{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:03:23Z","timestamp":1789128203741,"version":"build-2803163510"},"reference-count":33,"publisher":"Pharmaceutical Society of Japan","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological & Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2021,12,1]]},"DOI":"10.1248\/bpb.b21-00508","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T22:07:50Z","timestamp":1633471670000},"page":"1837-1842","source":"Crossref","is-referenced-by-count":6,"title":["The Ethyl Acetate Subfraction of <i>Polygonum cuspidatum<\/i> Root Containing Emodin Affect EBV Gene Expression and Induce EBV-Positive Cells Apoptosis"],"prefix":"10.1248","volume":"44","author":[{"given":"Ching-Yi","family":"Yiu","sequence":"first","affiliation":[{"name":"Department of Health and Nutrition, Chia-Nan University of Pharmacy and Science"},{"name":"Department of Otolaryngology, Chi Mei Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jhe","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Health and Nutrition, Chia-Nan University of Pharmacy and Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuey-Pin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Health and Nutrition, Chia-Nan University of Pharmacy and Science"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Roizman B, Carmichael LE, Deinhardt F, de-The G, Nahmias AJ, Plowright W, Rapp F, Sheldrick P, Takahashi M, Wolf K. Herpesviridae. Definition, provisional nomenclature, and taxonomy. Intervirology<\/i>, 16<\/b>, 201\u2013217 (1981).","DOI":"10.1159\/000149269"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Niedobitek G, Hamilton-Dutoit S, Herbst H, Finn T, Vetner M, Pallesen G, Stein H. Identification of Epstein-Barr virus-infected cells in tonsils of acute infectious mononucleosis by in situ<\/i> hybridization. Hum. Pathol.<\/i>, 20<\/b>, 796\u2013799 (1989).","DOI":"10.1016\/0046-8177(89)90075-0"},{"key":"3","unstructured":"3) Magrath I, Jain V, Bhatia K. Epstein-Barr virus and Burkitt\u2019s lymphoma. Semin. Cancer Biol.<\/i>, 3<\/b>, 285\u2013295 (1992)."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Jones JF, Shurin S, Abramowsky C, Tubbs RR, Sciotto CG, Wahl R, Sands J, Gottman D, Katz BZ, Sklar J. T-cell lymphomas containing Epstein-Barr viral DNA in patients with chronic Epstein-Barr virus infections. N. Engl. J. Med.<\/i>, 318<\/b>, 733\u2013741 (1988).","DOI":"10.1056\/NEJM198803243181203"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Weiss LM, Movahed LA, Warnke RA, Sklar J. Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin\u2019s disease. N. Engl. J. Med.<\/i>, 320<\/b>, 502\u2013506 (1989).","DOI":"10.1056\/NEJM198902233200806"},{"key":"6","unstructured":"6) Shibata D, Weiss LM. Epstein-Barr virus-associated gastric adenocarcinoma. Am. J. Pathol.<\/i>, 140<\/b>, 769\u2013774 (1992)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) zur Hausen H, Schulte-Holthausen H, Klein G, Henle W, Henle G, Clifford P, Santesson L. EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx. Nature<\/i>, 228<\/b>, 1056\u20131058 (1970).","DOI":"10.1038\/2281056a0"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Lindahl T, Adams A, Bjursell G, Bornkamm GW, Kaschka-Dierich C, Jehn U. Covalently closed circular duplex DNA of Epstein-Barr virus in a human lymphoid cell line. J. Mol. Biol.<\/i>, 102<\/b>, 511\u2013530 (1976).","DOI":"10.1016\/0022-2836(76)90331-4"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Miller G. The switch between latency and replication of Epstein-Barr virus. J. Infect. Dis.