{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T22:46:59Z","timestamp":1781563619699,"version":"3.54.5"},"reference-count":23,"publisher":"Pharmaceutical Society of Japan","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2021,1,1]]},"DOI":"10.1248\/bpb.b20-00616","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T22:06:24Z","timestamp":1603836384000},"page":"69-74","source":"Crossref","is-referenced-by-count":9,"title":["Pharmacokinetic Variability of Caffeine in Routinely Treated Preterm Infants: Preliminary Considerations on Developmental Changes of Systemic Clearance"],"prefix":"10.1248","volume":"44","author":[{"given":"Masato","family":"Taguchi","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacokinetics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukako","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Maternal and Perinatal Center, Toyama University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arisa","family":"Katsuma","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacokinetics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayane","family":"Mito","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacokinetics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Tamura","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Maternal and Perinatal Center, Toyama University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Makimoto","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Maternal and Perinatal Center, Toyama University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taketoshi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Maternal and Perinatal Center, Toyama University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","unstructured":"1) Moschino L, Zivanovic S, Hartley C, Trevisanuto D, Baraldi E, Roehr CC. Caffeine in preterm infants: where are we in 2020? <i>ERJ Open Res.<\/i>, <b>6<\/b>, 00330-2019 (2020)."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Aranda JV, Gorman W, Bergsteinsson H, Gunn T. Efficacy of caffeine in treatment of apnea in the low-birth-weight infant. <i>J. Pediatr.<\/i>, <b>90<\/b>, 467\u2013472 (1977).","DOI":"10.1016\/S0022-3476(77)80718-X"},{"key":"3","unstructured":"3) Skouroliakou M, Bacopoulou F, Markantonis SL. Caffeine <i>versus<\/i> theophylline for apnea of prematurity: a randomised controlled trial. <i>J. Paediatr. Child Health<\/i>, <b>45<\/b>, 587\u2013592 (2009)."},{"key":"4","unstructured":"4) Ali E, Rockman-Greenberg C, Moffatt M, Narvey M, Reed M, Jiang D. Caffeine is a risk factor for osteopenia of prematurity in preterm infants: a cohort study. <i>BMC Pediatr.<\/i>, <b>18<\/b>, 9 (2018)."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Nakaoka S, Kawasaki Y, Inomata S, Makimoto M, Yoshida T. Caffeine toxicity in a preterm neonate. <i>Pediatr. Neonatol.<\/i>, <b>58<\/b>, 380\u2013381 (2017).","DOI":"10.1016\/j.pedneo.2016.08.001"},{"key":"6","unstructured":"6) Tang-Liu DD, Williams RL, Riegelman S. Disposition of caffeine and its metabolites in man. <i>J. Pharmacol. Exp. Ther.<\/i>, <b>224<\/b>, 180\u2013185 (1983)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Aldridge A, Aranda JV, Neims AH. Caffeine metabolism in the newborn. <i>Clin. Pharmacol. Ther.<\/i>, <b>25<\/b>, 447\u2013453 (1979).","DOI":"10.1002\/cpt1979254447"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Aranda JV, Collinge JM, Zinman R, Watters G. Maturation of caffeine elimination in infancy. <i>Arch. Dis. Child.<\/i>, <b>54<\/b>, 946\u2013949 (1979).","DOI":"10.1136\/adc.54.12.946"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Koch G, Datta AN, Jost K, Schulzke SM, van den Anker J, Pfister M. Caffeine citrate dosing adjustments to assure stable caffeine concentrations in preterm neonates. <i>J. Pediatr.<\/i>, <b>191<\/b>, 50\u201356.e1 (2017).","DOI":"10.1016\/j.jpeds.2017.08.064"},{"key":"10","unstructured":"10) Gao XB, Zheng Y, Yang F, Wang CH, Jiang ZH, Wu YE, Jacqz-Aigrain E, Ni SQ, Zhao W. Developmental population pharmacokinetics of caffeine in Chinese premature infants with apnoea of prematurity: a post-marketing study to support paediatric labelling in China. <i>Br. J. Clin. Pharmacol.<\/i>, <b>2020<\/b>, 1\u201310 (2020)."