{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:47:28Z","timestamp":1783133248403,"version":"3.54.6"},"reference-count":22,"publisher":"Pharmaceutical Society of Japan","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2024,12,14]]},"DOI":"10.1248\/bpb.b24-00697","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T22:13:00Z","timestamp":1734127980000},"page":"2083-2091","source":"Crossref","is-referenced-by-count":5,"title":["Gum Arabic Enhances Hair Follicle-Targeting Drug Delivery of Minoxidil Nanocrystal Dispersions"],"prefix":"10.1248","volume":"47","author":[{"given":"Yoshihiro","family":"Oaku","sequence":"first","affiliation":[{"name":"Frontier Research Center, Taisho Pharmaceutical Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorato","family":"Shiroyama","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Kindai University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Otake","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Kindai University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Yajima","sequence":"additional","affiliation":[{"name":"Self-Medication Research Center, Research Headquarters, Taisho Pharmaceutical Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinari","family":"Abe","sequence":"additional","affiliation":[{"name":"Self-Medication Research Center, Research Headquarters, Taisho Pharmaceutical Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Support Office for Bioresource Research, Center for Translational Research, Fujita Health University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Nagai","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Kindai University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","unstructured":"1) Tsuzuki H, Watanabe N, Okamura K, Yamada H, Ogata F, Kawasaki N. Elucidation of hair loss factors and hair growth promoting effects of broccoli sprouts extract. <i>FRAGRANCE JOURNAL<\/i>, <b>44<\/b>, 14\u201320 (2016)."},{"key":"2","unstructured":"2) Tsunoda T. <i>Fine Chemical Series: Bases and Applications on Dispersion of Nano-particles<\/i>. CMC Publishing, Tokyo (2006)."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Otomo S. Hair growth effect of minoxidil. <i>Folia Pharmacol. Jpn.<\/i>, <b>119<\/b>, 167\u2013174 (2002).","DOI":"10.1254\/fpj.119.167"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Sugino M, Todo H, Sugibayashi K. Skin permeation and transdermal delivery systems of drugs: history to overcome barrier function in the stratum corneum. <i>Yakugaku Zasshi<\/i>, <b>129<\/b>, 1453\u20131458 (2009).","DOI":"10.1248\/yakushi.129.1453"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Alvarez-Rom\u00e1n R, Naik A, Kalia YN, Guy RH, Fessi H. Skin penetration and distribution of polymeric nanoparticles. <i>J. Control. Release<\/i>, <b>99<\/b>, 53\u201362 (2004).","DOI":"10.1016\/j.jconrel.2004.06.015"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Toll R, Jacobi U, Richter H, Lademann J, Schaefer H, Blume-Peytavi U. Penetration profile of microspheres in follicular targeting of terminal hair follicles. <i>J. Invest. Dermatol.<\/i>, <b>123<\/b>, 168\u2013176 (2004).","DOI":"10.1111\/j.0022-202X.2004.22717.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Vogt A, Combadiere B, Hadam S, Stieler KM, Lademann J, Schaefer H, Autran B, Sterry W, Blume-Peytavi U. 40\u2009nm, but not 750 or 1,500\u2009nm, nanoparticles enter epidermal CD1a+ cells after transcutaneous application on human skin. <i>J. Invest. Dermatol.<\/i>, <b>126<\/b>, 1316\u20131322 (2006).","DOI":"10.1038\/sj.jid.5700226"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Lademann J, Richter H, Teichmann A, Otberg N, Blume-Peytavi U, Luengo J, Wei\u00df B, Schaefer UF, Lehr CM, Wepf R, Sterry W. Nanoparticles\u2014an efficient carrier for drug delivery into the hair follicles. <i>Eur. J. Pharm. Biopharm.