{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:05:18Z","timestamp":1771041918552,"version":"3.50.1"},"reference-count":29,"publisher":"Pharmaceutical Society of Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2026,2,13]]},"DOI":"10.1248\/bpb.b25-00745","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T22:08:17Z","timestamp":1770934097000},"page":"310-315","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced Therapeutic Efficacy of Photodynamic Therapy Using Hybrid Liposomes Containing Indocyanine Green in a Triple-Negative Breast Cancer Mouse Model"],"prefix":"10.1248","volume":"49","author":[{"given":"Masaki","family":"Okumura","sequence":"first","affiliation":[{"name":"Division of Applied Life Sciences, Graduate School of Engineering, Sojo University, 4\u201322\u20131 Ikeda, Nishi-ku, Kumamoto 860\u20130082, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hinano","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Division of Applied Life Sciences, Graduate School of Engineering, Sojo University, 4\u201322\u20131 Ikeda, Nishi-ku, Kumamoto 860\u20130082, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junna","family":"Takai","sequence":"additional","affiliation":[{"name":"Division of Applied Life Sciences, Graduate School of Engineering, Sojo University, 4\u201322\u20131 Ikeda, Nishi-ku, Kumamoto 860\u20130082, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Goto","sequence":"additional","affiliation":[{"name":"Division of Applied Life Sciences, Graduate School of Engineering, Sojo University, 4\u201322\u20131 Ikeda, Nishi-ku, Kumamoto 860\u20130082, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Applied Life Sciences, Graduate School of Engineering, Sojo University, 4\u201322\u20131 Ikeda, Nishi-ku, Kumamoto 860\u20130082, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Ichihara","sequence":"additional","affiliation":[{"name":"Division of Applied Life Sciences, Graduate School of Engineering, Sojo University, 4\u201322\u20131 Ikeda, Nishi-ku, Kumamoto 860\u20130082, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Mondal S, Preetam S, Deshwal RK, Thapliyal S, Rustagi S, Alghamdi S, Talukdar N, Mishra R, Bora J, Banerjee S, Chakravarty Y, Malik S. Advances in prognostic and predictive biomarkers for breast cancer: Integrating multigene assays, hormone receptors, and emerging circulating biomarkers. <i>Clin. Chim. Acta<\/i>, <b>578<\/b>, 120513 (2026).","DOI":"10.1016\/j.cca.2025.120513"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Nguyen HM, Paulishak W, Oladejo M, Wood L. Dynamic tumor microenvironment, molecular heterogeneity, and distinct immunologic portrait of triple-negative breast cancer: an impact on classification and treatment approaches. <i>Breast Cancer<\/i>, <b>30<\/b>, 167\u2013186 (2023).","DOI":"10.1007\/s12282-022-01415-4"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Fallahpour S, Navaneelan T, De P, Borgo A. Breast cancer survival by molecular subtype: a population-based analysis of cancer registry data. <i>CMAJ Open<\/i>, <b>5<\/b>, E734\u2013E739 (2017).","DOI":"10.9778\/cmajo.20170030"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Diamond I, Granelli SG, McDonagh AF, Nielsen S, Wilson CB, Jaenicke R. Photodynamic therapy of malignant tumours. <i>Lancet<\/i>, <b>300<\/b>, 1175\u20131177 (1972).","DOI":"10.1016\/S0140-6736(72)92596-2"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Gao Y, Zhu L, Du Z, Xiong J, Ma R, Aili M, Alifu N, Dong B. Recent advances in near-infrared cyanine dye-based fluorescent nanoprobes for tumor imaging and therapy. <i>Int. J. Nanomedicine<\/i>, <b>20<\/b>, 13911\u201313937 (2025).","DOI":"10.2147\/IJN.S542880"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Ndongwe