{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T12:15:11Z","timestamp":1770639311611,"version":"3.49.0"},"reference-count":52,"publisher":"Pharmaceutical Society of Japan","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2020,10,1]]},"DOI":"10.1248\/bpb.b20-00093","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T22:06:44Z","timestamp":1597270004000},"page":"1490-1500","source":"Crossref","is-referenced-by-count":5,"title":["Antidepressant Activity of Euparin: Involvement of Monoaminergic Neurotransmitters and SAT1\/NMDAR2B\/BDNF Signal Pathway"],"prefix":"10.1248","volume":"43","author":[{"given":"Xu-meng","family":"Han","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Xinxiang Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Xinxiang Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-li","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Xinxiang Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-ru","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Xinxiang Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-hang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine Sciences, Xi\u2019an Jiaotong University Health Science Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He-qin","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Xinxiang Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-yu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy, Xinxiang Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) MacQueen G, Santaguida P, Keshavarz H, Jaworska N, Levine M, Beyene J, Raina P. Systematic review of clinical practice guidelines for failed antidepressant treatment response in major depressive disorder, dysthymia, and subthreshold depression in adults. <i>Can. J. Psychiatry<\/i>, <b>62<\/b>, 11\u201323 (2017).","DOI":"10.1177\/0706743716664885"},{"key":"2","unstructured":"2) Zhang Y, Chen Y, Ma L. Depression and cardiovascular disease in elderly: Current understanding. <i>J. Clin. Neurosci.<\/i>, <b>47<\/b>, 1\u20135 (2018)."},{"key":"3","unstructured":"3) Fellmeth G, Opondo C, Henderson J, Redshaw M, Mcneill J, Lynn F, Alderdice F. Identifying postnatal depression: comparison of a self-reported depression item with Edinburgh Postnatal Depression Scale scores at three months postpartum. <i>J. Affect. Disord.<\/i>, <b>251<\/b>, 8\u201314 (2019)."},{"key":"4","unstructured":"4) Ramos M, Berrogain C, Concha J, Lomba L, Garc\u00eda CB, Ribate MP. Pharmacogenetic studies: a tool to improve antidepressant therapy. <i>Drug Metab. Pers. Ther.<\/i>, <b>31<\/b>, 197\u2013204 (2016)."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Formolo DA, Lee TH, Yau SY. Increasing adiponergic system activity as a potential treatment for depressive disorders. <i>Mol. Neurobiol.<\/i>, <b>56<\/b>, 7966\u20137976 (2019).","DOI":"10.1007\/s12035-019-01644-3"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Arias-de la Torre J, Vilagut G, Mart\u00edn V, Molina AJ, Alonso J. Prevalence of major depressive disorder and association with personal and socio-economic factors. Results for Spain of the European Health Interview Survey 2014\u20132015. <i>J. Affect. Disord.<\/i>, <b>239<\/b>, 203\u2013207 (2018).","DOI":"10.1016\/j.jad.2018.06.051"},{"key":"7","unstructured":"7) Mrazek DA, Hornberger JC, Altar CA, Degtiar I. A review of the clinical, economic, and societal burden of treatment-resistant depression: 1996-2013. <i>Psychiatr. Serv.