<\/i>, 161<\/b>, 833\u2013844 (1990).","DOI":"10.1093\/infdis\/161.5.833"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) zur Hausen H, O\u2019Neill FJ, Freese UK, Hecker E. Persisting oncogenic herpesvirus induced by the tumour promotor TPA. Nature<\/i>, 272<\/b>, 373\u2013375 (1978).","DOI":"10.1038\/272373a0"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Luka J, Kallin B, Klein G. Induction of the Epstein-Barr virus (EBV) cycle in latently infected cells by n<\/i>-butyrate. Virology<\/i>, 94<\/b>, 228\u2013231 (1979).","DOI":"10.1016\/0042-6822(79)90455-0"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Giot JF, Mikaelian I, Buisson M, Manet E, Joab I, Nicolas JC, Sergeant A. Transcriptional interference between the EBV transcription factors EB1 and R: both DNA-binding and activation domains of EB1 are required. Nucleic Acids Res.<\/i>, 19<\/b>, 1251\u20131258 (1991).","DOI":"10.1093\/nar\/19.6.1251"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Fixman ED, Hayward GS, Hayward SD. Trans-acting requirements for replication of Epstein-Barr virus ori-Lyt. J. Virol.<\/i>, 66<\/b>, 5030\u20135039 (1992).","DOI":"10.1128\/jvi.66.8.5030-5039.1992"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Vaysberg M, Hatton O, Lambert SL, Snow AL, Wong B, Krams SM, Martinez OM. Tumor-derived variants of Epstein-Barr virus latent membrane protein 1 induce sustained Erk activation and c-Fos. J. Biol. Chem.<\/i>, 283<\/b>, 36573\u201336585 (2008).","DOI":"10.1074\/jbc.M802968200"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Gahn TA, Sugden B. An EBNA-1-dependent enhancer acts from a distance of 10 kilobase pairs to increase expression of the Epstein-Barr virus LMP gene. J. Virol.<\/i>, 69<\/b>, 2633\u20132636 (1995).","DOI":"10.1128\/jvi.69.4.2633-2636.1995"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Johannsen E, Koh E, Mosialos G, Tong X, Kieff E, Grossman SR. Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1. J. Virol.<\/i>, 69<\/b>, 253\u2013262 (1995).","DOI":"10.1128\/jvi.69.1.253-262.1995"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Chang Y, Lee HH, Chang SS, Hsu TY, Wang PW, Chang YS, Takada K, Tsai CH. Induction of Epstein-Barr virus latent membrane protein 1 by a lytic transactivator Rta. J. Virol.<\/i>, 78<\/b>, 13028\u201313036 (2004).","DOI":"10.1128\/JVI.78.23.13028-13036.2004"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Cerimele F, Battle T, Lynch R, Frank DA, Murad E, Cohen C, Macaron N, Sixbey J, Smith K, Watnick RS, Eliopoulos A, Shehata B, Arbiser JL. Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr virus (EBV)-positive versus<\/i> EBV-negative Burkitt\u2019s lymphoma. Proc. Natl. Acad. Sci. U.S.A.<\/i>, 102<\/b>, 175\u2013179 (2005).","DOI":"10.1073\/pnas.0408381102"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Yi T, Zhang H, Cai Z. Analysis of rhizoma polygoni cuspidati<\/i> by HPLC and HPLC-ESI\/MS. Phytochem. Anal.<\/i>, 18<\/b>, 387\u2013392 (2007).","DOI":"10.1002\/pca.993"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Duh PD, Lin TP, Huang SC, Chen SY, Chu CC, Chen JY, Chen CH. Anti-proliferative and apoptotic effects of Polygonum cuspidatum<\/i> and its bioactive compound, emodin, in colorectal carcinoma HT-29 cells. Int. J. Food Nutr. Sci.<\/i>, 5<\/b>, 16\u201324 (2018).","DOI":"10.15436\/2377-0619.18.1731"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Xiao K, Xuan L, Xu Y, Bai D, Zhong D. Constituents from Polygonum cuspidatum.<\/i> Chem. Pharm. Bull.<\/i>, 50<\/b>, 605\u2013608 (2002).","DOI":"10.1248\/cpb.50.605"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Chu X, Sun A, Liu R. Preparative isolation and purification of five compounds from the Chinese medicinal herb Polygonum cuspidatum<\/i> Sieb. et Zucc by high-speed counter-current chromatography. J. Chromatogr. A<\/i>, 1097<\/b>, 33\u201339 (2005).","DOI":"10.1016\/j.chroma.2005.08.008"},{"key":"23","unstructured":"23) Yiu CY, Chen SY, Chen YP, Lin TP. Inhibition of the ethanolic extract from Polygonum cuspidatum<\/i> root on the functions of Epstein-Barr virus latent membrane protein 1. J. Food Drug Anal.