{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T08:59:52Z","timestamp":1776502792972,"version":"3.51.2"},"reference-count":23,"publisher":"Pharmaceutical Society of Japan","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2020,6,1]]},"DOI":"10.1248\/bpb.b20-00034","type":"journal-article","created":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T22:04:35Z","timestamp":1590962675000},"page":"994-999","source":"Crossref","is-referenced-by-count":10,"title":["Inhibitory Effect of the Traditional Chinese Medicine &lt;i&gt;Ephedra sinica granules&lt;\/i&gt; on &lt;i&gt;Streptococcus pneumoniae&lt;\/i&gt; Pneumolysin"],"prefix":"10.1248","volume":"43","author":[{"given":"Yan","family":"Xu","sequence":"first","affiliation":[{"name":"Changchun University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Wei","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhong","family":"Ding","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Changchun University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinan","family":"Guo","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Changchun University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhou","family":"Sun","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibu","family":"Kong","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Guo","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Sun","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Varghese R, Jayaraman R, Veeraraghavan B. Current challenges in the accurate identification of <i>Streptococcus pneumoniae<\/i> and its serogroups\/serotypes in the vaccine era. <i>J. Microbiol. Methods<\/i>, <b>141<\/b>, 48\u201354 (2017).","DOI":"10.1016\/j.mimet.2017.07.015"},{"key":"2","unstructured":"2) Centers for Disease Control and Prevention (CDC). Progress in introduction of pneumococcal conjugate vaccine\u2014worldwide, 2000\u20132012. <i>MMWR Morb. Mortal. Wkly. Rep.<\/i>, <b>62<\/b>, 308\u2013311 (2013)."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Principi N, Esposito S. Prevention of community-acquired pneumonia with available pneumococcal vaccines. <i>Int. J. Mol. Sci.<\/i>, <b>18<\/b>, 30 (2016).","DOI":"10.3390\/ijms18010030"},{"key":"4","unstructured":"4) Wang J, Dou X, Song J, Lyu Y, Zhu X, Xu L, Li W, Shan A. Antimicrobial peptides: promising alternatives in the post feeding antibiotic era. <i>Med. Res. Rev.<\/i>, <b>39<\/b>, 831\u2013859 (2019)."},{"key":"5","unstructured":"5) V\u00e1zquez R, Garc\u00eda E, Garc\u00eda P. Phage lysins for fighting bacterial respiratory infections: a new generation of antimicrobials. <i>Front. Immunol.<\/i>, <b>9<\/b>, 2252 (2018)."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Esposito S, Principi N. Safety and tolerability of pneumococcal vaccines in children. <i>Expert Opin. Drug Saf.<\/i>, <b>15<\/b>, 777\u2013785 (2016).","DOI":"10.1517\/14740338.2016.1160056"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Burgos J, Falco V, Pahissa A. The increasing incidence of empyema. <i>Curr. Opin. Pulm. Med.<\/i>, <b>19<\/b>, 350\u2013356 (2013).","DOI":"10.1097\/MCP.0b013e3283606ab5"},{"key":"8","unstructured":"8) David B, Wolfender JL, Dias DA. The pharmaceutical industry and natural products: historical status and new trends. <i>Phytochem. Rev.<\/i>, <b>14<\/b>, 299\u2013315 (2015)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Song M, Teng Z, Li M, Niu X, Wang J, Deng X. Epigallocatechin gallate inhibits <i>Streptococcus pneumoniae<\/i> virulence by simultaneously targeting pneumolysin and sortase A. <i>J. Cell. Mol. Med.<\/i>, <b>21<\/b>, 2586\u20132598 (2017).","DOI":"10.1111\/jcmm.13179"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Wang J, Song M, Pan J, Shen X, Liu W, Zhang X, Li H, Deng X. Quercetin impairs <i>Streptococcus pneumoniae<\/i> biofilm formation by inhibiting sortase A activity. <i>J. Cell. Mol. Med.<\/i>, <b>22<\/b>, 6228\u20136237 (2018).","DOI":"10.1111\/jcmm.13910"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Zhou YL, Wang JF, Guo Y, Liu XQ, Liu SL, Niu XD, Wang Y, Deng XM. Discovery of a potential MCR-1 inhibitor that reverses polymyxin activity against clinical mcr-1-positive <i>Enterobacteriaceae<\/i>. <i>J. Infect.