T, Zhou A-A, Ganga NP, Matawo N, Sibanda U, Chidziwa TV, Witika BA, Krause RWM, Matlou GG, Siwe-Noundou X. The use of nanomaterials as drug delivery systems and anticancer agents in the treatment of triple-negative breast cancer: an updated review (year 2005 to date). <i>Discov. Nano<\/i>, <b>19<\/b>, 138\u2013161 (2024).","DOI":"10.1186\/s11671-024-04089-3"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Ueoka R, Moss RA, Swarup S, Matsumoto Y, Strauss G, Murakami Y. Extraordinary micellar enantioselectivity coupled to altered aggregate structure. <i>J. Am. Chem. Soc.<\/i>, <b>107<\/b>, 2185\u20132186 (1985).","DOI":"10.1021\/ja00293a067"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Ueoka R, Matsumoto Y, Kanno A, Tsuzaki K, Ichihara H. Marked Therapeutic effect of dimyristoylphosphatidylcholine liposomes on carcinoma mice model <i>in vivo<\/i>. <i>Biol. Pharm. Bull.<\/i>, <b>23<\/b>, 1262\u20131263 (2000).","DOI":"10.1248\/bpb.23.1262"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Ueoka R, Matsumoto Y, Hirose S, Goto K, Goto M, Furusaki S. Remarkably enhanced inhibitory effects of three-component hybrid liposomes including sugar surfactants on the growth of lung carcinoma cells. <i>Chem. Pharm. Bull.<\/i>, <b>50<\/b>, 563\u2013565 (2002).","DOI":"10.1248\/cpb.50.563"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Matsumoto Y, Iwamoto Y, Matsushita T, Ueoka R. Novel mechanism of hybrid liposomes-induced apoptosis in human tumor cells. <i>Int. J. Cancer<\/i>, <b>115<\/b>, 377\u2013382 (2005).","DOI":"10.1002\/ijc.20882"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Nagami H, Matsumoto Y, Ueoka R. Chemotherapy with hybrid liposomes for lymphoma without drugs <i>in vivo<\/i>. <i>Int. J. Pharm.<\/i>, <b>315<\/b>, 167\u2013172 (2006).","DOI":"10.1016\/j.ijpharm.2006.02.012"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Nagami H, Matsumoto Y, Ueoka R. Induction of apoptosis by hybrid liposomes for human breast tumor cells along with activation of caspases. <i>Biol. Pharm. Bull.<\/i>, <b>29<\/b>, 380\u2013381 (2006).","DOI":"10.1248\/bpb.29.380"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Umebayashi M, Matsumoto Y, Ueoka R. Inhibitory effects of three-component hybrid liposomes containing cationic lipids without drugs on the growth of human renal tumor cells <i>in vitro<\/i>. <i>Biol. Pharm. Bull.<\/i>, <b>31<\/b>, 1816\u20131817 (2008).","DOI":"10.1248\/bpb.31.1816"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Shimoda S, Ichihara H, Matsumoto Y, Ueoka R. Chemotherapy with hybrid liposomes for human breast tumors along with apoptosis <i>in vivo<\/i>. <i>Int. J. Pharm.<\/i>, <b>372<\/b>, 162\u2013168 (2009).","DOI":"10.1016\/j.ijpharm.2009.01.011"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Ichihara H, Ueno J, Umebayashi M, Matsumoto Y, Ueoka R. Chemotherapy with hybrid liposomes for acute lymphatic leukemia leading to apoptosis <i>in vivo<\/i>. <i>Int. J. Pharm.<\/i>, <b>406<\/b>, 173\u2013178 (2011).","DOI":"10.1016\/j.ijpharm.2010.12.041"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Ueoka R, Matsumoto Y, Goto K, Ichihara H, Komizu Y. Membrane targeted chemotherapy with hybrid liposomes for tumor cells leading to apoptosis. <i>Curr. Pharm. Des.<\/i>, <b>17<\/b>, 1709\u20131719 (2011).","DOI":"10.2174\/138161211796355128"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Ichihara H, Zako K, Komizu Y, Goto K, Ueoka R. Therapeutic effects of hybrid liposomes composed of phosphatidylcholine and docosahexaenoic acid on the hepatic metastasis of colon carcinoma along with apoptosis <i>in vivo<\/i>. <i>Biol. Pharm. Bull.