{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T16:23:10Z","timestamp":1648657390095},"reference-count":63,"publisher":"Pharmaceutical Society of Japan","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2021,12,1]]},"DOI":"10.1248\/bpb.b21-00543","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T22:12:06Z","timestamp":1638310326000},"page":"1851-1859","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of the Physical Characteristics and Behavior in ABC Transporter A1, A7 or Apolipoprotein E Knockout Mice with Lipid Transport Dysfunction"],"prefix":"10.1248","volume":"44","author":[{"given":"Hiromi","family":"Tsushima","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacology, College of Pharmacy, Kinjo Gakuin University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyo","family":"Yamada","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, College of Pharmacy, Kinjo Gakuin University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, College of Pharmacy, Kinjo Gakuin University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Ohkubo","sequence":"additional","affiliation":[{"name":"Department of Health and Nutrition, Sendai Shirayuri Women\u2019s College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Michikawa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumiko","family":"Abe-Dohmae","sequence":"additional","affiliation":[{"name":"Department of Food and Nutritional Sciences, Bioscience and Biotechnology, Chubu University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Takahashi K, Kimura Y, Nagata K, Yamamoto A, Matsuo M, Ueda K. ABC proteins: key molecules for lipid homeostasis. <i>Med. Mol. Morphol.<\/i>, <b>38<\/b>, 2\u201312 (2005).","DOI":"10.1007\/s00795-004-0278-8"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Kim WS, Weickert CS, Garner B. Role of ATP-binding cassette transporters in brain lipid transport and neurological disease. <i>J. Neurochem.<\/i>, <b>104<\/b>, 1145\u20131166 (2008).","DOI":"10.1111\/j.1471-4159.2007.05099.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Hartz AM, Bauer B. ABC transporters in the CNS\u2013an inventory. <i>Curr. Pharm. Biotechnol.<\/i>, <b>12<\/b>, 656\u2013673 (2011).","DOI":"10.2174\/138920111795164020"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) McNeish J, Aiello RJ, Guyot D, Turi T, Gabel C, Aldinger C, Hoppe KL, Roach ML, Royer LJ, de Wet J, Broccardo C, Chimini G, Francone OL. High dencity lipoprotein deficiency foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. <i>Proc. Natl. Acad. Sci. USA<\/i>, <b>97<\/b>, 4245\u20134250 (2000).","DOI":"10.1073\/pnas.97.8.4245"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Drobnik W, Lindenthal B, Lieser B, Ritter M, Weber TC, Liebisch G, Giesa U, Igel M, Borsukova H, Buchler C, Fung-Leung WP, Von Bergmann K, Schmiz G. ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism. <i>Gastroenterology<\/i>, <b>120<\/b>, 1203\u20131211 (2001).","DOI":"10.1053\/gast.2001.23250"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Wang N, Lan D, Gerbod-Giannone M, Linsel-Nitschke P, Jehle AW, Chen W, Martinez LO, Tall AR. ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux. <i>J. Biol. Chem.<\/i>, <b>278<\/b>, 42906\u201342912 (2003).","DOI":"10.1074\/jbc.M307831200"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Kim WS, Fitzgerald ML, Kang K, Okuhira K, Bell SA, Manning JJ, Koehn SL, Lu N, Moore KJ, Freeman MW. <i>Abca<\/i>7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations-I adipose mass and serum cholesterol levels. <i>J. Biol. Chem.<\/i>, <b>280<\/b>, 3989\u20133995 (2005).","DOI":"10.1074\/jbc.M412602200"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Tanaka N, Abe-Dohmae S, Iwamoto N, Yokoyama S. Roles of ATP-binding cassette transporter A7 in cholesterol homeostasis and host defense system. <i>J. Atheroscler Thromb.