{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:57:22Z","timestamp":1789383442346,"version":"build-2803163510"},"reference-count":62,"publisher":"Pharmaceutical Society of Japan","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2025,6,11]]},"DOI":"10.1248\/bpb.b25-00060","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T22:08:20Z","timestamp":1749593300000},"page":"812-824","source":"Crossref","is-referenced-by-count":4,"title":["Adipose-Derived Mesenchymal Stromal\/Stem Cells Reduce Inflammatory Responses and Partially Alleviate Skin Symptoms in Imiquimod-Induced Psoriasis-Like Dermatitis Model Mice"],"prefix":"10.1248","volume":"48","author":[{"given":"Ryohei","family":"Ogino","sequence":"first","affiliation":[{"name":"Department of Frontier Science for Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1\u20132\u20133 Kasumi, Minami-ku, Hiroshima 734\u20138553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Department of Frontier Science for Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1\u20132\u20133 Kasumi, Minami-ku, Hiroshima 734\u20138553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Hayashida","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Faculty of Medicine, Shimane University, 89\u20131 Enya-cho, Izumo, Shimane 693\u20138501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Taogoshi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Services, Hiroshima University Hospital, 1\u20132\u20133 Kasumi, Minami-ku, Hiroshima 734\u20138551, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoharu","family":"Yokooji","sequence":"additional","affiliation":[{"name":"Department of Frontier Science for Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1\u20132\u20133 Kasumi, Minami-ku, Hiroshima 734\u20138553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Services, Hiroshima University Hospital, 1\u20132\u20133 Kasumi, Minami-ku, Hiroshima 734\u20138551, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Griffiths CEM, Armstrong AW, Gudjonsson JE, Barker JNWN. Psoriasis. <i>Lancet<\/i>, <b>397<\/b>, 1301\u20131315 (2021).","DOI":"10.1016\/S0140-6736(20)32549-6"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Ding Y, Gong P, Jiang J, Feng C, Li Y, Su X, Bai X, Xu C, Liu C, Yang J, Fang J, Ji X, Chen Y, Li P, Guo L, Shao C, Shi Y. Mesenchymal stem\/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation <i>via<\/i> the TSG-6-neutrophil axis. <i>Cell Death Dis.<\/i>, <b>13<\/b>, 996 (2022).","DOI":"10.1038\/s41419-022-05445-w"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Chen Y, Hu Y, Zhou X, Zhao Z, Yu Q, Chen Z, Wang Y, Xu P, Yu Z, Guo C, Zhang X, Shi Y. Human umbilical cord-derived mesenchymal stem cells ameliorate psoriasis-like dermatitis by suppressing IL-17-producing <i>\u03b3\u03b4<\/i> T cells. <i>Cell Tissue Res.<\/i>, <b>388<\/b>, 549\u2013563 (2022).","DOI":"10.1007\/s00441-022-03616-x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Saeki H, Mabuchi T, Asahina A, Abe M, Igarashi A, Imafuku S, Okubo Y, Komine M, Sano S, Torii H, Morita A, Yotsuyanagi H, Watanabe A, Ohtsuki M. English version of Japanese guidance for use of biologics for psoriasis (the 2022 version). <i>J. Dermatol.<\/i>, <b>50<\/b>, e41\u2013e68 (2023).","DOI":"10.1111\/1346-8138.16691"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Ghoreschi K, Balato A, Enerb\u00e4ck C, Sabat R. Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis. <i>Lancet<\/i>, <b>397<\/b>, 754\u2013766 (2021).","DOI":"10.1016\/S0140-6736(21)00184-7"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Masson Regnault M, Shourick J, Jendoubi F, Tauber M, Paul C. Time to relapse after discontinuing systemic treatment for psoriasis: a systematic review. <i>Am. J. Clin. Dermatol.