{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:04:41Z","timestamp":1759565081648,"version":"3.41.0"},"reference-count":32,"publisher":"Pharmaceutical Society of Japan","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2025,6,28]]},"DOI":"10.1248\/bpb.b25-00233","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T22:07:38Z","timestamp":1751062058000},"page":"932-940","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacological Characteristics of Extracellular Ca&lt;sup&gt;2+&lt;\/sup&gt; Influx Pathways Responsible for Platelet-Activating Factor-Induced Contractions in Rat Esophagus Smooth Muscle: Involvement of L-Type, Receptor-Operated, and Store-Operated Ca&lt;sup&gt;2+&lt;\/sup&gt; Channels"],"prefix":"10.1248","volume":"48","author":[{"given":"Keisuke","family":"Obara","sequence":"first","affiliation":[{"name":"Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Otake","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mako","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momoko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Ura","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mio","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azusa","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kento","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taichi","family":"Kusakabe","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2\u20132\u20131 Miyama, Funabashi, Chiba 274\u20138510, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"doi-asserted-by":"crossref","unstructured":"1) Obara K, Yoshioka K, Tanaka Y. Effects of platelet-activating factor (PAF) on the mechanical activities of lower urinary tract and genital smooth muscles. <i>Biol. Pharm. Bull.<\/i>, <b>47<\/b>, 1467\u20131476 (2024).","key":"1","DOI":"10.1248\/bpb.b24-00440"},{"doi-asserted-by":"crossref","unstructured":"2) Obara K, Yoshioka K, Tanaka Y. Platelet-activating factor (PAF) in urinary bladder smooth muscle (UBSM): its novel role as a potential inducer of detrusor overactivity and the mechanisms underlying its effects in enhancing UBSM mechanical activities. <i>Yakugaku Zasshi<\/i>, <b>144<\/b>, 997\u20131007 (2024).","key":"2","DOI":"10.1248\/yakushi.24-00136"},{"doi-asserted-by":"crossref","unstructured":"3) Kamata K, Arai Y, Kasuya Y. Mechanism of the contractile response to platelet-activating factor (PAF) of the rat stomach fundus. I. PAF-induced contractile response and calcium mobilization. <i>Gen. Pharmacol.<\/i>, <b>24<\/b>, 1331\u20131336 (1993).","key":"3","DOI":"10.1016\/0306-3623(93)90415-T"},{"doi-asserted-by":"crossref","unstructured":"4) Obara K, Ichimura A, Arai T, Fujiwara M, Otake M, Yamada N, Yoshioka K, Kusakabe T, Takahashi K, Kato K, Tanaka Y. Platelet-activating factor contracts guinea pig esophageal muscularis mucosae by stimulating extracellular Ca<sup>2+<\/sup> influx through diltiazem-insensitive Ca<sup>2+<\/sup> channels. <i>J. Pharmacol. Sci.<\/i>, <b>154<\/b>, 256\u2013263 (2024).","key":"4","DOI":"10.1016\/j.jphs.2024.01.009"},{"doi-asserted-by":"crossref","unstructured":"5) Obara K, Takahashi S, Otake M, Fujiwara M, Yamashita M, Murata A, Yoshioka K, Tanaka Y. Platelet-activating factor (PAF) induces strong mechanical activities accompanied by basal tension increases in esophageal and gastric fundus smooth muscles from rat. <i>Biol. Pharm. Bull.