{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:30:05Z","timestamp":1759541405715},"reference-count":26,"publisher":"Pharmaceutical Society of Japan","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological & Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2021,4,1]]},"DOI":"10.1248\/bpb.b20-00806","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T22:07:17Z","timestamp":1617228437000},"page":"522-527","source":"Crossref","is-referenced-by-count":5,"title":["Dietary Fructooligosaccharides Reduce Mercury Levels in the Brain of Mice Exposed to Methylmercury"],"prefix":"10.1248","volume":"44","author":[{"given":"Masaaki","family":"Nagano","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, National Institute for Minamata Disease"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatake","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, National Institute for Minamata Disease"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Tada","sequence":"additional","affiliation":[{"name":"Department of Environment and Public Health, National Institute for Minamata Disease"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Seko","sequence":"additional","affiliation":[{"name":"Mount Fuji Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","unstructured":"1) National Research Council (U.S.) Committee on the Toxicological Effects of Methylmercury. Toxicological Effects of Methylmercury.<\/i> National Academies Press (U.S.), Washington DC, pp. 1\u2013344 (2000)."},{"key":"2","unstructured":"2) Sakamoto M, Kakita A, Wakabayashi K, Takahashi H, Nakano A, Akagi H. Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: a study with consecutive and moderate dose exposure throughout gestation and lactation periods. Brain Res.<\/i>, 949<\/b>, 51\u201359 (2002)."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Norseth T, Clarkson TW. Intestinal transport of 203<\/sup>Hg-labeled methyl mercury chloride. Role of biotransformation in rats. Arch. Environ. Health<\/i>, 22<\/b>, 568\u2013577 (1971).","DOI":"10.1080\/00039896.1971.10665903"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Rowland IR, Davies MJ, Grasso P. Metabolism of methylmercuric chloride by gastro-intestinal flora of the rat. Xenobiotica<\/i>, 8<\/b>, 37\u201343 (1978).","DOI":"10.3109\/00498257809060381"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Ishihara N, Suzuki T. Biotransformation of methylmercury in vitro.<\/i> Tohoku J. Exp. Med.<\/i>, 120<\/b>, 361\u2013363 (1976).","DOI":"10.1620\/tjem.120.361"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Yasutake A, Hirayama K. Evaluation of methylmercury biotransformation using rat liver slices. Arch. Toxicol.<\/i>, 75<\/b>, 400\u2013406 (2001).","DOI":"10.1007\/s002040100256"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Nakamura I, Hosokawa K, Tamura H, Miura T. Reduced mercury excretion with feces in germfree mice after oral administration of methyl mercury chloride. Bull. Environ. Contam. Toxicol.<\/i>, 17<\/b>, 528\u2013533 (1977).","DOI":"10.1007\/BF01685974"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Seko Y, Miura T, Takahashi M. Reduced decomposition and faecal excretion of methyl mercury in caecum-resected mice. Acta Pharmacol. Toxicol. <\/i>(Copenh), 50<\/b>, 117\u2013120 (1982).","DOI":"10.1111\/j.1600-0773.1982.tb00952.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Seko Y, Takahashi M, Hasegawa T, Miura T. Intestinal absorption of mercury in vitro<\/i> from intestinal contents of methylmercury administered mice. J. Health Sci.<\/i>, 47<\/b>, 508\u2013511 (2001).","DOI":"10.1248\/jhs.47.508"},{"key":"10","unstructured":"10) Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J. Nutr.<\/i>, 125<\/b>, 1401\u20131412 (1995)."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Hidaka H, Tashiro Y, Eida T. Proliferation of bifidobacteria by oligosaccharides and their useful effect on human health. Bifidobacteria and Microflora<\/i>, 10<\/b>, 65\u201379 (1991).","DOI":"10.12938\/bifidus1982.10.1_65"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Jinno S, Nakamura Y, Nagata M, Takahashi T. 1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice. Biosci. Biotechnol. Biochem.