{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:14:15Z","timestamp":1779891255730,"version":"3.53.1"},"reference-count":47,"publisher":"Pharmaceutical Society of Japan","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2025,5,17]]},"DOI":"10.1248\/bpb.b25-00008","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T22:09:55Z","timestamp":1747433395000},"page":"632-640","source":"Crossref","is-referenced-by-count":4,"title":["Supplementing with Vitamin D during Pregnancy Reduces Inflammation and Prevents Autism-Related Behaviors in Offspring Caused by Maternal Immune Activation"],"prefix":"10.1248","volume":"48","author":[{"given":"Xiao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Human Anatomy, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Atlad\u00f3ttir HO, Thorsen P, \u00d8stergaard L, Schendel DE, Lemcke S, Abdallah M, Parner ET. Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. <i>J. Autism Dev. Disord.<\/i>, <b>40<\/b>, 1423\u20131430 (2010).","DOI":"10.1007\/s10803-010-1006-y"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV, Hoeffer CA, Littman DR, Huh JR. The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. <i>Science<\/i>, <b>351<\/b>, 933\u2013939 (2016).","DOI":"10.1126\/science.aad0314"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Smith SE, Li J, Garbett K, Mirnics K, Patterson PH. Maternal immune activation alters fetal brain development through interleukin-6. <i>J. Neurosci.<\/i>, <b>27<\/b>, 10695\u201310702 (2007).","DOI":"10.1523\/JNEUROSCI.2178-07.2007"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Wang T, Zhang S, Luo M, Lu M, Wei L, Zhou X, Wang H, Xu D. Prenatal caffeine exposure induces autism-like behaviors in offspring under a high-fat diet <i>via<\/i> the gut microbiota-IL-17A-brain axis. <i>Ecotoxicol. Environ. Saf.<\/i>, <b>269<\/b>, 115797 (2024).","DOI":"10.1016\/j.ecoenv.2023.115797"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Zhang W, Mou Z, Zhong Q, Liu X, Yan L, Gou L, Chen Z, So K-F, Zhang L. Transcutaneous auricular vagus nerve stimulation improves social deficits through the inhibition of IL-17a signaling in a mouse model of autism. <i>Front. Psychiatry<\/i>, <b>15<\/b>, 1393549 (2024).","DOI":"10.3389\/fpsyt.2024.1393549"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Eyles DW. Vitamin D: brain and behavior. <i>JBMR Plus<\/i>, <b>5<\/b>, e10419 (2021).","DOI":"10.1002\/jbm4.10419"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Ao T, Kikuta J, Ishii M. The effects of vitamin D on immune system and inflammatory diseases. <i>Biomolecules<\/i>, <b>11<\/b>, 1624 (2020).","DOI":"10.3390\/biom11111624"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Gezen-Ak D, Dursun E, Yilmazer S. The effect of vitamin D treatment on nerve growth factor (NGF) release from hippocampal neurons. <i>Noro Psikiyatri Ars.<\/i>, <b>51<\/b>, 157\u2013162 (2014).","DOI":"10.4274\/npa.y7076"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Men\u00e9ndez SG, Manucha W. Vitamin D as a modulator of neuroinflammation: implications for brain health. <i>Curr. Pharm. Des.<\/i>, <b>30<\/b>, 323\u2013332 (2024).","DOI":"10.2174\/0113816128281314231219113942"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Dimitrov V, White JH. Vitamin D signaling in intestinal innate immunity and homeostasis. <i>Mol. Cell. Endocrinol.<\/i>, <b>453<\/b>, 68\u201378 (2017).","DOI":"10.1016\/j.mce.2017.04.010"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Marazziti D, Parra E, Palermo S, Barberi F, Buccianelli B, Ricciardulli S, Cappelli A, Mucci F, Dell\u2019Osso L. Vitamin D: a pleiotropic hormone with possible psychotropic activities. <i>Curr. Med. Chem.