{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:10:07Z","timestamp":1780758607294,"version":"3.54.1"},"reference-count":21,"publisher":"Pharmaceutical Society of Japan","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2020,12,1]]},"DOI":"10.1248\/bpb.b20-00614","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T22:07:19Z","timestamp":1601590039000},"page":"1917-1923","source":"Crossref","is-referenced-by-count":2,"title":["The Pharmacokinetics of Sildenafil May Be Affected by Intestinal Absorption Rate in Children Admitted to the Intensive Care Unit"],"prefix":"10.1248","volume":"43","author":[{"given":"Yukino","family":"Oya","sequence":"first","affiliation":[{"name":"Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Watahiki","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuki","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Hirono","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukiko","family":"Ichida","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Aoki","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Abrams D, Schulze-Neick I, Magee AG. Sildenafil as a selective pulmonary vasodilator in childhood primary pulmonary hypertension. <i>Heart<\/i>, <b>84<\/b>, e4 (2000).","DOI":"10.1136\/heart.84.2.e4"},{"key":"2","unstructured":"2) Matamis D, Pampori S, Papathanasiou A, Papakonstantinou P, Tsagourias M, Galiatsou E, Koulouras V, Nakos G. Inhaled NO and sildenafil combination in cardiac surgery patients with out-of-proportion pulmonary hypertension: acute effects on postoperative gas exchange and hemodynamics. <i>Circ. Heart Fail.<\/i>, <b>5<\/b>, 47\u201353 (2012)."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Namachivayam P, Theilen U, Butt WW, Cooper SM, Penny DJ, Shekerdemian LS. Sildenafil prevents rebound pulmonary hypertension after withdrawal of nitric oxide in children. <i>Am. J. Respir. Crit. Care Med.<\/i>, <b>174<\/b>, 1042\u20131047 (2006).","DOI":"10.1164\/rccm.200605-694OC"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Ahsman MJ, Witjes BC, Wildschut ED, Sluiter I, Vulto AG, Tibboel D, Mathot RA. Sildenafil exposure in neonates with pulmonary hypertension after administration <i>via<\/i> a nasogastric tube. <i>Arch. Dis. Child. Fetal Neonatal Ed.<\/i>, <b>95<\/b>, F109\u2013F114 (2010).","DOI":"10.1136\/adc.2009.168336"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Mehrotra N, Gupta M, Kovar A, Meibohm B. The role of pharmacokinetics and pharmacodynamics in phosphodiesterase-5 inhibitor therapy. <i>Int. J. Impot. Res.<\/i>, <b>19<\/b>, 253\u2013264 (2007).","DOI":"10.1038\/sj.ijir.3901522"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Kohno H, Ichida F, Hirono K, Ozawa S, Yoshimura N, Nakamura T, Akita C, Ishida K, Taguchi M. Plasma concentrations of tadalafil in children with pulmonary arterial hypertension. <i>Ther. Drug Monit.<\/i>, <b>36<\/b>, 576\u2013583 (2014).","DOI":"10.1097\/FTD.0000000000000055"},{"key":"7","unstructured":"7) Takahiro R, Nakamura S, Kohno H, Yoshimura N, Nakamura T, Ozawa S, Hirono K, Ichida K, Taguchi M. Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil <i>N<\/i>-demethylation and tadalafil demethylenation. <i>Biol. Pharm. Bull.<\/i>, <b>38<\/b>, 58\u201365 (2015)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Lacroix D, Sonnier M, Moncion A, Cheron G, Cresteil T. Expression of CYP3A in the human liver\u2014evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth. <i>Eur. J. Biochem.<\/i>, <b>247<\/b>, 625\u2013634 (1997).","DOI":"10.1111\/j.1432-1033.1997.00625.x"},{"key":"9","unstructured":"9) \u201cJCS 2018 Guideline on the clinical examinations for decision making of diagnosis and drug therapy in pediatric patients with congenital heart disease and cardiovascular disorder.\u201d : \u2039https:\/\/www.j-circ.or.jp\/cms\/wp-content\/uploads\/2020\/02\/JCS2018_Yasukochi.pdf\u203a, accessed 28 August, 2020."