{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:52:04Z","timestamp":1776919924934,"version":"3.51.2"},"reference-count":36,"publisher":"Pharmaceutical Society of Japan","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2022,1,1]]},"DOI":"10.1248\/bpb.b21-00532","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T22:07:39Z","timestamp":1635545259000},"page":"77-85","source":"Crossref","is-referenced-by-count":7,"title":["Indomethacin, a Non-steroidal Anti-inflammatory Drug, Induces Skin Dryness &lt;i&gt;via&lt;\/i&gt; PPAR\u03b3 in Mice"],"prefix":"10.1248","volume":"45","author":[{"given":"Kiyoko","family":"Maruyama","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Suzuka University of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Goto","sequence":"additional","affiliation":[{"name":"Research Laboratories, Nichinichi Pharmaceutical Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Hiramoto","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Suzuka University of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Suzuka University of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Ooi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Suzuka University of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Brooks P, Emery P, Evans JF, Fenner H, Hawkey CJ, Patrono C, Smolen J, Breedveld F, Day R, Dougados M, Ehrich EW, Gijon-Ba\u00f1os J, Kvien TK, Van Rijswijk MH, Warner T, Zeidler H. Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2. <i>Rheumatology <\/i>(Oxford), <b>38<\/b>, 779\u2013788 (1999).","DOI":"10.1093\/rheumatology\/38.8.779"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Vane J. Towards a better aspirin. <i>Nature<\/i>, <b>367<\/b>, 215\u2013216 (1994).","DOI":"10.1038\/367215a0"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Sekiguchi H, Inoue G, Nakazawa T, Imura T, Saito W, Uchida K, Miyagi M, Takahira N, Takaso M. Loxoprofen sodium and celecoxib for postoperative pain in patients after spinal surgery: a randomized comparative study. <i>J. Orthop. Sci.<\/i>, <b>20<\/b>, 617\u2013623 (2015).","DOI":"10.1007\/s00776-015-0726-4"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Graham DY, Opekun AR, Willingham FF, Qureshi WA. Visible small-intestinal mucosal injury in chronic NSAID users. <i>Clin. Gastroenterol. Hepatol.<\/i>, <b>3<\/b>, 55\u201359 (2005).","DOI":"10.1016\/S1542-3565(04)00603-2"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Yokoyama S, Hiramoto K, Koyama M, Ooi K. Skin disruption is associated with indomethacin-induced small intestinal injury in mice. <i>Exp. Dermatol.<\/i>, <b>23<\/b>, 659\u2013663 (2014).","DOI":"10.1111\/exd.12499"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Gruber BL, Schwartz LB, Ramamurthy NS, Irani AM, Marchese MJ. Activation of latent rheumatoid synovial collagenase by human mast cell tryptase. <i>J. Immunol.<\/i>, <b>140<\/b>, 3936\u20133942 (1988).","DOI":"10.4049\/jimmunol.140.11.3936"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. <i>Nature<\/i>, <b>347<\/b>, 645\u2013650 (1990).","DOI":"10.1038\/347645a0"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-\u03b3 is a negative regulator of macrophage activation. <i>Nature<\/i>, <b>391<\/b>, 79\u201382 (1998).","DOI":"10.1038\/34178"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Jiang C, Ting AT, Seed B. PPAR-\u03b3 agonists inhibit production of monocyte inflammatory cytokines. <i>Nature<\/i>, <b>391<\/b>, 82\u201386 (1998).","DOI":"10.1038\/34184"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Kuzumoto T, Tanigawa T, Higashimori A, Kitamura H, Nadatani Y, Otani K, Fukunaga S, Hosomi S, Tanaka F, Kamata N, Nagami Y, Taira K, Watanabe T, Fujiwara Y. Protective role of resolvin D1, a pro-resolving liquid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage. <i>PLOS ONE<\/i>, <b>16<\/b>, e0250862 (2021).","DOI":"10.1371\/journal.pone.0250862"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Shimada N, Sakata A, Igarashi T, Takeuchi M, Nishimura S. M1 macrophage infiltration exacerbate muscle\/bone atrophy after peripheral nerve injury. <i>BMC Musculoskelet. Disord.