{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T22:07:33Z","timestamp":1774649253938,"version":"3.50.1"},"reference-count":49,"publisher":"Pharmaceutical Society of Japan","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological & Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2020,7,1]]},"DOI":"10.1248\/bpb.b20-00097","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T22:16:21Z","timestamp":1593555381000},"page":"1111-1117","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus"],"prefix":"10.1248","volume":"43","author":[{"given":"Tsugunobu","family":"Andoh","sequence":"first","affiliation":[{"name":"Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"},{"name":"Department of Pathological Pharmacology, College of Pharmacy, Kinjo Gakuin University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Konno","sequence":"additional","affiliation":[{"name":"Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Tsuneyama","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Institute of Health Biosciences, Tokushima University Graduate School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Kuraishi","sequence":"additional","affiliation":[{"name":"Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","unstructured":"1) Koulentaki M, Ioannidou D, Stefanidou M, Maraki S, Drigiannakis I, Dimoulios P, Melono JM, Tosca A, Kouroumalis EA. Dermatological manifestations in primary biliary cirrhosis patients: a case control study. Am. J. Gastroenterol.<\/i>, 101<\/b>, 541\u2013546 (2006)."},{"key":"2","unstructured":"2) Rishe E, Azarm A, Bergasa NV. Itch in primary biliary cirrhosis: a patients\u2019 perspective. Acta Derm. Venereol.<\/i>, 88<\/b>, 34\u201337 (2008)."},{"key":"3","unstructured":"3) Hirschfield GM, Beuers U, Corpechot C, Invernizzi P, Jones D, Marzioni M, Schramm C. EASL (European Association for the Study of the Liver) Clinical Practice Guidelines: the diagnosis and management of patients with primary biliary cholangitis. J. Hepatol.<\/i>, 67<\/b>, 145\u2013172 (2017)."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Schoenfield L, Sjovall J, Perman E. Bile acids in the skin of patients with pruritic hepatobiliary disease. Nature<\/i>, 213<\/b>, 93\u201394 (1967).","DOI":"10.1038\/213093b0"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Thornton JR, Losowsky MS. Opioid peptides and primary biliary cirrhosis. BMJ<\/i>, 297<\/b>, 1501\u20131504 (1988).","DOI":"10.1136\/bmj.297.6662.1501"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Bergasa NV, Rothman RB, Vergalla J, Xu H, Swain MG, Jones EA. Central mu-opioid receptors are down-regulated in a rat model of cholestasis. J. Hepatol.<\/i>, 15<\/b>, 220\u2013224 (1992).","DOI":"10.1016\/0168-8278(92)90040-V"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Kremer AE, Martens JJ, Kulik W, Ru\u00ebff F, Kuiper EM, van Buuren HR, van Erpecum KJ, Kondrackiene J, Prieto J, Rust C, Geenes VL, Williamson C, Moolenaar WH, Beuers U, Oude Elferink RP. Lysophosphatidic acid is a potential mediator of cholestatic pruritus. Gastroenterology<\/i>, 139<\/b>, 1008\u20131018, 1018.e1 (2010).","DOI":"10.1053\/j.gastro.2010.05.009"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Alemi F, Kwon E, Poole DP, Lieu T, Lyo V, Cattaruzza F, Cevikbas F, Steinhoff M, Nassini R, Materazzi S, Guerrero-Alba R, Valdez-Morales E, Cottrell GS, Schoonjans K, Geppetti P, Vanner SJ, Bunnett NW, Corvera CU. The TGR5 receptor mediates bile acid-induced itch and analgesia. J. Clin. Invest.<\/i>, 123<\/b>, 1513\u20131530 (2013).","DOI":"10.1172\/JCI64551"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Becker BA, Plaa GL. The nature of alpha-naphthylisothiocyanate-induced cholestasis. Toxicol. Appl. Pharmacol.