<\/i>, <b>18<\/b>, 274\u2013281 (2011).","DOI":"10.5551\/jat.6726"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Tomioka M, Toda Y, Manucar NB, Akatsu H, Fukumoto M, Kono N, Arai H, Kioka N, Ueda K. Lysophosphatidylcholine export by human ABCA7. <i>Biochim. Biophys. Acta Mol. Cell Biol. Lipids<\/i>, <b>1862<\/b>, 658\u2013665 (2017).","DOI":"10.1016\/j.bbalip.2017.03.012"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Imaizumi K. Diet and atherosclerosis in apolipoprotein E-deficient mice. <i>Biosci. Biotechnol. Biochem.<\/i>, <b>75<\/b>, 1023\u20131035 (2011).","DOI":"10.1271\/bbb.110059"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Fuentes D, Fern\u00e1ndez N, Garc\u00eda Y, Garc\u00eda T, Morales AR, Men\u00e9ndez R. Age-related changes in the behavior of apolipoprotein E knockout mice. <i>Behav. Sci. (<\/i>Basel<i>)<\/i>, <b>8<\/b>, 33 (2018).","DOI":"10.3390\/bs8030033"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Aiello RJ, Brees D, Francone OL. ABCA1-deficient mice Insights into the role of monocyte lipid efflux in HDL formation and inflammation. <i>Arterioscler. Thromb. Vasc. Biol.<\/i>, <b>23<\/b>, 972\u2013980 (2003).","DOI":"10.1161\/01.ATV.0000054661.21499.FB"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Koseki M, Hirano K, Masuda D, Ikegami C, Tanaka M, Ota A, Sandoval JC, Nakagawa-Toyama Y, Sato SB, Kobayashi T, Shimada Y, Ohno-Iwashita Y, Matsuura F, Shimomura I, Yamashita S. Increase lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor-\u03b1 secretion in Abca1-deficient macrophages. <i>J. Lipid Res.<\/i>, <b>48<\/b>, 299\u2013306 (2007).","DOI":"10.1194\/jlr.M600428-JLR200"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) De Haan W, Bhattacharjee A, Ruddle P, Kang MH, Hayden MR. ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity. <i>J. Lipid Res.<\/i>, <b>55<\/b>, 516\u2013523 (2014).","DOI":"10.1194\/jlr.M045294"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Stamatikos A, Dronadula N, Ng P, Palmer D, Knight E, Wacker BK, Tang C, Kim F, Dichek DA. ABCA1 overexpression in endothelial cells <i>in vitro<\/i> enhances apoA1-mediated cholesterol efflux and decreases inflammation. <i>Hum. Gene Ther.<\/i>, <b>30<\/b>, 236\u2013248 (2019).","DOI":"10.1089\/hum.2018.120"},{"key":"16","unstructured":"16) Richard AJ, White U, Elks CM, Stephens JM. Adipose tissue: Physiology to metabolic dysfunction. (Feingold KR, Anawalt B, Boyce A, Chrousos G, de Herder WW, Dhatariya K, Dungan K, Grossman A, Hershman JM, Hofland J, Kalra S, Kaltsas G, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferr\u00e8re B, McGee EA, McLachlan R, Morley JE, New M, Purnell J, Sahay R, Singer F, Stratakis CA, Trence DL, Wilson DP eds.) Endotext [Internet]. MDText.com, Inc., South Dartmouth, MA (2000)."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Har-Paz I, Arieli E, Moran A. ApoE4 attenuates cortical neuronal activity in young behaving apoE4 rats. <i>Neurobiol. Dis.<\/i>, <b>155<\/b>, 105373 (2021).","DOI":"10.1016\/j.nbd.2021.105373"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Hayashi H. Lipid metabolism and glial lipoproteins in the central nervous system. <i>Biol. Pharm. Bull.<\/i>, <b>34<\/b>, 453\u2013461 (2011).","DOI":"10.1248\/bpb.34.453"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Parks JS, Chung S, Shelness GS. Hepatic ABC transporters and triglyceride metabolism. <i>Curr. Opin. Lipidol.<\/i>, <b>23<\/b>, 196\u2013200 (2012).","DOI":"10.1097\/MOL.0b013e328352dd1a"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Mahley RW. Central nervous system lipoproteins: ApoE and regulation of cholesterol metabolism. <i>Arterioscler. Thromb. Vasc. Biol.<\/i>, <b>36<\/b>, 1305\u20131315 (2016).","DOI":"10.1161\/ATVBAHA.116.307023"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Chai AB, Ammit AJ, Gelissen IC. Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation. <i>Respir. Res.<\/i>, <b>18<\/b>, 41 (2017).","DOI":"10.1186\/s12931-017-0526-9"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Rebeck GW. The role of APOE on lipid homeostasis and inflammation in normal brains. <i>J. Lipid Res.