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Dermatol.<\/i>, 29<\/b>, 621\u2013627 (2002).","DOI":"10.1111\/j.1346-8138.2002.tb00191.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Park TH, Park CH, Ha SK, Lee SH, Song KS, Lee HY, Han DS. Dry skin (xerosis) in patients undergoing maintenance haemodialysis: the role of decreased sweating oh the eccrine sweat gland. Nephrol. Dial. Transplant.<\/i>, 10<\/b>, 2269\u20132273 (1995).","DOI":"10.1093\/ndt\/10.12.2269"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Kano T, Nakamura M, Hashiguchi A, Sadanaga M, Morioka T, Mishima M, Nakano M. Skin pretreatments for shortening onset of dermal patch anesthesia with 3% GA MHPh 2 Na\u201310% lidocaine gel mixture. Anesth. Analg.<\/i>, 75<\/b>, 555\u2013557 (1992).","DOI":"10.1213\/00000539-199210000-00015"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Wallace MS, Ridgeway B, Jun E, Schulteis G, Rabussay D, Zhang L. Topical delivery of lidocaine in healthy volunteers by electroporation, electroincorporation, or iontophoresis: an evaluation of skin anesthesia. Reg. Anesth. Pain Med.<\/i>, 26<\/b>, 229\u2013238 (2001).","DOI":"10.1097\/00115550-200105000-00006"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Tachibana K, Tachibana S. Use of ultrasound to enhance the local anesthetic effect of topically applied aqueous lidocaine. Anesthesiology<\/i>, 78<\/b>, 1091\u20131096 (1993).","DOI":"10.1097\/00000542-199306000-00011"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Zempsky WT, Sullivan J, Paulson DM, Hoath SB. Evaluation of a low-dose lidocaine iontophoresis system for topical anesthesia in adults and children: a randomized, controlled trial. Clin. Ther.<\/i>, 26<\/b>, 1110\u20131119 (2004).","DOI":"10.1016\/S0149-2918(04)90183-X"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Dick IP, Scott RC. Pig ear skin as an in vitro<\/i> model for human skin permeability. J. Pharm. Pharmacol.<\/i>, 44<\/b>, 640\u2013645 (1992).","DOI":"10.1111\/j.2042-7158.1992.tb05485.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Bj\u00f6rklund S, Engblom J, Thuresson K, Sparr E. Glycerol and urea can be used to increase skin permeability in reduced hydration condition. Eur. J. Pharm. Sci.<\/i>, 50<\/b>, 638\u2013645 (2013).","DOI":"10.1016\/j.ejps.2013.04.022"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Maillard-Salin DG, B\u00e9court P, Couarraze G. A study of the adhesive-skin interface: correlation between adhesion and passage of a drug. Int. J. Pharm.<\/i>, 200<\/b>, 121\u2013126 (2000).","DOI":"10.1016\/S0378-5173(00)00369-0"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Takai Y, Hiramoto K, Nishimura Y, Ooi K. Sex differences of the inflammatory mediator level at the time of itch onset in patients with chronic venous disease. Yakugaku Zasshi<\/i>, 138<\/b>, 91\u201396 (2018).","DOI":"10.1248\/yakushi.17-00160"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Bartholomew JR, King T, Sahgal A, Vidimos AT. Varicose veins: newer, better treatments available. Cleve. Clin. J. Med.<\/i>, 72<\/b>, 312\u2013314, 319\u2013321, 325\u2013328 (2005).","DOI":"10.3949\/ccjm.72.4.312"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Beebe-Dimmer JL, Pfeifer JR, Engle JS, Schottenfeld D. The epidemiology of chronic venous insufficiency and varicose veins. Ann. Epidemiol.<\/i>, 15<\/b>, 175\u2013184 (2005).","DOI":"10.1016\/j.annepidem.2004.05.015"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Bergan JJ, Schmid-Schonbein GW, Smith PDC, Nicolaides AN, Boisseau MR, Eklof B. Mechanisms of disease: chronic venous disease. N. Engl. J. Med.