","DOI":"10.1016\/j.jep.2011.05.024"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Li XZ, Zhang SN, Wang KX, Liu HY, Yang ZM, Liu SM, Lu F. Neuroprotective effects of extract of <i>Acanthopanax senticosus<\/i> harms on SH-SY5Y cells overexpressing wild-type or A53T mutant \u03b1-synuclein. <i>Phytomedicine<\/i>, <b>21<\/b>, 704\u2013711 (2014).","DOI":"10.1016\/j.phymed.2013.10.012"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Liu SM, Li XZ, Zhang SN, Yang ZM, Wang KX, Lu F, Wang CZ, Yuan CS. <i>Acanthopanax senticosus<\/i> protects structure and function of mesencephalic mitochondria in a mouse model of Parkinson\u2019s disease. <i>Chin. J. Integr. Med.<\/i>, <b>24<\/b>, 835\u2013843 (2018).","DOI":"10.1007\/s11655-018-2935-5"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Wu F, Li H, Zhao L, Li X, You J, Jiang Q, Li S, Jin L, Xu Y. Protective effects of aqueous extract from <i>Acanthopanax senticosus<\/i> against corticosterone-induced neurotoxicity in PC12 cells. <i>J. Ethnopharmacol.<\/i>, <b>148<\/b>, 861\u2013868 (2013).","DOI":"10.1016\/j.jep.2013.05.026"},{"key":"17","unstructured":"17) Bohn B, Nebe CT, Birr C. Flow-cytometric studies with <i>Eleutherococcus senticosus<\/i> extract as an immunomodulatory agent. <i>Arzneimittelforschung<\/i>, <b>37<\/b>, 1193\u20131196 (1987)."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Kimura Y, Sumiyoshi M. Effects of various <i>Eleutherococcus senticosus<\/i> cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice. <i>J. Ethnopharmacol.<\/i>, <b>95<\/b>, 447\u2013453 (2004).","DOI":"10.1016\/j.jep.2004.08.027"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Schmolz MW, Sacher F, Aicher B. The synthesis of rantes, G-CSF, IL-4, IL-5, IL-6, IL-12 and IL-13 in human whole-blood cultures is modulated by an extract from <i>Eleutherococcus senticosus<\/i> L. roots. <i>Phytother. Res.<\/i>, <b>15<\/b>, 268\u2013270 (2001).","DOI":"10.1002\/ptr.746"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Smalinskiene A, Savickiene N, Zitkevicius V, Pangonyte D, Sadauskiene I, Kasauskas A, Ivanov L, Lesauskaite V, Savickas A, Rodovi\u010dius H. Effect of <i>Acanthopanax senticosus<\/i> on the accumulation of cadmium and on the immune response of spleen cells. <i>J. Toxicol. Environ. Health Part A<\/i>, <b>77<\/b>, 1311\u20131318 (2014).","DOI":"10.1080\/15287394.2014.924453"},{"key":"21","unstructured":"21) Wang RQ, Chang XQ, Wen ZY. Anti-inflammatory and immunology-enhancing potent effect of aqueous extract of <i>Acanthopanax senticosus.<\/i> <i>Tianjin J. Tradit. Chin. Med.<\/i>, <b>30<\/b>, 109\u2013111 (2013)."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Yoon TJ, Yoo YC, Lee SW, Shin KS, Choi WH, Hwang SH, Ha ES, Jo SK, Kim SH, Park WM. Anti-metastatic activity of <i>Acanthopanax senticosus<\/i> extract and its possible immunological mechanism of action. <i>J. Ethnopharmacol.<\/i>, <b>93<\/b>, 247\u2013253 (2004).","DOI":"10.1016\/j.jep.2004.03.052"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Miyazaki S, Oikawa H, Takekoshi H, Hoshizaki M, Ogata M, Fujikawa T. Anxiolytic effects of <i>Acanthopanax senticosus<\/i> HARMS occur <i>via<\/i> regulation of autonomic function and activate hippocampal BDNF\u2013TrkB signaling. <i>Molecules<\/i>, <b>24<\/b>, 132 (2018).","DOI":"10.3390\/molecules24010132"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Shiokawa Y, Miyauchi-Wakuda S, Kagota S, Maruyama-Fumoto K, Yamada S, Shinozuka K. <i>Acanthopanax senticosus<\/i> induces vasorelaxation <i>via<\/i> endothelial nitric oxide-dependent and -independent pathways. <i>Planta Med.