<\/i>, <b>58<\/b>, 1493\u20131499 (2017).","DOI":"10.1194\/jlr.R075408"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Aikawa T, Ren Y, Holm M-L, Asmann YW, Alam A, Fitzgerald ML, Bu G, Kanekiyo T. ABCA7 regulates brain fatty acid metabolism during LPS-induced acute inflammation. <i>Frontiers in Neuroscience<\/i>, <b>15<\/b>, 647974 (2021).","DOI":"10.3389\/fnins.2021.647974"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Sakae N, Liu C-C, Shinohara M, <i>et al.<\/i> ABCA7 deficiency accelerates amyloid-\u03b2 generation and Alzheimer\u2019s neuronal pathology. <i>J. Neurosci.<\/i>, <b>36<\/b>, 3848\u20133859 (2016).","DOI":"10.1523\/JNEUROSCI.3757-15.2016"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Chapkin RS, Wang N, Fan Y-Y, Lupton JR, Prior IA. Docosahexaenoic acid alters the size and distribution of cell surface microdomains. <i>Biochim. Biophys. Acta<\/i>, <b>1778<\/b>, 466\u2013471 (2008).","DOI":"10.1016\/j.bbamem.2007.11.003"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Heinrichs SC. Dietary \u03c9-3 fatty acid supplementation for optimizing neuronal structure and function. <i>Mol. Nutr. Food Res.<\/i>, <b>54<\/b>, 447\u2013456 (2010).","DOI":"10.1002\/mnfr.200900201"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Sohn J, Lin H, Fritch MR, Tuan RS. Influence of cholesterol\/caveolin-1\/caveolae homeostasis on membrane properties and substrate adhesion characteristics of adult human mesenchymal stem cells. <i>Stem Cell Res. Ther.<\/i>, <b>9<\/b>, 86 (2018).","DOI":"10.1186\/s13287-018-0830-4"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Rawat V, Wang S, Sima J, Bar R, Liraz O, Gundimeda U, Parekh T, Chan J, Johansson JO, Tang C, Chui HC, Harrington MG, Michaelson DM, Yassine HN. ApoE4 alters ABCA1 membrane trafficking in astrocytes. <i>J. Neurosci.<\/i>, <b>39<\/b>, 9611\u20139622 (2019).","DOI":"10.1523\/JNEUROSCI.1400-19.2019"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Adibhatla RM, Hatcher JF. Altered lipid metabolism in brain injury and disorder. <i>Subcell. Biochem.<\/i>, <b>49<\/b>, 241\u2013268 (2008).","DOI":"10.1007\/978-1-4020-8831-5_9"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Saher G, Stumpf SK. Cholesterol in myelin biogenesis and hypermyelinating disorder. <i>Biochim. Biophys. Acta<\/i>, <b>1851<\/b>, 1083\u20131094 (2015).","DOI":"10.1016\/j.bbalip.2015.02.010"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Zhang J, Liu Q. Cholesterol metabolism and homeostasis in the brain. <i>Protein Cell<\/i>, <b>6<\/b>, 254\u2013264 (2015).","DOI":"10.1007\/s13238-014-0131-3"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) de Chaves EP, Narayanaswami V. Apolipoprotein E and cholesterol in ageing and disease in the brain. <i>Future Lipidol.<\/i>, <b>3<\/b>, 505\u2013530 (2008).","DOI":"10.2217\/17460875.3.5.505"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Zhao QF, Yu JT, Tan MS, Tan L. ABCA7 in Alzheimer\u2019s disease. <i>Mol. Neurobiol.<\/i>, <b>51<\/b>, 1008\u20131016 (2015).","DOI":"10.1007\/s12035-014-8759-9"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Liu C-C, Liu C-C, Kanekiyo T, Xu H, Bu G. Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy. <i>Nat. Rev. Neurol.<\/i>, <b>9<\/b>, 106\u2013118 (2013).","DOI":"10.1038\/nrneurol.2012.263"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Huang Y, Mahley RW. Apolipoprotein E: structure and function lipid metabolism, neurobiology, and Alzheimer\u2019s disease. <i>Neurobiol. Dis.<\/i>, <b>72<\/b> (Pt. A), 3\u201312 (2014).","DOI":"10.1016\/j.nbd.2014.08.025"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Satoh K, Abe-Dohmae S, Yokoyama S, St. George-Hyslop P, Fraser P. ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing. <i>J. Biol. Chem.<\/i>, <b>290<\/b>, 24152\u201324165 (2015).","DOI":"10.1074\/jbc.M115.655076"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Forero DA, L\u00f3pez-Le\u00f3n S, Gonzalez-Giraldo Y, Dries DR, Pereira-Morales AJ, Jim\u00e9nez KM, Franco-Restrepo JE. APOE gene and neuropsychiatric disorder and endophenotypes: A comprehensive review. <i>Am. J. Med. Genet. B Neuropsychiatr. Genet.