<\/i>, <b>65<\/b>, 977\u2013987 (2014)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Zhao XJ, Zhao Z, Yang DD, Cao LL, Zhang L, Ji J, Gu J, Huang JY, Sun XL. Activation of ATP-sensitive potassium channel by iptakalim normalizes stress-induced HPA axis disorder and depressive behaviour by alleviating inflammation and oxidative stress in mouse hypothalamus. <i>Brain Res. Bull.<\/i>, <b>130<\/b>, 146\u2013155 (2017).","DOI":"10.1016\/j.brainresbull.2017.01.026"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) R\u00e9us GZ, Dos Santos MA, Abelaira HM, Titus SE, Carlessi AS, Matias BI, Bruchchen L, Florentino D, Vieira A, Petronilho F, Ceretta LB, Zugno AI, Quevedo J. Antioxidant treatment ameliorates experimental diabetes-induced depressive-like behaviour and reduces oxidative stress in brain and pancreas. <i>Diabetes Metab. Res. Rev.<\/i>, <b>32<\/b>, 278\u2013288 (2016).","DOI":"10.1002\/dmrr.2732"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Lim DW, Han T, Jung J, Song Y, Um MY, Yoon M, Kim YT, Cho S, Kim IH, Han D, Lee C, Lee J. Chlorogenic acid from hawthorn berry (<i>Crataegus pinnatifida<\/i> fruit) prevents stress hormone-induced depressive behavior, through monoamine oxidase B-reactive oxygen species signaling in hippocampal astrocytes of mice. <i>Mol. Nutr. Food Res.<\/i>, <b>62<\/b>, 1800029 (2018).","DOI":"10.1002\/mnfr.201800029"},{"key":"11","unstructured":"11) Gan T, Zhou XY, Fan GX, Ling HW, Ying CJ, Li W. Effect and mechanism of bamboo leaf flavonoids on depression in type 2 diabetic rats. <i>Zhonghua Yi Xue Za Zhi<\/i>, <b>99<\/b>, 1251\u20131255 (2019)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Yu H, Fan C, Yang L, Yu S, Song Q, Wang P, Mao X. Ginsenoside Rg1 prevents chronic stress-induced depression-like behaviors and neuronal structural plasticity in rats. <i>Cell. Physiol. Biochem.<\/i>, <b>48<\/b>, 2470\u20132482 (2018).","DOI":"10.1159\/000492684"},{"key":"13","unstructured":"13) Eatemadnia A, Ansari S, Abedi P, Najar S. The effect of <i>Hypericum perforatum<\/i> on postmenopausal symptoms and depression: a randomized controlled trial. <i>Complement. Ther. Med.<\/i>, <b>45<\/b>, 109\u2013113 (2019)."},{"key":"14","unstructured":"14) Khalil HS, Sedky NK, Amin KM, Abd Elhafez OM, Arafa RK. Visnagin and benzofuran scaffold-based molecules as selective cyclooxygenase-2 inhibitors with anti-inflammatory and analgesic properties: design, synthesis and molecular docking. <i>Future Med. Chem.<\/i>, <b>11<\/b>, 659\u2013676 (2019)."},{"key":"15","unstructured":"15) Baldisserotto A, Demurtas M, Lampronti I, Moi D, Balboni G, Vertuani S, Manfredini S, Onnis V. Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity. <i>Eur. J. Med. Chem.<\/i>, <b>156<\/b>, 118\u2013125 (2018)."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Dastmalchi S, Hamzeh-Mivehroud M, Ghafourian T, Hamzeiy H. Molecular modeling of histamine H3 receptor and QSAR studies on arylbenzofuran derived H3 antagonists. <i>J. Mol. Graph. Model.<\/i>, <b>26<\/b>, 834\u2013844 (2008).","DOI":"10.1016\/j.jmgm.2007.05.002"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Stuivenga M, Giltay EJ, Cools O, Roosens L, Neels H, Sabbe B. Evaluation of vilazodone for the treatment of depressive and anxiety disorders. <i>Expert Opin. Pharmacother.<\/i>, <b>20<\/b>, 251\u2013260 (2019).","DOI":"10.1080\/14656566.2018.1549542"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Pisani L, Barletta M, Soto-Otero R, Nicolotti O, Mendez-Alvarez E, Catto M, Introcaso A, Stefanachi A, Cellamare S, Altomare C, Carotti A. Discovery, biological evaluation, and structure\u2013activity and -selectivity relationships of 6\u2032-substituted (E)-2-(benzofuran-3(2H)-ylidene)-<i>N<\/i>-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors. <i>J. Med. Chem.