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Traumatic spinal cord injury-repair and regeneration. <i>Neurosurgery<\/i>, <b>80<\/b> (3S), S9\u2013S22 (2017).","DOI":"10.1093\/neuros\/nyw080"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Ahuja CS, Wilson JR, Nori S, Kotter MRN, Druschel C, Curt A, Fehlings MG. Traumatic spinal cord injury. <i>Nat. Rev. Dis. Primers<\/i>, <b>3<\/b>, 17018 (2017).","DOI":"10.1038\/nrdp.2017.18"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Singh A, Tetreault L, Kalsi-Ryan S, Nouri A, Fehlings MG. Global prevalence and incidence of traumatic spinal cord injury. <i>Clin. Epidemiol.<\/i>, <b>6<\/b>, 309\u2013331 (2014).","DOI":"10.2147\/CLEP.S68889"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) McDonald JW, Sadowsky C. Spinal-cord injury. <i>Lancet<\/i>, <b>359<\/b>, 417\u2013425 (2002).","DOI":"10.1016\/S0140-6736(02)07603-1"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Venkatesh K, Ghosh SK, Mullick M, Manivasagam G, Sen D. Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications. <i>Cell Tissue Res.<\/i>, <b>377<\/b>, 125\u2013151 (2019).","DOI":"10.1007\/s00441-019-03039-1"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Gesteira TF, Coulson-Thomas YM, Coulson-Thomas VJ. Anti-inflammatory properties of the glial scar. <i>Neural Regen. Res.<\/i>, <b>11<\/b>, 1742\u20131743 (2016).","DOI":"10.4103\/1673-5374.194710"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Orr MB, Gensel JC. Spinal cord injury scarring and inflammation: therapies targeting glial and inflammatory responses. <i>Neurotherapeutics<\/i>, <b>15<\/b>, 541\u2013553 (2018).","DOI":"10.1007\/s13311-018-0631-6"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Youn GS, Cho H, Kim D, Choi SY, Park J. Crosstalk between HDAC6 and Nox2-based NADPH oxidase mediates HIV-1 Tat-induced pro-inflammatory responses in astrocytes. <i>Redox Biol.<\/i>, <b>12<\/b>, 978\u2013986 (2017).","DOI":"10.1016\/j.redox.2017.05.001"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Tseng JH, Xie L, Song S, Xie Y, Allen L, Ajit D, Hong JS, Chen X, Meeker RB, Cohen TJ. The deacetylase HDAC6 mediates endogenous neuritic tau pathology. <i>Cell Rep.<\/i>, <b>20<\/b>, 2169\u20132183 (2017).","DOI":"10.1016\/j.celrep.2017.07.082"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Youn GS, Ju SM, Choi SY, Park J. HDAC6 mediates HIV-1 tat-induced proinflammatory responses by regulating MAPK-NF-kappaB\/AP-1 pathways in astrocytes. <i>Glia<\/i>, <b>63<\/b>, 1953\u20131965 (2015).","DOI":"10.1002\/glia.22865"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Song Y, Qin L, Yang R, Yang F, Kenechukwu NA, Zhao X, Zhou X, Wen X, Li L. Inhibition of HDAC6 alleviating lipopolysaccharide-induced p38MAPK phosphorylation and neuroinflammation in mice. <i>Pharm. Biol.<\/i>, <b>57<\/b>, 263\u2013268 (2019).","DOI":"10.1080\/13880209.2018.1563620"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Rivieccio MA, Brochier C, Willis DE, Walker BA, D\u2019Annibale MA, McLaughlin K, Siddiq A, Kozikowski AP, Jaffrey SR, Twiss JL, Ratan RR, Langley B. HDAC6 is a target for protection and regeneration following injury in the nervous system. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>106<\/b>, 19599\u201319604 (2009).","DOI":"10.1073\/pnas.0907935106"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Pulya S, Amin SA, Adhikari N, Biswas S, Jha T, Ghosh B. HDAC6 as privileged target in drug discovery: a perspective. <i>Pharmacol. Res.<\/i>, <b>163<\/b>, 105274 (2021).","DOI":"10.1016\/j.phrs.2020.105274"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Chen C, Liu A, Lu Q, Luo L, Li J, Ke J, Liu Y, Feng X. HDAC6 inhibitor ACY-1215 improves neuropathic pain and its comorbidities in rats of peripheral nerve injury by regulating neuroinflammation. <i>Chem. Biol. Interact.