<\/i>, <b>177<\/b>, 126\u2013142 (2018).","DOI":"10.1002\/ajmg.b.32516"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Abuznait AH, Kaddoumi A. Role of ABC transporters in the pathogenesis of Alzheimer\u2019s disease. <i>ACS Chem. Neurosci.<\/i>, <b>3<\/b>, 820\u2013831 (2012).","DOI":"10.1021\/cn300077c"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Yin Y, Wang Z. ApoE and neurodegenerative diseases in aging. <i>Adv. Exp. Med. Biol.<\/i>, <b>1086<\/b>, 77\u201392 (2018).","DOI":"10.1007\/978-981-13-1117-8_5"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Piedrahita JA, Zhang SF, Hagaman JR, Oliver PM, Maeda N. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gen targeting in embryonic stem cells. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>89<\/b>, 4471\u20134475 (1992).","DOI":"10.1073\/pnas.89.10.4471"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. <i>Can. J. Biochem.<\/i>, <b>37<\/b>, 911\u2013917 (1959).","DOI":"10.1139\/o59-099"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Yamauchi Y, Chang CCY, Hayashi M, Abe-Dohmae S, Reid PC, Chang T-Y, Yokoyama S. Intracellular cholesterol mobilization involved in the ABCA1\/apolipoprotein-mediated assembly of high density lipoprotein in fibroblasts. <i>J. Lipid Res.<\/i>, <b>45<\/b>, 1943\u20131951 (2004).","DOI":"10.1194\/jlr.M400264-JLR200"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Tsushima H, Yamada K, Miyazawa D, Mori M, Hashimoto Y, Ohkubo T, Hibino H, Okuyama H. Long-term high soybean oil feeding alters regulation of body temperature in rats. <i>Biol. Pharm. Bull.<\/i>, <b>37<\/b>, 1003\u20131013 (2014).","DOI":"10.1248\/bpb.b13-00977"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Wang Y-X, Halks-Miller M, Vergona R, Sullivan ME, Fitch R, Mallari C, Martin-McNulty B, da Cunha V, Freay A, Rubanyi GM, Kauser K. Increased aortic stiffness assessed by pulse wave velocity in apolipoprotein E-deficient mice. <i>Am. J. Physiol. Heart Circ. Physiol.<\/i>, <b>278<\/b>, H428\u2013H434 (2000).","DOI":"10.1152\/ajpheart.2000.278.2.H428"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Wang Y-X. Cardiovascular functional phenotypes and pharmacological responses in apolipoprotein E deficient mice. <i>Neurobiol. Aging<\/i>, <b>26<\/b>, 309\u2013316 (2005).","DOI":"10.1016\/j.neurobiolaging.2004.06.018"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Aikawa T, Holm M-L, Kanekiyo T. ABCA7 and pathogenic pathways of Alzheimer\u2019s disease. <i>Brain Sci.<\/i>, <b>8<\/b>, 27 (2018).","DOI":"10.3390\/brainsci8020027"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Bloise E, Ortiga-Carvalho TM, Reis FM, Lye SJ, Gibb W, Matthews SG. ATP-binding cassette transporters in reproduction: a new frontier. <i>Hum. Reprod. Update<\/i>, <b>22<\/b>, 164\u2013181 (2016).","DOI":"10.1093\/humupd\/dmv049"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Karasinska JM, Rinninger F, Lutjohann D, Ruddle P, Franciosi S, Kruit JK, Singaraja RR, Hirsch-Reinshagen V, Fan J, Brunham LR, Bissada N, Ramakrishnan R, Wellington CL, Parks JS, Hayden MR. Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neural structure and function. <i>J. Neurosci.<\/i>, <b>29<\/b>, 3579\u20133589 (2009).","DOI":"10.1523\/JNEUROSCI.4741-08.2009"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Fitz NF, Carter AY, Tapias V, Castranio EL, Kodali R, Lefterov I, Koldamova R. ABCA1 deficiency affects basal cognitive deficits and dendritic density in mice. <i>J. Alzheimers Dis.<\/i>, <b>56<\/b>, 1075\u20131085 (2017).","DOI":"10.3233\/JAD-161056"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Corona AW, Kodoma N, Casali BT, Landreth GE. ABCA1 is necessary for bexarotene-mediated clearance of soluble amyloid beta from the hippocampus of APP\/PS1 mice. <i>J. Neuroimmune Pharmacol.