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Bull."],"published-print":{"date-parts":[[2021,11,1]]},"DOI":"10.1248\/bpb.b21-00512","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T22:09:20Z","timestamp":1635718160000},"page":"1759-1766","source":"Crossref","is-referenced-by-count":16,"title":["Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice"],"prefix":"10.1248","volume":"44","author":[{"given":"Shotaro","family":"Michinaga","sequence":"first","affiliation":[{"name":"Department of Pharmacodynamics, Meiji Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Onishi","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahori","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Faculty of Pharmacy, Osaka Ohtani University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Mizuguchi","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Hishinuma","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Meiji Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Nag S, Manias JL, Stewart DJ. Pathology and new players in the pathogenesis of brain edema. <i>Acta Neuropathol.<\/i>, <b>118<\/b>, 197\u2013217 (2009).","DOI":"10.1007\/s00401-009-0541-0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Unterberg AW, Stover J, Kress B, Kiening KL. Edema and brain trauma. <i>Neuroscience<\/i>, <b>129<\/b>, 1021\u20131029 (2004).","DOI":"10.1016\/j.neuroscience.2004.06.046"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Simard JM, Kent TA, Chen M, Tarasov KV, Gerzanich V. Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. <i>Lancet Neurol.<\/i>, <b>6<\/b>, 258\u2013268 (2007).","DOI":"10.1016\/S1474-4422(07)70055-8"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Hatano N, Suzuki H, Itoh Y, Muraki K. TRPV4 partially participates in proliferation of human brain capillary endothelial cells. <i>Life Sci.<\/i>, <b>92<\/b>, 317\u2013324 (2013).","DOI":"10.1016\/j.lfs.2013.01.002"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Rakers C, Schmid M, Petzold GC. TRPV4 channels contribute to calcium transients in astrocytes and neurons during peri-infarct depolarizations in a stroke model. <i>Glia<\/i>, <b>65<\/b>, 1550\u20131561 (2017).","DOI":"10.1002\/glia.23183"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Borrachero-Conejo AI, Adams WR, Saracino E, Mola MG, Wang M, Posati T, Formaggio F, De Bellis M, Frigeri A, Caprini M, Hutchinson MR, Muccini M, Zamboni R, Nicchia GP, Mahadevan-Jansen A, Benfenati V. 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Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K\/Akt and upregulating p38 MAPK signaling pathways. <i>Cell Death Dis.<\/i>, <b>6<\/b>, e1775 (2015a).","DOI":"10.1038\/cddis.2015.146"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Lu KT, Huang TC, Tsai YH, Yang YL. Transient receptor potential vanilloid type 4 channels mediate Na-K-Cl-co-transporter-induced brain edema after traumatic brain injury. <i>J. Neurochem.<\/i>, <b>140<\/b>, 718\u2013727 (2017).","DOI":"10.1111\/jnc.13920"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Hoshi Y, Okabe K, Shibasaki K, Funatsu T, Matsuki N, Ikegaya Y, Koyama R. Ischemic brain injury leads to brain edema <i>via<\/i> hyperthermia-induced TRPV4 activation. <i>J. 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