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Toll-like receptor 2 and 4 mediate hyperglycemia induced macrovascular aortic endothelial cell inflammation and perturbation of the endothelial glycocalyx. <i>J. Diabetes Complications<\/i>, <b>30<\/b>, 563\u2013572 (2016).","DOI":"10.1016\/j.jdiacomp.2016.01.014"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Carrillo-Sepulveda MA, Spitler K, Pandey D, Berkowitz DE, Matsumoto T. Inhibition of TLR4 attenuates vascular dysfunction and oxidative stress in diabetic rats. <i>J. Mol. Med.<\/i>, <b>93<\/b>, 1341\u20131354 (2015).","DOI":"10.1007\/s00109-015-1318-7"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Al-Awar A, Kupai K, Veszelka M, Szucs G, Attieh Z, Murlasits Z, Torok S, Posa A, Varga C. Experimental diabetes mellitus in different animal models. <i>J. Diabetes Res.<\/i>, <b>2016<\/b>, 9051426 (2016).","DOI":"10.1155\/2016\/9051426"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Kamata K, Kobayashi T. Changes in superoxide dismutase mRNA expression by streptozotocin-induced diabetes. <i>Br. J. Pharmacol.<\/i>, <b>119<\/b>, 583\u2013589 (1996).","DOI":"10.1111\/j.1476-5381.1996.tb15712.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Leo CH, Hart JL, Woodman OL. Impairment of both nitric oxide-mediated and EDHF-type relaxation in small mesenteric arteries from rats with streptozotocin-induced diabetes. <i>Br. J. Pharmacol.<\/i>, <b>162<\/b>, 365\u2013377 (2011).","DOI":"10.1111\/j.1476-5381.2010.01023.x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Taguchi K, Hida M, Matsumoto T, Ikeuchi-Takahashi Y, Onishi H, Kobayashi T. Effect of short-term polyphenol treatment on endothelial dysfunction and thromboxane A2 levels in streptozotocin-induced diabetic mice. <i>Biol. Pharm. Bull.<\/i>, <b>37<\/b>, 1056\u20131061 (2014).","DOI":"10.1248\/bpb.b14-00157"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Matsumoto T, Kobayashi T, Kamata K. Alterations in EDHF-type relaxation and phosphodiesterase activity in mesenteric arteries from diabetic rats. <i>Am. J. Physiol. Heart Circ. Physiol.<\/i>, <b>285<\/b>, H283\u2013H291 (2003).","DOI":"10.1152\/ajpheart.00954.2002"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Matsumoto T, Miyamori K, Kobayashi T, Kamata K. Specific impairment of endothelium-derived hyperpolarizing factor-type relaxation in mesenteric arteries from streptozotocin-induced diabetic mice. <i>Vascul. Pharmacol.<\/i>, <b>44<\/b>, 450\u2013460 (2006).","DOI":"10.1016\/j.vph.2006.02.007"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Kawamoto T, Ii M, Kitazaki T, Iizawa Y, Kimura H. TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain. <i>Eur. J. 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Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes. <i>Cytokine<\/i>, <b>55<\/b>, 441\u2013445 (2011).","DOI":"10.1016\/j.cyto.2011.03.023"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Matsumoto T, Nakayama N, Ishida K, Kobayashi T, Kamata K. Eicosapentaenoic acid improves imbalance between vasodilator and vasoconstrictor actions of endothelium-derived factors in mesenteric arteries from rats at chronic stage of type 2 diabetes. <i>J. Pharmacol. Exp. Ther.<\/i>, <b>329<\/b>, 324\u2013334 (2009).","DOI":"10.1124\/jpet.108.148718"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Kramer B, Franca LM, Zhang Y, Paes AMA, Gerdes AM, Carrillo-Sepulveda MA. Western diet triggers Toll-like receptor 4 signaling-induced endothelial dysfunction in female Wistar rats. <i>Am. J. Physiol. Heart Circ. 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