<\/i>, <b>28<\/b>, 3843\u20133864 (2021).","DOI":"10.2174\/0929867328666201210104701"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Muskens J, Klip H, Zinkstok JR, van Dongen-Boomsma M, Staal WG. Vitamin D status in children with a psychiatric diagnosis, autism spectrum disorders, or internalizing disorders. <i>Front. Psychiatry<\/i>, <b>13<\/b>, 958556 (2022).","DOI":"10.3389\/fpsyt.2022.958556"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Li H, Ma J, Huang R, Wen Y, Liu G, Xuan M, Yang L, Yang J, Song L. Prevalence of vitamin D deficiency in the pregnant women: an observational study in Shanghai, China. <i>Arch. Public Health<\/i>, <b>78<\/b>, 31 (2020).","DOI":"10.1186\/s13690-020-00414-1"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Saraf R, Morton SM, Camargo CA Jr, Grant CC. Global summary of maternal and newborn vitamin D status-a systematic review. <i>Matern. Child Nutr.<\/i>, <b>12<\/b>, 647\u2013668 (2016).","DOI":"10.1111\/mcn.12210"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Tamang MK, Ali A, Pertile RN, Cui X, Alexander S, Nitert MD, Palmieri C, Eyles D. Developmental vitamin D-deficiency produces autism-relevant behaviours and gut-health associated alterations in a rat model. <i>Transl. Psychiatry<\/i>, <b>13<\/b>, 204 (2023).","DOI":"10.1038\/s41398-023-02513-3"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Whitehouse AJ, Holt BJ, Serralha M, Holt PG, Hart PH, Kusel MM. Maternal vitamin D levels and the autism phenotype among offspring. <i>J. Autism Dev. Disord.<\/i>, <b>43<\/b>, 1495\u20131504 (2013).","DOI":"10.1007\/s10803-012-1676-8"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Keim SA, Bodnar LM, Klebanoff MA. Maternal and cord blood 25(OH)-vitamin D concentrations in relation to child development and behaviour. <i>Paediatr. Perinat. Epidemiol.<\/i>, <b>28<\/b>, 434\u2013444 (2014).","DOI":"10.1111\/ppe.12135"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Fernell E, Bejerot S, Westerlund J, Miniscalco C, Simila H, Eyles D, Gillberg C, Humble M. Autism spectrum disorder and low vitamin D at birth: a sibling control study. <i>Mol. Autism.<\/i>, <b>6<\/b>, 3 (2015).","DOI":"10.1186\/2040-2392-6-3"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Wang T, Shan L, Du L, Feng J, Xu Z, Staal W, Jia F. Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder: a systematic review and meta-analysis. <i>Eur. Child Adolesc. Psychiatry<\/i>, <b>25<\/b>, 341\u2013350 (2016).","DOI":"10.1007\/s00787-015-0786-1"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Wang Z, Ding R, Wang J. The association between vitamin D status and autism spectrum disorder (ASD): a systematic review and meta-analysis. <i>Nutrients<\/i>, <b>13<\/b>, 86 (2020).","DOI":"10.3390\/nu13010086"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Javadfar Z, Abdollahzad H, Moludi J, Rezaeian S, Amirian H, Foroughi A, Nachvak S, Goharmehr N, Mostafai R. Effects of vitamin D supplementation on core symptoms, serum serotonin, and interleukin-6 in children with autism spectrum disorders: A randomized clinical trial. <i>Nutrition<\/i>, <b>79-80<\/b>, 110986 (2020).","DOI":"10.1016\/j.nut.2020.110986"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Abbarin D, Vafaei AA, Pour AR, Bandegi AR, Taherian A, Rahmani M, Jarrahi M, Sedaghat K. Vitamins D and E improve valproic acid-induced autistic-like behaviors and oxidative stress in the rat offspring. <i>Middle East J. Rehabil. Health Stud.<\/i>, <b>10<\/b>, e129627 (2023).","DOI":"10.5812\/mejrh-129627"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Vuillermot S, Luan W, Meyer U, Eyles D. Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation. <i>Mol. Autism.<\/i>, <b>8<\/b>, 9 (2017).","DOI":"10.1186\/s13229-017-0125-0"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Du L, Zhao G, Duan Z, Li F. Behavioral improvements in a valproic acid rat model of autism following vitamin D supplementation. <i>Psychiatry Res.