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Ultraviolet radiation oxidative stress affects eye health. <i>J. Biophotonics<\/i>, <b>11<\/b>, e201700377 (2018).","DOI":"10.1002\/jbio.201700377"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Iseli HP, K\u00f6rber N, Koch C, Karl A, Penk A, Huster D, Reichenbach A, Wiedemann P, Francke M. Scleral cross-linking by riboflavin and blue light application in young rabbits: damage threshold and eye growth inhibition. <i>Graefes Arch. Clin. Exp. Ophthalmol.<\/i>, <b>254<\/b>, 109\u2013122 (2016).","DOI":"10.1007\/s00417-015-3213-x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Parkinson TM, Ferguson E, Febbraro S, Bakhtyari A, King M, Mundasad M. Tolerance of ocular iontophoresis in healthy volunteers. <i>J. Ocul. Pharmacol. Ther.<\/i>, <b>19<\/b>, 145\u2013151 (2003).","DOI":"10.1089\/108076803321637672"},{"key":"4","unstructured":"4) UN. \u201cGlobally harmonized system of classification and labelling of chemicals (GHS Rev. 9, 2021).\u201d: \u2039http:\/\/unece.org\/transport\/standards\/transport\/dangerous-goods\/ghs-rev9-2021\u203a, accessed 20 January, 2023."},{"key":"5","unstructured":"5) OECD. \u201cTest No. 492: Reconstructed human cornea-like epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage. OECD Guidelines for the Testing of Chemicals, Section 4. 2019-06-18.\u201d: \u2039https:\/\/www.oecd-ilibrary.org\/environment\/test-no-492-reconstructed-human-cornea-like-epithelium-rhce-test-method-for-identifying-chemicals-not-requiring-classification-and-labelling-for-eye-irritation-or-serious-eye-damage_9789264242548-en\u203a, accessed 20 January, 2023."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Hikima T, Tojo K. Combined use of iontophoresis and other physical methods. <i>Percutaneous penetration enhancers: physical methods in penetration enhancement<\/i>. (Dragicevic N, Maibach H, ed.) Springer, Berlin, pp. 353\u2013367 (2017).","DOI":"10.1007\/978-3-662-53273-7_22"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Hughes L, Maurice DM. A fresh look at iontophoresis. <i>Arch. Ophthalmol.<\/i>, <b>102<\/b>, 1825\u20131829 (1984).","DOI":"10.1001\/archopht.1984.01040031483028"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Behar-Cohen FF, El Aouni A, Gautier S, David G, Davis J, Chapon P, Parel JM. Transscleral Coulomb-controlled iontophoresis of methylprednisolone into the rabbit eye: influence of duration of treatment, current intensity and drug concentration on ocular tissue and fluid levels. <i>Exp. Eye Res.<\/i>, <b>74<\/b>, 51\u201359 (2002).","DOI":"10.1006\/exer.2001.1098"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Gratieri T, Santer V, Kalia YN. Basic principles and current status of transcorneal and transscleral iontophoresis. <i>Expert Opin. Drug Deliv.<\/i>, <b>14<\/b>, 1091\u20131102 (2017).","DOI":"10.1080\/17425247.2017.1266334"},{"key":"10","unstructured":"10) Katoh M, Uemura N, Hamajima F, Ogasawara T, Hata K. Morphological characterization of a reconstructed human corneal epithelial model (LabCyte CORNEA-MODEL) as an alternative to the Draize eye test for the assessment of eye irritation. <i>Alternatives to Animal Testing and Experimentation (AATEX)<\/i>, <b>17<\/b>, 2\u20138 (2012)."},{"key":"11","unstructured":"11) J-TEC. \u201cLabCyte CORNEA-MODEL, Three-dimensional cultured human cornea epithelial model, User\u2019s manual.\u201d: \u2039https:\/\/www.jpte.co.jp\/en\/business\/LabCyte\/cornea-model\/documents\/LabCyte_CORNEA-MODEL_Instruction_Manual_Mar2017.pdf\u203a, accessed 20 January, 2023."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Hollinger MA. Toxicological aspects of topical silver pharmacuticals. <i>Crit. Rev. Toxicol.<\/i>, <b>26<\/b>, 255\u2013260 (1996).","DOI":"10.3109\/10408449609012524"},{"key":"13","unstructured":"13) Kiora Pharmacuticals. \u201cEyeGate announces top-line results for phase 3 trial of EGP-437 in anterior uveitis.\u201d: \u2039https:\/\/kiorapharma.com\/eyegate-announces-top-line-results-for-phase-3-trial-of-egp-437-in-anterior-uveitis\/\u203a, accessed 20 March, 2023."},{"key":"14","unstructured":"14) Cohen A, Patane MA, Reddy M, Assang C, From S. Clinical experience with the EyeGate<sup>\u00ae<\/sup> II delivery system (EGDS): safety and tolerability in healthy adult volunteers. <i>Invest. Ophthalmol. Vis. Sci.<\/i>, <b>52<\/b>, 3224 (2011)."}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/46\/7\/46_b23-00096\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T03:23:43Z","timestamp":1688181823000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/46\/7\/46_b23-00096\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,1]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b23-00096","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,1]]},"article-number":"b23-00096"}}