<\/i>, <b>353<\/b>, 109803 (2022).","DOI":"10.1016\/j.cbi.2022.109803"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Zheng Z, Zhou Y, Ye L, Lu Q, Zhang K, Zhang J, Xie L, Wu Y, Xu K, Zhang H, Xiao J. Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury. <i>Exp. Neurol.<\/i>, <b>324<\/b>, 113138 (2020).","DOI":"10.1016\/j.expneurol.2019.113138"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Cheng C, Shan W, Huang W, Ding Z, Cui G, Liu F, Lu W, Xu J, He W, Yin Z. ACY-1215 exhibits anti-inflammatory and chondroprotective effects in human osteoarthritis chondrocytes <i>via<\/i> inhibition of STAT3 and NF-\u03baB signaling pathways. <i>Biomed. Pharmacother.<\/i>, <b>109<\/b>, 2464\u20132471 (2019).","DOI":"10.1016\/j.biopha.2018.11.017"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Zhang W, Zhang H-y, Jiao F, Wang L, Zhang H, Gong Z. Histone deacetylase 6 inhibitor ACY-1215 protects against experimental acute liver failure by regulating the TLR4-MAPK\/NF-\u03baB pathway. <i>Biomed. Pharmacother.<\/i>, <b>97<\/b>, 818\u2013824 (2018).","DOI":"10.1016\/j.biopha.2017.10.103"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Zhang WB, Yang F, Wang Y, Jiao FZ, Zhang HY, Wang LW, Gong ZJ. Inhibition of HDAC6 attenuates LPS-induced inflammation in macrophages by regulating oxidative stress and suppressing the TLR4-MAPK\/NF-\u03baB pathways. <i>Biomed. Pharmacother.<\/i>, <b>117<\/b>, 109166 (2019).","DOI":"10.1016\/j.biopha.2019.109166"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Michelucci A, Bithell A, Burney MJ, Johnston CE, Wong KY, Teng SW, Desai J, Gumbleton N, Anderson G, Stanton LW, Williams BP, Buckley NJ. The neurogenic potential of astrocytes is regulated by inflammatory signals. <i>Mol. Neurobiol.<\/i>, <b>53<\/b>, 3724\u20133739 (2016).","DOI":"10.1007\/s12035-015-9296-x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Li S, Zhou J, Zhang J, Wang D, Ma J. Construction of rat spinal cord injury model based on Allen\u2019s animal model. <i>Saudi J. Biol. Sci.<\/i>, <b>26<\/b>, 2122\u20132126 (2019).","DOI":"10.1016\/j.sjbs.2019.09.033"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Middeldorp J, Hol EM. GFAP in health and disease. <i>Prog. Neurobiol.<\/i>, <b>93<\/b>, 421\u2013443 (2011).","DOI":"10.1016\/j.pneurobio.2011.01.005"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Yang Z, Wang KK. Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker. <i>Trends Neurosci.<\/i>, <b>38<\/b>, 364\u2013374 (2015).","DOI":"10.1016\/j.tins.2015.04.003"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Lu Y, Yang YY, Zhou MW, Liu N, Xing HY, Liu XX, Li F. Ketogenic diet attenuates oxidative stress and inflammation after spinal cord injury by activating Nrf2 and suppressing the NF-\u03baB signaling pathways. <i>Neurosci. Lett.<\/i>, <b>683<\/b>, 13\u201318 (2018).","DOI":"10.1016\/j.neulet.2018.06.016"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Herrmann JE, Imura T, Song B, Qi J, Ao Y, Nguyen TK, Korsak RA, Takeda K, Akira S, Sofroniew MV. STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. <i>J. Neurosci.<\/i>, <b>28<\/b>, 7231\u20137243 (2008).","DOI":"10.1523\/JNEUROSCI.1709-08.2008"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Babaloo H, Ebrahimi-Barough S, Derakhshan MA, Yazdankhah M, Lotfibakhshaiesh N, Soleimani M, Joghataei MT, Ai J. PCL\/gelatin nanofibrous scaffolds with human endometrial stem cells\/Schwann cells facilitate axon regeneration in spinal cord injury. <i>J. Cell. Physiol.<\/i>, <b>234<\/b>, 11060\u201311069 (2019).","DOI":"10.1002\/jcp.27936"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Hesp ZC, Goldstein EZ, Miranda CJ, Kaspar BK, McTigue DM. Chronic oligodendrogenesis and remyelination after spinal cord injury in mice and rats. <i>J. Neurosci.