{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:43:03Z","timestamp":1790109783673,"version":"4.0.1"},"reference-count":55,"publisher":"Pharmaceutical Society of Japan","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2021,8,1]]},"DOI":"10.1248\/bpb.b21-00178","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T22:10:51Z","timestamp":1623708651000},"page":"1067-1074","source":"Crossref","is-referenced-by-count":10,"title":["Acetaminophen Exerts an Analgesic Effect on Muscular Hyperalgesia in Repeated Cold-Stressed Rats through the Enhancement of the Descending Pain Inhibitory System Involving Spinal 5-HT&lt;sub&gt;3&lt;\/sub&gt; and Noradrenergic \u03b1&lt;sub&gt;2&lt;\/sub&gt; Receptors"],"prefix":"10.1248","volume":"44","author":[{"given":"Chiharu","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Self-Medication R&D Laboratories, Taisho Pharmaceutical Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Self-Medication R&D Laboratories, Taisho Pharmaceutical Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Fujimaru","sequence":"additional","affiliation":[{"name":"Self-Medication R&D Laboratories, Taisho Pharmaceutical Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Asano","sequence":"additional","affiliation":[{"name":"Self-Medication R&D Laboratories, Taisho Pharmaceutical Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Takaoka","sequence":"additional","affiliation":[{"name":"Self-Medication R&D Laboratories, Taisho Pharmaceutical Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Parihar JK, Jain VK, Chaturvedi P, Kaushik J, Jain G, Parihar AK. Computer and visual display terminals (VDT) vision syndrome (CVDTS). <i>Med. J. Armed Forces India<\/i>, <b>72<\/b>, 270\u2013276 (2016).","DOI":"10.1016\/j.mjafi.2016.03.016"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Visser B, van Die\u00ebn JH. Pathophysiology of upper extremity muscle disorders. <i>J. Electromyogr. Kinesiol.<\/i>, <b>16<\/b>, 1\u201316 (2006).","DOI":"10.1016\/j.jelekin.2005.06.005"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Larsson SE, Larsson R, Zhang Q, Cai H, \u00d6berg P\u00c5. Effects of psychophysiological stress on trapezius muscles blood flow and electromyography during static load. <i>Eur. J. Appl. Physiol. Occup. Physiol.<\/i>, <b>71<\/b>, 493\u2013498 (1995).","DOI":"10.1007\/BF00238550"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Maekawa K, Clark GT, Kuboki T. Intramuscular hypoperfusion, adrenergic receptors, and chronic muscle pain. <i>J. Pain<\/i>, <b>3<\/b>, 251\u2013260 (2002).","DOI":"10.1054\/jpai.2002.125923"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. <i>Nat. New Biol.<\/i>, <b>231<\/b>, 232\u2013235 (1971).","DOI":"10.1038\/newbio231232a0"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Ghanem CI, P\u00e9rez MJ, Manautou JE, Mottino AD. Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity. <i>Pharmacol. Res.<\/i>, <b>109<\/b>, 119\u2013131 (2016).","DOI":"10.1016\/j.phrs.2016.02.020"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Flower RJ, Vane JR. Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). <i>Nature<\/i>, <b>240<\/b>, 410\u2013411 (1972).","DOI":"10.1038\/240410a0"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Ossipov MH, Dussor GO, Porreca F. Central modulation of pain. <i>J. Clin. Invest.<\/i>, <b>120<\/b>, 3779\u20133787 (2010).","DOI":"10.1172\/JCI43766"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Yoshimura M, Furue H. Mechanisms for the anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cord. <i>J. Pharmacol. Sci.<\/i>, <b>101<\/b>, 107\u2013117 (2006).","DOI":"10.1254\/jphs.CRJ06008X"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Tj\u00f8lsen A, Lund A, Hole K. Antinociceptive effect of paracetamol in rats is partly dependent on spinal serotonergic systems. <i>Eur. J. Pharmacol.