<\/i>, <b>66<\/b>, 159\u2013164 (2007).","DOI":"10.1016\/j.ejpb.2006.10.019"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Patzelt A, Richter H, Knorr F, Sch\u00e4fer U, Lehr C, D\u00e4hne L, Sterry W, Lademann J. Selective follicular targeting by modification of the particle sizes. <i>J. Control. Release<\/i>, <b>150<\/b>, 45\u201348 (2011).","DOI":"10.1016\/j.jconrel.2010.11.015"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Nagai N, Iwai Y, Sakamoto A, Otake H, Oaku Y, Abe A, Nagahama T. Drug delivery system based on minoxidil nanoparticles promotes hair growth in C57BL\/6 mice. <i>Int. J. Nanomedicine<\/i>, <b>14<\/b>, 7921\u20137931 (2019).","DOI":"10.2147\/IJN.S225496"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Oaku Y, Abe A, Sasano Y, Sasaki F, Kubota C, Yamamoto N, Nagahama T, Nagai N. Minoxidil nanoparticles targeting hair follicles enhance hair growth in C57BL\/6 mice. <i>Pharmaceutics<\/i>, <b>14<\/b>, 947 (2022).","DOI":"10.3390\/pharmaceutics14050947"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) McLeod SD, Alvi NP, Zhou L, Dave Y, Chandler JW, Fiscella R. The effect of minoxidil on keratinocyte proliferation in cell culture. <i>Ophthalmic Res.<\/i>, <b>30<\/b>, 263\u2013270 (1998).","DOI":"10.1159\/000055483"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) O\u2019Keefe E, Payne RE Jr. Minoxidil: Inhibition of proliferation of keratinocytes <i>in vitro.<\/i> <i>J. Invest. Dermatol.<\/i>, <b>97<\/b>, 534\u2013536 (1991).","DOI":"10.1111\/1523-1747.ep12481560"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Nagai N, Ito Y, Okamoto N, Shimomura Y. A nanoparticle formulation reduces the corneal toxicity of indomethacin eye drops and enhances its corneal permeability. <i>Toxicology<\/i>, <b>319<\/b>, 53\u201362 (2014).","DOI":"10.1016\/j.tox.2014.02.012"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Koester J, Miroshnikova YA, Ghatak S, Chac\u00f3n-Mart\u00ednez CA, Morgner J, Li X, Atanassov L, Altm\u00fcller J, Birk DE, Koch M, Bloch W, Bartusel M, Niessen CM, Rada-Iglesias A, Wickstr\u00f6m SA. Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility. <i>Nat. Cell Biol.<\/i>, <b>23<\/b>, 771\u2013781 (2021).","DOI":"10.1038\/s41556-021-00705-x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Inoue K, Aoi N, Sato T, Yamauchi Y, Suga H, Eto H, Kato H, Araki J, Yoshimura K. Differential expression of stem-cell-associated markers in human hair follicle epithelial cells. <i>Lab. Invest.<\/i>, <b>89<\/b>, 844\u2013856 (2009).","DOI":"10.1038\/labinvest.2009.48"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Sidney LE, Branch MJ, Dunphy SE, Dua HS, Hopkinson A. Concise review: Evidence for CD34 as a common marker for diverse progenitors. <i>Stem Cells<\/i>, <b>32<\/b>, 1380\u20131389 (2014).","DOI":"10.1002\/stem.1661"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Rosenblum MD, Olasz E, Woodliff JE, Johnson BD, Konkol MC, Gerber KA, Orentas RJ, Sandford G, Truitt RL. CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance. <i>Blood<\/i>, <b>103<\/b>, 2691\u20132698 (2004).","DOI":"10.1182\/blood-2003-09-3184"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Yu K, Chen Z, Gorczynski R. Effect of CD200 and CD200R1 expression within tissue grafts on increased graft survival in allogeneic recipients. <i>Immunol. Lett.<\/i>, <b>149<\/b>, 1\u20138 (2013).","DOI":"10.1016\/j.imlet.2012.11.004"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Kobayashi T, Iwasaki T, Amagai M, Ohyama M. Canine follicle stem cell candidates reside in the bulge and share characteristic features with human bulge cells. <i>J. Invest. Dermatol.<\/i>, <b>130<\/b>, 1988\u20131995 (2010).","DOI":"10.1038\/jid.2010.68"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Kloepper JE, Tiede S, Brinckmann J, Reinhardt DP, Meyer W, Faessler R, Paus R. Immunophenotyping of the human bulge region: the quest to define useful <i>in situ<\/i> markers for human epithelial hair follicle stem cells and their niche. <i>Exp. Dermatol.<\/i>, <b>17<\/b>, 592\u2013609 (2008).","DOI":"10.1111\/j.1600-0625.2008.00720.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Ohyama M, Terunuma A, Tock CL, Radonovich MF, Pise-Masison CA, Hopping SB, Brady JN, Udey MC, Vogel JC. Characterization and isolation of stem cell-enriched human hair follicle bulge cells. <i>J. Clin. Invest.<\/i>, <b>116<\/b>, 249\u2013260 (2006).","DOI":"10.1172\/JCI26043"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/47\/12\/47_b24-00697\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T03:28:10Z","timestamp":1734146890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/47\/12\/47_b24-00697\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,14]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b24-00697","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,14]]},"article-number":"b24-00697"}}