<\/i>, <b>35<\/b>, 1274\u20131290 (2015).","DOI":"10.1523\/JNEUROSCI.2568-14.2015"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Ding Z, Dai C, Zhong L, Liu R, Gao W, Zhang H, Yin Z. Neuregulin-1 converts reactive astrocytes toward oligodendrocyte lineage cells <i>via<\/i> upregulating the PI3K-AKT-mTOR pathway to repair spinal cord injury. <i>Biomed. Pharmacother.<\/i>, <b>134<\/b>, 111168 (2021).","DOI":"10.1016\/j.biopha.2020.111168"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Fan H, Tang HB, Chen Z, Wang HQ, Zhang L, Jiang Y, Li T, Yang CF, Wang XY, Li X, Wu SX, Zhang GL. Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages\/microglia polarization and affords neuroprotection after spinal cord injury. <i>J. Neuroinflammation<\/i>, <b>17<\/b>, 295 (2020).","DOI":"10.1186\/s12974-020-01973-4"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Hellenbrand DJ, Quinn CM, Piper ZJ, Morehouse CN, Fixel JA, Hanna AS. Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration. <i>J. Neuroinflammation<\/i>, <b>18<\/b>, 284 (2021).","DOI":"10.1186\/s12974-021-02337-2"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Brockie S, Hong J, Fehlings MG. The role of microglia in modulating neuroinflammation after spinal cord injury. <i>Int. J. Mol. Sci.<\/i>, <b>22<\/b>, 9706 (2021).","DOI":"10.3390\/ijms22189706"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Anwar MA, Al Shehabi TS, Eid AH. Inflammogenesis of secondary spinal cord injury. <i>Front. Cell. Neurosci.<\/i>, <b>10<\/b>, 98 (2016).","DOI":"10.3389\/fncel.2016.00098"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. <i>Acta Neuropathol.<\/i>, <b>119<\/b>, 7\u201335 (2010).","DOI":"10.1007\/s00401-009-0619-8"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Buffo A, Rite I, Tripathi P, Lepier A, Colak D, Horn AP, Mori T, G\u00f6tz M. Origin and progeny of reactive gliosis: a source of multipotent cells in the injured brain. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>105<\/b>, 3581\u20133586 (2008).","DOI":"10.1073\/pnas.0709002105"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Clarke SR, Shetty AK, Bradley JL, Turner DA. Reactive astrocytes express the embryonic intermediate neurofilament nestin. <i>Neuroreport<\/i>, <b>5<\/b>, 1885\u20131888 (1994).","DOI":"10.1097\/00001756-199410000-00011"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Lee JH, Mahendran A, Yao Y, Ngo L, Venta-Perez G, Choy ML, Kim N, Ham WS, Breslow R, Marks PA. Development of a histone deacetylase 6 inhibitor and its biological effects. <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>110<\/b>, 15704\u201315709 (2013).","DOI":"10.1073\/pnas.1313893110"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Liu L, Zhou X, Shetty S, Hou G, Wang Q, Fu J. HDAC6 inhibition blocks inflammatory signaling and caspase-1 activation in LPS-induced acute lung injury. <i>Toxicol. Appl. Pharmacol.<\/i>, <b>370<\/b>, 178\u2013183 (2019).","DOI":"10.1016\/j.taap.2019.03.017"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Yan B, Xie S, Liu Y, Liu W, Li D, Liu M, Luo HR, Zhou J. Histone deacetylase 6 modulates macrophage infiltration during inflammation. <i>Theranostics<\/i>, <b>8<\/b>, 2927\u20132938 (2018).","DOI":"10.7150\/thno.25317"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Chang P, Bhatti UF, Williams AM, Dennahy IS, Liu B, Li Y, Alam HB. Inhibition of histone deacetylase 6 attenuates intestinal inflammation and apoptosis in a rodent model of hemorrhagic shock. <i>J. Trauma Acute Care Surg.<\/i>, <b>86<\/b>, 874\u2013880 (2019).","DOI":"10.1097\/TA.0000000000002169"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Dallavalle S, Pisano C, Zunino F. Development and therapeutic impact of HDAC6-selective inhibitors. <i>Biochem. Pharmacol.