<\/i>, <b>48<\/b>, 563\u2013570 (2025).","key":"5","DOI":"10.1248\/bpb.b25-00125"},{"doi-asserted-by":"crossref","unstructured":"6) Parkman HP, James AN, Ryan JP. The contractile action of platelet-activating factor on gallbladder smooth muscle. <i>Am. J. Physiol. Gastrointest. Liver Physiol.<\/i>, <b>279<\/b>, G67\u2013G72 (2000).","key":"6","DOI":"10.1152\/ajpgi.2000.279.1.G67"},{"doi-asserted-by":"crossref","unstructured":"7) Jeanneton O, Delvaux M, Botella A, Frexinos J, Bueno L. Platelet-activating factor (PAF) induces a contraction of isolated smooth muscle cells from guinea pig ileum: intracellular pathway involved. <i>J. Pharmacol. Exp. Ther.<\/i>, <b>267<\/b>, 31\u201337 (1993).","key":"7","DOI":"10.1016\/S0022-3565(25)39442-5"},{"doi-asserted-by":"crossref","unstructured":"8) Obara K, Kaneko M, Yamashita M, Liu G, Yoshioka K, Tanaka Y. Platelet-activating factor (PAF) enhances guinea pig detrusor smooth muscle contractile activities by stimulating voltage-dependent Ca<sup>2+<\/sup> channels and store-operated Ca<sup>2+<\/sup> channels. <i>J. Pharmacol. Sci.<\/i>, <b>152<\/b>, 123\u2013127 (2023).","key":"8","DOI":"10.1016\/j.jphs.2023.04.004"},{"doi-asserted-by":"crossref","unstructured":"9) Liu G, Obara K, Yoshioka K, Tanaka Y. Pharmacological studies on the Ca<sup>2+<\/sup> influx pathways in platelet-activating factor (PAF)-induced mouse urinary bladder smooth muscle contraction. <i>Biol. Pharm. Bull.<\/i>, <b>46<\/b>, 997\u20131003 (2023).","key":"9","DOI":"10.1248\/bpb.b22-00923"},{"doi-asserted-by":"crossref","unstructured":"10) Liu G, Kaneko M, Yoshioka K, Obara K, Tanaka Y. Platelet-activating factor (PAF) strongly enhances contractile mechanical activities in guinea pig and mouse urinary bladder. <i>Sci. Rep.<\/i>, <b>12<\/b>, 2783 (2022).","key":"10","DOI":"10.1038\/s41598-022-06535-7"},{"doi-asserted-by":"crossref","unstructured":"11) Pfeiffer S, Leopold E, Schmidt K, Brunner F, Mayer B. Inhibition of nitric oxide synthesis by N<sup>G<\/sup>-nitro-l-arginine methyl ester (l-NAME): requirement for bioactivation to the free acid, N<sup>G<\/sup>-nitro-l-arginine. <i>Br. J. Pharmacol.<\/i>, <b>118<\/b>, 1433\u20131440 (1996).","key":"11","DOI":"10.1111\/j.1476-5381.1996.tb15557.x"},{"doi-asserted-by":"crossref","unstructured":"12) Obara K, Kobayashi Y, Chino D, Tanaka Y. Effect of distigmine on the contractile response of guinea pig urinary bladder to electrical field stimulation. <i>Eur. J. Pharmacol.<\/i>, <b>809<\/b>, 209\u2013214 (2017).","key":"12","DOI":"10.1016\/j.ejphar.2017.05.031"},{"doi-asserted-by":"crossref","unstructured":"13) Kanaya S, Katzung BG. Effects of diltiazem on transmembrane potential and current of right ventricular papillary muscle of ferrets. <i>J. Pharmacol. Exp. Ther.<\/i>, <b>228<\/b>, 245\u2013251 (1984).","key":"13","DOI":"10.1016\/S0022-3565(25)21558-0"},{"doi-asserted-by":"crossref","unstructured":"14) Krautwurst D, Degtiar VE, Schultz G, Hescheler J. The isoquinoline derivative LOE 908 selectively blocks vasopressin-activated nonselective cation currents in A7r5 aortic smooth muscle cells. <i>Naunyn Schmiedebergs Arch. Pharmacol.