{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:17:21Z","timestamp":1783948641667,"version":"3.55.0"},"reference-count":15,"publisher":"Pharmaceutical Society of Japan","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2025,11,28]]},"DOI":"10.1248\/bpb.b25-00466","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T22:08:28Z","timestamp":1764281308000},"page":"1810-1812","source":"Crossref","is-referenced-by-count":1,"title":["Protective Effects of Maternal Administration of a Standardized Extract of Cultured &lt;i&gt;Lentinula edodes&lt;\/i&gt; Mycelia against Radiation-Induced Fetal Morphological Abnormalities"],"prefix":"10.1248","volume":"48","author":[{"given":"Shigeki","family":"Adachi","sequence":"first","affiliation":[{"name":"Department of Cellular Immunology, Research Institute for Microbial Diseases, Osaka University, 3\u20131 Yamadaoka, Suita, Osaka 565\u20130871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Tougan","sequence":"additional","affiliation":[{"name":"Department of Cellular Immunology, Research Institute for Microbial Diseases, Osaka University, 3\u20131 Yamadaoka, Suita, Osaka 565\u20130871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiyo","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Cellular Immunology, Research Institute for Microbial Diseases, Osaka University, 3\u20131 Yamadaoka, Suita, Osaka 565\u20130871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Takanari","sequence":"additional","affiliation":[{"name":"Amino Up Co., Ltd., 363\u201332 Shin-ei, Kiyota-ku, Sapporo 004\u20130839, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Wakame","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Department of Pharmacy, Hokkaido University of Science, 15\u20134\u20131 Maeda 7, Teine-ku, Sapporo 006\u20138585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Aoshi","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1\u201312\u20134 Sakamoto, Nagasaki 852\u20138523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisei","family":"Nomura","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine, Osaka University, 2\u20132 Yamadaoka, Suita, Osaka 565\u20130871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Chang DS, Lasley FD, Das IJ, Mendonca MS, Dynlacht JR. Radiation effects in the embryo and fetus. <i>Basic Radiotherapy Physics and Biology<\/i>, 349\u2013353 (2021).","DOI":"10.1007\/978-3-030-61899-5_35"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Kim SH, Lee JH, Oh H, Kim SR, Lee CS, Jo SK, Kim TH, Lee YS. Dependence of malformation upon gestational age and exposed dose of gamma radiation. <i>J. Radiat. Res.<\/i>, <b>42<\/b>, 255\u2013264 (2001).","DOI":"10.1269\/jrr.42.255"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Meng X, Liang H, Luo L. Antitumor polysaccharides from mushrooms: a review on the structural characteristics, antitumor mechanisms and immunomodulating activities. <i>Carbohydr. Res.<\/i>, <b>424<\/b>, 30\u201341 (2016).","DOI":"10.1016\/j.carres.2016.02.008"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Pan M, Kong F, Xing L, Yao L, Li Y, Liu Y, Li C, Li L. The structural characterization and immunomodulatory activity of polysaccharides from <i>Pleurotus abieticola<\/i> fruiting bodies. <i>Nutrients<\/i>, <b>14<\/b>, 4410 (2022).","DOI":"10.3390\/nu14204410"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Park HJ, Boo S, Park I, Shin MS, Takahashi T, Takanari J, Homma K, Kang I. AHCC<sup>\u00ae<\/sup>, a standardized extract of cultured <i>Lentinula edodes<\/i> mycelia, promotes the anti-tumor effect of dual immune checkpoint blockade effect in murine colon cancer. <i>Front. Immunol.<\/i>, <b>13<\/b>, 875872 (2022).","DOI":"10.3389\/fimmu.2022.875872"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Ritz BW. Supplementation with active hexose correlated compound increases survival following infectious challenge in mice. <i>Nutr Rev.<\/i>, <b>66<\/b>, 526\u2013531 (2008).","DOI":"10.1111\/j.1753-4887.2008.00085.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Stoecklein VM, Osuka A, Ishikawa S, Lederer MR, Wanke-Jellinek L, Lederer JA. Radiation exposure induces inflammasome pathway activation in immune cells. <i>J. Immunol.<\/i>, <b>194<\/b>, 1178\u20131189 (2015).","DOI":"10.4049\/jimmunol.1303051"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Nomura T, Hata S, Kusafuka T. Suppression of developmental anomalies by maternal macrophages in mice. <i>J. Exp. Med.<\/i>, <b>172<\/b>, 1325\u20131330 (1990).","DOI":"10.1084\/jem.172.5.1325"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Cherayil BJ, Jain N. From womb to world: exploring the immunological connections between mother and child. <i>Immunohorizons<\/i>, <b>8<\/b>, 552\u2013562 (2024).","DOI":"10.4049\/immunohorizons.2400032"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Hourtovenko C, Sreetharan S, Tharmalingam S, Tai TC. Impact of ionizing radiation exposure on placental function and implications for fetal programming. <i>Int. J. Mol. Sci.<\/i>, <b>25<\/b>, 9862 (2024).","DOI":"10.3390\/ijms25189862"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Hofsink N, Groenink L, Pl\u00f6sch T. The fetal programming effect of maternal immune activation (MIA) on the offspring\u2019s immune system. <i>Semin. Immunopathol.<\/i>, <b>46<\/b>, 14 (2024).","DOI":"10.1007\/s00281-024-01023-8"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Kaisanlahti A, Turunen J, Byts N, <i>et al<\/i>. Maternal microbiota communicates with the fetus through microbiota-derived extracellular vesicles. <i>Microbiome<\/i>, <b>11<\/b>, 249 (2023).","DOI":"10.1186\/s40168-023-01694-9"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Husso A, Pessa-Morikawa T, Koistinen VM, K\u00e4rkk\u00e4inen O, Kwon HN, Lahti L, Iivanainen A, Hanhineva K, Niku M. Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta. <i>BMC Biol.<\/i>, <b>21<\/b>, 207 (2023).","DOI":"10.1186\/s12915-023-01709-9"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Singh A, Adam A, Rodriguez L, Peng BH, Wang B, Xie X, Shi PY, Homma K, Wang T. Oral supplementation with AHCC<sup>\u00ae<\/sup>, a standardized extract of cultured <i>Lentinula edodes<\/i> mycelia, enhances host resistance against SARS-CoV-2 infection. <i>Pathogens<\/i>, <b>12<\/b>, 554 (2023).","DOI":"10.3390\/pathogens12040554"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, Kirsch DG, Macvittie TJ, Mason KA, Medhora MM, Moulder JE, Okunieff P, Otterson MF, Robbins ME, Smathers JB, McBride WH. Animal models for medical countermeasures to radiation exposure. <i>Radiat. Res.<\/i>, <b>174<\/b>, 793\u2013808 (2010).","DOI":"10.1667\/RR1880.1"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/48\/11\/48_b25-00466\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T03:24:13Z","timestamp":1764386653000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/48\/11\/48_b25-00466\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b25-00466","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"article-number":"b25-00466"}}