<\/i>, <b>253<\/b>, 28\u201332 (2017).","DOI":"10.1016\/j.psychres.2017.03.003"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Al-Yatama FI, AlOtaibi F, Al-Bader MD, Al-Shoumer KA. The effect of clothing on vitamin D status, bone turnover markers, and bone mineral density in young Kuwaiti females. <i>Int. J. Endocrinol.<\/i>, <b>2019<\/b>, 6794837 (2019).","DOI":"10.1155\/2019\/6794837"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Doncheva N, Mihaylova A, Zlatanova H, Ivanovska M, Delev D, Murdjeva M, Kostadinov I. Vitamin D<sub>3<\/sub> exerts immunomodulatory and memory improving properties in rats with lipopolysaccharide-induced inflammation. <i>Folia Med.<\/i>, <b>64<\/b>, 770\u2013781 (2022).","DOI":"10.3897\/folmed.64.e67739"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Tang G, Gudsnuk K, Kuo S, Cotrina M, Rosoklija G, Sosunov A, Sonders M, Kanter E, Castagna C, Yamamoto A, Yue Z, Arancio O, Peterson B, Champagne F, Dwork A, Goldman J, Sulzer D. Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits. <i>Neuron<\/i>, <b>83<\/b>, 1131\u20131143 (2014).","DOI":"10.1016\/j.neuron.2014.07.040"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Malkova NV, Yu CZ, Hsiao EY, Moore MJ, Patterson PH. Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. <i>Brain Behav. Immun.<\/i>, <b>26<\/b>, 607\u2013616 (2012).","DOI":"10.1016\/j.bbi.2012.01.011"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Yang J, Qi F, Yao Z. Neonatal Bacillus Calmette-Gu\u00e9rin vaccination alleviates lipopolysaccharide-induced neurobehavioral impairments and neuroinflammation in adult mice. <i>Mol. Med. Rep.<\/i>, <b>14<\/b>, 1574\u20131586 (2016).","DOI":"10.3892\/mmr.2016.5425"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Sano T, Huang W, Hall J, Yang Y, Chen A, Gavzy S, Lee J, Ziel J, Miraldi E, Domingos A, Bonneau R, Littman D. An IL-23R\/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses. <i>Cell<\/i>, <b>164<\/b>, 324 (2016).","DOI":"10.1016\/j.cell.2015.12.047"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Lord C, Cook E, Leventhal B, Amaral D. Autism spectrum disorders. <i>Neuron<\/i>, <b>28<\/b>, 355\u2013363 (2000).","DOI":"10.1016\/S0896-6273(00)00115-X"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Skokauskas N, Gallagher L. Psychosis, affective disorders and anxiety in autistic spectrum disorder: prevalence and nosological considerations. <i>Psychopathology<\/i>, <b>43<\/b>, 8\u201316 (2010).","DOI":"10.1159\/000255958"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Uhlar CM, Whitehead AS. Serum amyloid A, the major vertebrate acute-phase reactant. <i>Eur. J. Biochem.<\/i>, <b>265<\/b>, 501\u2013523 (1999).","DOI":"10.1046\/j.1432-1327.1999.00657.x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Shi W, Inoue M, Minami M, Takeda K, Matsumoto M, Matsuda Y, Kishimoto T, Akira S, Watanabe T. The genomic structure and chromosomal localization of the mouse STAT3 gene. <i>Int. Immunol.<\/i>, <b>8<\/b>, 1205\u20131211 (1996).","DOI":"10.1093\/intimm\/8.8.1205"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Hodge DR, Hurt EM, Farrar WL. The role of IL-6 and STAT3 in inflammation and cancer. <i>European Journal of Cancer<\/i>, <b>41<\/b>, 2502\u20132512 (2005).","DOI":"10.1016\/j.ejca.2005.08.016"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Lee JW, Stone ML, Porrett PM, <i>et al<\/i>. Hepatocytes direct the formation of a pro-metastatic niche in the liver. <i>Nature<\/i>, <b>567<\/b>, 249\u2013252 (2019).","DOI":"10.1038\/s41586-019-1004-y"},{"key":"37","unstructured":"37) Council NR. Nutrition CoA, Nutrition SoLA. <i>Nutrient requirements of laboratory animals<\/i>, National Research Council, U.S.A. (1995)."