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Medicinal chemistry strategies in the discovery and optimization of HBV core protein allosteric modulators (2018\u20132022). <i>Chin. Chem. Lett.<\/i>, <b>34<\/b>, 108349 (2023).","DOI":"10.1016\/j.cclet.2023.108349"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Feng S, Gao L, Han XC, Hu TS, Hu YM, Liu HX, Thomas AW, Yan ZP, Yang S, Young JAT, Yun HY, Zhu W, Shen HC. Discovery of small molecule therapeutics for treatment of chronic HBV infection. <i>ACS Infect. Dis.<\/i>, <b>4<\/b>, 257\u2013277 (2018).","DOI":"10.1021\/acsinfecdis.7b00144"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Klumpp K, Shimada T, Allweiss L, Volz T, L\u00fctgehetmann M, Hartman G, Flores OA, Lam AM, Dandri M. 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