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Med.<\/i>, <b>363<\/b>, 711\u2013723 (2010)."},{"key":"10","unstructured":"10) Kwon ED, Drake CG, Scher HI, <i>et al.<\/i> Ipilimumab <i>versus<\/i> placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial. <i>Lancet Oncol.<\/i>, <b>15<\/b>, 700\u2013712 (2014)."},{"key":"11","unstructured":"11) Eggermont AM, Chiarion-Sileni V, Grob JJ, <i>et al.<\/i> Adjuvant ipilimumab <i>versus<\/i> placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial. <i>Lancet Oncol.<\/i>, <b>16<\/b>, 522\u2013530 (2015)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Robert C, Schachter J, Long GV, <i>et al.<\/i> Pembrolizumab <i>versus<\/i> ipilimumab in advanced melanoma. <i>N. Engl. J. 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