<\/i>, 355<\/b>, 488\u2013498 (2006).","DOI":"10.1056\/NEJMra055289"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Bradbury A, Evans C, Allan P, Lee A, Ruckley CV, Fowkes FG. What are the symptoms of varicose veins? Edinburgh vein study cross sectional population survey. BMJ<\/i>, 318<\/b>, 353\u2013356 (1999).","DOI":"10.1136\/bmj.318.7180.353"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Kinet JP. The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology. Annu. Rev. Immunol.<\/i>, 17<\/b>, 931\u2013972 (1999).","DOI":"10.1146\/annurev.immunol.17.1.931"},{"key":"26","unstructured":"26) Snyder RJ. Venous leg ulcers in the elderly patient: associated stress, social support, and coping. Ostomy Wound Manage.<\/i>, 52<\/b>, 58\u201366, 68 (2006)."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Solomon S. POMC-derived peptides and their biological action. Ann. N. Y. Acad. 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Immunol.<\/i>, 3<\/b>, 169 (2012).","DOI":"10.3389\/fimmu.2012.00169"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Okuyama K, Hamanaka Y, Kawano T, Ohkawara Y, Takayanagi M, Kikuchi T, Ohno I. T cell subsets related with a sex difference in IL-5 production. Int. Arch. Allergy Immunol.<\/i>, 155<\/b> (Suppl. 1), 21\u201326 (2011).","DOI":"10.1159\/000327261"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Okuyama K, Kashimura T, Kawano T, Ohkawara Y, Takayanagi M, Kikuchi T, Ohno I. Higher sensitivity of male CD4+ T cells to suppressive effects of CD8+ T cells on IL-5 production compared to female CD4+ T cells. Int. Arch. Allergy Immunol.<\/i>, 158<\/b> (Suppl. 1), 35\u201341 (2012).","DOI":"10.1159\/000337759"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Verma-Gandhu M, Verdu EF, Bercik P, Blennerhassett PA, Al-Mutawaly N, Ghia JE, Collins SM. 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Photobiol.<\/i>, 92<\/b>, 728\u2013734 (2016).","DOI":"10.1111\/php.12620"},{"key":"36","unstructured":"36) Higurashi K, Iizuka N, Yoshimura H, Tanaka T, Nomoto S. Evaluation of colorimeteric method for zinc, using clinical chemistry analyzer. Biomedical Research on Trace Elements<\/i>, 18<\/b>, 380\u2013385 (2007)."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Ogawa Y, Kawamura T, Shimada S. Zinc and skin biology. Arch. Biochem. Biophys.<\/i>, 611<\/b>, 113\u2013119 (2016).","DOI":"10.1016\/j.abb.2016.06.003"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Chvapil M. Effect of zinc on cells and biomembranes. Med. Clin. North Am.<\/i>, 60<\/b>, 799\u2013812 (1976).","DOI":"10.1016\/S0025-7125(16)31862-4"},{"key":"39","unstructured":"39) The Japanese Society of Clinical Nutrition. \u201cPractice guideline for zinc deficiency.\u201d: \u2039http:\/\/jscn.gr.jp\/pdf\/aen2018.pdf\u203a, accessed 8 September, 2019."},{"key":"40","unstructured":"40) Okada R, Matukawa K, Kobayashi T, Miyakoshi Y. Seasonal changes in water content of the forearm skin (stratum corneum). Jpn. J. Biometeor.<\/i>, 52<\/b>, 131\u2013137 (2015)."},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Deguchi M, Jose H, Nishida K, Ooi K. Transepidermal water loss (TEWL)-decreasing effect by administration of zinc in the elderly people. Yakugaku Zasshi<\/i>, 140<\/b>, 313\u2013318 (2020).","DOI":"10.1248\/yakushi.19-00198"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Murakami Y, Nagae H, Maehori N, Sekijima H, Ooi K. 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