<\/i>, 21<\/b>, 20\u201326 (2013)."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Yiu CY, Chen SY, Huang CW, Yeh DB, Lin TP. Inhibitory effects of Polygonum cuspidatum<\/i> on the Epstein-Barr virus lytic cycle. J. Food Drug Anal.<\/i>, 19<\/b>, 107\u2013113 (2011).","DOI":"10.38212\/2224-6614.2234"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Yiu CY, Chen SY, Yang TH, Chang CJ, Yeh DB, Chen YJ, Lin TP. Inhibition of Epstein-Barr virus lytic cycle by an ethyl acetate subfraction separated from Polygonum cuspidatum<\/i> root and its major component, emodin. Molecules<\/i>, 19<\/b>, 1258\u20131272 (2014).","DOI":"10.3390\/molecules19011258"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Andrei G, Trompet E, Snoeck R. Novel therapeutics for Epstein-Barr virus. Molecules<\/i>, 24<\/b>, 997\u20131017 (2019).","DOI":"10.3390\/molecules24050997"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Chang JS, Liu HW, Wang KC, Chen MC, Chiang LC, Hua YC, Lin CC. Ethanol extract of Polygonum cuspidatum<\/i> inhibits hepatitis B virus in a stable HBV-producing cell line. Antiviral Res.<\/i>, 66<\/b>, 29\u201334 (2005).","DOI":"10.1016\/j.antiviral.2004.12.006"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Kuo YT, Liu CH, Li JW, Lin CJ, Jassey A, Wu HN, Perng GC, Yen MH, Lin LT. Identification of the phytobioactive Polygonum cuspidatum<\/i> as an antiviral source for restricting dengue virus entry. Sci. Rep.<\/i>, 10<\/b>, 16378 (2020).","DOI":"10.1038\/s41598-020-71849-3"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Hammerschmidt W, Sugden B, Baichwal VR. The transforming domain alone of the latent membrane protein of Epstein-Barr virus is toxic to cells when expressed at high levels. J. Virol.<\/i>, 63<\/b>, 2469\u20132475 (1989).","DOI":"10.1128\/jvi.63.6.2469-2475.1989"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Nitta T, Chiba A, Yamashita A, Rowe M, Isra\u00ebl A, Reth M, Yamamoto N, Yamaoka S. NF-\u03baB is required for cell death induction by latent membrane protein 1 of Epstein-Barr virus. Cell. Signal.<\/i>, 15<\/b>, 423\u2013433 (2003).","DOI":"10.1016\/S0898-6568(02)00141-9"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Brocqueville G, Ndour PA, Ouk TS, Le Goff A, De Witte C, Mougel A, Coll J, Fafeur V, Le Bourhis X, Adriaenssens E. LMP1-induced cell death may contribute to the emergency of its oncogenic property. PLOS ONE<\/i>, 8<\/b>, e60743 (2013).","DOI":"10.1371\/journal.pone.0060743"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Chang Y, Lee HH, Chang SS, Hsu TY, Wang PW, Chang YS, Takada K, Tsai CH. Induction of Epstein-Barr virus latent membrane protein 1 by a lytic transactivator Rta. J. Virol.<\/i>, 78<\/b>, 13028\u201313036 (2004).","DOI":"10.1128\/JVI.78.23.13028-13036.2004"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Zhu X, Wang K, Zhang K, Zhu L, Zhou F. Ziyuglycoside II induces cell cycle arrest and apoptosis through activation of ROS\/JNK pathway in human breast cancer cells. Toxicol. Lett.<\/i>, 227<\/b>, 65\u201373 (2014).","DOI":"10.1016\/j.toxlet.2014.03.015"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/44\/12\/44_b21-00508\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T04:39:35Z","timestamp":1715143175000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/44\/12\/44_b21-00508\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b21-00508","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,1]]},"article-number":"b21-00508"}}