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Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease. <i>Age <\/i>(Dordr.), <b>36<\/b>, 9729 (2014).","DOI":"10.1007\/s11357-014-9729-x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Campos C, Pera A, Lopez-Fernandez I, Alonso C, Tarazona R, Solana R. Proinflammatory status influences NK cells subsets in the elderly. <i>Immunol. Lett.<\/i>, <b>162<\/b> (1 Pt. B), 298\u2013302 (2014).","DOI":"10.1016\/j.imlet.2014.06.015"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Sempowski G, Thomasch J, Gooding M, Hale L, Edwards L, Ciafaloni E, Sanders D, Massey J, Douek D, Koup R, Haynes B. Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis. <i>J. 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Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. <i>Lancet<\/i>, <b>355<\/b>, 1875\u20131881 (2000).","DOI":"10.1016\/S0140-6736(00)02293-5"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Poulin JF, Viswanathan MN, Harris JM, Komanduri KV, Wieder E, Ringuette N, Jenkins M, McCune JM, S\u00e9kaly RP. Direct evidence for thymic function in adult humans. <i>J. Exp. Med.<\/i>, <b>190<\/b>, 479\u2013486 (1999).","DOI":"10.1084\/jem.190.4.479"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Lynch HE, Goldberg GL, Chidgey A, Van den Brink MRM, Boyd R, Sempowski GD. Thymic involution and immune reconstitution. <i>Trends Immunol.<\/i>, <b>30<\/b>, 366\u2013373 (2009).","DOI":"10.1016\/j.it.2009.04.003"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Ye P, Kirschner DE, Kourtis AP. The thymus during HIV disease: role in pathogenesis and in immune recovery. <i>Curr. 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Prostaglandin-modulated interaction of thymic progenitor cells with blood vessels during estradiol-induced thymic involution. <i>BPB Rep.<\/i>, <b>2<\/b>, 39\u201347 (2019).","DOI":"10.1248\/bpbreports.2.4_39"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Houtkooper RH, Argmann C, Houten SM, Cant\u00f3 C, Jeninga EH, Andreux PA, Thomas C, Doenlen R, Schoonjans K, Auwerx J. The metabolic footprint of aging in mice. <i>Sci. Rep.<\/i>, <b>1<\/b>, 134 (2011).","DOI":"10.1038\/srep00134"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Nakayama K, Yoshida T, Nakayama Y, Iguchi N, Namba Y, Konishi M, Hasegawa H. Activation of macrophages mediates dietary restriction-induced splenic involution. <i>Life Sci.<\/i>, <b>310<\/b>, 121068 (2022).","DOI":"10.1016\/j.lfs.2022.121068"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Hasegawa H, Nakayama K. Malnutrition-induced involution of lymph nodes in mice. <i>BPB Rep.<\/i>, <b>5<\/b>, 133\u2013139 (2022).","DOI":"10.1248\/bpbreports.5.6_133"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Gui J, Zhu X, Dohkan J, Cheng L, Barnes PF, Su D-M. The aged thymus shows normal recruitment of lymphohematopoietic progenitors but has defects in thymic epithelial cells. <i>Int. Immunol.<\/i>, <b>19<\/b>, 1201\u20131211 (2007).","DOI":"10.1093\/intimm\/dxm095"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Garc\u00eda-Ceca J, Jim\u00e9nez E, Alfaro D, Cejalvo T, Chumley MJ, Henkemeyer M, Mu\u00f1oz J-J, Zapata AG. On the role of Eph signalling in thymus histogenesis; EphB2\/B3 and the organizing of the thymic epithelial network. <i>Int. J. Dev. Biol.<\/i>, <b>53<\/b>, 971\u2013982 (2009).","DOI":"10.1387\/ijdb.082702jg"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Chinn IK, Blackburn CC, Manley NR, Sempowski GD. 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Effect of early pregnancy on the expression of prostaglandin synthases in the ovine thymus. <i>Theriogenology<\/i>, <b>136<\/b>, 166\u2013171 (2019).","DOI":"10.1016\/j.theriogenology.2019.06.040"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Ueno T, Saito F, Gray DH, Kuse S, Hieshima K, Nakano H, Kakiuchi T, Lipp M, Boyd RL, Takahama Y. CCR7 signals are essential for cortex-medulla migration of developing thymocytes. <i>J. Exp. Med.<\/i>, <b>200<\/b>, 493\u2013505 (2004).","DOI":"10.1084\/jem.20040643"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Kurobe H, Liu C, Ueno T, Saito F, Ohigashi I, Seach N, Arakaki R, Hayashi Y, Kitagawa T, Lipp M, Boyd RL, Takahama Y. CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. <i>Immunity<\/i>, <b>24<\/b>, 165\u2013177 (2006).","DOI":"10.1016\/j.immuni.2005.12.011"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Perera J, Huang H. The development and function of thymic B cells. <i>Cell. Mol. Life Sci.<\/i>, <b>72<\/b>, 2657\u20132663 (2015).","DOI":"10.1007\/s00018-015-1895-1"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Hodge DL, Reynolds D, Cerb\u00e1n FM, Correa SG, Baez NS, Young HA, Rodriguez-Galan MC. MCP-1\/CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious\/inflammatory processes. <i>Eur. J. Immunol.<\/i>, <b>42<\/b>, 2644\u20132654 (2012).","DOI":"10.1002\/eji.201242408"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Palmer DB. The effect of age on thymic function. <i>Front. 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