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Skin barrier damage and itch: review of mechanisms, topical management and future directions. <i>Acta Derm. Venereol.<\/i>, <b>99<\/b>, 1201\u20131209 (2019).","DOI":"10.2340\/00015555-3296"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Silverberg JI, Hinami K, Trick WE, Cella D. Itch in the general internal medicine setting: a cross-sectional study of prevalence and quality-of-life effects. <i>Am. J. Clin. Dermatol.<\/i>, <b>17<\/b>, 681\u2013690 (2016).","DOI":"10.1007\/s40257-016-0215-3"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Nikrodhanond AA, Ortiga-Carvalho TM, Shibusawa N, Hashimoto K, Liao XH, Refetoff S, Yamada M, Mori M, Wondisford FE. Dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis. <i>J. Biol. Chem.<\/i>, <b>281<\/b>, 5000\u20135007 (2006).","DOI":"10.1074\/jbc.M511530200"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Ishibashi H, Nakahata Y, Eto K, Nabekura J. Excitation of locus coeruleus noradrenergic neurons by thyrotropin-releasing hormone. <i>J. Physiol.<\/i>, <b>587<\/b>, 5709\u20135722 (2009).","DOI":"10.1113\/jphysiol.2009.181420"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Tanabe M, Tokuda Y, Takasu K, Ono K, Honda M, Ono H. The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects <i>via<\/i> distinct descending monoaminergic systems. <i>Br. J. Pharmacol.<\/i>, <b>150<\/b>, 403\u2013414 (2007).","DOI":"10.1038\/sj.bjp.0707125"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Eto K, Kim SK, Nabekura J, Ishibashi H. Taltirelin, a thyrotropin-releasing hormone analog, alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain. <i>Brain Res.<\/i>, <b>1414<\/b>, 50\u201357 (2011).","DOI":"10.1016\/j.brainres.2011.07.065"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Zheng C, Chen G, Tan Y, Zeng W, Peng Q, Wang J, Cheng C, Yang X, Nie S, Xu Y, Zhang Z, Papa SM, Ye K, Cao X. TRH Analog, taltirelin protects dopaminergic neurons from neurotoxicity of MPTP and rotenone. <i>Front. Cell. Neurosci.<\/i>, <b>12<\/b>, 485 (2018).","DOI":"10.3389\/fncel.2018.00485"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Gotoh Y, Andoh T, Kuraishi Y. Noradrenergic regulation of itch transmission in the spinal cord mediated by \u03b1-adrenoceptors. <i>Neuropharmacology<\/i>, <b>61<\/b>, 825\u2013831 (2011).","DOI":"10.1016\/j.neuropharm.2011.05.030"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Koga K, Shiraishi Y, Yamagata R, Tozaki-Saitoh H, Shiratori-Hayashi M, Tsuda M. Intrinsic braking role of descending locus coeruleus noradrenergic neurons in acute and chronic itch in mice. <i>Mol. Brain<\/i>, <b>13<\/b>, 144 (2020).","DOI":"10.1186\/s13041-020-00688-0"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Shiraishi Y, Koga K, Yamagata R, Hatada I, Shiratori-Hayashi M, Tsuda M. \u03b11A-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice. <i>Mol. Brain<\/i>, <b>14<\/b>, 55 (2021).","DOI":"10.1186\/s13041-021-00768-9"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Wong L-S, Wu T, Lee C-H. Inflammatory and noninflammatory itch: implications in pathophysiology-directed treatments. <i>Int. J. Mol. Sci.<\/i>, <b>18<\/b>, 1485 (2017).","DOI":"10.3390\/ijms18071485"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, Hasegawa A, Nakahara T, Hachisuka J, Akira S, Okano H, Furue M, Inoue K, Tsuda M. STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch. <i>Nat. Med.<\/i>, <b>21<\/b>, 927\u2013931 (2015).","DOI":"10.1038\/nm.3912"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Koga K, Yamagata R, Kohno K, Yamane T, Shiratori-Hayashi M, Kohro Y, Tozaki-Saitoh H, Tsuda M. Sensitization of spinal itch transmission neurons in a mouse model of chronic itch requires an astrocytic factor. <i>J. Allergy Clin. Immunol.<\/i>, <b>145<\/b>, 183\u2013191.e10 (2020).","DOI":"10.1016\/j.jaci.2019.09.034"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Mahmoud O, Oladipo O, Mahmoud RH, Yosipovitch G. Itch: from the skin to the brain\u2014peripheral and central neural sensitization in chronic itch. <i>Front. Mol. Neurosci.<\/i>, <b>16<\/b>, 1272230 (2023).","DOI":"10.3389\/fnmol.2023.1272230"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Shimada SG, LaMotte RH. Behavioral differentiation between itch and pain in mouse. <i>Pain<\/i>, <b>139<\/b>, 681\u2013687 (2008).","DOI":"10.1016\/j.pain.2008.08.002"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/47\/11\/47_b24-00449\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T03:28:01Z","timestamp":1732937281000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/47\/11\/47_b24-00449\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b24-00449","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"type":"print","value":"0918-6158"},{"type":"electronic","value":"1347-5215"}],"subject":[],"published":{"date-parts":[[2024,11,27]]},"article-number":"b24-00449"}}