<\/i>, <b>23<\/b>, 433\u2013447 (2022).","DOI":"10.1007\/s40257-022-00679-y"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Ogino R, Hayashida K, Yamakawa S, Morita E. Adipose-derived stem cells promote intussusceptive lymphangiogenesis by restricting dermal fibrosis in irradiated tissue of mice. <i>Int. J. Mol. Sci.<\/i>, <b>21<\/b>, 3885 (2020).","DOI":"10.3390\/ijms21113885"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Ogino R, Yokooji T, Hayashida M, Suda S, Yamakawa S, Hayashida K. Emerging anti-inflammatory pharmacotherapy and cell-based therapy for lymphedema. <i>Int. J. Mol. Sci.<\/i>, <b>23<\/b>, 7614 (2022).","DOI":"10.3390\/ijms23147614"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Lightner AL, Irving PM, Lord GM, Betancourt A. Stem cells and stem cell-derived factors for the treatment of inflammatory bowel disease with a particular focus on perianal fistulizing disease: a minireview on future perspectives. <i>BioDrugs<\/i>, <b>38<\/b>, 527\u2013539 (2024).","DOI":"10.1007\/s40259-024-00661-6"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Wang LT, Liu KJ, Sytwu HK, Yen ML, Yen BL. Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell-free products and human pluripotent stem cell-derived mesenchymal stem cells. <i>Stem Cells Transl. Med.<\/i>, <b>10<\/b>, 1288\u20131303 (2021).","DOI":"10.1002\/sctm.21-0021"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Liu H, Li R, Liu T, Yang L, Yin G, Xie Q. Immunomodulatory effects of mesenchymal stem cells and mesenchymal stem cell-derived extracellular vesicles in rheumatoid arthritis. <i>Front. Immunol.<\/i>, <b>11<\/b>, 1912 (2020).","DOI":"10.3389\/fimmu.2020.01912"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) De Jesus MM, Santiago JS, Trinidad CV, See ME, Semon KR, Fernandez MO Jr, Chung FS. Autologous adipose-derived mesenchymal stromal cells for the treatment of psoriasis vulgaris and psoriatic arthritis: a case report. <i>Cell Transplant.<\/i>, <b>25<\/b>, 2063\u20132069 (2016).","DOI":"10.3727\/096368916X691998"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Chen H, Niu JW, Ning HM, Pan X, Li XB, Li Y, Wang DH, Hu LD, Sheng HX, Xu M, Zhang L, Zhang B. Treatment of psoriasis with mesenchymal stem cells. <i>Am. J. Med.<\/i>, <b>129<\/b>, e13\u2013e14 (2016).","DOI":"10.1016\/j.amjmed.2015.11.001"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Comella K, Parlo M, Daly R, Dominessy K. First-in-man intravenous implantation of stromal vascular fraction in psoriasis: a case study. <i>Int. Med. Case Rep. J.<\/i>, <b>11<\/b>, 59\u201364 (2018).","DOI":"10.2147\/IMCRJ.S163612"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Seetharaman R, Mahmood A, Kshatriya P, Patel D, Srivastava A. Mesenchymal stem cell conditioned media ameliorate psoriasis vulgaris: a case study. <i>Case Rep. Dermatol. Med.<\/i>, <b>2019<\/b>, 8309103 (2019).","DOI":"10.1155\/2019\/8309103"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Yao D, Ye S, He Z, Huang Y, Deng J, Wen Z, Chen X, Li H, Han Q, Deng H, Zhao RC, Lu C. Adipose-derived mesenchymal stem cells (AD-MSCs) in the treatment for psoriasis: results of a single-arm pilot trial. <i>Ann. Transl. Med.<\/i>, <b>9<\/b>, 1653 (2021).","DOI":"10.21037\/atm-21-5028"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Cheng L, Wang S, Peng C, <i>et al<\/i>. Human umbilical cord mesenchymal stem cells for psoriasis: a phase 1\/2a, single-arm study. <i>Signal Transduct. Target. Ther.<\/i>, <b>7<\/b>, 263 (2022).","DOI":"10.1038\/s41392-022-01059-y"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Tang L, Yao D, He Z, Ye S, Chen X, Huang Y, Han Q, Zeng X, Zheng X, Liu T, Wang Z, Zhao RC, Zheng G, Lu C. Distinct adaptive immune receptor feature of adipose-derived mesenchymal stem cells (AD-MSCs) treatment of psoriasis. <i>Arch. Dermatol. Res.