<\/i>, <b>349<\/b>, 301\u2013307 (1994).","key":"14","DOI":"10.1007\/BF00169297"},{"doi-asserted-by":"crossref","unstructured":"15) Tanaka Y, Imai T, Igarashi T, Takayanagi K, Otsuka K, Yamaki F, Tanaka H, Shigenobu K. Comparison of the Ca<sup>2+<\/sup> entry channels responsible for mechanical responses of guinea-pig aorta to noradrenaline and thapsigargin using SK&amp;F 96365 and LOE 908. <i>Naunyn Schmiedebergs Arch. Pharmacol.<\/i>, <b>362<\/b>, 160\u2013168 (2000).","key":"15","DOI":"10.1007\/s002100000272"},{"doi-asserted-by":"crossref","unstructured":"16) Thorneloe KS, Cheung M, Bao W, <i>et al<\/i>. An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. <i>Sci. Transl. Med.<\/i>, <b>4<\/b>, 159ra148 (2012).","key":"16","DOI":"10.1126\/scitranslmed.3004276"},{"doi-asserted-by":"crossref","unstructured":"17) Maier T, Follmann M, Hessler G, Kleemann HW, Hachtel S, Fuchs B, Weissmann N, Linz W, Schmidt T, L\u00f6hn M, Schroeter K, Wang L, R\u00fctten H, Str\u00fcbing C. Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. <i>Br. J. Pharmacol.<\/i>, <b>172<\/b>, 3650\u20133660 (2015).","key":"17","DOI":"10.1111\/bph.13151"},{"doi-asserted-by":"crossref","unstructured":"18) Schleifer H, Doleschal B, Lichtenegger M, Oppenrieder R, Derler I, Frischauf I, Glasnov TN, Kappe CO, Romanin C, Groschner K. Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca<sup>2+<\/sup> entry pathways. <i>Br. J. Pharmacol.<\/i>, <b>167<\/b>, 1712\u20131722 (2012).","key":"18","DOI":"10.1111\/j.1476-5381.2012.02126.x"},{"doi-asserted-by":"crossref","unstructured":"19) Zhang X, Xin P, Yoast RE, Emrich SM, Johnson MT, Pathak T, Benson JC, Azimi I, Gill DL, Monteith GR, Trebak M. Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels. <i>Cell Calcium<\/i>, <b>91<\/b>, 102281 (2020).","key":"19","DOI":"10.1016\/j.ceca.2020.102281"},{"doi-asserted-by":"crossref","unstructured":"20) Horinouchi T, Terada K, Higashi T, Miwa S. Endothelin receptor signaling: new insight into its regulatory mechanisms. <i>J. Pharmacol. Sci.<\/i>, <b>123<\/b>, 85\u2013101 (2013).","key":"20","DOI":"10.1254\/jphs.13R02CR"},{"doi-asserted-by":"crossref","unstructured":"21) Wang Y, Deng X, Hewavitharana T, Soboloff J, Gill DL. Stim, ORAI and TRPC channels in the control of calcium entry signals in smooth muscle. <i>Clin. Exp. Pharmacol. Physiol.<\/i>, <b>35<\/b>, 1127\u20131133 (2008).","key":"21","DOI":"10.1111\/j.1440-1681.2008.05018.x"},{"doi-asserted-by":"crossref","unstructured":"22) Yang X-R, Lin M-J, McIntosh LS, Sham JSK. Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle. <i>Am. J. Physiol. Lung Cell. Mol. Physiol.<\/i>, <b>290<\/b>, L1267\u2013L1276 (2006).","key":"22","DOI":"10.1152\/ajplung.00515.2005"},{"doi-asserted-by":"crossref","unstructured":"23) Yang H, Hou C, Xiao W, Qiu Y. The role of mechanosensitive ion channels in the gastrointestinal tract. <i>Front. Physiol.<\/i>, <b>13<\/b>, 904203 (2022).","key":"23","DOI":"10.3389\/fphys.2022.904203"},{"doi-asserted-by":"crossref","unstructured":"24) Retailleau K, Duprat F, Arhatte M, Ranade SS, Peyronnet R, Martins JR, Jodar M, Moro C, Offermanns S, Feng Y, Demolombe S, Patel A, Honor\u00e9 E. Piezo1 in smooth muscle cells is involved in hypertension-dependent arterial remodeling. <i>Cell Rep.<\/i>, <b>13<\/b>, 1161\u20131171 (2015).","key":"24","DOI":"10.1016\/j.celrep.2015.09.072"},{"doi-asserted-by":"crossref","unstructured":"25) Cheng KT, Ong HL, Liu X, Ambudkar IS. Contribution and regulation of TRPC channels in store-operated Ca<sup>2+<\/sup> entry. <i>Curr. Top. Membr.