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Nankodo Co., Ltd., Tokyo (2014)."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Lohsiriwat V. Approach to hemorrhoids. <i>Curr. Gastroenterol. Rep.<\/i>, <b>15<\/b>, 332 (2013).","DOI":"10.1007\/s11894-013-0332-6"},{"key":"3","unstructured":"3) Lohsiriwat V. Hemorrhoids: from basic pathophysiology to clinical management. <i>World J. Gastroenterol.<\/i>, <b>18<\/b>, 2009\u20132017 (2012)."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Thomson WH. The nature and cause of haemorrhoids. <i>Proc. R. Soc. Med.<\/i>, <b>68<\/b>, 574\u2013575 (1975).","DOI":"10.1177\/003591577506800916"},{"key":"5","unstructured":"5) Ganz RA. The evaluation and treatment of hemorrhoids: a guide for the gastroenterologist. <i>Clin. Gastroenterol. Hepatol.<\/i>, <b>11<\/b>, 593\u2013603 (2013)."},{"key":"6","unstructured":"6) Sun Z, Migaly J. Review of hemorrhoid disease: Presentation and management. <i>Clin. Colon Rectal Surg.<\/i>, <b>29<\/b>, 22\u201329 (2016)."},{"key":"7","unstructured":"7) Lee JH, Kim HE, Kang JH, Shin JY, Song YM. Factors associated with hemorrhoids in Korean adults: Korean national health and nutrition examination survey. <i>Korean J. Fam. Med<\/i>, <b>35<\/b>, 227\u2013236 (2014)."},{"key":"8","unstructured":"8) Everhart JE, Ruhl CE. Burden of digestive diseases in the United States part II: lower gastrointestinal diseases. <i>Gastroenterology<\/i>, <b>136<\/b>, 741\u2013754 (2009)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Nagaraj SV, Mori A, Reddy M. Association of hemorrhoid vascular injuries with cigarette smoking\u2014an evaluation with interesting prospects. <i>Surg. J.<\/i>, <b>5<\/b>, e172\u2013e176 (2019).","DOI":"10.1055\/s-0039-1700497"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Pigot F, Siproudhis L, Allaert FA. Risk factors associated with hemorrhoidal symptoms in specialized consultation. <i>Gastroenterol. Clin. Biol.<\/i>, <b>29<\/b>, 1270\u20131274 (2005).","DOI":"10.1016\/S0399-8320(05)82220-1"},{"key":"11","unstructured":"11) Loder PB, Kamm MA, Nicholls RJ, Phillips RK. Haemorrhoids: pathology, pathophysiology and aetiology. <i>Br. J. Surg.<\/i>, <b>81<\/b>, 946\u2013954 (1994)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Ueki T, Nakashima M. Relationship between constipation and medication. <i>J. UOEH<\/i>, <b>41<\/b>, 145\u2013151 (2019).","DOI":"10.7888\/juoeh.41.145"},{"key":"13","unstructured":"13) World Gastroenterology Organisation. \u201cWorld Gastroenterology Organisation Global Guidelines, constipation: a global perspective\u2014world gastroenterology.\u201d: \u2039https:\/\/www.worldgastroenterology.org\/UserFiles\/file\/guidelines\/constipation-english-2010.pdf\u203a, accessed 2 July, 2020."},{"key":"14","unstructured":"14) De Hert M, Hudyana H, Dockx L, Bernagie C, Sweers K, Tack J, Leucht S, Peuskens J. Second-generation antipsychotics and constipation: a review of the literature. <i>Eur. Psychiatry<\/i>, <b>26<\/b>, 34\u201344 (2011)."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Yamana T. Japanese practice guidelines for anal disorders I. hemorrhoids. <i>J. Anus. Rectum. Colon.<\/i>, <b>1<\/b>, 89\u201399 (2018).","DOI":"10.23922\/jarc.2017-018"},{"key":"16","unstructured":"16) Ministry of Health. Labour and Welfare. \u201cComprehensive survey of living conditions.\u201d: \u2039https:\/\/www.mhlw.go.jp\/toukei\/list\/20-21tyousa.html\u203a, accessed 2 July, 2020."},{"key":"17","unstructured":"17) Ministry of Health. Labour and Welfare. \u201cQ &amp; A about the Comprehensive Survey of Living Conditions in 2016.\u201d: \u2039https:\/\/www.mhlw.go.jp\/toukei\/list\/dl\/20-21a-03.pdf\u203a, accessed 2 July, 2020."