<\/i>, 7<\/b>, 680\u2013685 (1965).","DOI":"10.1016\/0041-008X(65)90125-0"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Kreek MJ, Peterson RE, Sleisenger MH, Jeffries GH. Effects of ethinylestradiol-induced cholestasis on bile flow and biliary excretion of estradiol and estradiol glucuronide by the rat. Proc. Soc. Exp. Biol. Med.<\/i>, 131<\/b>, 646\u2013650 (1969).","DOI":"10.3181\/00379727-131-33944"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Chen M, Li ZX, Wang Q, Xiang HB. Altered expression of differential genes in thoracic spinal cord involved in experimental cholestatic itch mouse model. Curr. Med. Sci.<\/i>, 38<\/b>, 679\u2013683 (2018).","DOI":"10.1007\/s11596-018-1930-1"},{"key":"12","unstructured":"12) Kountouras J, Billing BH, Scheuer PJ. Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. Br. J. Exp. Pathol.<\/i>, 65<\/b>, 305\u2013311 (1984)."},{"key":"13","unstructured":"13) Mariotti V, Cadamuro M, Spirli C, Fiorotto R, Strazzabosco M, Fabris L. Animal models of cholestasis: An update on inflammatory cholangiopathies. Biochim. Biophys. Acta Mol. Basis. Dis.<\/i>, 1865<\/b>, 954\u2013964 (2019)."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Yamaguchi T, Nagasawa T, Satoh M, Kuraishi Y. Itch-associated response induced by intradermal serotonin through 5-HT2<\/sub> receptors in mice. Neurosci. Res.<\/i>, 35<\/b>, 77\u201383 (1999).","DOI":"10.1016\/S0168-0102(99)00070-X"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Schreiber S, Backer MM, Yanai J, Pick CG. The antinociceptive effect of fluvoxamine. Eur. Neuropsychopharmacol.<\/i>, 6<\/b>, 281\u2013284 (1996).","DOI":"10.1016\/S0924-977X(96)00031-4"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Gotoh Y, Andoh T, Kuraishi Y. Clonidine inhibits itch-related response through stimulation of \u03b12-adrenoceptors in the spinal cord in mice. Eur. J. Pharmacol.<\/i>, 650<\/b>, 215\u2013219 (2011).","DOI":"10.1016\/j.ejphar.2010.10.011"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Gotoh Y, Andoh T, Kuraishi Y. Noradrenergic regulation of itch transmission in the spinal cord mediated by \u03b1-adrenoceptors. Neuropharmacology<\/i>, 61<\/b>, 825\u2013831 (2011).","DOI":"10.1016\/j.neuropharm.2011.05.030"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Andoh T, Kuraishi Y. Inhibitory effects of azelastine on substance P-induced itch-associated response in mice. Eur. J. Pharmacol.<\/i>, 436<\/b>, 235\u2013239 (2002).","DOI":"10.1016\/S0014-2999(01)01617-X"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Li S, Andoh T, Zhang Q, Uta D, Kuraishi Y. \u03b22-Microglobulin, interleukin-31, and arachidonic acid metabolites (leukotriene B4<\/sub> and thromboxane A2<\/sub>) are involved in chronic renal failure-associated itch-associated responses in mice. Eur. J. Pharmacol.<\/i>, 847<\/b>, 19\u201325 (2019).","DOI":"10.1016\/j.ejphar.2019.01.017"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Ohtsuka E, Kawai S, Ichikawa T, Nojima H, Kitagawa K, Shirai Y, Kamimura K, Kuraishi Y. Roles of mast cells and histamine in mosquito bite-induced allergic itch-associated responses in mice. Jpn. J. Pharmacol.<\/i>, 86<\/b>, 97\u2013105 (2001).","DOI":"10.1254\/jjp.86.97"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Suzuki T, Ueta K, Tamagaki S, Mashimo T. Antiallodynic and antihyperalgesic effect of milnacipran in mice with spinal nerve ligation. Anesth. Analg.<\/i>, 106<\/b>, 1309\u20131315 (2008).","DOI":"10.1213\/ane.0b013e318167889a"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Tsujii K, Andoh T, Ui H, Lee JB, Kuraishi Y. Involvement of tryptase and proteinase-activated receptor-2 in spontaneous itch-associated response in mice with atopy-like dermatitis. J. Pharmacol. Sci.<\/i>, 109<\/b>, 388\u2013395 (2009).","DOI":"10.1254\/jphs.08332FP"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Kuraishi Y, Nagasawa T, Hayashi K, Satoh M. Scratching behavior induced by pruritogenic but not algesiogenic agents in mice. Eur. J. Pharmacol.