<\/i>, <b>193<\/b>, 193\u2013201 (1991).","DOI":"10.1016\/0014-2999(91)90036-P"},{"key":"11","unstructured":"11) Pelissier T, Alloui A, Caussade F, Dubray C, Cloarec A, Lavarenne J, Eschalier A. Paracetamol exerts a spinal antinociceptive effect involving an indirect interaction with 5-hydroxytryptamine<sub>3<\/sub> receptors: <i>in vivo<\/i> and <i>in vitro<\/i> evidence. <i>J. Pharmacol. Exp. Ther.<\/i>, <b>278<\/b>, 8\u201314 (1996)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Ohara H, Kawamura M, Namimatsu A, Miura T, Yoneda R, Hata T. Mechanism of hyperalgesia in SART stressed (repeated cold stress) mice: antinociceptive effect of neurotropin. <i>Jpn. J. Pharmacol.<\/i>, <b>57<\/b>, 243\u2013250 (1991).","DOI":"10.1254\/jjp.57.243"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Okai H, Okazaki R, Yoshida H, Namba H, Taguchi K, Yamamoto A, Miura T, Kawamura M. Antinoiceptive effects of Neurotropin in repeated cold stressed rats: influences of chemical denervation of monoaminergic descending inhibitory neurons. <i>PAIN RESEARCH<\/i>, <b>25<\/b>, 179\u2013188 (2010).","DOI":"10.11154\/pain.25.179"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Nasu T, Taguchi T, Mizumura K. Persistent deep mechanical hyperalgesia induced by repeated cold stress in rats. <i>Eur. J. Pain<\/i>, <b>14<\/b>, 236\u2013244 (2010).","DOI":"10.1016\/j.ejpain.2009.05.009"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Kita T, Hata T, Yoneda R, Okage T. Stress state caused by alteration of rhythms in environmental temperature, and the functional changes in mice and rats. <i>Nihon Yakurigaku Zasshi<\/i>, <b>71<\/b>, 195\u2013210 (1975).","DOI":"10.1254\/fpj.71.195"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Wakatsuki K, T-Uchimura Y, Matsubara T, Nasu T, Mizumura K, Taguchi T. Peripheral nociceptive mechanisms in an experimental rat model of fibromyalgia induced by repeated cold stress. <i>Neurosci. Res.<\/i>, <b>162<\/b>, 22\u201330 (2021).","DOI":"10.1016\/j.neures.2019.12.015"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Kawamura M, Ohara H, Go K, Koga Y, Ienaga K. Neurotropin induces antinociceptive effect by enhancing descending pain inhibitory systems involving 5-HT<sub>3<\/sub> and noradrenergic \u03b1<sub>2<\/sub> receptors in spinal dorsal horn. <i>Life Sci.<\/i>, <b>62<\/b>, 2181\u20132190 (1998).","DOI":"10.1016\/S0024-3205(98)00195-7"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Bansevicius D, Westgaard RH, Jensen C. Mental stress of long duration: EMG activity, perceived tension, fatigue, and pain development in pain-free subjects. <i>Headache<\/i>, <b>37<\/b>, 499\u2013510 (1997).","DOI":"10.1046\/j.1526-4610.1997.3708499.x"},{"key":"19","unstructured":"19) Ito G, Fujimori H, Fujimaru Y, Yamamoto D, Hanawa T. The effects and clinical benefits of Chikenpaikokyuho on shoulder and back pain. <i>Jpn. J. Med. Pharm. Sci.<\/i>, <b>69<\/b>, 499\u2013508 (2013)."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Bianchi M, Martucci C, Ferrario P, Franchi S, Sacerdote P. Increased tumor necrosis factor-\u03b1 and prostaglandin E<sub>2<\/sub> concentrations in the cerebrospinal fluid of rats with inflammatory hyperalgesia: the effects of analgesic drugs. <i>Anesth. Analg.<\/i>, <b>104<\/b>, 949\u2013954 (2007).","DOI":"10.1213\/01.ane.0000258060.89380.27"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Li T, Wang T, Wang L, Liu R, Zhang L, Zhai R, Fu F. Antinociceptive effects of rotigotine-loaded microspheres and its synergistic interactions with analgesics in inflammatory pain in rats. <i>Eur. J. Pharmacol.