<\/i>, 78<\/b>, 861\u2013866 (2014).","DOI":"10.1080\/09168451.2014.905179"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Chen HL, Fan YH, Chen ME, Chan Y. Unhydrolyzed and hydrolyzed Konjac glucomannans modulated cecal and fecal microflora in Balb\/c mice. Nutrition<\/i>, 21<\/b>, 1059\u20131064 (2005).","DOI":"10.1016\/j.nut.2005.02.008"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Yeh SL, Lin MS, Chen HL. Inhibitory effects of a soluble dietary fiber from Amorphophallus konjac<\/i> on cytotoxicity and DNA damage induced by fecal water in Caco-2 cells. Planta Med.<\/i>, 73<\/b>, 1384\u20131388 (2007).","DOI":"10.1055\/s-2007-990228"},{"key":"15","unstructured":"15) Nielsen JB, Andersen O. Methyl mercuric chloride toxicokinetics in mice. I: effects of strain, sex, route of administration and dose. Pharmacol. Toxicol.<\/i>, 68<\/b>, 201\u2013207 (1991)."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Rowland IR, Mallett AK, Flynn J, Hargreaves RJ. The effect of various dietary fibres on tissue concentration and chemical form of mercury after methylmercury exposure in mice. Arch. Toxicol.<\/i>, 59<\/b>, 94\u201398 (1986).","DOI":"10.1007\/BF00286730"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Uchikawa T, Yasutake A, Kumamoto Y, Maruyama I, Kumamoto S, Ando Y. The influence of Parachlorella beyerinckii<\/i> CK-5 on the absorption and excretion of methylmercury in mice. J. Toxicol. Sci.<\/i>, 35<\/b>, 101\u2013105 (2010).","DOI":"10.2131\/jts.35.101"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Yasutake A, Nagano M, Nakano A. Simple method for methylmercury estimation in biological samples using atomic absorption spectroscopy. J. Health Sci.<\/i>, 51<\/b>, 220\u2013223 (2005).","DOI":"10.1248\/jhs.51.220"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Hirayama K, Yasutake A. Effects of reactive oxygen modulators on in vivo<\/i> demethylation of methylmercury. J. Health Sci.<\/i>, 45<\/b>, 24\u201327 (1999).","DOI":"10.1248\/jhs.45.24"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Nakamura S, Kondo N, Yamaguchi Y, Hashiguchi M, Tanabe K, Ushiroda C, Kawahashi-Tokuhisa M, Yui K, Miyakoda M, Oku T. Daily feeding of fructooligosaccharide or glucomannan delays onset of senescence in SAMP8 mice. Gastroenterol. Res. Pract.<\/i>, 2014<\/b>, 303184 (2014).","DOI":"10.1155\/2014\/303184"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Liu TW, Cephas KD, Holscher HD, Kerr KR, Mangian HF, Tappenden KA, Swanson KS. Nondigestible fructans alter gastrointestinal barrier function, gene expression, histomorphology, and the microbiota profiles of diet-induced obese C57BL\/6J mice. J. Nutr.<\/i>, 146<\/b>, 949\u2013956 (2016).","DOI":"10.3945\/jn.115.227504"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Szklany K, Wopereis H, de Waard C, van Wageningen T, An R, van Limpt K, Knol J, Garssen J, Knippels LMJ, Belzer C, Kraneveld AD. Supplementation of dietary non-digestible oligosaccharides from birth onwards improve social and reduce anxiety-like behavior in male BALB\/c mice. Nutr. Neurosci.<\/i>, 23<\/b>, 896\u2013910 (2020).","DOI":"10.1080\/1028415X.2019.1576362"},{"key":"23","unstructured":"23) Hosono A. Immunomodulation by Bacteroides<\/i> species. Journal of Intestinal Microbiology.<\/i>, 27<\/b>, 203\u2013209 (2013)."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Nakanishi Y, Murashima K, Ohara H, Suzuki T, Hayashi H, Sakamoto M, Fukasawa T, Kubota H, Hosono A, Kono T, Kaminogawa S, Benno Y. Increase in terminal restriction fragments of Bacteroidetes<\/i>-derived 16S rRNA genes after administration of short-chain fructooligosaccharides. Appl. Environ. Microbiol.<\/i>, 72<\/b>, 6271\u20136276 (2006).","DOI":"10.1128\/AEM.00477-06"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Rowland IR. Factors affecting metabolic activity of the intestinal microflora. Drug Metab. Rev.<\/i>, 19<\/b>, 243\u2013261 (1988).","DOI":"10.3109\/03602538808994135"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Endo H, Tamura K, Fukasawa T, Kanegae M, Koga J. Comparison of fructooligosaccharide utilization by Lactobacillus<\/i> and Bacteroides<\/i> species. Biosci. Biotechnol. Biochem.<\/i>, 76<\/b>, 176\u2013179 (2012).","DOI":"10.1271\/bbb.110496"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/44\/4\/44_b20-00806\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T03:29:37Z","timestamp":1617420577000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/44\/4\/44_b20-00806\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b20-00806","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,1]]}}}