<\/i>, <b>71<\/b>, 149\u2013179 (2013).","key":"25","DOI":"10.1016\/B978-0-12-407870-3.00007-X"},{"doi-asserted-by":"crossref","unstructured":"26) Waldherr L, Tiffner A, Mishra D, Sallinger M, Schober R, Frischauf I, Schmidt T, Handl V, Sagmeister P, K\u00f6ckinger M, Derler I, \u00dc\u00e7al M, Bonhenry D, Patz S, Schindl R. Blockage of store-operated Ca<sup>2+<\/sup> influx by Synta66 is mediated by direct inhibition of the Ca<sup>2+<\/sup>-selective Orai1 pore. <i>Cancers (Basel)<\/i>, <b>12<\/b>, 2876 (2020).","key":"26","DOI":"10.3390\/cancers12102876"},{"doi-asserted-by":"crossref","unstructured":"27) Xu K, Shimizu M, Yamashita T, Fujiwara M, Oikawa S, Ou G, Takazakura N, Kusakabe T, Takahashi K, Kato K, Yoshioka K, Obara K, Tanaka Y. Inhibitory mechanisms of docosahexaenoic acid on carbachol-, angiotensin II-, and bradykinin-induced contractions in guinea pig gastric fundus smooth muscle. <i>Sci. Rep.<\/i>, <b>14<\/b>, 11720 (2024).","key":"27","DOI":"10.1038\/s41598-024-62578-y"},{"doi-asserted-by":"crossref","unstructured":"28) Obara K, Yoshioka K, De Dios Regadera M, Matsuyama Y, Yashiro A, Miyokawa M, Iura R, Tanaka Y. Phenylephrine-induced contraction in guinea pig thoracic aorta is triggered by stimulation of <i>\u03b1<\/i><sub>1L<\/sub>-adrenoceptors functionally coupled with store-operated Ca<sup>2+<\/sup> channels and voltage-dependent Ca<sup>2+<\/sup> channels. <i>Biol. Pharm. Bull.<\/i>, <b>46<\/b>, 309\u2013319 (2023).","key":"28","DOI":"10.1248\/bpb.b22-00754"},{"doi-asserted-by":"crossref","unstructured":"29) Vadas P, Gold M, Perelman B, Liss GM, Lack G, Blyth T, Simons FE, Simons KJ, Cass D, Yeung J. Platelet-Activating Factor, PAF acetylhydrolase, and severe anaphylaxis. <i>N. Engl. J. Med.<\/i>, <b>358<\/b>, 28\u201335 (2008).","key":"29","DOI":"10.1056\/NEJMoa070030"},{"doi-asserted-by":"crossref","unstructured":"30) McFadzean I, Gibson A. The developing relationship between receptor-operated and store-operated calcium channels in smooth muscle. <i>Br. J. Pharmacol.<\/i>, <b>135<\/b>, 1\u201313 (2002).","key":"30","DOI":"10.1038\/sj.bjp.0704468"},{"doi-asserted-by":"crossref","unstructured":"31) Horinouchi T, Terada K, Higa T, Aoyagi H, Nishiya T, Suzuki H, Miwa S. Function and regulation of endothelin type A receptor-operated transient receptor potential canonical channels. <i>J. Pharmacol. Sci.<\/i>, <b>117<\/b>, 295\u2013306 (2011).","key":"31","DOI":"10.1254\/jphs.11162FP"},{"doi-asserted-by":"crossref","unstructured":"32) Parekh AB, Putney JW Jr. Store-operated calcium channels. <i>Physiol. Rev.<\/i>, <b>85<\/b>, 757\u2013810 (2005).","key":"32","DOI":"10.1152\/physrev.00057.2003"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/48\/6\/48_b25-00233\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T03:25:00Z","timestamp":1751081100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/48\/6\/48_b25-00233\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,28]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b25-00233","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"type":"print","value":"0918-6158"},{"type":"electronic","value":"1347-5215"}],"subject":[],"published":{"date-parts":[[2025,6,28]]},"article-number":"b25-00233"}}