<\/i>, <b>84<\/b>, 756\u2013765 (2012).","DOI":"10.1016\/j.bcp.2012.06.014"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Liao S, Liu Y, Kong Y, Shi H, Xu B, Tang B, Li C, Chen Y, Chen J, Du J, Zhang Y. A bionic multichannel nanofiber conduit carrying Tubastatin A for repairing injured spinal cord. <i>Mater. Today Bio<\/i>, <b>17<\/b>, 100454 (2022).","DOI":"10.1016\/j.mtbio.2022.100454"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Wu C, Pan Y, Wang L, Liu M, Tu P, Chen S, Shi L, Yan D, Ma Y, Guo Y. Inhibition of HDAC6 promotes microvascular endothelial cells to phagocytize myelin debris and reduces inflammatory response to accelerate the repair of spinal cord injury. <i>CNS Neurosci. Ther.<\/i>, <b>30<\/b>, e14439 (2024).","DOI":"10.1111\/cns.14439"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Zhang XH, Qin M, Wu HP, Khamis MY, Li YH, Ma LY, Liu HM. A review of progress in histone deacetylase 6 inhibitors research: structural specificity and functional diversity. <i>J. Med. Chem.<\/i>, <b>64<\/b>, 1362\u20131391 (2021).","DOI":"10.1021\/acs.jmedchem.0c01782"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Li J, Yu M, Fu S, Liu D, Tan Y. Role of selective histone deacetylase 6 inhibitor ACY-1215 in cancer and other human diseases. <i>Front. Pharmacol.<\/i>, <b>13<\/b>, 907981 (2022).","DOI":"10.3389\/fphar.2022.907981"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Wang N, Bartlow P, Ouyang Q, Xie XQ. Recent advances in antimultiple myeloma drug development. <i>Pharm. Pat. Anal.<\/i>, <b>3<\/b>, 261\u2013277 (2014).","DOI":"10.4155\/ppa.14.18"},{"key":"45","unstructured":"45) Chen Q, Wang Y, Jiao F, Shi C, Pei M, Wang L, Gong Z. Histone deacetylase 6 inhibitor ACY1215 ameliorates mitochondrial dynamic and function injury in hepatocytes by activating AMPK signaling pathway in acute liver failure mice. <i>Histol. Histopathol.<\/i>, <b>35<\/b>, 1047\u20131058 (2020)."},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Lin CF, Hsu KC, HuangFu WC, Lin TE, Huang HL, Pan SL. Investigating the potential effects of selective histone deacetylase 6 inhibitor ACY1215 on infarct size in rats with cardiac ischemia-reperfusion injury. <i>BMC Pharmacol. Toxicol.<\/i>, <b>21<\/b>, 21 (2020).","DOI":"10.1186\/s40360-020-0400-0"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Huang ZY, Xia Y, Hu KH, Zeng SL, Wu LQ, Liu SS, Zhi C, Lai ML, Chen DM, Xie LC, Yuan ZM. Histone deacetylase 6 promotes growth of glioblastoma through the MKK7\/JNK\/c-Jun signaling pathway. <i>J. Neurochem.<\/i>, <b>152<\/b>, 221\u2013234 (2019).","DOI":"10.1111\/jnc.14849"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Mao CX, Wen X, Jin S, Zhang YQ. Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in Drosophila. <i>Dis. Model. Mech.<\/i>, <b>10<\/b>, 1245\u20131252 (2017).","DOI":"10.1242\/dmm.028316"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Ma J, Huo X, Jarpe MB, Kavelaars A, Heijnen CJ. Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment. <i>Acta Neuropathol. Commun.<\/i>, <b>6<\/b>, 103 (2018).","DOI":"10.1186\/s40478-018-0604-3"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Wang DM, Wang B, Liu YM, Dong XH, Su YW, Li SQ. Protective effects of ACY-1215 against chemotherapy-related cognitive impairment and brain damage in mice. <i>Neurochem. Res.<\/i>, <b>44<\/b>, 2460\u20132469 (2019).","DOI":"10.1007\/s11064-019-02882-6"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Zhang L, Liu C, Wu J, Tao JJ, Sui XL, Yao ZG, Xu YF, Huang L, Zhu H, Sheng SL, Qin C. Tubastatin A\/ACY-1215 improves cognition in Alzheimer\u2019s disease transgenic mice. <i>J. Alzheimers Dis.<\/i>, <b>41<\/b>, 1193\u20131205 (2014).","DOI":"10.3233\/JAD-140066"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Bethea JR, Castro M, Keane RW, Lee TT, Dietrich WD, Yezierski RP. Traumatic spinal cord injury induces nuclear factor-\u03baB activation. <i>J. Neurosci.