<\/i>, <b>56<\/b>, 2651\u20132664 (2013).","DOI":"10.1021\/jm4000769"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Ezzatzadeh E, Hossaini Z. Green synthesis and antioxidant activity of novel series of benzofurans from euparin extracted of petasites hybridus. <i>Nat. Prod. Res.<\/i>, <b>33<\/b>, 1617\u20131623 (2019).","DOI":"10.1080\/14786419.2018.1428598"},{"key":"20","unstructured":"20) Visintini Jaime MF, Campos RH, Martino VS, Cavallaro LV, Muschietti LV. Antipoliovirus activity of the organic extract of eupatorium buniifolium: Isolation of euparin as an active compound. <i>Evid. Based Complement. Alternat. Med.<\/i>, <b>2013<\/b>, 402364 (2013)."},{"key":"21","unstructured":"21) Mohammadi M, Yousefi M, Habibi Z, Dastan D. Chemical composition and antioxidant activity of the essential oil of aerial parts of <i>Petasites albus<\/i> from Iran: a good natural source of euparin. <i>Nat. Prod. Res.<\/i>, <b>26<\/b>, 291\u2013297 (2012)."},{"key":"22","unstructured":"22) Lv QQ, Wu WJ, Guo XL, Liu RL, Yang YP, Zhou DS, Zhang JX, Liu JY. Antidepressant activity of astilbin: involvement of monoaminergic neurotransmitters and BDNF signal pathway. <i>Biol. Pharm. Bull.<\/i>, <b>37<\/b>, 987\u2013995 (2014)."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Jiao H, Yan Z, Ma Q, Li X, Jiang Y, Liu Y, Chen J. Influence of Xiaoyaosan on depressive-like behaviors in chronic stress-depressed rats through regulating tryptophan metabolism in hippocampus. <i>Neuropsychiatr. Dis. Treat.<\/i>, <b>15<\/b>, 21\u201331 (2018).","DOI":"10.2147\/NDT.S185295"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Blazevic S, Merkler M, Persic D, Hranilovic D. Chronic postnatal monoamine oxidase inhibition affects affiliative behavior in rat pupso. <i>Pharmacol. Biochem. Behav.<\/i>, <b>153<\/b>, 60\u201368 (2017).","DOI":"10.1016\/j.pbb.2016.12.008"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Sturza A, Popoiu CM, Ionic\u0103 M, Duicu OM, Olariu S, Muntean DM, Boia ES. Monoamine oxidase-related vascular oxidative stress in diseases associated with inflammatory burden. <i>Oxid. Med. Cell. Longev.<\/i>, <b>2019<\/b>, 8954201 (2019).","DOI":"10.1155\/2019\/8954201"},{"key":"26","unstructured":"26) Shehu A, Magaji MG, Yau J, Ahmed A. Methanol stem bark extract of Adansonia digitata ameliorates chronic unpredictable mild stress-induced depression-like behavior: involvement of the HPA axis, BDNF, and stress biomarkers pathways. <i>J. Basic Clin. Physiol. Pharmacol.<\/i>, <b>30<\/b>, (2019)."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Garabadu D, Srivastava N, Murti Y. Calotropis procera attenuates chronic unpredictable mild stress-induced depression in experimental animals. <i>Metab. Brain Dis.<\/i>, <b>34<\/b>, 1635\u20131647 (2019).","DOI":"10.1007\/s11011-019-00471-8"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Rao C, Shi H, Zhou C, Zhu D, Zhao M, Wang Z, Yang Y, Chen J, Liao L, Tang J, Wu Y, Zhou J, Cheng K, Xie P. Hypothalamic proteomic analysis reveals dysregulation of glutamate balance and energy metabolism in a mouse model of chronic mild stress-induced depression. <i>Neurochem. Res.<\/i>, <b>41<\/b>, 2443\u20132456 (2016).","DOI":"10.1007\/s11064-016-1957-2"},{"key":"29","unstructured":"29) Yeung AWK, Georgieva MG, Atanasov AG, Tzvetkov NT. Monoamine oxidases (MAOs) as privileged molecular targets in neuroscience: research literature analysis. <i>Front. Mol. Neurosci.