<\/i>, <b>891<\/b>, 173693 (2021).","DOI":"10.1016\/j.ejphar.2020.173693"},{"key":"22","unstructured":"22) Adams SS, McCullough KF, Nicholson JS. The pharmacological properties of ibuprofen, an anti-inflammatory, analgesic and antipyretic agent. <i>Arch. Int. Pharmacodyn. Ther.<\/i>, <b>178<\/b>, 115\u2013129 (1969)."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Craft RM, Hewitt KA, Britch SC. Antinociception produced by nonsteroidal anti-inflammatory drugs in female <i>vs.<\/i> male rats. <i>Behav. Pharmacol.<\/i>, <b>32<\/b>, 153\u2013169 (2021).","DOI":"10.1097\/FBP.0000000000000584"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Kaur S, Bijjem KR, Sharma PL. Anti-inflammatory and antihyperalgesic effects of the combination of ibuprofen and hemin in adjuvant-induced arthritis in the Wistar rat. <i>Inflammopharmacology<\/i>, <b>19<\/b>, 265\u2013272 (2011).","DOI":"10.1007\/s10787-011-0090-8"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Kalra BS, Shalini, Chaturvedi S, Tayal V, Gupta U. Evaluation of gastric tolerability, antinociceptive and antiinflammatory activity of combination NSAIDs in rats. <i>Indian J. Dent. Res.<\/i>, <b>20<\/b>, 418\u2013422 (2009).","DOI":"10.4103\/0970-9290.59439"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Yamaura K, Shimada M, Nakayama N, Ueno K. Protective effects of goldenseal (<i>Hydrastis canadensis<\/i> L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in rats. <i>Pharmacognosy Res.<\/i>, <b>3<\/b>, 250\u2013255 (2011).","DOI":"10.4103\/0974-8490.89745"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Aprioku J, Nwidu LL, Amadi CN. Evaluation of toxicological profile of ibuprofen in Wistar Albino rats. <i>Am. J. Biomed. Sci.<\/i>, <b>6<\/b>, 32\u201340 (2014).","DOI":"10.5099\/aj140100032"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) H\u00f6gest\u00e4tt ED, J\u00f6nsson BA, Ermund A, Andersson DA, Bj\u00f6rk H, Alexander JP, Cravatt BF, Basbaum AI, Zygmunt PM. Conversion of acetaminophen to the bioactive <i>N<\/i>-acylphenolamine AM404 <i>via<\/i> fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. <i>J. Biol. Chem.<\/i>, <b>280<\/b>, 31405\u201331412 (2005).","DOI":"10.1074\/jbc.M501489200"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Mallet C, Barri\u00e8re DA, Ermund A, J\u00f6nsson BA, Eschalier A, Zygmunt PM, H\u00f6gest\u00e4tt ED. TRPV1 in brain is involved in acetaminophen-induced antinociception. <i>PLoS ONE<\/i>, <b>5<\/b>, e12748 (2010).","DOI":"10.1371\/journal.pone.0012748"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Klinger-Gratz PP, Ralvenius WT, Neumann E, Kato A, Nyilas R, Lele Z, Katona I, Zeilhofer HU. Acetaminophen relieves inflammatory pain through CB<sub>1<\/sub> cannabinoid receptors in the rostral ventromedial medulla. <i>J. Neurosci.<\/i>, <b>38<\/b>, 322\u2013334 (2018).","DOI":"10.1523\/JNEUROSCI.1945-17.2017"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Alloui A, Chassaing C, Schmidt J, Ardid D, Dubray C, Cloarec A, Eschalier A. Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats. <i>Eur. J. Pharmacol.<\/i>, <b>443<\/b>, 71\u201377 (2002).","DOI":"10.1016\/S0014-2999(02)01578-9"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Kia HK, Miquel MC, McKernan RM, Laporte AM, Lombard MC, Bourgoin S, Hamon M, Verg\u00e9 D. Localization of 5-HT<sub>3<\/sub> receptors in the rat spinal cord: immunohistochemistry and <i>in situ<\/i> hybridization. <i>Neuroreport<\/i>, <b>6<\/b>, 257\u2013261 (1995).","DOI":"10.1097\/00001756-199501000-00008"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Laporte AM, Koscielniak T, Ponchant M, Verg\u00e9 D, Hamon M, Gozlan H. Quantitative autoradiographic mapping of 5-HT<sub>3<\/sub> receptors in the rat CNS using [<sup>125<\/sup>I]iodo-zacopride and [<sup>3<\/sup>H]zacopride as radioligands. <i>Synapse<\/i>, <b>10<\/b>, 271\u2013281 (1992).","DOI":"10.1002\/syn.890100402"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Alhaider AA, Lei SZ, Wilcox GL. Spinal 5-HT<sub>3<\/sub> receptor-mediated antinociception: possible release of GABA. <i>J. Neurosci.