<\/i>, 275<\/b>, 229\u2013233 (1995).","DOI":"10.1016\/0014-2999(94)00780-B"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Bergasa NV, Alling DW, Talbot TL, Swain MG, Yurdaydin C, Turner ML, Schmitt JM, Walker EC, Jones EA. Effects of naloxone infusions in patients with the pruritus of cholestasis. A double-blind, randomized, controlled trial. Ann. Intern. Med.<\/i>, 123<\/b>, 161\u2013167 (1995).","DOI":"10.7326\/0003-4819-123-3-199508010-00001"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Monroe EW. Efficacy and safety of nalmefene in patients with severe pruritis caused by chronic urticaria and atopic dermatitis. J. Am. Acad. Dermatol.<\/i>, 21<\/b>, 135\u2013136 (1989).","DOI":"10.1016\/S0190-9622(89)80353-6"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Peer G, Kivity S, Agami O, Fireman E, Silverberg D, Blum M, Iaina A. Randomised crossover trial of naltrexone in uraemic pruritus. Lancet<\/i>, 348<\/b>, 1552\u20131554 (1996).","DOI":"10.1016\/S0140-6736(96)04176-1"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Akiyama T, Carstens MI, Carstens E. Differential itch- and pain-related behavioral responses and \u00b5-opoid modulation in mice. Acta Derm. Venereol.<\/i>, 90<\/b>, 575\u2013581 (2010).","DOI":"10.2340\/00015555-0962"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Kuraishi Y, Yageta Y, Konno M, Andoh T, Yamaguchi-Miyamoto T, Nojima H. Intracisternal, but not intrathecal, injection of naloxone inhibits cutaneous itch-related response in mice. Biol. Pharm. Bull.<\/i>, 31<\/b>, 2143\u20132145 (2008).","DOI":"10.1248\/bpb.31.2143"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Yamaguchi T, Kitagawa K, Kuraishi Y. Itch-associated response and antinociception induced by intracisternal endomorphins in mice. Jpn. J. Pharmacol.<\/i>, 78<\/b>, 337\u2013343 (1998).","DOI":"10.1254\/jjp.78.337"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Kuraishi Y, Yamaguchi T, Miyamoto T. Itch-scratch responses induced by opioids through central mu opioid receptors in mice. J. Biomed. Sci.<\/i>, 7<\/b>, 248\u2013252 (2000).","DOI":"10.1007\/BF02255473"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Sumi R, Fukuda K, Irishio K, Hattori M, Sawai Y, Kogita S, Igura T, Yamaguchi Y, Matsumoto Y, Nakahara M, Shinomura Y, Imai Y. Current status of pruritus in chronic liver diseases and efficacy of nalfurafine hydrochloride. Kanzo<\/i>, 58<\/b>, 486\u2013493 (2017).","DOI":"10.2957\/kanzo.58.486"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Kumagai H, Ebata T, Takamori K, Miyasato K, Muramatsu T, Nakamoto H, Kurihara M, Yanagita T, Suzuki H. Efficacy and safety of a novel \u0138-agonist for managing intractable pruritus in dialysis patients. Am. J. Nephrol.<\/i>, 36<\/b>, 175\u2013183 (2012).","DOI":"10.1159\/000341268"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Nakasone T, Sato T, Matsushima Y, Inoue T, Kamei C. Characteristics of scratching behavior in ADJM mice (atopic dermatitis from Japanese mice). Immunopharmacol. Immunotoxicol.<\/i>, 37<\/b>, 202\u2013206 (2015).","DOI":"10.3109\/08923973.2014.1001903"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Kardon AP, Polg\u00e1r E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron<\/i>, 82<\/b>, 573\u2013586 (2014).","DOI":"10.1016\/j.neuron.2014.02.046"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Elliott G, Vanwersch R, Soeberdt M, Metze D, Lotts T, St\u00e4nder S, Abels C. Topical nalfurafine exhibits anti-inflammatory and anti-pruritic effects in a murine model of AD. J. Dermatol. Sci.<\/i>, 84<\/b>, 351\u2013354 (2016).","DOI":"10.1016\/j.jdermsci.2016.09.008"},{"key":"36","unstructured":"36) Mela M, Mancuso A, Burroughs AK. Review article: pruritus in cholestatic and other liver diseases. Aliment. Pharmacol. Ther.<\/i>, 17<\/b>, 857\u2013870 (2003)."},{"key":"37","unstructured":"37) Fjellner B, H\u00e4germark \u00d6. Pruritus in polycythemia vera: treatment with aspirin and possibility of platelet involvement. Acta Derm. Venereol..