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Djukic M, Sostmann N, Bertsch T, Mecke M, Nessler S, Manig A, Hanisch U-K, Triebel J, Bollheimer LC, Sieber C, Nau R. Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice. <i>J. Neuroinflammation<\/i>, <b>12<\/b>, 208 (2015).","DOI":"10.1186\/s12974-014-0208-1"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Agrawal T, Gupta GK, Agrawal DK. Vitamin D supplementation reduces airway hyperresponsiveness and allergic airway inflammation in a murine model. <i>Clin. Exp. Allergy<\/i>, <b>43<\/b>, 672\u2013683 (2013).","DOI":"10.1111\/cea.12102"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Huang F, Ju Y, Wang H, Li YN. Maternal vitamin D deficiency impairs Treg and Breg responses in offspring mice and deteriorates allergic airway inflammation. <i>Allergy Asthma Clin. Immunol.<\/i>, <b>16<\/b>, 89 (2020).","DOI":"10.1186\/s13223-020-00487-1"},{"key":"41","unstructured":"41) Belenchia AM, Johnson SA, Kieschnick AC, Rosenfeld CS, Peterson CA. Time course of vitamin D depletion and repletion in reproductive-age female C57BL\/6 mice. <i>Comp. Med.<\/i>, <b>67<\/b>, 483\u2013490 (2017)."},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Palmer MT, Lee YK, Maynard CL, Oliver JR, Bikle DD, Jetten AM, Weaver CT. Lineage-specific effects of 1,25-dihydroxyvitamin D<sub>3<\/sub> on the development of effector CD<sub>4<\/sub> T cells. <i>J. Biol. Chem.<\/i>, <b>286<\/b>, 997\u20131004 (2011).","DOI":"10.1074\/jbc.M110.163790"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Smolders J, Thewissen M, Peelen E, Menheere P, Cohen Tervaert JW, Damoiseaux J, Hupperts R. Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis. <i>PLOS ONE<\/i>, <b>4<\/b>, e6635 (2009).","DOI":"10.1371\/journal.pone.0006635"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Ivanov  II, Atarashi  K, Manel  N, Brodie  E, Shima  T, Karaoz  U, Wei  D, Goldfarb  KC, Santee  CA, Lynch  SV, Tanoue  T, Imaoka  A, Itoh  K, Takeda  K, Umesaki  Y, Honda  K, Littman  DR. Induction of intestinal Th17 cells by segmented filamentous bacteria. <i>Cell<\/i>, <b>139<\/b>, 485\u2013498 (2009).","DOI":"10.1016\/j.cell.2009.09.033"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Kim S, Kim H, Yim Y, Ha S, Atarashi K, Tan T, Longman R, Honda K, Littman D, Choi G, Huh J. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. <i>Nature<\/i>, <b>549<\/b>, 528\u2013532 (2017).","DOI":"10.1038\/nature23910"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Lee JY, Hall JA, Kroehling L, Wu L, Najar T, Nguyen HH, Lin WY, Yeung ST, Silva HM, Li D, Hine A, Loke P, Hudesman D, Martin JC, Kenigsberg E, Merad M, Khanna KM, Littman DR. Serum amyloid A proteins induce pathogenic Th17 cells and promote inflammatory disease. <i>Cell<\/i>, <b>180<\/b>, 79\u201391.e16 (2020).","DOI":"10.1016\/j.cell.2019.11.026"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Shab-Bidar S, Neyestani T, Djazayery A, Eshraghian M, Houshiarrad A, Kalayi A, Shariatzadeh N, Khalaji N, Gharavi A. Improvement of vitamin D status resulted in amelioration of biomarkers of systemic inflammation in the subjects with type 2 diabetes. <i>Diabetes Metab. Res. Rev.<\/i>, <b>28<\/b>, 424\u2013430 (2012).","DOI":"10.1002\/dmrr.2290"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/48\/5\/48_b25-00008\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T03:41:18Z","timestamp":1747453278000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/48\/5\/48_b25-00008\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,17]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b25-00008","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,17]]},"article-number":"b25-00008"}}