<\/i>, <b>11<\/b>, 61\u201372 (2016).","DOI":"10.1007\/s11481-015-9627-8"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Logge W, Cheng D, Chesworth R, Bhatia S, Garner B, Kim WS, Karl T. Role of <i>abca7<\/i> in mouse behaviors relevant to neurodegenerative diseases. <i>PLOS ONE<\/i>, <b>7<\/b>, e45959 (2012).","DOI":"10.1371\/journal.pone.0045959"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Zhao N, Liu C-C, Qiao W, Bu G. Apolipoprotein E, receptors and modulation of Alzheimer\u2019s disease. <i>Biol. Psychiatry<\/i>, <b>83<\/b>, 347\u2013357 (2018).","DOI":"10.1016\/j.biopsych.2017.03.003"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Kawabata A. Prostaglandins and pain\u2014an update. <i>Biol. Pharm. Bull.<\/i>, <b>34<\/b>, 1170\u20131173 (2011).","DOI":"10.1248\/bpb.34.1170"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Fullerton SM, Strittmatter WJ, Matthew WD. Peripheral sensory nerve defects apolipoprotein E knockout mice. <i>Exp. Neurol.<\/i>, <b>153<\/b>, 156\u2013163 (1998).","DOI":"10.1006\/exnr.1998.6872"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Hashikawa-Hobara N, Hashikawa N, Yutani C, Zamami Y, Jin X, Takatori S, Mio M, Kawasaki H. The Akt-nitric oxide-cGMP pathway contributes to nerve growth factor-mediated neurite outgrowth in apolipoprotein E knockout mice. <i>J. Pharmacol. Exp. Ther.<\/i>, <b>338<\/b>, 694\u2013700 (2011).","DOI":"10.1124\/jpet.111.181487"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Iannitti T, Graham A, Dolan S. Increased central and peripheral inflammation and inflammatory hyperalgesia in Zucker rat model of leptin receptor deficiency and genetic obesity. <i>Exp. Physiol.<\/i>, <b>97<\/b>, 1236\u20131245 (2012).","DOI":"10.1113\/expphysiol.2011.064220"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Totsch SK, Sorge RE. Immune system involvement in specific pain conditions. <i>Mol. Pain<\/i>, <b>13<\/b>, 1\u201317 (2017).","DOI":"10.1177\/1744806917724559"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Zhang A, Lee YC. Mechanisms for joint pain in Rheumatoid Arthritis (RA): from cytokines to central sensation. <i>Curr. Osteoporos. Rep.<\/i>, <b>16<\/b>, 603\u2013610 (2018).","DOI":"10.1007\/s11914-018-0473-5"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Sun L, Li H, Tai LW, Gu P, Cheung CW. Adiponectin regulates thermal nociception in a mouse model of neuropathic pain. <i>Br. J. Anaesth.<\/i>, <b>120<\/b>, 1356\u20131367 (2018).","DOI":"10.1016\/j.bja.2018.01.016"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Santodomingo-Garzon T, Cunha TM, Verri WA Jr, Valerio D, Parada CA, Poole S, Ferreira SH, Cunha FQ. Atorvastatin inhibits inflammatory hypernociception. <i>Br. J. Pharmacol.<\/i>, <b>149<\/b>, 14\u201322 (2009).","DOI":"10.1038\/sj.bjp.0706836"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61) Shi XQ, Lim TK, Lee S, Zhao YQ, Zhang J. Statins alleviate experimental nerve injury-induced neuropathic pain. <i>Pain<\/i>, <b>152<\/b>, 1033\u20131043 (2011).","DOI":"10.1016\/j.pain.2011.01.006"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62) Lutfy K, Eitan S, Bryant CD, Yang YC, Saliminejad N, Walwyn W, Kieffer BL, Takeshima H, Carroll FI, Maidment NT, Evanns CJ. Buprenorphine-induced antinociception is mediated by \u03bc-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors. <i>J. Neurosci.<\/i>, <b>23<\/b>, 10331\u2013110337 (2003).","DOI":"10.1523\/JNEUROSCI.23-32-10331.2003"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63) Khroyan TV, Polgar WE, Jiang F, Zaveri NT, Toll L. Nociceptin\/Orphanin FQ receptor activation attenuates antinociception induced by mixed nociception\/orphanin FQ\/\u03bc-opioid receptor agonist. <i>J. Pharmacol. Exp. Ther.<\/i>, <b>331<\/b>, 946\u2013953 (2009).","DOI":"10.1124\/jpet.109.156711"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/44\/12\/44_b21-00543\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T04:06:38Z","timestamp":1638590798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/44\/12\/44_b21-00543\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":63,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b21-00543","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,1]]},"article-number":"b21-00543"}}