<\/i>, 59<\/b>, 505\u2013512 (1979)."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Raderer M, M\u00fcller C, Scheithauer W. Ondansetron for pruritus due to cholestasis. N. Engl. J. Med.<\/i>, 330<\/b>, 1540 (1994).","DOI":"10.1056\/NEJM199405263302117"},{"key":"39","unstructured":"39) Jones EA, Molenaar HA, Oosting J. Ondansetron and pruritus in chronic liver disease: a controlled study. Hepatogastroenterology<\/i>, 54<\/b>, 1196\u20131199 (2007)."},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Molino M, Barnathan ES, Numerof R, Clark J, Dreyer M, Cumashi A, Hoxie JA, Schechter N, Woolkalis M, Brass LF. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J. Biol. Chem.<\/i>, 272<\/b>, 4043\u20134049 (1997).","DOI":"10.1074\/jbc.272.7.4043"},{"key":"41","unstructured":"41) Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Blaber M, Blaber SI, Scarisbrick I, Diamandis EP, Hollenberg MD. Kallikrein-mediated cell signaling: targenting proteinase-activated receptor (PARs). Biol. Chem.<\/i>, 387<\/b>, 817\u2013824 (2006)."},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Andoh T, Tsujii K, Kuraishi Y. Increase in pruritogenic kallikrein 5 in the skin of NC mice with chronic dermatitis. Exp. Dermatol.<\/i>, 24<\/b>, 978\u2013980 (2015).","DOI":"10.1111\/exd.12828"},{"key":"43","unstructured":"43) St\u00e4nder S, B\u00f6ckenholt B, Sch\u00fcrmeyer-Horst F, Weishaupt C, Heuft G, Luger TA, Schneider G. Treatment of chronic pruritus with the selective serotonin re-uptake inhibitors paroxetine and fluvoxamine: results of an open-labelled, two-arm proof-of-concept study. Acta Derm. Venereol.<\/i>, 89<\/b>, 45\u201351 (2009)."},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Mayo MJ, Handem I, Saldana S, Jacobe H, Getachew Y, Rush AJ. Sertraline as a first-line treatment for cholestatic pruritus. Hepatology<\/i>, 45<\/b>, 666\u2013674 (2007).","DOI":"10.1002\/hep.21553"},{"key":"45","unstructured":"45) Hashimoto K. Sigma-1 receptors and selective serotonin reuptake inhibitors: clinical implications of their relationship. Cent. Nerv. Syst. Agents Med. Chem.<\/i>, 9<\/b>, 197\u2013204 (2009)."},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Matsushima Y, Terada K, Kamei C, Sugimoto Y. Sertraline inhibits nerve growth factor-induced neurite outgrowth in PC12 cells via<\/i> a mechanism involving the sigma-1 receptor. Eur. J. Pharmacol.<\/i>, 853<\/b>, 129\u2013135 (2019).","DOI":"10.1016\/j.ejphar.2019.03.032"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Ort\u00edz-Renter\u00eda M, Ju\u00e1rez-Contreras R, Gonz\u00e1lez-Ram\u00edrez R, Islas LD, Sierra-Ram\u00edrez F, Llorente I, Simon SA, Hiriart M, Rosenbaum T, Morales-L\u00e1zaro SL. TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain. Proc. Natl. Acad. Sci. U.S.A.<\/i>, 115<\/b>, E1657\u2013E1666 (2018).","DOI":"10.1073\/pnas.1715972115"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Moore C, Gupta R, Jordt SE, Chen Y, Liedtke WB. Regulation of pain and itch by TRP channels. Neurosci. Bull.<\/i>, 34<\/b>, 120\u2013142 (2018).","DOI":"10.1007\/s12264-017-0200-8"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Andoh T, Gotoh Y, Kuraishi Y. Milnacipran inhibits itch-related responses in mice through the enhancement of noradrenergic transmission in the spinal cord. J. Pharmacol. Sci.<\/i>, 123<\/b>, 199\u2013202 (2013).","DOI":"10.1254\/jphs.13122SC"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/43\/7\/43_b20-00097\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T03:18:47Z","timestamp":1593832727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/43\/7\/43_b20-00097\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,1]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b20-00097","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,1]]}}}