{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T05:38:54Z","timestamp":1740202734078,"version":"3.37.3"},"reference-count":17,"publisher":"Pharmaceutical Society of Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2025,2,21]]},"DOI":"10.1248\/bpb.b24-00797","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T22:14:25Z","timestamp":1740089665000},"page":"144-150","source":"Crossref","is-referenced-by-count":0,"title":["&lt;i&gt;\u03b1&lt;\/i&gt;&lt;sub&gt;1&lt;\/sub&gt;-Adrenoceptor Blockade by Class I Antiarrhythmic Drugs in Guinea Pig Thoracic Aorta as Revealed by Mechanical and Fluorescence Displacement Analysis"],"prefix":"10.1248","volume":"48","author":[{"given":"Iyuki","family":"Namekata","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maika","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiro","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Tsukada","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayaka","family":"Kawazoe","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniaki","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Miyahara","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikaru","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Ono K, Iwasaki Y, Akao M, <i>et al<\/i>. JCS\/JHRS 2020 guideline on pharmacotherapy of cardiac arrhythmias. <i>Circ. J<\/i>., <b>86<\/b>, 1790\u20131924 (2022).","DOI":"10.1253\/circj.CJ-22-0285"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Lei M, Wu L, Terrar DA, Huang CL. Modernized classification of cardiac antiarrhythmic drugs. <i>Circulation<\/i>, <b>138<\/b>, 1879\u20131896 (2018).","DOI":"10.1161\/CIRCULATIONAHA.118.035455"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Belardinelli L, Liu G, Smith-Maxwell C, Wang WQ, El-Bizri N, Hirakawa R, Karpinski S, Li CH, Hu L, Li XJ, Crumb W, Wu L, Koltun D, Zablocki J, Yao L, Dhalla AK, Rajamani S, Shryock JC. A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias. <i>J. Pharmacol. Exp. Ther<\/i>., <b>344<\/b>, 23\u201332 (2013).","DOI":"10.1124\/jpet.112.198887"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Irie M, Hiiro H, Hamaguchi S, Namekata I, Tanaka H. Involvement of the persistent Na<sup>+<\/sup> current in the diastolic depolarization and automaticity of the guinea pig pulmonary vein myocardium. <i>J. Pharmacol. Sci<\/i>., <b>141<\/b>, 9\u201316 (2019).","DOI":"10.1016\/j.jphs.2019.08.003"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) del Pozo BF, Perez-Vizcaino F, Villamor E, Zaragoza F, Tamargo J. Stereoselective effects of the enantiomers, quinidine and quinine, on depolarization- and agonist-mediated responses in rat isolated aorta. <i>Br. J. Pharmacol<\/i>., <b>117<\/b>, 105\u2013110 (1996).","DOI":"10.1111\/j.1476-5381.1996.tb15161.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Virsolvy A, Farah C, Pertuit N, Kong L, Lacampagne A, Reboul C, Aimond F, Richard S. Antagonism of Nav channels and <i>\u03b1<\/i><sub>1<\/sub>-adrenergic receptors contributes to vascular smooth muscle effects of ranolazine. <i>Sci. Rep<\/i>., <b>5<\/b>, 17969 (2015).","DOI":"10.1038\/srep17969"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Obara K, Yoshioka K, De Dios Regadera M, Matsuyama Y, Yashiro A, Miyokawa M, Iura R, Tanaka Y. Phenylephrine-induced contraction in guinea pig thoracic aorta is triggered by stimulation of <i>\u03b1<\/i><sub>1L<\/sub>-adrenoceptors functionally coupled with store-operated Ca<sup>2+<\/sup> channels and voltage-dependent Ca<sup>2+<\/sup> channels. <i>Biol. Pharm. Bull<\/i>., <b>46<\/b>, 309\u2013319 (2023).","DOI":"10.1248\/bpb.b22-00754"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Daly CJ, Ross RA, Whyte J, Henstridge CM, Irving AJ, McGrath JC. Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and \u2019cannabinoid-like\u2019 receptors in small arteries. <i>Br. J. Pharmacol<\/i>., <b>159<\/b>, 787\u2013796 (2010).","DOI":"10.1111\/j.1476-5381.2009.00608.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Arunlakshana O, Schild HO. Some quantitative uses of drug antagonists. <i>Br. J. Pharmacol. Chemother<\/i>., <b>14<\/b>, 48\u201358 (1959).","DOI":"10.1111\/j.1476-5381.1959.tb00928.x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Carr\u00f3n R, Perez-Vizcaino F, Delpon E, Tamargo J. Effects of propafenone on <sup>45<\/sup>Ca movements and contractile responses in vascular smooth muscle. <i>Br. J. Pharmacol<\/i>., <b>103<\/b>, 1453\u20131457 (1991).","DOI":"10.1111\/j.1476-5381.1991.tb09810.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Mariano DJ, Schomer SJ, Rea RF. Effects of quinidine on vascular resistance and sympathetic nerve activity in humans. <i>J. Am. Coll. Cardiol<\/i>., <b>20<\/b>, 1411\u20131416 (1992).","DOI":"10.1016\/0735-1097(92)90256-M"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Hashimoto K, Komori S, Ishii M, Kamiya J. Effective plasma concentrations of aprindine in canine ventricular arrhythmias. <i>J. Cardiovasc. Pharmacol<\/i>., <b>6<\/b>, 12\u201319 (1984).","DOI":"10.1097\/00005344-198401000-00003"},{"key":"13","unstructured":"13) Yamazaki K, Sasaki Y, Furuta S. Effectiveness of intravenous administration of aprindine for conversion of paroxysmal atrial fibrillation. <i>Therapeutic Research<\/i>, <b>14<\/b>, 229\u2013235 (1993)."},{"key":"14","unstructured":"14) Rigaud M, Jouret G, Canal M, Bardet J, Flouvat B, Bourdarias JP. Hemodynamic effects of a new antiarrhythmic agent: cibenzoline. <i>J. Pharmacol<\/i>., <b>16<\/b>, 247\u2013257 (1985)."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Kawakami S, Kambayashi R, Takada K, Aimoto M, Nagasawa Y, Takahara A. Role of cardiac <i>\u03b1<\/i><sub>1<\/sub>-adrenoreceptors for the torsadogenic action of IKr blocker nifekalant in the anesthetized atrioventricular block rabbit. <i>J. Pharmacol. Sci<\/i>., <b>150<\/b>, 67\u201373 (2022).","DOI":"10.1016\/j.jphs.2022.07.003"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Ha\u00efssaguerre M, Ja\u00efs P, Shah DC, Takahashi A, Hocini M, Quiniou G, Garrigue S, Le Mouroux A, Le M\u00e9tayer P, Cl\u00e9menty J. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. <i>N. Engl. J. Med<\/i>., <b>339<\/b>, 659\u2013666 (1998).","DOI":"10.1056\/NEJM199809033391003"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Irie M, Tsuneoka Y, Shimobayashi M, Hasegawa N, Tanaka Y, Mochizuki S, Ichige S, Hamaguchi S, Namekata I, Tanaka H. Involvement of alpha- and beta-adrenoceptors in the automaticity of the isolated guinea pig pulmonary vein myocardium. <i>J. Pharmacol. Sci<\/i>., <b>133<\/b>, 247\u2013253 (2017).","DOI":"10.1016\/j.jphs.2017.03.003"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/48\/2\/48_b24-00797\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T03:27:24Z","timestamp":1740194844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/48\/2\/48_b24-00797\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,21]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b24-00797","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"type":"print","value":"0918-6158"},{"type":"electronic","value":"1347-5215"}],"subject":[],"published":{"date-parts":[[2025,2,21]]},"article-number":"b24-00797"}}