<\/i>, <b>18<\/b>, 3251\u20133260 (1998).","DOI":"10.1523\/JNEUROSCI.18-09-03251.1998"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Lee HH, Lee SG, Shin JS, Lee HY, Yoon K, Ji YW, Jang DS, Lee KT. p-Coumaroyl anthocyanin mixture isolated from tuber epidermis of <i>Solanum tuberosum<\/i> attenuates reactive oxygen species and pro-inflammatory mediators by suppressing NF-\u03baB and STAT1\/3 signaling in LPS-induced RAW264.7 macrophages. <i>Biol. Pharm. Bull.<\/i>, <b>40<\/b>, 1894\u20131902 (2017).","DOI":"10.1248\/bpb.b17-00362"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Lauder SN, Carty SM, Carpenter CE, Hill RJ, Talamas F, Bondeson J, Brennan P, Williams AS. Interleukin-1\u03b2 induced activation of nuclear factor-\u03bab can be inhibited by novel pharmacological agents in osteoarthritis. <i>Rheumatology <\/i>(Oxford), <b>46<\/b>, 752\u2013758 (2007).","DOI":"10.1093\/rheumatology\/kel419"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Brambilla R, Bracchi-Ricard V, Hu WH, Frydel B, Bramwell A, Karmally S, Green EJ, Bethea JR. Inhibition of astroglial nuclear factor \u03baB reduces inflammation and improves functional recovery after spinal cord injury. <i>J. Exp. Med.<\/i>, <b>202<\/b>, 145\u2013156 (2005).","DOI":"10.1084\/jem.20041918"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) La Rosa G, Cardali S, Genovese T, Conti A, Di Paola R, La Torre D, Cacciola F, Cuzzocrea S. Inhibition of the nuclear factor-\u03baB activation with pyrrolidine dithiocarbamate attenuating inflammation and oxidative stress after experimental spinal cord trauma in rats. <i>J. Neurosurg. Spine<\/i>, <b>1<\/b>, 311\u2013321 (2004).","DOI":"10.3171\/spi.2004.1.3.0311"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Xu L, Botchway BOA, Zhang S, Zhou J, Liu X. Inhibition of NF-\u03baB signaling pathway by resveratrol improves spinal cord injury. <i>Front. Neurosci.<\/i>, <b>12<\/b>, 690 (2018).","DOI":"10.3389\/fnins.2018.00690"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Tang R, Botchway BOA, Meng Y, Zhang Y, Zhou C, Jiang J, Liu X. The inhibition of inflammatory signaling pathway by secretory leukocyte protease inhibitor can improve spinal cord injury. <i>Cell. Mol. Neurobiol.<\/i>, <b>40<\/b>, 1067\u20131073 (2020).","DOI":"10.1007\/s10571-020-00799-1"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Karova K, Wainwright JV, Machova-Urdzikova L, Pisal RV, Schmidt M, Jendelova P, Jhanwar-Uniyal M. Transplantation of neural precursors generated from spinal progenitor cells reduces inflammation in spinal cord injury <i>via<\/i> NF-\u03baB pathway inhibition. <i>J. Neuroinflammation<\/i>, <b>16<\/b>, 12 (2019).","DOI":"10.1186\/s12974-019-1394-7"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Ding W, Cai C, Zhu X, Wang J, Jiang Q. Parthenolide ameliorates neurological deficits and neuroinflammation in mice with traumatic brain injury by suppressing STAT3\/NF-\u03baB and inflammasome activation. <i>Int. Immunopharmacol.<\/i>, <b>108<\/b>, 108913 (2022).","DOI":"10.1016\/j.intimp.2022.108913"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61) Zhang D, Jing B, Chen ZN, Li X, Shi HM, Zheng YC, Chang SQ, Gao L, Zhao GP. Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting nerve repair <i>via<\/i> the TLR4\/NF-\u03baB pathway. <i>CNS Neurosci. Ther.<\/i>, <b>29<\/b>, 1000\u20131011 (2023).","DOI":"10.1111\/cns.14060"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62) Wang B, Lin W. Edaravone protects against pancreatic and intestinal injury after acute pancreatitis <i>via<\/i> nuclear factor-\u03baB signaling in mice. <i>Biol. Pharm. Bull.<\/i>, <b>43<\/b>, 509\u2013515 (2020).","DOI":"10.1248\/bpb.b19-00944"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63) Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. <i>Nature<\/i>, <b>480<\/b>, 372\u2013375 (2011).","DOI":"10.1038\/nature10594"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64) Gaojian T, Dingfei Q, Linwei L, Xiaowei W, Zheng Z, Wei L, Tong Z, Benxiang N, Yanning Q, Wei Z, Jian C. Parthenolide promotes the repair of spinal cord injury by modulating M1\/M2 polarization <i>via<\/i> the NF-\u03baB and STAT 1\/3 signaling pathway. <i>Cell Death Discov.