},{"key":"18","unstructured":"18) Statistics Bureau of Japan. \u201ce-Stat.\u201d: \u2039https:\/\/www.e-stat.go.jp\u203a, accessed 2 July, 2020."},{"key":"19","unstructured":"19) Itoh H, Saito T, Nojiri S, Hiratsuka Y, Yokoyama K. National burden of the pharmaceutical cost of wet compresses and its cost predictors: nationwide cross-sectional study in Japan. <i>Health Econ. Rev.<\/i>, <b>9<\/b>, 20 (2019)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Sakakibara Y, Ochibe T, Amari S, Tohkin M. Study on the risk factors for postoperative delirium using the national health insurance claims database in Japan. <i>Jpn. J. Pharm. Health Care Sci.<\/i>, <b>45<\/b>, 195\u2013207 (2019).","DOI":"10.5649\/jjphcs.45.195"},{"key":"21","unstructured":"21) Ministry of Health. Labour and Welfare. \u201cExplanation of the 2nd NDB Open Data Japan.\u201d: \u2039https:\/\/www.mhlw.go.jp\/file\/06-Seisakujouhou-12400000-Hokenkyoku\/0000193322.pdf\u203a, accessed 2 July, 2020."},{"key":"22","unstructured":"22) Kato G. History of the secondary use of national database of health insurance claims and specific health checkups of Japan (NDB). <i>Transactions of the Japanese Society for Medical and Biological Engineering<\/i>, <b>55<\/b>, 143\u2013150 (2017)."},{"key":"23","unstructured":"23) Tsuhita K. Lifestyle-related diseases prevention strategy based on specific health checkup mega-data. <i>J. Natl. Inst. Public Health<\/i>, <b>63<\/b>, 438\u2013448 (2014)."},{"key":"24","unstructured":"24) Matsuda S, Fujimoto K. \u201cAnalysis using NDB open data, JAPIC NEWS February No. 418, pp. 4\u20135 (2019).\u201d: \u2039https:\/\/www.japic.or.jp\/service\/whats_new\/japicnews\/pdf\/JAPICNEWS19-02.pdf\u203a, accessed 2 July, 2020."},{"key":"25","unstructured":"25) Ministry of Health. Labour and Welfare. \u201cThe 2nd NDB Open Data Japan.\u201d: \u2039www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/0000177221.html\u203a, accessed 2 July, 2020."},{"key":"26","unstructured":"26) Statistics Bureau of Japan. \u201cHousehold members (over 20 years old), smoking status, prefectures-21 major cities (re-listed), gender, age (5 years old).\u201d: \u2039https:\/\/www.e-stat.go.jp\/stat-search\/files?page=1&amp;query=%E5%96%AB%E7%85%99%E3%80%80%EF%BC%92%EF%BC%98&amp;layout=dataset&amp;stat_infid=000031595567&amp;metadata=1&amp;data=1\u203a, accessed 2 July, 2020."},{"key":"27","unstructured":"27) Statistics Bureau of Japan. \u201cHousehold members (20 years old and over), frequency of drinking, prefectures-21 major cities (re-listed), gender, age (5 years old).\u201d: \u2039https:\/\/www.e-stat.go.jp\/stat-search\/files?page=1&amp;query=%E9%A3%B2%E9%85%92&amp;layout=dataset&amp;toukei=00450061&amp;kikan=00450&amp;tstat=000001114975&amp;stat_infid=000031595566&amp;result_page=1&amp;metadata=1&amp;data=1\u203a, accessed 2 July, 2020."},{"key":"28","unstructured":"28) Statistics Bureau of Japan. \u201cAverage number of steps (20\u201364 years old, gender, prefecture, age adjustment).\u201d: \u2039https:\/\/www.e-stat.go.jp\/stat-search\/files?page=1&amp;query=%E6%AD%A9%E6%95%B0&amp;layout=dataset&amp;toukei=00450171&amp;tstat=000001041744&amp;cycle=7&amp;tclass1=000001111535&amp;stat_infid=000031666337&amp;metadata=1&amp;data=1\u203a, accessed 2 July, 2020."},{"key":"29","unstructured":"29) Statistics Bureau of Japan. \u201cNatural environment.\u201d; \u2039https:\/\/www.e-stat.go.jp\/stat-search\/files?page=1&amp;query=%E6%B0%97%E6%B8%A9%E3%80%80%EF%BC%92%EF%BC%90%EF%BC%91%EF%BC%96&amp;layout=dataset&amp;stat_infid=000031368974&amp;metadata=1&amp;data=1\u203a, accessed 2 July, 2020."