<\/i>, <b>85<\/b>, 1080\u20131087 (2019).","DOI":"10.1055\/a-0978-5214"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Miyauchi-Wakuda S, Kagota S, Maruyama-Fumoto K, Wakuda H, Yamada S, Shinozuka K. Effect of royal jelly on mouse isolated ileum and gastrointestinal motility. <i>J. Med. Food<\/i>, <b>22<\/b>, 789\u2013796 (2019).","DOI":"10.1089\/jmf.2018.4340"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Abu-Dalu R, Zhang JM, Hanani M. The actions of ketotifen on intestinal smooth muscles. <i>Eur. J. Pharmacol.<\/i>, <b>309<\/b>, 189\u2013193 (1996).","DOI":"10.1016\/0014-2999(96)00342-1"},{"key":"27","unstructured":"27) Yamane S, Kanno T, Nakamura H, Fujino H, Murayama T. Hydrogen sulfide-mediated regulation of contractility in the mouse ileum with electrical stimulation: Roles of l-cysteine, cystathionine \u03b2-synthase, and K<sup>+<\/sup> channels. <i>Eur. J. Pharmacol.<\/i>, <b>740<\/b>, 112\u2013120 (2014)."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Zizzo MG, Bonomo A, Belluardo N, Mul\u00e8 F, Serio R. A1 receptors mediate adenosine inhibitory effects in mouse ileum <i>via<\/i> activation of potassium channels. <i>Life Sci.<\/i>, <b>84<\/b>, 772\u2013778 (2009).","DOI":"10.1016\/j.lfs.2009.03.006"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Nair AB, Jacob S. A simple practice guide for dose conversion between animals and human. <i>J. Basic Clin. Pharm.<\/i>, <b>7<\/b>, 27\u201331 (2016).","DOI":"10.4103\/0976-0105.177703"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Donovan JL, DeVane CL, Chavin KD, Taylor RM, Markowitz JS. Siberian ginseng (<i>Eleutheroccus senticosus<\/i>) effects on CYP2D6 and CYP3A4 activity in normal volunteers. <i>Drug Metab. Dispos.<\/i>, <b>31<\/b>, 519\u2013522 (2003).","DOI":"10.1124\/dmd.31.5.519"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Takahashi T, Kaku T, Sato T, Watanabe K, Sato J. Effects of <i>Acanthopanax senticosus<\/i> HARMS extract on drug transport in human intestinal cell line Caco-2. <i>J. Nat. Med.<\/i>, <b>64<\/b>, 55\u201362 (2010).","DOI":"10.1007\/s11418-009-0371-3"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Gorzalczany S, S\u00fclsen V, Redko F, Vescina C, Muschietti L, Martino V, Acevedo C. Choleretic and antispasmodic effects of <i>Lippia integrifolia<\/i> aqueous extract. <i>Rev. Bras. Farmacogn.<\/i>, <b>18<\/b>, 16\u201320 (2008).","DOI":"10.1590\/S0102-695X2008000100005"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) T\u00f3th B, Barth\u00f3 L, Vasas A, S\u00e1ndor Z, Jedlinszki N, Pinke G, Hohmann J. Dual excitatory and smooth muscle-relaxing effect of Sideritis montana extract on guinea-pig ileum. <i>Nat. Prod. Commun.<\/i>, <b>10<\/b>, 487\u2013490 (2015).","DOI":"10.1177\/1934578X1501000327"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Kaneda T, Sasaki N, Urakawa N, Shimizu K. Effects of chlorogenic acid on carbachol-induced contraction of mouse urinary bladder. <i>J. Pharmacol. Sci.<\/i>, <b>136<\/b>, 26\u201330 (2018).","DOI":"10.1016\/j.jphs.2017.12.006"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Amano Y, Honda H, Nukada Y, Ikeda N, Yamane M, Nakano K, Kameyama A, Morita O. 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