<\/i>, <b>6<\/b>, 97 (2020).","DOI":"10.1038\/s41420-020-00333-8"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65) Zhang Y, Zhao Q, Chen Q, Xu L, Yi S. Transcriptional control of peripheral nerve regeneration. <i>Mol. Neurobiol.<\/i>, <b>60<\/b>, 329\u2013341 (2023).","DOI":"10.1007\/s12035-022-03090-0"},{"key":"66","unstructured":"66) Ju C, Ma YG, Zuo XS, Wang XK, Song ZW, Zhang ZH, Zhu ZJ, Li X, Liang ZW, Ding T, Wang Z, Hu XY. Potential targets and mechanisms of photobiomodulation for spinal cord injury. <i>Neural Regen. Res.<\/i>, <b>18<\/b>, 1782\u20131788 (2023)."},{"key":"67","doi-asserted-by":"crossref","unstructured":"67) Xiao S, Zhang Y, Liu Z, Li A, Tong W, Xiong X, Nie J, Zhong N, Zhu G, Liu J, Liu Z. Alpinetin inhibits neuroinflammation and neuronal apoptosis <i>via<\/i> targeting the JAK2\/STAT3 signaling pathway in spinal cord injury. <i>CNS Neurosci. Ther.<\/i>, <b>29<\/b>, 1094\u20131108 (2023).","DOI":"10.1111\/cns.14085"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68) Shin MK, Sasaki F, Ki DW, Win NN, Morita H, Hayakawa Y. Identification of <i>Ophiocordyceps gracilioides<\/i> by its anti-tumor effects through targeting the NF\u03baB-STAT3-IL-6 inflammatory pathway. <i>Biol. Pharm. Bull.<\/i>, <b>44<\/b>, 686\u2013690 (2021).","DOI":"10.1248\/bpb.b20-01032"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69) Yang Q, Li S, Zhou Z, Fu M, Yang X, Hao K, Liu Y. HDAC6 inhibitor Cay10603 inhibits high glucose-induced oxidative stress, inflammation and apoptosis in retinal pigment epithelial cells <i>via<\/i> regulating NF-\u03baB and NLRP3 inflammasome pathway. <i>Gen. Physiol. Biophys.<\/i>, <b>39<\/b>, 169\u2013177 (2020).","DOI":"10.4149\/gpb_2019058"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70) Barter MJ, Butcher A, Wang H, Tsompani D, Galler M, Rumsby EL, Culley KL, Clark IM, Young DA. HDAC6 regulates NF-\u03baB signalling to control chondrocyte IL-1-induced MMP and inflammatory gene expression. <i>Sci. Rep.<\/i>, <b>12<\/b>, 6640 (2022).","DOI":"10.1038\/s41598-022-10518-z"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71) Fu X, Wang Y, Fu W, Liu D, Zhang C-y, Wang Q, Tong X. The combination of adipose-derived Schwann-like cells and acellular nerve allografts promotes sciatic nerve regeneration and repair through the JAK2\/STAT3 signaling pathway in rats. <i>Neuroscience<\/i>, <b>422<\/b>, 134\u2013145 (2019).","DOI":"10.1016\/j.neuroscience.2019.10.018"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72) Tsuda M, Kohro Y, Yano T, Tsujikawa T, Kitano J, Tozaki-Saitoh H, Koyanagi S, Ohdo S, Ji RR, Salter MW, Inoue K. JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats. <i>Brain<\/i>, <b>134<\/b>, 1127\u20131139 (2011).","DOI":"10.1093\/brain\/awr025"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73) David S, Zarruk JG, Ghasemlou N. Inflammatory pathways in spinal cord injury. <i>Int. Rev. Neurobiol.<\/i>, <b>106<\/b>, 127\u2013152 (2012).","DOI":"10.1016\/B978-0-12-407178-0.00006-5"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74) Karimi-Abdolrezaee S, Billakanti R. Reactive astrogliosis after spinal cord injury-beneficial and detrimental effects. <i>Mol. Neurobiol.<\/i>, <b>46<\/b>, 251\u2013264 (2012).","DOI":"10.1007\/s12035-012-8287-4"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/47\/10\/47_b23-00603\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T03:28:08Z","timestamp":1730518088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/47\/10\/47_b23-00603\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,30]]},"references-count":74,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b23-00603","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,30]]},"article-number":"b23-00603"}}