},{"key":"11","unstructured":"11) Kuwayama K, Tsujikawa K, Miyaguchi H, Kanamori T, Iwata YT, Inoue H. Time-course measurements of caffeine and its metabolites extracted from fingertips after coffee intake: a preliminary study for the detection of drugs from fingerprints. <i>Anal. Bioanal. Chem.<\/i>, <b>405<\/b>, 3945\u20133952 (2013)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Babu AR, Thippeswamy B, Vinod AB, Ramakishore EG, Anand S, Senthil D. Determination of theophylline in rabbit plasma by triple quadrupole LC\/MS. <i>Pharm. Methods<\/i>, <b>2<\/b>, 211\u2013217 (2011).","DOI":"10.4103\/2229-4708.93388"},{"key":"13","unstructured":"13) Dubois D, Dubois EF. A formula to estimate the approximate surface area if height and weight be known. <i>Nutrition<\/i>, <b>5<\/b>, 303\u2013311, discussion, 312\u2013313 (1989)."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Nakashima T, Inoue H, Fujiyoshi J, Matsumoto N. Longitudinal analysis of serum cystatin C for estimating the glomerular filtration rate in preterm infants. <i>Pediatr. Nephrol.<\/i>, <b>31<\/b>, 983\u2013989 (2016).","DOI":"10.1007\/s00467-015-3309-x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Uemura O, Nagai T, Ishikura K, Ito S, Hataya H, Gotoh Y, Fujita N, Akioka Y, Kaneko T, Honda M. Cystatin C-based equation for estimating glomerular filtration rate in Japanese children and adolescents. <i>Clin. Exp. Nephrol.<\/i>, <b>18<\/b>, 718\u2013725 (2014).","DOI":"10.1007\/s10157-013-0910-9"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Dobson NR, Liu X, Rhein LM, Darnall RA, Corwin MJ, McEntire BL, Ward RM, James LP, Sherwin CM, Heeren TC, Hunt CE. Salivary caffeine concentrations are comparable to plasma concentrations in preterm infants receiving extended caffeine therapy. <i>Br. J. Clin. Pharmacol.<\/i>, <b>82<\/b>, 754\u2013761 (2016).","DOI":"10.1111\/bcp.13001"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Johnson TN, Rostami-Hodjegan A, Tucker GT. Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children. <i>Clin. Pharmacokinet.<\/i>, <b>45<\/b>, 931\u2013956 (2006).","DOI":"10.2165\/00003088-200645090-00005"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Aperia A, Broberger O, Elinder G, Herin P, Zetterstr\u00f6m R. Postnatal development of renal function in pre-term and full-term infants. <i>Acta Paediatr. Scand.<\/i>, <b>70<\/b>, 183\u2013187 (1981).","DOI":"10.1111\/j.1651-2227.1981.tb05539.x"},{"key":"19","unstructured":"19) Rhodin MM, Anderson BJ, Peters AM, Coulthard MG, Wilkins B, Cole M, Chatelut E, Grubb A, Veal GJ, Keir MJ, Holford NHG. Human renal function maturation: a quantitative description using weight and postmenstrual age. <i>Pediatr. Nephrol.<\/i>, <b>24<\/b>, 67\u201376 (2009)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Arant BS Jr. Developmental patterns of renal functional maturation compared in the human neonate. <i>J. Pediatr.<\/i>, <b>92<\/b>, 705\u2013712 (1978).","DOI":"10.1016\/S0022-3476(78)80133-4"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Coulthard MG. Maturation of glomerular filtration in preterm and mature babies. <i>Early Hum. Dev.<\/i>, <b>11<\/b>, 281\u2013292 (1985).","DOI":"10.1016\/0378-3782(85)90082-9"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Mihatsch WA, Muche R, Pohlandt F. The renal phosphate threshold decreases with increasing postmenstrual age in very low birth weight infants. <i>Pediatr. Res.<\/i>, <b>40<\/b>, 300\u2013303 (1996).","DOI":"10.1203\/00006450-199608000-00018"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) de Wildt SN, Kerkvliet KT, Wezenberg MG, Ottink S, Hop WC, Vulto AG, van Den Anker JN. Use of saliva in therapeutic drug monitoring of caffeine in preterm infants. <i>Ther. Drug Monit.<\/i>, <b>23<\/b>, 250\u2013254 (2001).","DOI":"10.1097\/00007691-200106000-00011"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/44\/1\/44_b20-00616\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T03:21:07Z","timestamp":1609557667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/44\/1\/44_b20-00616\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b20-00616","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,1]]}}}