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Drug use before and during pregnancy in Japan: the Japan environment and children\u2019s study. <i>Pharmacy<\/i> (Basel), <b>5<\/b>, 21 (2017).","DOI":"10.3390\/pharmacy5020021"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Fujii Y, Hirokawa K, Kobuke Y, Kubota T, Yoshitake T, Haraguchi K, Honda Y, Kobayashi H, Harada KH. Use of nonprescription and prescription drugs and drug information sources among breastfeeding women in Japan: a cross-sectional study. <i>Int. J. Environ. Res. Public Health<\/i>, <b>19<\/b>, 11722 (2022).","DOI":"10.3390\/ijerph191811722"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Ji L, Brki\u0107 J, Liu M, Fu G, Peng C, Wang YL. Placental trophoblast cell differentiation: physiological regulation and pathological relevance to preeclampsia. <i>Mol. Aspects Med.<\/i>, <b>34<\/b>, 981\u20131023 (2013).","DOI":"10.1016\/j.mam.2012.12.008"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Tetro N, Moushaev S, Rubinchik-Stern M, Eyal S. The placental barrier: the gate and the fate in drug distribution. <i>Pharm. Res.<\/i>, <b>35<\/b>, 71 (2018).","DOI":"10.1007\/s11095-017-2286-0"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Avachat C, Barry JM, Lyu X, Sherwin CM, Birnbaum AK. Management of anti-seizure medications during pregnancy: advancements in the past decade. <i>Pharmaceutics<\/i>, <b>14<\/b>, 2733 (2022).","DOI":"10.3390\/pharmaceutics14122733"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Sabers A, Perucca E, Vajda F. Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. <i>Lancet Neurol.<\/i>, <b>10<\/b>, 609\u2013617 (2011).","DOI":"10.1016\/S1474-4422(11)70107-7"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Herzog AG, Mandle HB, Cahill KE, Fowler KM, Hauser WA. Predictors of unintended pregnancy in women with epilepsy. <i>Neurology<\/i>, <b>88<\/b>, 728\u2013733 (2017).","DOI":"10.1212\/WNL.0000000000003637"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Furugen A, Kobayashi M, Nishimura A, Takamura S, Narumi K, Yamada T, Iseki K. Quantification of new antiepileptic drugs by liquid chromatography\/electrospray ionization tandem mass spectrometry and its application to cellular uptake experiment using human placental choriocarcinoma BeWo cells. <i>J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.<\/i>, <b>1002<\/b>, 228\u2013233 (2015).","DOI":"10.1016\/j.jchromb.2015.08.031"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Furugen A, Ishiguro Y, Kobayashi M, Narumi K, Nishimura A, Hirano T, Iseki K. Involvement of l-type amino acid transporter 1 in the transport of gabapentin into human placental choriocarcinoma cells. <i>Reprod. Toxicol.<\/i>, <b>67<\/b>, 48\u201355 (2017).","DOI":"10.1016\/j.reprotox.2016.11.002"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Hasegawa N, Furugen A, Ono K, Koishikawa M, Miyazawa Y, Nishimura A, Umazume T, Narumi K, Kobayashi M, Iseki K. Cellular uptake properties of lamotrigine in human placental cell lines: investigation of involvement of organic cation transporters (<i>SLC22A1-5<\/i>). <i>Drug Metab. 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Evaluation of the effects of antiepileptic drugs on folic acid uptake by human placental choriocarcinoma cells. <i>Toxicol. In Vitro<\/i>, <b>48<\/b>, 104\u2013110 (2018).","DOI":"10.1016\/j.tiv.2017.12.003"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Miyazawa Y, Furugen A, Aoyagi R, Kosugi H, Nishimura A, Umazume T, Narumi K, Kobayashi M. Kobayashi M. Alteration in folate carrier expression via histone deacetylase inhibition in BeWo human placental choriocarcinoma cells. <i>Toxicol. In Vitro<\/i>, <b>101<\/b>, 105934 (2024).","DOI":"10.1016\/j.tiv.2024.105934"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Meador KJ, Baker GA, Browning N, Cohen MJ, Bromley RL, Clayton-Smith J, Kalayjian LA, Kanner A, Liporace JD, Pennell PB, Privitera M, Loring DW. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study. <i>Lancet Neurol.<\/i>, <b>12<\/b>, 244\u2013252 (2013).","DOI":"10.1016\/S1474-4422(12)70323-X"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Christensen J, Gr\u00f8nborg TK, S\u00f8rensen MJ, Schendel D, Parner ET, Pedersen LH, Vestergaard M. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. <i>JAMA<\/i>, <b>309<\/b>, 1696\u20131703 (2013).","DOI":"10.1001\/jama.2013.2270"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Furugen A, Kanno Y, Ohyama N, Kurosawa Y, Jinno N, Narumi K, Iseki K, Kobayashi M. Effects of valproate, an HDAC inhibitor, on the expression of folate carriers and folate metabolism-related genes in the placenta of rats. <i>Drug Metab. 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Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect. <i>Lancet<\/i>, <b>387<\/b>, 475\u2013490 (2016).","DOI":"10.1016\/S0140-6736(15)01024-7"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Mazer-Amirshahi M, Samiee-Zafarghandy S, Gray G, van den Anker JN. Trends in pregnancy labeling and data quality for US-approved pharmaceuticals. <i>Am. J. Obstet. Gynecol.<\/i>, <b>211<\/b>, 690.e1\u2013690.e11 (2014).","DOI":"10.1016\/j.ajog.2014.06.013"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Anderson PO, Sauberan JB. Modeling drug passage into human milk. <i>Clin. Pharmacol. Ther.<\/i>, <b>100<\/b>, 42\u201352 (2016).","DOI":"10.1002\/cpt.377"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Ballard O, Morrow AL. Human milk composition: nutrients and bioactive factors. <i>Pediatr. Clin. 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Simple and validated method to quantify lacosamide in human breast milk and plasma using UPLC\/MS\/MS and its application to estimate drug transfer into breast milk. <i>J. Pharm. Health Care Sci.<\/i>, <b>9<\/b>, 26 (2023).","DOI":"10.1186\/s40780-023-00295-w"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Tamaki R, Noshiro K, Furugen A, Nishimura A, Asano H, Watari H, Kobayashi M, Umazume T. Breast milk concentrations of acetaminophen and diclofenac\u2014unexpectedly high mammary transfer of the general-purpose drug acetaminophen. <i>BMC Pregnancy Childbirth<\/i>, <b>24<\/b>, 90 (2024).","DOI":"10.1186\/s12884-024-06287-4"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Ishikawa H, Furugen A, Nishimura A, Umazume T, Ishikawa S, Aoyagi R, Narumi K, Okamoto K, Takekuma Y, Sugawara M, Kobayashi M. Validated UPLC-MS\/MS method for quantification of melatonin receptor agonists and dual orexin receptor antagonists in human plasma and breast milk: application to quantify suvorexant and lemborexant in clinical samples. <i>J. Pharm. Biomed. Anal.<\/i>, <b>251<\/b>, 116432 (2024).","DOI":"10.1016\/j.jpba.2024.116432"},{"key":"31","unstructured":"31) Einarson A, Selby P, Koren G. Abrupt discontinuation of psychotropic drugs during pregnancy: fear of teratogenic risk and impact of counselling. <i>J. Psychiatry Neurosci.<\/i>, <b>26<\/b>, 44\u201348 (2001)."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Oo CY, Kuhn RJ, Desai N, Wright CE, McNamara PJ. Pharmacokinetics in lactating women: prediction of alprazolam transfer into milk. <i>Br. J. Clin. Pharmacol.<\/i>, <b>40<\/b>, 231\u2013236 (1995).","DOI":"10.1111\/j.1365-2125.1995.tb05778.x"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Okuda S, Qureshi ZP, Yanagida Y, Ito C, Homma Y, Tokita S. 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Contribution of protein binding, lipid partitioning, and asymmetrical transport to drug transfer into milk in mouse <i>versus<\/i> human. <i>Pharm. 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