<\/i>, <b>78<\/b>, 364\u2013372 (2019).","DOI":"10.1016\/j.jinf.2019.03.004"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Wang J, Qiu J, Tan W, Zhang Y, Wang H, Zhou X, Liu S, Feng H, Li W, Niu X, Deng X. Fisetin inhibits <i>Listeria monocytogenes<\/i> virulence by interfering with the oligomerization of listeriolysin O. <i>J. Infect. Dis.<\/i>, <b>211<\/b>, 1376\u20131387 (2015).","DOI":"10.1093\/infdis\/jiu520"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Li H, Chen Y, Zhang B, Niu X, Song M, Luo Z, Lu G, Liu B, Zhao X, Wang J, Deng X. Inhibition of sortase A by chalcone prevents <i>Listeria monocytogenes<\/i> infection. <i>Biochem. Pharmacol.<\/i>, <b>106<\/b>, 19\u201329 (2016).","DOI":"10.1016\/j.bcp.2016.01.018"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Shen X, Niu X, Li G, Deng X, Wang J. Amentoflavone ameliorates <i>Streptococcus<\/i> suis-induced infection <i>in vitro<\/i> and <i>in vivo.<\/i> <i>Appl. Environ. Microbiol.<\/i>, <b>84<\/b>, e01804-18 (2018).","DOI":"10.1128\/AEM.01804-18"},{"key":"15","unstructured":"15) Vale PF, McNally L, Doeschl-Wilson A, King KC, Popat R, Domingo-Sananes MR, Allen JE, Soares MP, Kummerli R. Beyond killing: can we find new ways to manage infection? <i>Evol. Med. Public Health<\/i>, <b>2016<\/b>, 148\u2013157 (2016)."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Jiao SQ, Sun YQ, Zhang DX, Gao Q, Jin Y, Liu H, Ma Y, Yang Y, Porth I, Mao JF. Development of novel EST-SSR markers for <i>Ephedra sinica<\/i> (Ephedraceae) by transcriptome database mining. <i>Appl. Plant Sci.<\/i>, <b>7<\/b>, e01212 (2019).","DOI":"10.1002\/aps3.1212"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Zhang BM, Wang ZB, Xin P, Wang QH, Bu H, Kuang HX. Phytochemistry and pharmacology of genus <i>Ephedra<\/i>. <i>Chin. J. Nat. Med.<\/i>, <b>16<\/b>, 811\u2013828 (2018).","DOI":"10.1016\/S1875-5364(18)30123-7"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Anderson R, Feldman C. Pneumolysin as a potential therapeutic target in severe pneumococcal disease. <i>J. Infect.<\/i>, <b>74<\/b>, 527\u2013544 (2017).","DOI":"10.1016\/j.jinf.2017.03.005"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Lemon JK, Weiser JN. Degradation products of the extracellular pathogen <i>Streptococcus pneumoniae<\/i> access the cytosol <i>via<\/i> its pore-forming toxin. <i>MBio<\/i>, <b>6<\/b>, e02110-14 (2015).","DOI":"10.1128\/mBio.02110-14"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Karmakar M, Katsnelson M, Malak HA, Greene NG, Howell SJ, Hise AG, Camilli A, Kadioglu A, Dubyak GR, Pearlman E. Neutrophil IL-1\u03b2 processing induced by pneumolysin is mediated by the NLRP3\/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux. <i>J. Immunol.<\/i>, <b>194<\/b>, 1763\u20131775 (2015).","DOI":"10.4049\/jimmunol.1401624"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Zafar MA, Wang Y, Hamaguchi S, Weiser JN. Host-to-host transmission of <i>Streptococcus<\/i> <i>pneumoniae<\/i> is driven by its inflammatory toxin, pneumolysin. <i>Cell Host Microbe<\/i>, <b>21<\/b>, 73\u201383 (2017).","DOI":"10.1016\/j.chom.2016.12.005"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Rayner CF, Jackson AD, Rutman A, Dewar A, Mitchell TJ, Andrew PW, Cole PJ, Wilson R. Interaction of pneumolysin-sufficient and -deficient isogenic variants of <i>Streptococcus pneumoniae<\/i> with human respiratory mucosa. <i>Infect. Immun.<\/i>, <b>63<\/b>, 442\u2013447 (1995).","DOI":"10.1128\/IAI.63.2.442-447.1995"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Mitchell TJ, Dalziel CE. The biology of pneumolysin. <i>Subcell. Biochem.<\/i>, <b>80<\/b>, 145\u2013160 (2014).","DOI":"10.1007\/978-94-017-8881-6_8"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/43\/6\/43_b20-00034\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T03:20:41Z","timestamp":1591413641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/43\/6\/43_b20-00034\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b20-00034","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,1]]}}}