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An integrative view of the pathophysiological events leading to cisplatin nephrotoxicity. <i>Crit. Rev. Toxicol.<\/i>, <b>41<\/b>, 803\u2013821 (2011).","DOI":"10.3109\/10408444.2011.602662"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Eras J, Perazella MA. NSAIDs and the kidney revisited: are selective cyclooxygenase-2 inhibitors safe? <i>Am. J. Med. Sci.<\/i>, <b>321<\/b>, 181\u2013190 (2001).","DOI":"10.1097\/00000441-200103000-00005"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Ozkan G, Ulusoy S, Orem A, Alkanat M, Mungan S, Yulug E, Yucesan FB. How does colistin-induced nephropathy develop and can it be treated? <i>Antimicrob. Agents Chemother.<\/i>, <b>57<\/b>, 3463\u20133469 (2013).","DOI":"10.1128\/AAC.00343-13"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Pabla N, Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. <i>Kidney Int.<\/i>, <b>73<\/b>, 994\u20131007 (2008).","DOI":"10.1038\/sj.ki.5002786"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Dasari S, Tchounwou PB. Cisplatin in cancer therapy: molecular mechanisms of action. <i>Eur. J. Pharmacol.<\/i>, <b>740<\/b>, 364\u2013378 (2014).","DOI":"10.1016\/j.ejphar.2014.07.025"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Lebwohl D, Canetta R. Clinical development of platinum complexes in cancer therapy: an historical perspective and an update. <i>Eur. J. Cancer<\/i>, <b>34<\/b>, 1522\u20131534 (1998).","DOI":"10.1016\/S0959-8049(98)00224-X"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Tsang RY, Al-Fayea T, Au HJ. Cisplatin overdose: toxicities and management. <i>Drug Saf.<\/i>, <b>32<\/b>, 1109\u20131122 (2009).","DOI":"10.2165\/11316640-000000000-00000"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Aydinoz S, Uzun G, Cermik H, Atasoyu EM, Yildiz S, Karagoz B, Evrenkaya R. Effects of different doses of hyperbaric oxygen on cisplatin-induced nephrotoxicity. <i>Ren. Fail.<\/i>, <b>29<\/b>, 257\u2013263 (2007).","DOI":"10.1080\/08860220601166487"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Hatakeyama S, Shida T, Yamaguchi H. Risk factors for severe hyponatremia related to cisplatin: a retrospective case-control study. <i>Biol. Pharm. Bull.<\/i>, <b>42<\/b>, 1891\u20131897 (2019).","DOI":"10.1248\/bpb.b19-00477"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Ma ZN, Liu Z, Wang Z, Ren S, Tang S, Wang YP, Xiao SY, Chen C, Li W. Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing ROS-mediated activation of MAPK and NF-\u03baB signaling pathways. <i>Food Chem. Toxicol.<\/i>, <b>110<\/b>, 62\u201373 (2017).","DOI":"10.1016\/j.fct.2017.10.006"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Marullo R, Werner E, Degtyareva N, Moore B, Altavilla G, Ramalingam SS, Doetsch PW. Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions. <i>PLOS ONE<\/i>, <b>8<\/b>, e81162 (2013).","DOI":"10.1371\/journal.pone.0081162"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Cassidy H, Radford R, Slyne J, O\u2019Connell S, Slattery C, Ryan MP, McMorrow T. The role of MAPK in drug-induced kidney injury. <i>J. 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Toxicol.<\/i>, <b>25<\/b>, 374\u2013382 (2005).","DOI":"10.1002\/jat.1081"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Okur ME, Ayla S, Karadag AE, Cicek Polat D, Demirci S, Seckin I. Opuntia ficus indica fruits ameliorate cisplatin-induced nephrotoxicity in mice. <i>Biol. Pharm. Bull.<\/i>, <b>43<\/b>, 831\u2013838 (2020).","DOI":"10.1248\/bpb.b19-01044"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Soodvilai S, Meetam P, Siangjong L, Chokchaisiri R, Suksamrarn A, Soodvilai S. Germacrone reduces cisplatin-induced toxicity of renal proximal tubular cells <i>via<\/i> inhibition of organic cation transporter. <i>Biol. Pharm. Bull.<\/i>, <b>43<\/b>, 1693\u20131698 (2020).","DOI":"10.1248\/bpb.b20-00392"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Sultana S, Verma K, Khan R. Nephroprotective efficacy of chrysin against cisplatin-induced toxicity <i>via<\/i> attenuation of oxidative stress. <i>J. Pharm. 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Med.<\/i>, <b>2012<\/b>, 473637 (2012).","DOI":"10.1155\/2012\/473637"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Chahyadi A, Hartati R, Wirasutisna KR, Elfahmi. <i>Boesenbergia pandurata<\/i> Roxb., an Indonesian medicinal plant: phytochemistry, biological activity, plant biotechnology. <i>Procedia Chem.<\/i>, <b>13<\/b>, 13\u201337 (2014).","DOI":"10.1016\/j.proche.2014.12.003"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Kim D-Y, Kim M-S, Sa B-K, Kim M-B, Hwang J-K. <i>Boesenbergia pandurata<\/i> attenuates diet-induced obesity by activating AMP-activated protein kinase and regulating lipid metabolism. <i>Int. J. Mol. Sci.