<\/i>, <b>21<\/b>, 44 (2020).","DOI":"10.1186\/s12891-020-3069-z"},{"key":"12","unstructured":"12) Liang S, Shi L-Y, Duan J-Y, Liu H-H, Wang T-T, Li C-Y. Celecoxib reduces inflammation and angiogenesis in mice with adenomayosis. <i>Am. J. Transl. Res.<\/i>, <b>13<\/b>, 2858\u20132866 (2021)."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Chen J, Yang H, Sheng Z. Ellagic acid activated PPAR signaling pathway to protect ileums against castor oil-induced diarrhea in mice: application of transcriptome analysis in drug screening. <i>Front. Pharmacol.<\/i>, <b>10<\/b>, 1681 (2020).","DOI":"10.3389\/fphar.2019.01681"},{"key":"14","unstructured":"14) Washizaki K, Kanto H, Yoshida K, Chung L, Takada Y, Motomura A, Nomura S, Akatsuka M, Ishikawa A. The objective technique for evaluating of dry skin symptom in the skin disease. <i>To\u0304ho\u0304 Igakkai zasshi (Journal of the Medical Society of Toho University)<\/i>, <b>63<\/b>, 39\u201342 (2016)."},{"key":"15","unstructured":"15) Ohno H. Effects of ionized water nanodroplets (mist) released from an air-conditioner on the biophysical and biomechanical propertyes of skin in low humidity rooms. <i>Jpn. J. Biometeor<\/i>, <b>53<\/b>, 113\u2013121 (2016). doi: 10.11227\/seikisho.53.113."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Piao X, Miura R, Miyake S, Komazawa-Sakon S, Koike M, Shindo R, Takeda J, Hasegawa A, Abe R, Nishiyama C, Mikami T, Yagita H, Uchiyama Y, Nakano H. Blockade of TNF receptor superfamily 1 (TNFR1)-dependent and TNFR1-independent cell death is crucial for normal epidermal differentiation. <i>J. Allergy Clin. Immunol.<\/i>, <b>143<\/b>, 213\u2013228.e10 (2019).","DOI":"10.1016\/j.jaci.2018.02.043"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Barel AO, Clarys P. Study of the stratum corneum barrier function by transepidermal water loss measurements: comparison between two commercial instruments: Evaporimeter and Tewameter. <i>Skin Pharmacol.<\/i>, <b>8<\/b>, 186\u2013195 (1995).","DOI":"10.1159\/000211345"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Berardesca E. EEMCO guidance for the assessment of stratum corneum hydration: electrical methods. <i>Skin Res. Technol.<\/i>, <b>3<\/b>, 126\u2013132 (1997).","DOI":"10.1111\/j.1600-0846.1997.tb00174.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Lod\u00e9n M, Olsson H, Ax\u00e9ll T, Linde YW. Friction, capacitance and transepidermal water loss (TEWL) in dry atopic and normal skin. <i>Br. J. Dermatol.<\/i>, <b>126<\/b>, 137\u2013141 (1992).","DOI":"10.1111\/j.1365-2133.1992.tb07810.x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Varani J, Warner RL, Gharaee-Kermani M, Phan SH, Kang S, Chung JH, Wang ZQ, Datta SC, Fisher GJ, Voorhees JJ. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. <i>J. Invest. Dermatol.<\/i>, <b>114<\/b>, 480\u2013486 (2000).","DOI":"10.1046\/j.1523-1747.2000.00902.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Iddamalgoda A, Le QT, Ito K, Tanaka K, Kojima H, Kido H. Mast cell tryptase and photoaging: possible involvement in the degradation of extra cellular matrix and basement membrane proteins. <i>Arch. Dermatol. Res.<\/i>, <b>300<\/b> (Suppl. 1), S69\u2013S76 (2008).","DOI":"10.1007\/s00403-007-0806-1"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Yokoyama S, Hiramoto K, Koyama M, Ooi K. Impaired skin barrier function in mice with colon carcinoma induced by azoxymethane and dextran sodium sulfate. <i>Biol. Pharm. Bull.<\/i>, <b>38<\/b>, 947\u2013950 (2015).","DOI":"10.1248\/bpb.b15-00208"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Bax HJ, Keeble AH, Gould HJ. Cytokinergic IgE action in mast cell activation. <i>Front. Immunol.<\/i>, <b>3<\/b>, 229 (2012).","DOI":"10.3389\/fimmu.2012.00229"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Metcalfe DD, Baram D, Mekori YA. Mast cells. <i>Physiol. Rev.<\/i>, <b>77<\/b>, 1033\u20131079 (1997).","DOI":"10.1152\/physrev.1997.77.4.1033"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Higuchi K, Yoda Y, Amagase K, Kato S, Tokioka S, Murano M, Takeuchi K, Umegaki E. Prevention of NSAID-induced small intestinal mucosal injury: prophylactic potential of lansoprazole. <i>J. Clin. Biochem. Nutr.