<\/i>, <b>316<\/b>, 542 (2024).","DOI":"10.1007\/s00403-024-03296-3"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Dairov A, Sekenova A, Alimbek S, Nurkina A, Shakhatbayev M, Kumasheva V, Kuanysh S, Adish Z, Issabekova A, Ogay V. Psoriasis: the versatility of mesenchymal stem cell and exosome therapies. <i>Biomolecules<\/i>, <b>14<\/b>, 1351 (2024).","DOI":"10.3390\/biom14111351"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Thompson M, Mei SHJ, Wolfe D, Champagne J, Fergusson D, Stewart DJ, Sullivan KJ, Doxtator E, Lalu M, English SW, Granton J, Hutton B, Marshall J, Maybee A, Walley KR, Santos CD, Winston B, McIntyre L. Cell therapy with intravascular administration of mesenchymal stromal cells continues to appear safe: an updated systematic review and meta-analysis. <i>EClinicalMedicine<\/i>, <b>19<\/b>, 100249 (2020).","DOI":"10.1016\/j.eclinm.2019.100249"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Strong AL, Bowles AC, Wise RM, Morand JP, Dutreil MF, Gimble JM, Bunnell BA. Human adipose stromal\/stem cells from obese donors show reduced efficacy in halting disease progression in the experimental autoimmune encephalomyelitis model of multiple sclerosis. <i>Stem Cells<\/i>, <b>34<\/b>, 614\u2013626 (2016).","DOI":"10.1002\/stem.2272"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Alicka M, Major P, Wysocki M, Marycz K. Adipose-derived mesenchymal stem cells isolated from patients with type 2 diabetes show reduced \u201cStemness\u201d through an altered secretome profile, impaired anti-oxidative protection, and mitochondrial dynamics deterioration. <i>J. Clin. Med.<\/i>, <b>8<\/b>, 765 (2019).","DOI":"10.3390\/jcm8060765"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Eirin A, Thaler R, Glasstetter LM, Xing L, Zhu XY, Osborne AC, Mondesir R, Bhagwate AV, Lerman A, van Wijnen AJ, Ler-man LO. Obesity-driven mitochondrial dysfunction in human adipose tissue-derived mesenchymal stem\/stromal cells involves epigenetic changes. <i>Cell Death Dis.<\/i>, <b>15<\/b>, 387 (2024).","DOI":"10.1038\/s41419-024-06774-8"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Nakajima K, Sano S. Mouse models of psoriasis and their relevance. <i>J. Dermatol.<\/i>, <b>45<\/b>, 252\u2013263 (2018).","DOI":"10.1111\/1346-8138.14112"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) van der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD, Cornelissen F, Mus AM, Florencia E, Prens EP, Lubberts E. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated <i>via<\/i> the IL-23\/IL-17 axis. <i>J. Immunol.<\/i>, <b>182<\/b>, 5836\u20135845 (2009).","DOI":"10.4049\/jimmunol.0802999"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Gangwar RS, Gudjonsson JE, Ward NL. Mouse Models of psoriasis: a comprehensive review. <i>J. Invest. Dermatol.<\/i>, <b>142<\/b> (3 Pt. B), 884\u2013897 (2022).","DOI":"10.1016\/j.jid.2021.06.019"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Swindell WR, Johnston A, Carbajal S, Han G, Wohn C, Lu J, Xing X, Nair RP, Voorhees JJ, Elder JT, Wang XJ, Sano S, Prens EP, DiGiovanni J, Pittelkow MR, Ward NL, Gudjonsson JE. Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis. <i>PLOS ONE<\/i>, <b>6<\/b>, e18266 (2011).","DOI":"10.1371\/journal.pone.0018266"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Swindell WR, Michaels KA, Sutter AJ, Diaconu D, Fritz Y, Xing X, Sarkar MK, Liang Y, Tsoi A, Gudjonsson JE, Ward NL. Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis. <i>Genome Med.<\/i>, <b>9<\/b>, 24 (2017).","DOI":"10.1186\/s13073-017-0415-3"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Rokunohe A, Matsuzaki Y, Rokunohe D, Sakuraba Y, Fukui T, Nakano H, Sawamura D. Immunosuppressive effect of adipose-derived stromal cells on imiquimod-induced psoriasis in mice. <i>J. Dermatol. Sci.<\/i>, <b>82<\/b>, 50\u201353 (2016).","DOI":"10.1016\/j.jdermsci.2015.12.007"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Sah SK, Park KH, Yun CO, Kang KS, Kim TY. Effects of human mesenchymal stem cells transduced with superoxide dismutase on imiquimod-induced psoriasis-like skin inflammation in mice. <i>Antioxid. Redox Signal.