<\/i>, <b>34<\/b>, 901\u2013905 (2011).","DOI":"10.1248\/bpb.34.901"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Ichihara H, Hino M, Umebayashi M, Matsumoto Y, Ueoka R. Intravenous injection of hybrid liposomes suppresses the liver metastases in xenograft mouse models of colorectal cancer <i>in vivo<\/i>. <i>Eur. J. Med. Chem.<\/i>, <b>57<\/b>, 143\u2013148 (2012).","DOI":"10.1016\/j.ejmech.2012.08.040"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Hino M, Ichihara H, Matsumoto Y, Ueoka R. Anti-tumor effects of cationic hybrid liposomes against colon carcinoma along with apoptosis <i>in vitro<\/i>. <i>Biol. Pharm. Bull.<\/i>, <b>35<\/b>, 2097\u20132101 (2012).","DOI":"10.1248\/bpb.b12-00633"},{"key":"20","unstructured":"20) Ichihara H, Nakagawa S, Matsuoka Y, Yoshida K, Matsumoto Y, Ueoka R. Nanotherapy with hybrid liposomes for colorectal cancer along with apoptosis <i>in vitro<\/i> and <i>in vivo<\/i>. <i>Anticancer Res.<\/i>, <b>34<\/b>, 4701\u20134708 (2014)."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Ichihara H, Hino M, Ueoka R, Matsumoto Y. Therapeutic effects of cationic hybrid liposomes on the hepatic metastasis of colon carcinoma along with apoptosis <i>in vivo<\/i>. <i>Biol. Pharm. Bull.<\/i>, <b>37<\/b>, 498\u2013503 (2014).","DOI":"10.1248\/bpb.b13-00764"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Ichihara H, Okumura M, Matsumoto Y. Therapeutic effects of hybrid liposomes against xenograft mouse model of colorectal cancer <i>in vivo<\/i> due to long-term accumulation. <i>Anticancer Res.<\/i>, <b>36<\/b>, 5875\u20135882 (2016).","DOI":"10.21873\/anticanres.11173"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Okumura M, Ichihara H, Matsumoto Y. Hybrid liposomes showing enhanced accumulation in tumors as theranostic agents in the orthotopic graft model mouse of colorectal cancer. <i>Drug Deliv.<\/i>, <b>25<\/b>, 1192\u20131199 (2018).","DOI":"10.1080\/10717544.2018.1475517"},{"key":"24","unstructured":"24) Ichihara H, Nagami H, Kiyokawa T, Matsumoto Y, Ueoka R. Chemotherapy using hybrid liposomes along with induction of apoptosis. <i>Anticancer Res.<\/i>, <b>28<\/b><b> (<\/b>2B<b>)<\/b>, 1187\u20131195 (2008)."},{"key":"25","unstructured":"25) Okumura M, Otsuka H, Takai J, Goto K, Matsumoto Y, Ichihara H. Growth suppression of triple-negative breast cancer cells by the photodynamic therapy effect of hybrid liposomes containing indocyanine green. <i>J. Carcinog. Mutagen.<\/i>, <b>16<\/b>, 1000470-1-5 (2025)."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Ono A, Hattori S, Kariya R, Iwanaga S, Taura M, Harada H, Suzu S, Okada S. Comparative study of human hematopoietic cell engraftment into BALB\/c and C57BL\/6 strain of rag-2\/jak3 double-deficient mice. <i>BioMed Res. Int.<\/i>, <b>2011<\/b>, 539748 (2011).","DOI":"10.1155\/2011\/539748"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Ravanat JL, Di Mascio P, Martinez GR, Medeiros MHG, Cadet J. Singlet oxygen induces oxidation of cellular DNA. <i>J. Biol. Chem.<\/i>, <b>275<\/b>, 40601\u201340604 (2000).","DOI":"10.1074\/jbc.M006681200"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Gregoriadis G, Wills EJ, Swain CP, Tavill AS. Drug-carrier potential of liposomes in cancer chemotherapy. <i>Lancet<\/i>, <b>2<\/b>, 1313\u20131316 (1974).","DOI":"10.1016\/S0140-6736(74)90682-5"},{"key":"29","unstructured":"29) Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. <i>Cancer Res.<\/i>, <b>46<\/b>, 6387\u20136392 (1986)."}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/49\/2\/49_b25-00745\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:26:20Z","timestamp":1771039580000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/49\/2\/49_b25-00745\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b25-00745","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]},"article-number":"b25-00745"}}