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Protein tyrosine kinase 7 is essential for tubular morphogenesis of the Wolffian duct. <i>Dev. Biol.<\/i>, <b>412<\/b>, 219\u2013233 (2016).","DOI":"10.1016\/j.ydbio.2016.02.029"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Xu B, Santos SAA, Hinton BT. Protein tyrosine kinase 7 regulates extracellular matrix integrity and mesenchymal intracellular RAC1 and myosin II activities during Wolffian duct morphogenesis. <i>Dev. Biol.<\/i>, <b>438<\/b>, 33\u201343 (2018).","DOI":"10.1016\/j.ydbio.2018.03.011"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Antoniassi T, J\u00fanior FNF, Spessoto LCF, Guerra LH, Campos SS, Taboga S. Anti-fibrotic effect of mycophenolate mofetil on Peyronie\u2019s disease experimentally induced with TGF-\u03b2. <i>Int. J. Impot. Res.<\/i>, <b>32<\/b>, 201\u2013206 (2020).","DOI":"10.1038\/s41443-019-0138-7"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Yamada G, Hashimoto D, Fujimoto K, Nakata M, Asamura S, Kawakami Y, Lwigale P. Topohistological alignments of ocular\/penile organs. <i>Anat. Sci. Int.<\/i>, (2025), in press.","DOI":"10.1007\/s12565-025-00844-3"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Erikson A, Ortegren J, Hompland T, de Lange Davies C, Lindgren M. Quantification of the second-order nonlinear susceptibility of collagen I using a laser scanning microscope. <i>J. Biomed. Opt.<\/i>, <b>12<\/b>, 044002 (2007).","DOI":"10.1117\/1.2772311"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Hashimoto D, Kajimoto M, Ueda Y, Hyuga T, Fujimoto K, Inoue S, Suzuki K, Kataoka T, Kimura K, Yamada G. 3D reconstruction and histopathological analyses on murine corporal body. <i>Reprod. Med. Biol.<\/i>, <b>20<\/b>, 199\u2013207 (2021).","DOI":"10.1002\/rmb2.12369"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Hashimoto D, Fujimoto K, Kim SW, Lee YS, Nakata M, Suzuki K, Wada Y, Asamura S, Yamada G. Emerging structural and pathological analyses on the erectile organ, corpus cavernous containing sinusoids. <i>Reprod. Med. Biol.<\/i>, <b>22<\/b>, e12539 (2023).","DOI":"10.1002\/rmb2.12539"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Fujimoto K, Hashimoto D, Kim SW, Lee YS, Suzuki T, Nakata M, Kumegawa S, Asamura S, Yamada G. Novel erectile analyses revealed augmentable penile Lyve-1, the lymphatic marker, expression. <i>Reprod. Med. Biol.<\/i>, <b>23<\/b>, e12570 (2024).","DOI":"10.1002\/rmb2.12570"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Jang JY, Koh YJ, Lee SH, Lee J, Kim KH, Kim D, Koh GY, Yoo OJ. Conditional ablation of LYVE-1+ cells unveils defensive roles of lymphatic vessels in intestine and lymph nodes. <i>Blood<\/i>, <b>122<\/b>, 2151\u20132161 (2013).","DOI":"10.1182\/blood-2013-01-478941"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Hashimoto D, Fujimoto K, Morioka S, Ayabe S, Kataoka T, Fukumura R, Ueda Y, Kajimoto M, Hyuga T, Suzuki K, Hara I, Asamura S, Wakana S, Yoshiki A, Gondo Y, Tamura M, Sasaki T, Yamada G. Establishment of mouse line showing inducible priapism-like phenotypes. <i>Reprod. Med. Biol.<\/i>, <b>21<\/b>, e12472 (2022).","DOI":"10.1002\/rmb2.12472"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Mas M. Molecular mechanisms of penile erection. <i>Arch. Esp. Urol.<\/i>, <b>63<\/b>, 589\u2013598 (2010).","DOI":"10.4321\/S0004-06142010000800004"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Zhu TC, Finlay JC. The role of photodynamic therapy (PDT) physics. <i>Med. 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