<\/i>, <b>12<\/b>, 143 (2019)."},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Martins J, Brijesh S. Anti-depressant activity of <i>Erythrina variegata<\/i> bark extract and regulation of monoamine oxidase activities in mice. <i>J. Ethnopharmacol.<\/i>, <b>248<\/b>, 112280 (2020).","DOI":"10.1016\/j.jep.2019.112280"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Prins LH, Petzer JP, Malan SF. Inhibition of monoamine oxidase by indole and benzofuran derivatives. <i>Eur. J. Med. Chem.<\/i>, <b>45<\/b>, 4458\u20134466 (2010).","DOI":"10.1016\/j.ejmech.2010.07.005"},{"key":"32","unstructured":"32) Israel JA. Combining stimulants and monoamine oxidase inhibitors: a reexamination of the literature and a report of a new treatment combination. <i>Prim. Care Companion CNS Disord.<\/i>, <b>17<\/b>, 15bro1836 (2015)."},{"key":"33","unstructured":"33) Wimbiscus M, Kostenko O, Malone D. MAO inhibitors: risks, benefits, and lore. <i>Cleve. Clin. J. Med.<\/i>, <b>77<\/b>, 859\u2013882 (2010)."},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Delini-Stula A, Baier D, Kohnen R, Laux G, Philipp M, Scholz HJ. Undesirable blood pressure changes under naturalistic treatment with moclobemide, a reversible MAO-A inhibitor\u2014results of the drug utilization observation studies. <i>Pharmacopsychiatry<\/i>, <b>32<\/b>, 61\u201367 (1999).","DOI":"10.1055\/s-2007-979193"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Vav\u00e1kov\u00e1 M, \u010eura\u010dkov\u00e1 Z, Trebatick\u00e1 J. Markers of oxidative stress and neuroprogression in depression disorder. <i>Oxid. Med. Cell. Longev.<\/i>, <b>2015<\/b>, 898393 (2015).","DOI":"10.1155\/2015\/898393"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) R\u00e9us GZ, Carlessi AS, Silva RH, Ceretta LB, Quevedo J. Relationship of oxidative stress as a link between diabetes mellitus and major depressive disorder. <i>Oxid. Med. Cell. Longev.<\/i>, <b>2019<\/b>, 8637970 (2019).","DOI":"10.1155\/2019\/8637970"},{"key":"37","unstructured":"37) Liu W, Ge T, Leng Y, Pan Z, Fan J, Yang W, Cui R. The role of neural plasticity in depression: from hippocampus to prefrontal cortex. <i>Neural Plast.<\/i>, <b>2017<\/b>, 6871089 (2017)."},{"key":"38","unstructured":"38) Whirledge S, Cidlowski JA. A role for glucocorticoids in stress-impaired reproduction: beyond the hypothalamus and pituitary. <i>Endocrinology<\/i>, <b>154<\/b>, 4450\u20134468 (2013)."},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Treadway MT, Waskom ML, Dillon DG, Holmes AJ, Park MTM, Chakravarty MM, Dutra SJ, Polli FE, Iosifescu DV, Fava M, Gabrieli JDE, Pizzagalli DA. Illness progression, recent stress, and morphometry of hippocampal subfields and medial prefrontal cortex in major depression. <i>Biol. Psychiatry<\/i>, <b>77<\/b>, 285\u2013294 (2015).","DOI":"10.1016\/j.biopsych.2014.06.018"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Miller EK, Cohen JD. An integrative theory of prefrontal cortex function. <i>Annu. Rev. Neurosci.<\/i>, <b>24<\/b>, 167\u2013202 (2001).","DOI":"10.1146\/annurev.neuro.24.1.167"},{"key":"41","unstructured":"41) Duman RS, Aghajanian GK. Synaptic dysfunction in depression: potential therapeutic targets. <i>Science<\/i>, <b>338<\/b>, 68\u201372 (2012)."},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Pantazatos SP, Andrews SJ, Dunning-Broadbent J, Pang J, Huang YY, Arango V, Nagy PL, John Mann J. Isoform-level brain expression profiling of the spermidine\/spermine N1-acetyltransferase1 (SAT1) gene in major depression and suicide. <i>Neurobiol. Dis.