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Yaroshenko DV, Grigoriev AV, Sidorova AA, Kartsova LA. Chromatographic determination of sildenafil in blood plasma using spectrophotometric and mass-spectrometric detection. <i>J. Anal. Chem.<\/i>, <b>68<\/b>, 801\u2013808 (2013).","DOI":"10.1134\/S1061934813090128"},{"key":"11","unstructured":"11) Nichols DJ, Muirhead GJ, Harness JA. Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality. <i>Br. J. Clin. Pharmacol.<\/i>, <b>53<\/b> (Suppl. 1), 5S\u201312S (2002)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Muirhead GJ, Rance DJ, Walker DK, Wastall P. Comparative human pharmacokinetics and metabolism of single-dose oral and intravenous sildenafil. <i>Br. J. Clin. Pharmacol.<\/i>, <b>53<\/b> (Suppl. 1), 13S\u201320S (2002).","DOI":"10.1046\/j.06-5251.2001.00028.x"},{"key":"13","unstructured":"13) Osman MA, El Maghraby GM, Hedaya MA. Intestinal absorption and presystemic disposition of sildenafil citrate in the rabbit: evidence for site-dependent absorptive clearance. <i>Biopharm. Drug Dispos.<\/i>, <b>27<\/b>, 93\u2013102 (2006)."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Okabe H, Mizukami A, Taguchi M, Aiba T, Yasuhara M, Hashimoto Y. The increased intestinal absorption rate is responsible for the reduced hepatic first-pass extraction of propranolol in rats with cisplatin-induced renal dysfunction. <i>J. Pharm. Pharmacol.<\/i>, <b>55<\/b>, 479\u2013486 (2003).","DOI":"10.1211\/002235702982"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Fruhwald S, Holzer P, Metzler H. Intestinal motility disturbances in intensive care patients pathogenesis and clinical impact. <i>Intensive Care Med.<\/i>, <b>33<\/b>, 36\u201344 (2007).","DOI":"10.1007\/s00134-006-0452-7"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Mutlu GM, Mutlu EA, Factor P. GI complications in patients receiving mechanical ventilation. <i>Chest<\/i>, <b>119<\/b>, 1222\u20131241 (2001).","DOI":"10.1378\/chest.119.4.1222"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Fuder H, Muscholl E. Heteroreceptor-mediated modulation of noradrenaline and acetylcholine release from peripheral nerves. <i>Rev. Physiol. Biochem. Pharmacol.<\/i>, <b>126<\/b>, 265\u2013412 (1995).","DOI":"10.1007\/BFb0049778"},{"key":"18","unstructured":"18) D\u2019Ancona G, Baillot R, Poirier B, Dagenais F, Saez-de-Ibarra JI, Bauset R, Mathieu P, Doyle D. Determinants of gastrointestinal complications in cardiac surgery. <i>Tex. Heart Inst. J.<\/i>, <b>30<\/b>, 280\u2013285 (2003)."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Morisawa T, Takahashi T, Sasanuma N, Mabuchi S, Takeda K, Hori N, Ohashi N, Ide T, Domen K, Nishi S. Passive exercise of the lower limbs and trunk alleviates decreased intestinal motility in patients in the intensive care unit after cardiovascular surgery. <i>J. Phys. Ther. Sci.<\/i>, <b>29<\/b>, 312\u2013316 (2017).","DOI":"10.1589\/jpts.29.312"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Olgu\u00edn HJ, Mart\u00ednez HO, P\u00e9rez CF, Mendiola BR, Espinosa LR, ChpinosaPacheco JL, P\u00e9rez JF, Maga\u00f1a IM. Pharmacokinetics of sildenafil in children with pulmonary arterial hypertension. <i>World J. Pediatr.<\/i>, <b>13<\/b>, 588\u2013592 (2017).","DOI":"10.1007\/s12519-017-0043-4"},{"key":"21","unstructured":"21) Wang R, Burnett AL, Heller WH, Omori K, Kotera J, Kikkawa K, Yee S, Day WW, DiDonato K, Peterson CA. Selectivity of avanafil, a PDE5 inhibitor for the treatment of erectile dysfunction: implications for clinical safety and improved tolerability. <i>J. Sex. Med.<\/i>, <b>9<\/b>, 2122\u20132129 (2012)."}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/43\/12\/43_b20-00614\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T03:30:16Z","timestamp":1607139016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/43\/12\/43_b20-00614\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b20-00614","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,1]]}}}