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Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents. <i>J. Pharmacol. Sci.<\/i>, <b>95<\/b>, 374\u2013380 (2004).","DOI":"10.1254\/jphs.FPJ04014X"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Torregrossa MM, Jutkiewicz EM, Mosberg HI, Balboni G, Watson SJ, Woods JH. Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats. <i>Brain Res.<\/i>, <b>1069<\/b>, 172\u2013181 (2006).","DOI":"10.1016\/j.brainres.2005.11.005"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Reddy DS, Kaur G, Kulkarni SK. Sigma (sigma1) receptor mediated anti-depressant-like effects of neurosteroids in the Porsolt forced swim test. <i>Neuroreport<\/i>, <b>9<\/b>, 3069\u20133073 (1998).","DOI":"10.1097\/00001756-199809140-00028"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Kreil G, Barra D, Simmaco M, Erspamer V, Erspamer GF, Negri L, Severini C, Corsi R, Melchiorri P. Deltorphin, a novel amphibian skin peptide with high selectivity and affinity for delta opioid receptors. <i>Eur. J. Pharmacol.<\/i>, <b>162<\/b>, 123\u2013128 (1989).","DOI":"10.1016\/0014-2999(89)90611-0"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Erspamer V, Melchiorri P, Falconieri-Erspamer G, Negri L, Corsi R, Severini C, Barra D, Simmaco M, Kreil G. Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sites. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>86<\/b>, 5188\u20135192 (1989).","DOI":"10.1073\/pnas.86.13.5188"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Sasaki Y, Ambo A, Suzuki K. [D-Ala2]deltorphin II analogs with high affinity and selectivity for delta-opioid receptor. <i>Biochem. Biophys. Res. Commun.<\/i>, <b>180<\/b>, 822\u2013827 (1991).","DOI":"10.1016\/S0006-291X(05)81138-6"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Chiba T, Murase H, Ambo A, Sasaki Y. Antinociceptive activity of deltorphin analogs in the formalin test. <i>Life Sci.<\/i>, <b>59<\/b>, 1717\u20131722 (1996).","DOI":"10.1016\/S0024-3205(96)00508-5"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Mizoguchi H, Narita M, Nagase H, Suzuki T, Quock RM, Tseng LF. Use of antisense oligodeoxynucleotide to determine delta-opioid receptor involvement in [D-Ala2]deltorphin II-induced locomotor hyperactivity. <i>Life Sci.<\/i>, <b>59<\/b>, PL69\u2013PL73 (1996).","DOI":"10.1016\/0024-3205(96)00307-4"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Tseng LF, Collins KA, Portoghese PS. Spinal delta 2 but not delta 1 opioid receptors are involved in intracerebroventricular beta-endorphin-induced antinociception in the mouse. <i>Life Sci.<\/i>, <b>52<\/b>, PL211\u2013PL215 (1993).","DOI":"10.1016\/0024-3205(93)90062-8"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Sofuoglu M, Portoghese PS, Takemori AE. 7-Benzylidenenaltrexone (BNTX): a selective delta 1 opioid receptor antagonist in the mouse spinal cord. <i>Life Sci.<\/i>, <b>52<\/b>, 769\u2013775 (1993).","DOI":"10.1016\/0024-3205(93)90240-4"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Lever JR, Scheffel U. Selective <i>in vivo<\/i> binding of [3H]naltriben to delta-opioid receptors in mouse brain. <i>Eur. J. Pharmacol.<\/i>, <b>350<\/b>, 335\u2013344 (1998).","DOI":"10.1016\/S0014-2999(98)00268-4"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Takahashi K, Nakagawasai O, Nemoto W, Kadota S, Isono J, Odaira T, Sakuma W, Arai Y, Tadano T, Tan-No K. Memantine ameliorates depressive-like behaviors by regulating hippocampal cell proliferation and neuroprotection in olfactory bulbectomized mice. <i>Neuropharmacology<\/i>, <b>137<\/b>, 141\u2013155 (2018).","DOI":"10.1016\/j.neuropharm.2018.04.013"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Nakagawasai O, Yamada K, Sakuma W, Takahashi K, Odaira T, Yamagata R, Nemoto W, Ejima A, Sato K, Tan-No K. A novel dipeptide derived from porcine liver hydrolysate induces recovery from physical fatigue in a mouse model. <i>J. Funct. 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