<\/i>, <b>79<\/b>, 123\u2013134 (2015).","DOI":"10.1016\/j.nbd.2015.04.014"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Chen D, Qi X, Zhuang R, Cao J, Xu Y, Huang X, Li Y. Prenatal propofol exposure downregulates NMDA receptor expression and causes cognitive and emotional disorders in rats. <i>Eur. J. Pharmacol.<\/i>, <b>843<\/b>, 268\u2013276 (2019).","DOI":"10.1016\/j.ejphar.2018.11.032"},{"key":"44","unstructured":"44) Williams K. Modulation and block of ion channels: a new biology of polyamines. <i>Cell. Signal.<\/i>, <b>9<\/b>, 1\u201313 (1997)."},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Endo D, Kon S, Sato T, Toyama F, Katsura Y, Nakauchi Y, Takayama-Watanabe E, Watanabe A. NMDA-type glutamate receptors mediate the acrosome reaction and motility initiation in newt sperm. <i>Mol. Reprod. Dev.<\/i>, <b>86<\/b>, 1106\u20131115 (2019).","DOI":"10.1002\/mrd.23225"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Tao X, Finkbeiner S, Arnold DB, Shaywitz AJ, Greenberg ME. Ca<sup>2+<\/sup> influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. <i>Neuron<\/i>, <b>20<\/b>, 709\u2013726 (1998).","DOI":"10.1016\/S0896-6273(00)81010-7"},{"key":"47","unstructured":"47) Marini AM, Popolo M, Pan H, Blondeau N, Lipsky RH. Brain adaptation to stressful stimuli: a new perspective on potential therapeutic approaches based on BDNF and NMDA receptors. <i>CNS Neurol. Disord. Drug Targets<\/i>, <b>7<\/b>, 382\u2013390 (2008)."},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Dou M, Gong A, Liang H, Wang Q, Wu Y, Ma A, Han L. Improvement of symptoms in a rat model of depression through combined zinc and folic acid administration <i>via<\/i> up-regulation of the Trk B and NMDA. <i>Neurosci. Lett.<\/i>, <b>683<\/b>, 196\u2013201 (2018).","DOI":"10.1016\/j.neulet.2018.07.036"},{"key":"49","unstructured":"49) Naoi M, Maruyama W, Shamoto-Nagai M. Type A monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis. <i>J. Neural Transm.<\/i> (Vienna), <b>125<\/b>, 53\u201366 (2018)."},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Yang Y, Ju W, Zhang H, Sun L. Effect of Ketamine on LTP and NMDAR EPSC in hippocampus of the chronic social defeat stress mice model of depression. <i>Front. Behav. Neurosci.<\/i>, <b>12<\/b>, 229 (2018).","DOI":"10.3389\/fnbeh.2018.00229"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) R\u00e9us GZ, Abaleira HM, Michels M, Tomaz DB, dos Santos MA, Carlessi AS, Matias BI, Leffa DD, Damiani AP, Gomes VdeC, Andrade VM, Dal-Pizzol F, Landeira-Fernadez J, Quevedo J. Anxious phenotypes plus environmental stressors are related to brain DNA damage and changes in NMDA receptor subunits and glutamate uptake. <i>Mutat. Res.<\/i>, <b>772<\/b>, 30\u201337 (2015).","DOI":"10.1016\/j.mrfmmm.2014.12.005"},{"key":"52","unstructured":"52) Maeng S, Zarate CA Jr. The role of glutamate in mood disorders: results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant effects. <i>Curr. Psychiatry Rep.<\/i>, <b>9<\/b>, 467\u2013474 (2007)."}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/43\/10\/43_b20-00093\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T03:11:12Z","timestamp":1601694672000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/43\/10\/43_b20-00093\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b20-00093","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,1]]}}}