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Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts. <i>Br. J. Pharmacol.<\/i>, <b>154<\/b>, 1528\u20131537 (2008).","DOI":"10.1038\/bjp.2008.240"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Sugiyama A, Hashimoto K. Effects of gastrointestinal prokinetic agents, TKS159 and cisapride, on the in situ canine heart assessed by cardiohemodynamic and electrophysiological monitoring. <i>Toxicol. Appl. Pharmacol.<\/i>, <b>152<\/b>, 261\u2013269 (1998).","DOI":"10.1006\/taap.1998.8494"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Takahara A, Fujiwara K, Ohtsuki A, Oka T, Namekata I, Tanaka H. Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs. <i>J. Pharmacol. 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Torsadogenic potential of HCN channel blocker ivabradine assessed in the rabbit proarrhythmia model. <i>Biol. Pharm. Bull.<\/i>, <b>44<\/b>, 1796\u20131799 (2021).","DOI":"10.1248\/bpb.b21-00605"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Kawakami S, Takada K, Aimoto M, Nagasawa Y, Kusakabe T, Kato K, Takahara A. The antiarrhythmic action of the Na<sup>+<\/sup>\/Ca<sup>2+<\/sup> exchanger inhibitor SEA0400 on drug-induced long QT syndrome depends on the severity of proarrhythmic conditions in anesthetized atrioventricular block rabbits. <i>Biol. Pharm. Bull.<\/i>, <b>46<\/b>, 1120\u20131127 (2023).","DOI":"10.1248\/bpb.b23-00202"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Takahara A, Sugiyama A, Ishida Y, Satoh Y, Wang K, Nakamura Y, Hashimoto K. Long-term bradycardia caused by atrioventricular block can remodel the canine heart to detect the histamine H<sub>1<\/sub> blocker terfenadine-induced torsades de pointes arrhythmias. <i>Br. J. 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Blockade of <i>I<\/i><sub>Ks<\/sub> by HMR 1556 increases the reverse rate-dependence of refractoriness prolongation by dofetilide in isolated rabbit ventricles. <i>Br. J. Pharmacol.<\/i>, <b>148<\/b>, 255\u2013263 (2006).","DOI":"10.1038\/sj.bjp.0706721"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Nagasawa Y, Shimoda A, Shiratori H, Morishita T, Sakuma K, Chiba T, Cao X, Kawakami S, Aimoto M, Miyazaki C, Sato S, Takahashi M, Shimizu K, Shirai K, Takahara A. Analysis of effects of acute hypovolemia on arterial stiffness in rabbits monitored with cardio-ankle vascular index. <i>J. Pharmacol. Sci.<\/i>, <b>148<\/b>, 331\u2013336 (2022).","DOI":"10.1016\/j.jphs.2022.01.008"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) S\u00e1nchez-Chapula J. Effects of metoprolol on action potential and membrane currents in guinea-pig ventricular myocytes. <i>Naunyn Schmiedebergs Arch. 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