<\/i>, <b>45<\/b>, 125\u2013130 (2009).","DOI":"10.3164\/jcbn.SR09-58"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Coppelli G, Guaita E, Spaggiari S, Coruzzi G. Gastric effects of the selective cyclooxygenase-2 inhibitor, celecoxib, in the rat. <i>Dig. Liver Dis.<\/i>, <b>36<\/b>, 265\u2013270 (2004).","DOI":"10.1016\/j.dld.2003.12.012"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Tegeder I, Pfeilschifter J, Geisslinger G. Cyclooxygenase-independent actions of cyclooxygenase inhibitors. <i>FASEB J.<\/i>, <b>15<\/b>, 2057\u20132072 (2001).","DOI":"10.1096\/fj.01-0390rev"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Maeyama K, Emi M, Chihara K. Role of PPAR\u03b3 in inflammatory response related to mast cells. <i>Nippon Yakurigaku Zasshi<\/i>, <b>122<\/b>, 325\u2013330 (2003).","DOI":"10.1254\/fpj.122.325"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Bouhlel MA, Derudas B, Rigamonti E, Di\u00e8vart R, Brozek J, Haulon S, Zawadzki C, Jude B, Torpier G, Marx N, Staels B, Chinetti-Gbaguidi G. PPAR\u03b3 activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. <i>Cell Metab.<\/i>, <b>6<\/b>, 137\u2013143 (2007).","DOI":"10.1016\/j.cmet.2007.06.010"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, Red Eagle A, Vats D, Brombacher F, Ferrante AW, Chawla A. Macrophage-specific PPAR\u03b3 controls alternative activation and improves insulin resistance. <i>Nature<\/i>, <b>447<\/b>, 1116\u20131120 (2007).","DOI":"10.1038\/nature05894"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Engeroff P, Fellmann M, Yerly D, Bachmann MF, Vogel M. A novel recycling mechanism of native IgE-antigen complexes in human B cells facilities transfer of antigen to dendritic cells for antigen presentation. <i>J. Allergy Clin. Immunol.<\/i>, <b>142<\/b>, 557\u2013568.e6 (2018).","DOI":"10.1016\/j.jaci.2017.09.024"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Bonnefoy JY, Gauchat JF, Life P, Graber P, Aubry JP, Lecoanet-Henchoz S. Regulation of IgE synthesis by CD23\/CD21 interaction. <i>Int. Arch. Allergy Immunol.<\/i>, <b>107<\/b>, 40\u201342 (1995).","DOI":"10.1159\/000236924"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Ashida Y, Denda M, Hirao T. Histamine H1 and H2receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment. <i>J. Invest. Dermatol.<\/i>, <b>116<\/b>, 261\u2013265 (2001).","DOI":"10.1046\/j.1523-1747.2001.01238.x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Wood LC, Elias PM, Sequeira-Martin SM, Grunfeld C, Feingold KR. Occlusion lowers cytokine mRNA levels in essential fatty acid-deficient and normal mouse epidermis, but not after acute barrier disruption. <i>J. Invest. Dermatol.<\/i>, <b>103<\/b>, 834\u2013838 (1994).","DOI":"10.1111\/1523-1747.ep12413597"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Kim BE, Howell MD, Guttman-Yassky E, Gilleaudeau PM, Cardinale IR, Boguniewicz M, Krueger JG, Leung DY. TNF-\u03b1 downergulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-\u03b1 antagonists to improve skin barrier. <i>J. Invest. Dermatol.<\/i>, <b>131<\/b>, 1272\u20131279 (2011).","DOI":"10.1038\/jid.2011.24"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Demerjian M, Man M-Q, Choi E-H, Brown BE, Crumrine D, Chang S, Mauro T, Elias PM, Feingold KR. Topical treatment with thiazolidinediones, activators of peroxisome proliferator-activated receptor-gamma, normalizes epidermal homeostasis in a murine hyperproliferative disease model. <i>Exp. Dermatol.<\/i>, <b>15<\/b>, 154\u2013160 (2006).","DOI":"10.1111\/j.1600-0625.2006.00402.x"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/45\/1\/45_b21-00532\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T04:57:46Z","timestamp":1673672266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/45\/1\/45_b21-00532\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b21-00532","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,1]]},"article-number":"b21-00532"}}