<\/i>, <b>24<\/b>, 233\u2013248 (2017).","DOI":"10.1089\/ars.2015.6368"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Lee YS, Sah SK, Lee JH, Seo KW, Kang KS, Kim TY. Human umbilical cord blood-derived mesenchymal stem cells ameliorate psoriasis-like skin inflammation in mice. <i>Biochem. Biophys. Rep.<\/i>, <b>9<\/b>, 281\u2013288 (2017).","DOI":"10.1016\/j.bbrep.2016.10.002"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Imai Y, Yamahara K, Hamada A, Fujimori Y, Yamanishi K. Human amnion-derived mesenchymal stem cells ameliorate imiquimod-induced psoriasiform dermatitis in mice. <i>J. Dermatol.<\/i>, <b>46<\/b>, 276\u2013278 (2019).","DOI":"10.1111\/1346-8138.14768"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Kim CH, Lim CY, Lee JH, Kim KC, Ahn JY, Lee EJ. Human embryonic stem cells-derived mesenchymal stem cells reduce the symptom of psoriasis in imiquimod-induced skin model. <i>Tissue Eng. Regen. Med.<\/i>, <b>16<\/b>, 93\u2013102 (2019).","DOI":"10.1007\/s13770-018-0165-3"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Chen M, Peng J, Xie Q, Xiao N, Su X, Mei H, Lu Y, Zhou J, Dai Y, Wang S, Li C, Lin G, Cheng L. Mesenchymal stem cells alleviate moderate-to-severe psoriasis by reducing the production of type I interferon (Ifn-I) by plasmacytoid dendritic cells (pDCs). <i>Stem Cells Int.<\/i>, <b>2019<\/b>, 6961052 (2019).","DOI":"10.1155\/2019\/6961052"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Ye Z, Liang Y, Lin B, Li Y, Chai X, Lian J, Zhang X, Che Z, Zeng J. Gingiva-derived mesenchymal stem cells attenuate imiquimod- (Imq-) induced murine psoriasis-like skin inflammation. <i>Stem Cells Int.<\/i>, <b>2022<\/b>, 6544514 (2022).","DOI":"10.1155\/2022\/6544514"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Zhang Y, Yan J, Li Z, Zheng J, Sun Q. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate psoriasis-like skin inflammation. <i>J. Interferon Cytokine Res.<\/i>, <b>42<\/b>, 8\u201318 (2022).","DOI":"10.1089\/jir.2021.0146"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Cuesta-Gomez N, Medina-Ruiz L, Graham GJ, Campbell JDM. IL-6 and TGF-\u03b2-secreting adoptively-transferred murine mesenchymal stromal cells accelerate healing of psoriasis-like skin inflammation and upregulate IL-17A and TGF-\u03b2. <i>Int. J. Mol. Sci.<\/i>, <b>24<\/b>, 10132 (2023).","DOI":"10.3390\/ijms241210132"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Johnston A, Xing X, Wolterink L, Barnes DH, Yin Z, Reingold L, Kahlenberg JM, Harms PW, Gudjonsson JE. IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis. <i>J. Allergy Clin. Immunol.<\/i>, <b>140<\/b>, 109\u2013120 (2017).","DOI":"10.1016\/j.jaci.2016.08.056"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Wu DH, Zhang MM, Li N, Li X, Cai QW, Yu WL, Liu LP, Zhu W, Lu CJ. PSORI-CM02 alleviates IMQ-induced mouse dermatitis <i>via<\/i> differentially regulating pro- and anti-inflammatory cytokines targeting of Th2 specific transcript factor GATA3. <i>Biomed. Pharmacother.<\/i>, <b>110<\/b>, 265\u2013274 (2019).","DOI":"10.1016\/j.biopha.2018.11.092"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Ohgane K, Yoshioka H. Quantification of gel bands by an Image J Macro, band\/peak quantification tool. <i>protocols.io<\/i> (2019).","DOI":"10.17504\/protocols.io.7vghn3w"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Viswanathan S, Shi Y, Galipeau J, Krampera M, Leblanc K, Martin I, Nolta J, Phinney DG, Sensebe L. Mesenchymal stem <i>versus<\/i> stromal cells: International Society for Cell &amp; Gene Therapy (ISCT<sup>\u00ae<\/sup>) Mesenchymal Stromal Cell committee position statement on nomenclature. <i>Cytotherapy<\/i>, <b>21<\/b>, 1019\u20131024 (2019).","DOI":"10.1016\/j.jcyt.2019.08.002"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop DJ, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. <i>Cytotherapy<\/i>, <b>8<\/b>, 315\u2013317 (2006).","DOI":"10.1080\/14653240600855905"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Hwang I, Jo K, Shin KC, Kim JI, Ji Y, Park YJ, Park J, Jeon YG, Ka S, Suk S, Noh HL, Choe SS, Alfadda AA, Kim JK, Kim S, Kim JB. GABA-stimulated adipose-derived stem cells suppress subcutaneous adipose inflammation in obesity. <i>Proc. Natl. Acad. Sci. U.S.A<\/i>, <b>116<\/b>, 11936\u201311945 (2019).","DOI":"10.1073\/pnas.1822067116"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Yoshiki R, Kabashima K, Honda T, Nakamizo S, Sawada Y, Sugita K, Yoshioka H, Ohmori S, Malissen B, Tokura Y, Naka-mura M. IL-23 from Langerhans cells is required for the development of imiquimod-induced psoriasis-like dermatitis by induction of IL-17A-producing <i>\u03b3\u03b4<\/i> T cells. <i>J. Invest. Dermatol.<\/i>, <b>134<\/b>, 1912\u20131921 (2014).","DOI":"10.1038\/jid.2014.98"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Gilliet M, Conrad C, Geiges M, Cozzio A, Th\u00fcrlimann W, Burg G, Nestle FO, Dummer R. Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors. <i>Arch. Dermatol.<\/i>, <b>140<\/b>, 1490\u20131495 (2004).","DOI":"10.1001\/archderm.140.12.1490"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Moos S, Mohebiany AN, Waisman A, Kurschus FC. Imiquimod-induced psoriasis in mice depends on the IL-17 signaling of keratinocytes. <i>J. Invest. Dermatol.<\/i>, <b>139<\/b>, 1110\u20131117 (2019).","DOI":"10.1016\/j.jid.2019.01.006"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Walter A, Sch\u00e4fer M, Cecconi V, Matter C, Urosevic-Maiwald M, Belloni B, Sch\u00f6newolf N, Dummer R, Bloch W, Werner S, Beer HD, Knuth A, van den Broek M. Aldara activates TLR7-independent immune defence. <i>Nat. Commun.<\/i>, <b>4<\/b>, 1560 (2013).","DOI":"10.1038\/ncomms2566"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Stra\u00df S, Geiger J, Martorelli M, Geiger S, Cloos N, Keppler M, Fischer T, Riexinger L, Schwamborn A, Guezguez J, Sp\u00e4th N, Cruces S, Guse JH, Sandri TL, Burnet M, Laufer S. Isostearic acid is an active component of imiquimod formulations used to induce psoriaform disease models. <i>Inflammopharmacology<\/i>, <b>31<\/b>, 799\u2013812 (2023).","DOI":"10.1007\/s10787-023-01175-3"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Shimizu T, Kamata M, Fukaya S, Hayashi K, Fukuyasu A, Tanaka T, Ishikawa T, Ohnishi T, Tada Y. Anti-IL-17A and IL-23p19 antibodies but not anti-TNF<i>\u03b1<\/i> antibody induce expansion of regulatory T cells and restoration of their suppressive function in imiquimod-induced psoriasiform dermatitis. <i>J. Dermatol. Sci.<\/i>, <b>95<\/b>, 90\u201398 (2019).","DOI":"10.1016\/j.jdermsci.2019.07.006"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Li Q, Liu W, Gao S, Mao Y, Xin Y. Application of imiquimod-induced murine psoriasis model in evaluating interleukin-17A antagonist. <i>BMC Immunol.<\/i>, <b>22<\/b>, 11 (2021).","DOI":"10.1186\/s12865-021-00401-3"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) D\u2019Erme AM, Wilsmann-Theis D, Wagenpfeil J, H\u00f6lzel M, Ferring-Schmitt S, Sternberg S, Wittmann M, Peters B, Bosio A, Bieber T, Wenzel J. IL-36<i>\u03b3<\/i> (IL-1F9) is a biomarker for psoriasis skin lesions. <i>J. Invest. Dermatol.<\/i>, <b>135<\/b>, 1025\u20131032 (2015).","DOI":"10.1038\/jid.2014.532"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Samotij D, Szcz\u0119ch J, Reich A. Generalized pustular psoriasis: divergence of innate and adaptive immunity. <i>Int. J. Mol. Sci.