<\/i>, <b>11<\/b>, 1881\u20131888 (1991).","DOI":"10.1523\/JNEUROSCI.11-07-01881.1991"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Kawamata T, Omote K, Toriyabe M, Yamamoto H, Namiki A. The activation of 5-HT<sub>3<\/sub> receptors evokes GABA release in the spinal cord. <i>Brain Res.<\/i>, <b>978<\/b>, 250\u2013255 (2003).","DOI":"10.1016\/S0006-8993(03)02952-4"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Fukushima T, Ohtsubo T, Tsuda M, Yanagawa Y, Hori Y. Facilitatory actions of serotonin type 3 receptors on GABAergic inhibitory synaptic transmission in the spinal superficial dorsal horn. <i>J. Neurophysiol.<\/i>, <b>102<\/b>, 1459\u20131471 (2009).","DOI":"10.1152\/jn.91160.2008"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Mendiguren A, Pineda J. Cannabinoids enhance <i>N<\/i>-methyl-D-aspartate-induced excitation of locus coeruleus neurons by CB<sub>1<\/sub> receptors in rat brain slices. <i>Neurosci. Lett.<\/i>, <b>363<\/b>, 1\u20135 (2004).","DOI":"10.1016\/j.neulet.2004.02.073"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Stone LS, Broberger C, Vulchanova L, Wilcox GL, H\u00f6kfelt T, Riedl MS, Elde R. Differential distribution of \u03b1<sub>2A<\/sub> and \u03b1<sub>2C<\/sub> adrenergic receptor immunoreactivity in the rat spinal cord. <i>J. Neurosci.<\/i>, <b>18<\/b>, 5928\u20135937 (1998).","DOI":"10.1523\/JNEUROSCI.18-15-05928.1998"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Ueda M, Oyama T, Kuraishi Y, Akaike A, Satoh M. Alpha2-adrenoceptor-mediated inhibition of capsaicin-evoked release of glutamate from rat spinal dorsal horn slices. <i>Neurosci. Lett.<\/i>, <b>188<\/b>, 137\u2013139 (1995).","DOI":"10.1016\/0304-3940(95)11397-F"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Kawasaki Y, Kumamoto E, Furue H, Yoshimura M. \u03b1<sub>2<\/sub> adrenoceptor-mediated presynaptic inhibition of primary afferent glutamatergic transmission in rat substantia gelatinosa neurons. <i>Anesthesiology<\/i>, <b>98<\/b>, 682\u2013689 (2003).","DOI":"10.1097\/00000542-200303000-00016"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Okano K, Ueda M, Kuraishi Y, Satoh M. Effect of repeated cold stress on capsaicin-evoked release of glutamate from rat spinal dorsal horn slices. <i>Neurosci. Res.<\/i>, <b>29<\/b>, 319\u2013324 (1997).","DOI":"10.1016\/S0168-0102(97)00101-6"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Okano K, Kuraishi Y, Satoh M. Effects of intrathecally injected glutamate and substance P antagonists on repeated cold stress-induced hyperalgesia in rats. <i>Biol. Pharm. Bull.<\/i>, <b>18<\/b>, 42\u201344 (1995).","DOI":"10.1248\/bpb.18.42"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Danysz W, Jonsson G, Minor BG, Post C, Archer T. Spinal and locus coeruleus noradrenergic lesions abolish the analgesic effects of 5-methoxy-<i>N,N<\/i>-dimethyltryptamine. <i>Behav. Neural Biol.