},{"key":"30","unstructured":"30) Ministry of Health. Labour and Welfare. \u201cPopulation by age (5-year age group) and sex for prefectures-total population, October 1, 2015.\u201d: \u2039https:\/\/www.e-stat.go.jp\/stat-search\/file-download?statInfId=000031495550&amp;fileKind=0\u203a, accessed 2 July, 2020."},{"key":"31","unstructured":"31) Ministry of Internal Affairs and Communications. \u201cDivision 87\u2013DRUGS AND RELATED COMMODITIES.\u201d: \u2039https:\/\/www.soumu.go.jp\/main_content\/000294493.pdf\u203a, accessed 2 July, 2020."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Everitt BS. <i>Cluster Analysis<\/i>. 5th Edition, John Wiley &amp; Sons, Ltd., New York (2011).","DOI":"10.1002\/9780470977811"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Ekici U, Kartal A, Ferhatoglu MF. Association between hemorrhoids and lower extremity chronic venous insufficiency. <i>Cureus<\/i>, <b>11<\/b>, e4502 (2019).","DOI":"10.7759\/cureus.4502"},{"key":"34","unstructured":"34) Lohsiriwat V. Treatment of hemorrhoids: a coloproctologist\u2019s view. <i>World J. Gastroenterol.<\/i>, <b>21<\/b>, 9245\u20139252 (2015)."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Acheson AG, Scholefield JH. Management of haemorrhoids. <i>BMJ<\/i>, <b>336<\/b>, 380\u2013383 (2008).","DOI":"10.1136\/bmj.39465.674745.80"},{"key":"36","unstructured":"36) Kaidar-Person O, Person B, Wexner SD. Hemorrhoidal disease: a comprehensive review. <i>J. Am. Coll. Surg.<\/i>, <b>204<\/b>, 102\u2013117 (2007)."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Rivadeneira DE, Steele SR, Ternent C, Chalasani S, Buie WD, Rafferty JL. Practice parameters for the management of hemorrhoids (revised 2010). <i>Dis. Colon Rectum<\/i>, <b>54<\/b>, 1059\u20131064 (2011).","DOI":"10.1097\/DCR.0b013e318225513d"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Peery AF, Sandler RS, Galanko JA, Bresalier RS, Figueiredo JC, Ahnen DJ, Barry EL, Baron JA. Risk factors for hemorrhoids on screening colonoscopy. <i>PLOS ONE<\/i>, <b>10<\/b>, e0139100 (2015).","DOI":"10.1371\/journal.pone.0139100"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Riss S, Weiser FA, Schwameis K, Riss T, Mittlb\u00f6ck M, Steiner G, Stift A. The prevalence of hemorrhoids in adults. <i>Int. J. Colorectal Dis.<\/i>, <b>27<\/b>, 215\u2013220 (2012).","DOI":"10.1007\/s00384-011-1316-3"},{"key":"40","unstructured":"40) Okumura Y, Sakata N, Shimizu S, Matsui H. Research department report: promoting academic use of the national databases: pitfalls of the National Database of Health Insurance Claims and Specific Health Checkups. <i>Monthly Institute for Health Economics and Policy<\/i>, <b>268<\/b>, 16\u201325 (2017)."},{"key":"41","unstructured":"41) Goto M, Takeda M, Kainuma Y, Suijyou Y. Factors and measures for non-examination from the viewpoint of a questionnaire survey of non-participants in specific health check-ups. <i>Journal of Health and Welfare Statistics<\/i>, <b>58<\/b>, 34\u201339 (2011)."},{"key":"42","unstructured":"42) Umetsu R, Abe J, Ueda N, Kato Y, Nakayama Y, Kinosada Y, Nakamura M. Adverse event trends associated with over-the-counter drugs: data mining of the Japanese adverse drug event report database. <i>Yakugaku Zasshi<\/i>, <b>135<\/b>, 991\u20131000 (2015)."}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/43\/12\/43_b20-00157\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T03:29:23Z","timestamp":1607138963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/43\/12\/43_b20-00157\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b20-00157","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,1]]}}}