<\/i>, <b>22<\/b>, 9048 (2021).","DOI":"10.3390\/ijms22169048"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Giannoudaki E, Stefanska AM, Lawler H, Leon G, Hernandez Santana YE, Hassan N, Russell SE, Horan R, Sweeney C, Pres-ton RS, Mantovani A, Garlanda C, Fallon PG, Walsh PT. SIGIRR negatively regulates IL-36-driven psoriasiform inflammation and neutrophil infiltration in the skin. <i>J. Immunol.<\/i>, <b>207<\/b>, 651\u2013660 (2021).","DOI":"10.4049\/jimmunol.2100237"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Chi HH, Hua KF, Lin YC, Chu CL, Hsieh CY, Hsu YJ, Ka SM, Tsai YL, Liu FC, Chen A. IL-36 signaling facilitates activation of the NLRP3 inflammasome and IL-23\/IL-17 axis in renal inflammation and fibrosis. <i>J. Am. Soc. Nephrol.<\/i>, <b>28<\/b>, 2022\u20132037 (2017).","DOI":"10.1681\/ASN.2016080840"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Zhan ZY, Jiang M, Zhang ZH, An YM, Wang XY, Wu YL, Nan JX, Lian LH. NETs contribute to psoriasiform skin inflammation: a novel therapeutic approach targeting IL-36 cytokines by a small molecule tetrahydroxystilbene glucoside. <i>Phytomedicine<\/i>, <b>131<\/b>, 155783 (2024).","DOI":"10.1016\/j.phymed.2024.155783"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Ganesan R, Raymond EL, Mennerich D, <i>et al<\/i>. Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies. <i>MAbs<\/i>, <b>9<\/b>, 1143\u20131154 (2017).","DOI":"10.1080\/19420862.2017.1353853"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Fischer B, K\u00fcbelbeck T, Kolb A, Ringen J, Waisman A, Wittmann M, Karbach S, K\u00f6lsch SM, Kramer D. IL-17A-driven psoriasis is critically dependent on IL-36 signaling. <i>Front. Immunol.<\/i>, <b>14<\/b>, 1256133 (2023).","DOI":"10.3389\/fimmu.2023.1256133"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Zhang ZH, Zhan ZY, Jiang M, Wang XY, Quan SL, Wu YL, Nan JX, Lian LH. Casting NETs on psoriasis: the modulation of inflammatory feedback targeting IL-36\/IL-36R axis. <i>Int. Immunopharmacol.<\/i>, <b>142<\/b> (Pt. B), 113190  (2024).","DOI":"10.1016\/j.intimp.2024.113190"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Jiang D, Muschhammer J, Qi Y, K\u00fcgler A, de Vries JC, Saffarzadeh M, Sindrilaru A, Beken SV, Wlaschek M, Kluth MA, Ganss C, Frank NY, Frank MH, Preissner KT, Scharffetter-Kochanek K. Suppression of neutrophil-mediated tissue damage\u2014a novel skill of mesenchymal stem cells. <i>Stem Cells<\/i>, <b>34<\/b>, 2393\u20132406 (2016).","DOI":"10.1002\/stem.2417"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Chen L, Liu Y, Wang Z, Zhang L, Xu Y, Li Y, Zhang L, Wang G, Yang S, Xue G. Mesenchymal stem cell-derived extracellular vesicles protect against abdominal aortic aneurysm formation by inhibiting NET-induced ferroptosis. <i>Exp. Mol. Med.<\/i>, <b>55<\/b>, 939\u2013951 (2023).","DOI":"10.1038\/s12276-023-00986-2"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61) Nagase K, Okada A, Matsuda J, Ichikawa D, Hattori Y, Kanazawa H. A thermoresponsive cationic block copolymer brush-grafted silica bead interface for temperature-modulated separation of adipose-derived stem cells. <i>Colloids Surf. B Biointerfaces<\/i>, <b>220<\/b>, 112928 (2022).","DOI":"10.1016\/j.colsurfb.2022.112928"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62) Nagase K, Wakayama H, Matsuda J, Kojima N, Kanazawa H. Thermoresponsive mixed polymer brush to effectively control the adhesion and separation of stem cells by altering temperature. <i>Mater. Today Bio<\/i>, <b>20<\/b>, 100627 (2023).","DOI":"10.1016\/j.mtbio.2023.100627"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/48\/6\/48_b25-00060\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T03:34:29Z","timestamp":1749872069000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/48\/6\/48_b25-00060\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,11]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b25-00060","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,11]]},"article-number":"b25-00060"}}