<\/i>, <b>46<\/b>, 71\u201386 (1986).","DOI":"10.1016\/S0163-1047(86)90916-7"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Nakagawa I, Omote K, Kitahata LM, Collins JG, Murata K. Serotonergic mediation of spinal analgesia and its interaction with noradrenergic systems. <i>Anesthesiology<\/i>, <b>73<\/b>, 474\u2013478 (1990).","DOI":"10.1097\/00000542-199009000-00017"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Holden JE, Proudfit HK. Enkephalin neurons that project to the A7 catecholamine cell group are located in nuclei that modulate nociception: ventromedial medulla. <i>Neuroscience<\/i>, <b>83<\/b>, 929\u2013947 (1998).","DOI":"10.1016\/S0306-4522(97)00437-5"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Yeomans DC, Proudfit HK. Projections of substance P-immunoreactive neurons located in the ventromedial medulla to the A7 noradrenergic nucleus of the rat demonstrated using retrograde tracing combined with immunocytochemistry. <i>Brain Res.<\/i>, <b>532<\/b>, 329\u2013332 (1990).","DOI":"10.1016\/0006-8993(90)91777-E"},{"key":"47","unstructured":"47) Cui M, Feng Y, McAdoo DJ, Willis WD. Periaqueductal gray stimulation-induced inhibition of nociceptive dorsal horn neurons in rats is associated with the release of norepinephrine, serotonin, and amino acids. <i>J. Pharmacol. Exp. Ther.<\/i>, <b>289<\/b>, 868\u2013876 (1999)."},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Barbaro NM, Hammond DL, Fields HL. Effects of intrathecally administered methysergide and yohimbine on microstimulation-produced antinociception in the rat. <i>Brain Res.<\/i>, <b>343<\/b>, 223\u2013229 (1985).","DOI":"10.1016\/0006-8993(85)90738-3"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Olave MJ, Maxwell DJ. Neurokinin-1 projection cells in the rat dorsal horn receive synaptic contacts from axons that possess \u03b1<sub>2C<\/sub>-adrenergic receptors. <i>J. Neurosci.<\/i>, <b>23<\/b>, 6837\u20136846 (2003).","DOI":"10.1523\/JNEUROSCI.23-17-06837.2003"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Veli\u00e7a P, Bunce CM. Prostaglandins in muscle regeneration. <i>J. Muscle Res. Cell Motil.<\/i>, <b>29<\/b>, 163\u2013167 (2008).","DOI":"10.1007\/s10974-008-9154-9"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Monda M, Vicidomini C, Viggiano A, Sampaolo S, Di Iorio G, Viggiano A, Viggiano E, De Luca B. Inhibition of prostaglandin synthesis reduces the induction of MyoD expression in rat soleus muscle. <i>J. Muscle Res. Cell Motil.<\/i>, <b>30<\/b>, 139\u2013144 (2009).","DOI":"10.1007\/s10974-009-9182-0"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Larsson R, Oberg PA, Larsson SE. Changes of trapezius muscle blood flow and electromyography in chronic neck pain due to trapezius myalgia. <i>Pain<\/i>, <b>79<\/b>, 45\u201350 (1999).","DOI":"10.1016\/S0304-3959(98)00144-4"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Fern\u00e1ndez-de-Las-Pe\u00f1as C, Alonso-Blanco C, Cuadrado ML, Gerwin RD, Pareja JA. Myofascial trigger points and their relationship to headache clinical parameters in chronic tension-type headache. <i>Headache<\/i>, <b>46<\/b>, 1264\u20131272 (2006).","DOI":"10.1111\/j.1526-4610.2006.00440.x"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Jensen R, Rasmussen BK, Pedersen B, Olesen J. Muscle tenderness and pressure pain thresholds in headache. A population study. <i>Pain<\/i>, <b>52<\/b>, 193\u2013199 (1993).","DOI":"10.1016\/0304-3959(93)90131-8"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Bendtsen L, Jensen R. Treating tension-type headache\u2014an expert opinion. <i>Expert Opin. Pharmacother.<\/i>, <b>12<\/b>, 1099\u20131109 (2011).","DOI":"10.1517\/14656566.2011.548806"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/44\/8\/44_b21-00178\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T04:12:10Z","timestamp":1628309530000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/44\/8\/44_b21-00178\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,1]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b21-00178","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,1]]},"article-number":"b21-00178"}}