<\/i>, <b>13<\/b>, 994\u20131005 (2012).","DOI":"10.3390\/ijms13010994"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Tuchinda P, Reutrakul V, Claeson P, Pongprayoon U, Sematong T, Santisuk T, Taylor WC. 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Oxidant mechanisms in toxic acute renal failure. <i>Drug Metab. Rev.<\/i>, <b>31<\/b>, 971\u2013997 (1999).","DOI":"10.1081\/DMR-100101947"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Ciarimboli G, Deuster D, Knief A, Sperling M, Holtkamp M, Edemir B, Pavenst\u00e4dt H, Lanvers-Kaminsky C, am Zehnhoff-Dinnesen A, Schinkel AH, Koepsell H, J\u00fcrgens H, Schlatter E. Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions. <i>Am. J. Pathol.<\/i>, <b>176<\/b>, 1169\u20131180 (2010).","DOI":"10.2353\/ajpath.2010.090610"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Filipski KK, Mathijssen RH, Mikkelsen TS, Schinkel AH, Sparreboom A. Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity. <i>Clin. Pharmacol. Ther.<\/i>, <b>86<\/b>, 396\u2013402 (2009).","DOI":"10.1038\/clpt.2009.139"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Kim D, Lee MS, Jo K, Lee KE, Hwang JK. Therapeutic potential of panduratin A, LKB1-dependent AMP-activated protein kinase stimulator, with activation of PPAR\u03b1\/\u03b4 for the treatment of obesity. <i>Diabetes Obes. Metab.<\/i>, <b>13<\/b>, 584\u2013593 (2011).","DOI":"10.1111\/j.1463-1326.2011.01379.x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Kim MS, Pyun HB, Hwang JK. Panduratin A, an activator of PPAR-\u03b1\/\u03b4, suppresses the development of oxazolone-induced atopic dermatitis-like symptoms in hairless mice. <i>Life Sci.<\/i>, <b>100<\/b>, 45\u201354 (2014).","DOI":"10.1016\/j.lfs.2014.01.076"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Lai SL, Mustafa MR, Wong PF. Panduratin A induces protective autophagy in melanoma <i>via<\/i> the AMPK and mTOR pathway. <i>Phytomedicine<\/i>, <b>42<\/b>, 144\u2013151 (2018).","DOI":"10.1016\/j.phymed.2018.03.027"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Mishra J, Mori K, Ma Q, Kelly C, Barasch J, Devarajan P. Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. <i>Am. J. Nephrol.<\/i>, <b>24<\/b>, 307\u2013315 (2004).","DOI":"10.1159\/000078452"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Kim H, Kim MB, Kim C, Hwang JK. Inhibitory effects of panduratin A on periodontitis-induced inflammation and osteoclastogenesis through inhibition of MAPK pathways <i>in vitro.<\/i> <i>J. Microbiol. Biotechnol.<\/i>, <b>28<\/b>, 190\u2013198 (2018).","DOI":"10.4014\/jmb.1707.07042"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Yun J-M, Kwon H, Hwang J-K. <i>In vitro<\/i> anti-inflammatory activity of panduratin A isolated from kaempferia pandurata in RAW264.7 cells. <i>Planta Med.<\/i>, <b>69<\/b>, 1102\u20131108 (2003).","DOI":"10.1055\/s-2003-45190"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Aschauer L, Carta G, Vogelsang N, Schlatter E, Jennings P. Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC\/TERT1. <i>Toxicol. In Vitro<\/i>, <b>30<\/b> (1 Pt. A), 95\u2013105 (2015).","DOI":"10.1016\/j.tiv.2014.12.003"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Ma FY, Liu J, Nikolic-Paterson DJ. The role of stress-activated protein kinase signaling in renal pathophysiology. <i>Braz. J. Med. Biol. Res.<\/i>, <b>42<\/b>, 29\u201337 (2009).","DOI":"10.1590\/S0100-879X2008005000049"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Nowak G. Protein kinase C-\u03b1 and ERK1\/2 mediate mitochondrial dysfunction, decreases in active Na transport, and cisplatin-induced apoptosis in renal cells. <i>J. Biol. Chem.<\/i>, <b>277<\/b>, 43377\u201343388 (2002).","DOI":"10.1074\/jbc.M206373200"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Oh GS, Kim HJ, Choi JH, Shen A, Choe SK, Karna A, Lee SH, Jo HJ, Yang SH, Kwak TH, Lee CH, Park R, So HS. Pharmacological activation of NQO1 increases NAD<sup>+<\/sup> levels and attenuates cisplatin-mediated acute kidney injury in mice. <i>Kidney Int.<\/i>, <b>85<\/b>, 547\u2013560 (2014).","DOI":"10.1038\/ki.2013.330"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Sohn JH, Han K-L, Lee S-H, Hwang J-K. Protective effects of panduratin A against oxidative damage of <i>tert<\/i>-butylhydroperoxide in human HepG2 cells. <i>Biol. Pharm. Bull.<\/i>, <b>28<\/b>, 1083\u20131086 (2005).","DOI":"10.1248\/bpb.28.1083"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Harrach S, Ciarimboli G. Role of transporters in the distribution of platinum-based drugs. <i>Front. Pharmacol.<\/i>, <b>6<\/b>, 85 (2015).","DOI":"10.3389\/fphar.2015.00085"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Katsuda H, Yamashita M, Katsura H, Yu J, Waki Y, Nagata N, Sai Y, Miyamoto K. Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity. <i>Biol. Pharm. 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